Document Type
Article
Publication Date
1-6-2026
Original Citation
Baron J,
Johnson C,
Schor M,
Olley D,
Nickel L,
Felix V,
Bello SM,
Greene C,
Lichenstein R,
Bisordi K,
Koka R,
Bearer C,
Macatangay R,
Ada N,
Ballenger K,
Bliss E,
Colliver L,
Dobbins G,
Heitzig H,
Dixon S,
Semesky P,
Garth J,
Fairchild M,
Gaskin P,
Zahid S,
Castillo R,
Edwards S,
Widjaja A,
Usui Y,
Lynch E,
Clarkson M,
Detwiler T,
Schriml L.
The DO-KB knowledgebase 2026 update: expanding programmatic and language access. Nucleic Acids Res. 2026;54(D1):D1425-D36
Keywords
JMG, Humans, Knowledge Bases, Biological Ontologies, Disease, Software, Internet, Language
JAX Source
Nucleic Acids Res. 2026;54(D1):D1425-D36
ISSN
1362-4962
PMID
41296549
DOI
https://doi.org/10.1093/nar/gkaf1213
Grant
National Institutes of Health – National Human Genome Research Institute (NHGRI) [1U24HG012557-01]; the anatomy work was funded by National Institutes of Health – National Institute of General Medical Sciences (NIH/NIGMS) 1R01GM149620 (University of Kentucky). Funding to pay the Open Access publication charges for this article was provided by NIH/NHGRI [1U24HG012557-01]
Abstract
The Human Disease Ontology Knowledgebase (DO-KB; https://disease-ontology.org/), a Global Core Biodata Resource, serves as a reference framework for multiscale biomedical data integration and analysis, within a unifying etiology-based disease classification. In this 2026 update of the Human Disease Ontology (DO) and DO-KB resource, we present significant advances in programmatic data retrieval and disease representation since our previous NARdb publication. Here we report on the development of a DO Nosology education program, the Spanish translation of the DO website and ontology content, and expansion of disease knowledge representation.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.