The mouse Gene Expression Database (GXD): 2026 update.

Authors

• Constance M. Smith, The Jackson LaboratoryFollow
• Terry F. Hayamizu, The Jackson LaboratoryFollow
• Jacqueline H. Finger, The Jackson LaboratoryFollow
• Ingeborg J. McCright, The Jackson LaboratoryFollow
• Jingxia Xu, The Jackson LaboratoryFollow
• Jeff Campbell, The Jackson LaboratoryFollow
• Lori E. Corbani, The Jackson LaboratoryFollow
• Jake Emerson, University of MaineFollow
• Pete J. Frost, The JackFollow
• Hongping Liang, The Jackson LaboratoryFollow
• Joel E Richardson, The Jackson LaboratoryFollow
• Richard M. Baldarelli, The Jackson LaboratoryFollow
• Martin Ringwald, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

1-6-2026

Original Citation

Smith CM, Hayamizu TF, Finger JH, McCright IJ, Xu J, Campbell J, Corbani LE, Emerson J, Frost PJ, Liang H, Richardson J, Baldarelli RM, Ringwald M. The mouse Gene Expression Database (GXD): 2026 update. Nucleic Acids Res. 2026;54(D1):D1190–D6.

Keywords

JMG, JGM, Animals, Mice, Databases, Genetic, Gene Expression Profiling, Transcriptome, Software, RNA-Seq, Gene Expression

JAX Source

Nucleic Acids Res. 2026;54(D1):D1190–D6.

ISSN

1362-4962

PMID

41261740

DOI

https://doi.org/10.1093/nar/gkaf1236

Grant

This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Develop- ment (NICHD) of the National Institutes of Health (NIH) [HD062499]. Funding to pay the Open Access publication charges for this article was provided by NIH [HD062499].

Abstract

The Gene Expression Database (GXD; https://www.informatics.jax.org/expression.shtml) is an extensive, well-curated community resource that provides detailed information about gene expression patterns in mouse strains and mutants, with a particular emphasis on development. For over 25 years, GXD has systematically curated the scientific literature and collaborated with large-scale expression projects to compile and integrate detailed expression data from multiple assay types, including RNA in situ hybridization, immunohistochemistry, in situ reporter (knock-in), RT-PCR, northern blot, and western blot experiments. In recent years, GXD has expanded its scope to include bulk RNA-Seq data, imported from the EMBL-EBI Expression Atlas. Since our last report in 2021, we continued to add data to GXD on a daily basis, and we implemented new search and display features. These include: (i) searches for qualitative differential gene expression and expression profiles that include both classical types of expression data and RNA-Seq data; (ii) browsing, searching, and filtering for cell-type-specific gene expression information; and (iii) an enhancement of our RNA-Seq and microarray experiment metadata index and search to allow users to quickly and reliably find bulk, single-cell, or spatial RNA-Seq data in the public repositories.