Submissions from 2016
IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG., S Samanta, H Sun, H L Goel, B Pursell, C Chang, A Khan, D L Greiner, S Cao, E Lim, Leonard D. Shultz, and A M Mercurio
Modulation of unloading-induced bone loss in mice with altered ERK signaling., Jeyantt S Sankaran, Bing Li, Leah Rae Donahue, and Stefan Judex
The neonate versus adult mammalian immune system in cardiac repair and regeneration., Susanne Sattler and Nadia Rosenthal
Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice., Sarah Adams Schoenrock, Daniel Oreper, Nancy Young, Robin Betsch Ervin, Molly A. Bogue, William Valdar, and Lisa M Tarantino
Show and tell: disclosure and data sharing in experimental pathology., Paul N. Schofield, Jerrold M. Ward, and John P Sundberg
The Genetic Basis of Baculum Size and Shape Variation in Mice., Nicholas G Schultz, Jesse Ingels, Andrew Hillhouse, Keegan Wardwell, Peter L Chang, James M Cheverud, Cathleen Lutz, Lu Lu, Robert W Williams, and Matthew D Dean
Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans., David V. Serreze, Marijke Niens, John Kulik, and Teresa P DiLorenzo
Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice., Isabelle Serr, Rainer W Fürst, Peter Achenbach, Martin G Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard D. Shultz, Richard A Willis, Anette-Gabriele Ziegler, and Carolin Daniel
Mutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and Mice., Ranad Shaheen, Shams Anazi, Tawfeg Ben-Omran, Mohammed Zain Seidahmed, L Brianna Caddle, Kristina Palmer, Rehab Ali, Tarfa Alshidi, Samya Hagos, Leslie Goodwin, Mais Hashem, Salma M Wakil, Mohamed Abouelhoda, Dilek Colak, Stephen A. Murray, and Fowzan S Alkuraya
Searching the Mouse Genome Informatics (MGI) Resources for Information on Mouse Biology from Genotype to Phenotype., David R. Shaw
Block network mapping approach to quantitative trait locus analysis., Zeina Z Shreif, Daniel Mario Gatti, and Vipul Periwal
C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury., Sean M Silverman, Byung-Jin Kim, Gareth R Howell, Joselyn Miller, Simon W M John, Robert J Wordinger, and Abbot F Clark
Variable patterns of ectopic mineralization in Enpp1asj-2J mice, a model for generalized arterial calcification of infancy., Sarah Y Siu, Nathaniel A Dyment, David W Rowe, John P Sundberg, Jouni Uitto, and Qiaoli Li
Maternal IL-6 can cause T-cell-mediated juvenile alopecia by non-scarring follicular dystrophy in mice., Stephen E P Smith, Rachel L G Maus, Tessa R Davis, John P Sundberg, Diana Gil, and Adam G Schrum
Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease., Ileana Soto, Weronika Grabowska, Kristen D. Onos, Leah C. Graham, Harriet M. Jackson, Stephen N. Simeone, and Gareth R Howell
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity., Tomokazu Souma, Stuart W Tompson, Benjamin R Thomson, Owen M Siggs, Krishnakumar Kizhatil, Shinji Yamaguchi, Liang Feng, Vachiranee Limviphuvadh, Kristina N Whisenhunt, Sebastian Maurer-Stroh, Tammy L Yanovitch, Luba Kalaydjieva, Dimitar N Azmanov, Simone Finzi, Lucia Mauri, Shahrbanou Javadiyan, Emmanuelle Souzeau, Tiger Zhou, Alex W Hewitt, Bethany Kloss, Kathryn P Burdon, David A Mackey, Keri F Allen, Jonathan B Ruddle, Sing-Hui Lim, Steve Rozen, Khanh-Nhat Tran-Viet, Xiaorong Liu, Simon W M John, Janey L Wiggs, Francesca Pasutto, Jamie E Craig, Jing Jin, Susan E Quaggin, and Terri L Young
Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency., Stefka D Spassieva, Xiaojie Ji, Ye Liu, Kenneth Gable, Jacek Bielawski, Teresa M Dunn, Erhard Bieberich, and Lihong Zhao
Synaptic Deficits at Neuromuscular Junctions in Two Mouse Models of Charcot-Marie-Tooth Type 2d., Emily L Spaulding, James N Sleigh, Kathryn H. Morelli, Martin J Pinter, Robert W. Burgess, and Kevin L. Seburn
Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment., Jessica R Spengler, Kerry J Lavender, Cynthia Martellaro, Aaron Carmody, Andreas Kurth, James G. Keck, Greg Saturday, Dana P Scott, Stuart T Nichol, Kim J Hasenkrug, Christina F Spiropoulou, Heinz Feldmann, and Joseph Prescott
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer., Randy Strong, Richard A Miller, Adam Antebi, Clinton M Astle, Molly A. Bogue, Martin S Denzel, Elizabeth Fernandez, Kevin Flurkey, Karyn L Hamilton, Dudley W Lamming, Martin A Javors, João Pedro de Magalhães, Paul Anthony Martinez, Joe M McCord, Benjamin F Miller, Michael Müller, James F Nelson, Juliet Ndukum, G Ed Rainger, Arlan Richardson, David M Sabatini, Adam B Salmon, James W Simpkins, Wilma T Steegenga, Nancy L Nadon, and David E Harrison
Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders., S J Sukoff Rizzo
Methodological Considerations for Optimizing and Validating Behavioral Assays., Stacey J Sukoff Rizzo and Jill L Silverman
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth., Kuo-Hui Su, Junyue Cao, Zijian Tang, Siyuan Dai, Yishu He, Stephen B. Sampson, Ivor J Benjamin, and Chengkai Dai
Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders., Kuo-Hui Su and Chengkai Dai
Protein quantity-quality balance licenses growth., Kuo-Hui Su and Chengkai Dai
Approaches to Investigating Complex Genetic Traits in a Large-Scale Inbred Mouse Aging Study., John P Sundberg, A Berndt, Beth A. Sundberg, Kathleen A Silva, Victoria E. Kennedy, R S Smith, T K Cooper, and P N Schofield
Dermal lymphatic dilation in a mouse model of alopecia areata., John P Sundberg, C Herbert Pratt, Kathleen A Silva, Victoria E. Kennedy, Timothy M Stearns, Beth A. Sundberg, Lloyd E King, and Harm HogenEsch
Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening., John P Sundberg, Kathleen A Silva, Lloyd E King, and C Herbert Pratt
Longevity as a complex genetic trait., George L. Sutphin and Ron Korstanje
WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning., George L. Sutphin, J Matthew Mahoney, Keith Sheppard, David O Walton, and Ron Korstanje
3D-GNOME: an integrated web service for structural modeling of the 3D genome., Przemyslaw Szalaj, Paul J Michalski, Przemysław Wróblewski, Zhonghui Tang, Michal Kadlof, Giovanni Mazzocco, Yijun Ruan, and Dariusz Plewczynski
An integrated 3-Dimensional Genome Modeling Engine for data-driven simulation of spatial genome organization., Przemysław Szałaj, Zhonghui Tang, Paul Michalski, Michal J Pietal, Oscar Junhong Luo, Michał Sadowski, Xingwang Li, Kamen Radew, Yijun Ruan, and Dariusz Plewczynski
Molecular Genetic Analysis of Ovarian Brenner Tumors and Associated Mucinous Epithelial Neoplasms: High Variant Concordance and Identification of Mutually Exclusive RAS Driver Mutations and MYC Amplification., Laura J Tafe, Kristen E Muller, Guruprasad Ananda, Talia Mitchell, Vanessa Spotlow, Sara E. Patterson, Gregory J Tsongalis, and Susan Mockus
Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR., Derek J C Tai, Ashok Ragavendran, Poornima Manavalan, Alexei Stortchevoi, Catarina M Seabra, Serkan Erdin, Ryan L Collins, Ian Blumenthal, Xiaoli Chen, Yiping Shen, Mustafa Sahin, Chengsheng Zhang, Charles Lee, James F Gusella, and Michael E Talkowski
A link between planar polarity and staircase-like bundle architecture in hair cells., Basile Tarchini, Abby Tadenev, Nicholas Devanney, and Michel Cayouette
QuIN: A Web Server for Querying and Visualizing Chromatin Interaction Networks., Asa Thibodeau, Eladio J Márquez, Oscar Junhong Luo, Yijun Ruan, Francesca Menghi, Dong-Guk Shin, Michael L. Stitzel, Paola Vera-Licona, and Duygu Ucar
Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice., Airlia C S Thompson, Matthew D Bruss, John C Price, Cyrus F Khambatta, William E Holmes, Marc Colangelo, Marcy Dalidd, Lindsay S Roberts, Clinton M Astle, David E Harrison, and Marc K Hellerstein
Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis., Cong Tian, Belinda S. Harris, and Kenneth R. Johnson
Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice., Kärt Tomberg, Rami Khoriaty, Randal J Westrick, Heather Fairfield, Laura G Reinholdt, Gary L Brodsky, Pavel Davizon-Castillo, David Ginsburg, and Jorge Di Paola
The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents., P M Treuting, J M Snyder, Y Ikeno, P N Schofield, J M Ward, and John P Sundberg
Gene regulation knowledge commons: community action takes care of DNA binding transcription factors., Sushil Tripathi, Steven Vercruysse, Konika Chawla, Karen R. Christie, Judith A. Blake, Rachael P Huntley, Sandra Orchard, Henning Hermjakob, Liv Thommesen, Astrid Lægreid, and Martin Kuiper
Effect of Advanced HIV Infection on the Respiratory Microbiome., Homer L Twigg, Kenneth S Knox, Jin Zhou, Kristina A Crothers, David E Nelson, Evelyn Toh, Richard B Day, Huaiying Lin, Xiang Gao, Qunfeng Dong, Deming Mi, Barry P Katz, Erica Sodergren Weinstock, and George M. Weinstock
Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross., Anna L. Tyler, Leah Rae Donahue, Gary A. Churchill, and Gregory W. Carter
Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity., Martin Vaeth, Miriam Eckstein, Patrick J Shaw, Lina Kozhaya, Jun Yang, Friederike Berberich-Siebelt, Robert Clancy, Derya Unutmaz, and Stefan Feske
Delivery of Cas9 Protein into Mouse Zygotes through a Series of Electroporation Dramatically Increases the Efficiency of Model Creation., Wenbo Wang, Peter M Kutny, Shannon L. Byers, Charles J Longstaff, Michael J DaCosta, Changhong Pang, Yingfan Zhang, Robert A. Taft, F William Buaas, and Haoyi Wang
Genome-Wide Probing of RNA Structures In Vitro Using Nucleases and Deep Sequencing., Yue Wan, Kun Qu, Zhengqing Ouyang, and Howard Y Chang
Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L., Ayobami Ward, Jessica Hopkins, Matthew Mckay, Stephen A Murray, and Philip W Jordan
Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective case-control study., Barbara B Warner, Elena Deych, Yanjiao Zhou, Carla Hall-Moore, George M. Weinstock, Erica Sodergren Weinstock, Nurmohammad Shaikh, Julie A Hoffmann, Laura A Linneman, Aaron Hamvas, Geetika Khanna, Lucina C Rouggly-Nickless, I Malick Ndao, Berkley A Shands, Marilyn Escobedo, Janice E Sullivan, Paula G Radmacher, William D Shannon, and Phillip I Tarr
A Glimpse of Microbial Power in Preventive Medicine., George M. Weinstock
Role of Clinicogenomics in Infectious Disease Diagnostics and Public Health Microbiology., Lars F Westblade, Alex van Belkum, Adam Grundhoff, George M. Weinstock, Eric G Pamer, Mark J Pallen, and W Michael Dunne
Editing the Mouse Genome Using the CRISPR-Cas9 System., Adam Williams, Jorge Henao-Mejia, and Richard A Flavell
Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma., Pete A. Williams, James R Tribble, Keating W. Pepper, Stephen D Cross, B Paul Morgan, James E Morgan, Simon W M John, and Gareth R Howell
Prolonging Reproductive Life after Cancer: The Need for Fertoprotective Therapies., Terri L Woodard and Ewelina Bolcun-Filas
In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells., Yusuke Yamamoto, Gang Ning, Brooke E Howitt, Karishma Mehra, Lingyan Wu, Xia Wang, Yue Hong, Florian Kern, Tay Seok Wei, Ting Zhang, Niranjan Nagarajan, Debargha Basuli, Suzy Torti, Molly Brewer, Mahesh Choolani, Frank McKeon, Christopher P Crum, and Wa Xian
Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test., E E Young, C D Bryant, S E Lee, X Peng, B Cook, H K Nair, K J Dreher, X Zhang, A A Palmer, J M Chung, J S Mogil, Elissa J Chesler, and W R Lariviere
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging., Kira Young, Sneha Borikar, Rebecca Bell, Lauren Kuffler, Vivek M. Philip, and Jennifer J. Trowbridge
Open chromatin profiling as a novel strategy for identifying cancer cell of origin., Kira Young and Jennifer J. Trowbridge
Ectopic mineralization of cartilage and collagen-rich tendons and ligaments in Enpp1asj-2J mice., Jieyu Zhang, Nathaniel A Dyment, David W Rowe, Sarah Y Siu, John P Sundberg, Jouni Uitto, and Qiaoli Li
Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders., Wen Zhang, Lifeng Zhang, Bo Liang, David Schroeder, Zhong-Wei Zhang, Gregory A. Cox, Yun Li, and Da-Ting Lin
Crim1 regulates integrin signaling in murine lens development., Ying Zhang, Jieqing Fan, Joshua W K Ho, Tommy Hu, Stephen C Kneeland, Xueping Fan, Qiongchao Xi, Michael A Sellarole, Wilhelmine N de Vries, Weining Lu, Salil A Lachke, Richard A Lang, Simon W M John, and Richard L Maas
DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization., Hengguang Zhao, Sandra Rieger, Koichiro Abe, Martin Hewison, and Thomas S Lisse
Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze., Yanjiao Zhou, Leonard B Bacharier, Megan Isaacson-Schmid, Jack Baty, Kenneth B Schechtman, Geneline Sajol, Kristine Wylie, Gregory A Storch, Mario Castro, and Avraham Beigelman
Metagenomic Approach for Identification of the Pathogens Associated with Diarrhea in Stool Specimens., Yanjiao Zhou, Kristine M Wylie, Rana E El Feghaly, Kathie A Mihindukulasuriya, Alexis Elward, David B Haslam, Gregory A Storch, and George M. Weinstock
HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure., Chenchen Zou, Yuping Zhang, and Zhengqing Ouyang
Computational inference of H3K4me3 and H3K27ac domain length., Julian Zubek, Michael L. Stitzel, Duygu Ucar, and Dariusz M Plewczynski
Mouse Models for Drug Discovery. Can New Tools and Technology Improve Translational Power?, Aamir Zuberi and Cathleen Lutz