Document Type
Article
Publication Date
1-19-2026
Original Citation
Prateek G,
Chen Z,
Wright K,
Di Francesco A,
Jojic V,
Churchill G,
Raj A.
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice. Nat Commun. 2026;17(1):1689.
Keywords
JMG, SS1, Animals, Longevity, Female, Mice, Homeostasis, Body Weight, Aging, Energy Metabolism, Phenotype, Longitudinal Studies, Quantitative Trait Loci, Adaptation, Physiological
JAX Source
Nat Commun. 2026;17(1):1689.
ISSN
2041-1723
PMID
41549098
DOI
https://doi.org/10.1038/s41467-026-68392-6
Abstract
Dense temporal measurements of physiological health, using simple and consistent assays, are essential to characterize biological processes associated with aging and evaluate the effectiveness of interventions on these processes. We measured body weight in 960 genetically diverse female mice, every 7-10 days over the full course of their lifespan. We used a state space model to characterize the trajectories of body weight throughout life and derived novel traits capturing the dynamics of body weight, 10 of which were both heritable and associated with lifespan. Genetic mapping of these body weight-derived traits identified 5 genomic loci, none of which were previously mapped to body weight. We observed that the ability to maintain stable body weight, despite fluctuations in energy intake and expenditure, was positively associated with lifespan in an age-dependent manner and mapped to a genomic locus linked to energy homeostasis. Our results highlight how dense longitudinal measurements of physiological phenotypes offer new insights into the biology of aging.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.