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Submissions from 2016

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OmniSearch: a semantic search system based on the Ontology for MIcroRNA Target (OMIT) for microRNA-target gene interaction data., Jingshan Huang, Fernando Gutierrez, Harrison J Strachan, Dejing Dou, Weili Huang, Barry Smith, Judith A. Blake, Karen Eilbeck, Darren A Natale, Yu Lin, Bin Wu, Nisansa de Silva, Xiaowei Wang, Zixing Liu, Glen M Borchert, Ming Tan, and Alan Ruttenberg

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Guidelines for the functional annotation of microRNAs using the Gene Ontology., Rachael P Huntley, Dmitry Sitnikov, Marija Orlic-Milacic, Rama Balakrishnan, Peter D'Eustachio, Marc E Gillespie, Doug Howe, Anastasia Z Kalea, Lars Maegdefessel, David Osumi-Sutherland, Victoria Petri, Jennifer R Smith, Kimberly Van Auken, Valerie Wood, Anna Zampetaki, Manuel Mayr, and Ruth C Lovering

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Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation., Ryuta Ishimura, Gabor Nagy, Ivan Dotu, Jeffrey H Chuang, and Susan L. Ackerman

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Alternate-locus aware variant calling in whole genome sequencing., Marten Jäger, Max Schubach, Tomasz Zemojtel, Knut Reinert, Deanna M Church, and Peter N Robinson

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Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice., Shweta Jain, Giljun Park, Thomas J. Sproule, Gregory J. Christianson, Caroline M. Leeth, Hongsheng Wang, Derry C. Roopenian, and Herbert C Morse

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Improved B cell development in humanized NOD-scid IL2Rγ(null) mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3., Sonal Jangalwe, Leonard D. Shultz, Anuja Mathew, and Michael A Brehm

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An inquiry into the causes and effects of the variolae (or Cow-pox. 1798)., Alfred B Jenson, Shin-Je Ghim, and John P Sundberg

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Heritability of in vitro phenotypes exhibited by murine adipose-derived stromal cells., Zixuan Jiang, David E Harrison, Makayla E Parsons, Susan McClatchy, Lawrence Jacobs, and Robert Pazdro

Lysosomal Trafficking Regulator (LYST)., Xiaojie Ji, Bo Chang, Juergen K. Naggert, and Patsy M. Nishina

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Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, θ., Xiaojie Ji, Ye Liu, Ronald E. Hurd, Jieping Wang, Bernie Fitzmaurice, Patsy M. Nishina, and Bo Chang

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MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs)., Joongho Joh, Shin-Je Ghim, Paula M Chilton, John P Sundberg, Jino Park, Sarah A Wilcher, Mary L Proctor, and A Bennett Jenson

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A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice., Kenneth R. Johnson, Leona H. Gagnon, and Bo Chang

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Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder., Julie M Jones, Louise A. Dionne, James Dell'Orco, Rachel Parent, Jamie N Krueger, Xiaoyang Cheng, Sulayman D Dib-Hajj, Rosie K Bunton-Stasyshyn, Lisa M Sharkey, James J Dowling, Geoffrey G Murphy, Vikram G Shakkottai, Peter Shrager, and Miriam H Meisler

Genetic and tissue level muscle-bone interactions during unloading and reambulation., S Judex, W Zhang, Leah Rae Donahue, and E Ozcivici

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Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung., Seung-Hyun Jung, Min Sung Kim, Sung-Hak Lee, Hyun-Chun Park, Hyun Joo Choi, Leeso Maeng, Ki Ouk Min, Jeana Kim, Tae In Park, Ok Ran Shin, Tae-Jung Kim, Haidong Xu, Kyo Young Lee, Tae-Min Kim, Sang Yong Song, Charles Lee, Yeun-Jun Chung, and Sug Hyung Lee

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Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β., Agata Jurczyk, Anetta Nowosielska, Natalia Przewozniak, Ken-Edwin Aryee, Philip DiIorio, David Blodgett, Chaoxing Yang, Martha Campbell-Thompson, Mark Atkinson, Leonard D. Shultz, Ann Rittenhouse, David Harlan, Dale Greiner, and Rita Bortell

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Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function., Ulrike Kaufmann, Patrick J Shaw, Lina Kozhaya, Raju Subramanian, Kevin Gaida, Derya Unutmaz, Helen J McBride, and Stefan Feske

Humanized Mouse Models for Transplant Immunology., L L Kenney, Leonard D. Shultz, D L Greiner, and M A Brehm

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HIV-Infected Children Have Lower Frequencies of CD8+ Mucosal-Associated Invariant T (MAIT) Cells that Correlate with Innate, Th17 and Th22 Cell Subsets., Alka Khaitan, Max Kilberg, Adam Kravietz, Tiina Ilmet, Cihan Tastan, Mussa Mwamzuka, Fatma Marshed, Mengling Liu, Aabid Ahmed, William Borkowsky, and Derya Unutmaz

FOXP3+Helios+ Regulatory T Cells, Immune Activation, and Advancing Disease in HIV-Infected Children., Alka Khaitan, Adam Kravietz, Mussa Mwamzuka, Fatma Marshed, Tiina Ilmet, Swalehe Said, Aabid Ahmed, William Borkowsky, and Derya Unutmaz

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An In Vitro Perfusion System to Enhance Outflow Studies in Mouse Eyes., Krishnakumar Kizhatil, Arthur Chlebowski, Nicholas G Tolman, Nelson F Freeburg, Margaret M Ryan, Nicholas N Shaw, Alexander D M Kokini, Jeffrey K Marchant, and Simon W M John

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Sudden acquired retinal degeneration syndrome (SARDS) - a review and proposed strategies toward a better understanding of pathogenesis, early diagnosis, and therapy., András M Komáromy, Kenneth L Abrams, John R Heckenlively, Steven K Lundy, David J Maggs, Caroline M Leeth, Puliyur S MohanKumar, Simon M Petersen-Jones, David V. Serreze, and Alexandra van der Woerdt

Comparison of the acute ultraviolet photoresponse in congenic albino hairless C57BL/6J mice relative to outbred SKH1 hairless mice., Raymond L Konger, Ethel Derr-Yellin, Delaram Hojati, Cathleen Lutz, and John P Sundberg

Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria., Ron Korstanje, Konstantin Deutsch, Patricia Bolanos-Palmieri, Nils Hanke, Patricia Schroder, Lynne Staggs, Jan H Bräsen, Ian S D Roberts, Susan Sheehan, Holly S Savage, Hermann Haller, and Mario Schiffer

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The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan., Jonathan J Kotzin, Sean P Spencer, Sam J McCright, Dinesh B Uthaya Kumar, Magalie A Collet, Walter K Mowel, Ellen N Elliott, Asli Uyar, Michelle A Makiya, Margaret C Dunagin, Christian C D Harman, Anthony T Virtue, Stella Zhu, Will Bailis, Judith Stein, Cynthia Hughes, Arjun Raj, E John Wherry, Loyal A Goff, Amy D Klion, John L Rinn, Adam Williams, Richard A Flavell, and Jorge Henao-Mejia

Bright-Field Imaging and Optical Coherence Tomography of the Mouse Posterior Eye., Mark P Krebs, Mei Xiao, Keith Sheppard, Wanda L. Hicks, and Patsy M. Nishina

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Computational inference of a genomic pluripotency signature in human and mouse stem cells., Esra Kurum, Bérénice A Benayoun, Ankit Malhotra, Joshy George, and Duygu Ucar

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The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina., Marine Lacomme, Basile Tarchini, Camille Boudreau-Pinsonneault, Carine Monat, and Michel Cayouette

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multiClust: An R-package for Identifying Biologically Relevant Clusters in Cancer Transcriptome Profiles, Nathan Lawlor, Alec Fabbri, Peiyong Guan, Joshy George, and Radha Krishna Murthy Karuturi

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Diversity Exiting the Academy: Influential Factors for the Career Choice of Well-Represented and Underrepresented Minority Scientists., Rebekah L Layton, Patrick D Brandt, Ashalla M Freeman, Jessica R Harrell, Joshua D Hall, and Melanie Sinche

CRIPT exonic deletion and a novel missense mutation in a female with short stature, dysmorphic features, microcephaly, and pigmentary abnormalities., Magalie S Leduc, Zhiyv Niu, Weimin Bi, Wenmiao Zhu, Irene Miloslavskaya, Theodore Chiang, Haley Streff, John R Seavitt, Stephen A Murray, Christine Eng, Audrey Chan, Yaping Yang, and Seema R Lalani

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Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans., Benjamin P Lee, Luke C Pilling, Florence Emond, Kevin Flurkey, David E Harrison, Rong Yuan, Luanne L. Peters, George A Kuchel, Luigi Ferrucci, David Melzer, and Lorna W Harries

B-lymphocytes expressing an immunoglobulin specificity recognizing the pancreatic ß-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice., Caroline M. Leeth, Jeremy Racine, Harold D. Chapman, Berta Arpa, Jorge Carrillo, Jorge Carrascal, Qiming Wang, Jeremy Ratiu, Leire Egia-Mendikute, Estela Rosell-Mases, Thomas Stratmann, Joan Verdaguer, and David V. Serreze

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The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter., Sérgio Carvalho Leite, Paula Sampaio, Vera Filipe Sousa, Joana Nogueira-Rodrigues, Rita Pinto-Costa, Luanne L. Peters, Pedro Brites, and Mónica Mendes Sousa

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Analysis of protein-coding genetic variation in 60,706 humans., Monkol Lek, Konrad J Karczewski, Eric V Minikel, Kaitlin E Samocha, Eric Banks, Timothy Fennell, Anne H O'Donnell-Luria, James S Ware, Andrew J Hill, Beryl B Cummings, Taru Tukiainen, Daniel P Birnbaum, Jack A Kosmicki, Laramie E Duncan, Karol Estrada, Fengmei Zhao, James Zou, Emma Pierce-Hoffman, Joanne Berghout, David N Cooper, Nicole Deflaux, Mark DePristo, Ron Do, Jason Flannick, Menachem Fromer, Laura Gauthier, Jackie Goldstein, Namrata Gupta, Daniel Howrigan, Adam Kiezun, Mitja I Kurki, Ami Levy Moonshine, Pradeep Natarajan, Lorena Orozco, Gina M Peloso, Ryan Poplin, Manuel A Rivas, Valentin Ruano-Rubio, Samuel A Rose, Douglas M Ruderfer, Khalid Shakir, Peter D Stenson, Christine Stevens, Brett P Thomas, Grace Tiao, Maria T Tusie-Luna, Ben Weisburd, Hong-Hee Won, Dongmei Yu, David M Altshuler, Diego Ardissino, Michael Boehnke, John Danesh, Stacey Donnelly, Roberto Elosua, Jose C Florez, Stacey B Gabriel, Gad Getz, Stephen J Glatt, Christina M Hultman, Sekar Kathiresan, Markku Laakso, Steven McCarroll, Mark I McCarthy, Dermot McGovern, Ruth McPherson, Benjamin M Neale, Aarno Palotie, Shaun M Purcell, Danish Saleheen, Jeremiah M Scharf, Pamela Sklar, Patrick F Sullivan, Jaakko Tuomilehto, Ming T Tsuang, Hugh C Watkins, James G Wilson, Mark J Daly, and Daniel G MacArthur

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Penetrance of Congenital Heart Disease in a Mouse Model of Down Syndrome Depends on a Trisomic Potentiator of a Disomic Modifier., Huiqing Li, Sarah Edie, Donna Klinedinst, Jun Seop Jeong, Seth Blackshaw, Cheryl L Maslen, and Roger H Reeves

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Time of Initiating Enzyme Replacement Therapy Affects Immune Abnormalities and Disease Severity in Patients with Gaucher Disease., Renuka Pudi Limgala, Chidima Ioanou, Matthew Plassmeyer, Mark Ryherd, Lina Kozhaya, Lauren Austin, Cem Abidoglu, Derya Unutmaz, Oral Alpan, and Ozlem Goker-Alpan

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Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer., Tzu-Yin Lin, Yuanpei Li, Qiangqiang Liu, Jui-Lin Chen, Hongyong Zhang, Diana Lac, Hua Zhang, Katherine W Ferrara, Sebastian Wachsmann-Hogiu, Tianhong Li, Susan Airhart, Ralph deVere White, Kit S Lam, and Chong-Xian Pan

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Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis., Qiaoli Li, Annerose Berndt, Beth A. Sundberg, Kathleen A Silva, Victoria E. Kennedy, Clinton L Cario, Matthew A Richardson, Thomas H Chase, Paul N Schofield, Jouni Uitto, and John P Sundberg

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Dual Effects of Bisphosphonates on Ectopic Skin and Vascular Soft Tissue Mineralization versus Bone Microarchitecture in a Mouse Model of Generalized Arterial Calcification of Infancy., Qiaoli Li, Joshua Kingman, John P Sundberg, Michael A Levine, and Jouni Uitto

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Comparative transcriptomic profiling of hydrogen peroxide signaling networks in zebrafish and human keratinocytes: Implications toward conservation, migration and wound healing., Thomas S Lisse, Benjamin L King, and Sandra Rieger

Patient-Derived Tumor Xenografts: Why Now?, Edison T. Liu, Carol J Bult, and Leonard D. Shultz

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Animal-based studies will be essential for precision medicine., K C Kent Lloyd, Peter N Robinson, and Calum A MacRae

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Organization, evolution and functions of the human and mouse Ly6/uPAR family genes., Chelsea L Loughner, Elspeth A Bruford, Monica McAndrews, Emili E Delp, Sudha Swamynathan, and Shivalingappa K Swamynathan

Simple, Efficient CRISPR-Cas9-Mediated Gene Editing in Mice: Strategies and Methods., Benjamin E. Low, Peter M Kutny, and Michael V. Wiles

Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice., Benjamin E. Low, Robert A. Taft, and Michael V. Wiles

A Humanized Mouse Model to Study Human Albumin and Albumin Conjugates Pharmacokinetics., Benjamin E. Low and Michael V. Wiles

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Anatomical and Gene Expression Changes in the Retinal Pigmented Epithelium Atrophy 1 (rpea1) Mouse: A Potential Model of Serous Retinal Detachment., Gabriel Luna, Geoffrey P Lewis, Kenneth A Linberg, Bo Chang, Quiri Hu, Peter J Munson, Arvydas Maminishkis, Sheldon S Miller, and Steven K Fisher

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Autoimmune manifestations in aged mice arise from early-life immune dysregulation., Tamer I Mahmoud, Jingya Wang, Jodi L Karnell, Qiming Wang, Shu Wang, Brian Naiman, Phillip Gross, Philip Z Brohawn, Chris Morehouse, Jordan Aoyama, Clive Wasserfall, Laura Carter, Mark A Atkinson, David V. Serreze, Helen Braley-Mullen, Tomas Mustelin, Roland Kolbeck, Ronald Herbst, and Rachel Ettinger

Report of the National Heart, Lung, and Blood Institute Working Group on Sex Differences Research in Cardiovascular Disease: Scientific Questions and Challenges., Christine Maric-Bilkan, Arthur P Arnold, Doris A Taylor, Melinda Dwinell, Susan E Howlett, Nanette Wenger, Jane F Reckelhoff, Kathryn Sandberg, Gary Churchill, Ellis Levin, and Martha S Lundberg

Testing the Feasibility of Remote Patient Monitoring in Prenatal Care Using a Mobile App and Connected Devices: A Prospective Observational Trial., Kathryn I Marko, Jill M Krapf, Andrew C Meltzer, Julia Oh, Nihar Ganju, Anjali G Martinez, Sheetal G Sheth, and Nancy D Gaba

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Longitudinal Prediction of the Infant Gut Microbiome with Dynamic Bayesian Networks., Michael J McGeachie, Joanne E Sordillo, Travis Gibson, George M. Weinstock, Yang-Yu Liu, Diane R Gold, Scott T Weiss, and Augusto Litonjua

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Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption., Natalie S McGuier, William C Griffin, Justin T Gass, Audrey E Padula, Elissa J Chesler, and Patrick J Mulholland

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The tandem duplicator phenotype as a distinct genomic configuration in cancer., Francesca Menghi, Koichiro Inaki, XingYi Woo, Pooja A Kumar, Krzysztof R. Grzeda, Ankit Malhotra, Vinod Yadav, Hyunsoo Kim, Eladio J Marquez, Duygu Ucar, Phung T Shreckengast, Joel P. Wagner, George MacIntyre, Krishna R Murthy Karuturi, Ralph Scully, James Keck, Jeffrey H Chuang, and Edison Liu

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Reply to Watkins et al.: Whole-genome sequencing-based identification of diverse tandem duplicator phenotypes in human cancers., Francesca Menghi and Edison Liu

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A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours., Regino Mercado-Lubo, Yuanwei Zhang, Liang Zhao, Kyle Rossi, Xiang Wu, Yekui Zou, Antonio Castillo, Jack Leonard, Rita Bortell, Dale L Greiner, Leonard D. Shultz, Gang Han, and Beth A McCormick

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β-catenin-mediated adhesion is required for successful preimplantation mouse embryo development., Daniel Messerschmidt, Wilhelmine N de Vries, Chanchao Lorthongpanich, Sathish Balu, Davor Solter, and Barbara B Knowles

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Towards a standard ontology metadata model., Hua Min, Stuart Turner, Sherri de Coronado, Brian Davis, Trish Whetzel, Robert R. Freimuth, Harold R. Solbrig, Richard Kiefer, Grace Stafford, Lawrence Wright, and Riki Ohira

Clinical Trials in Precision Oncology., Susan Mockus, Sara E. Patterson, Cara M. Statz, Carol J Bult, and Gregory J Tsongalis

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The Mouse Universal Genotyping Array: From Substrains to Subspecies., Andrew P Morgan, Chen-Ping Fu, Chia-Yu Kao, Catherine E Welsh, John P Didion, Liran Yadgary, Leeanna Hyacinth, Martin T Ferris, Timothy A Bell, Darla R Miller, Paola Giusti-Rodriguez, Randal J Nonneman, Kevin D Cook, Jason K Whitmire, Lisa E Gralinski, Mark Keller, Alan D Attie, Gary Churchill, Petko M. Petkov, Patrick F Sullivan, Jennifer R Brennan, Leonard McMillan, and Fernando Pardo-Manuel de Villena

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Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness., Nicholas M Morton, Jasmina Beltram, Roderick N Carter, Zoi Michailidou, Gregor Gorjanc, Clare McFadden, Martin E Barrios-Llerena, Sergio Rodriguez-Cuenca, Matthew T G Gibbins, Rhona E Aird, José Maria Moreno-Navarrete, Steven C. Munger, Karen L. Svenson, Annalisa Gastaldello, Lynne Ramage, Gregorio Naredo, Maximilian Zeyda, Zhao V Wang, Alexander F Howie, Aila Saari, Petra Sipilä, Thomas M Stulnig, Vilmundur Gudnason, Christopher J Kenyon, Jonathan R Seckl, Brian R Walker, Scott P Webster, Donald R Dunbar, Gary A Churchill, Antonio Vidal-Puig, José Manuel Fernandez-Real, Valur Emilsson, and Simon Horvat

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Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury., Jill Moser, Joris van Ark, Marcory C van Dijk, Dale L Greiner, Leonard D. Shultz, Harry van Goor, and Jan-Luuk Hillebrands

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The real cost of sequencing: scaling computation to keep pace with data generation., Paul Muir, Shantao Li, Shaoke Lou, Daifeng Wang, Daniel J Spakowicz, Leonidas Salichos, Jing Zhang, George M. Weinstock, Farren Isaacs, Joel Rozowsky, and Mark Gerstein

NIA Interventions testing program: A Collaborative approach for investigating interventions to promote healthy aging., Nancy L. Nadon, Richard A. Miller, Randy Strong, and David E Harrison

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YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17., K Saidas Nair, Mihai Cosma, Narayanan Raghupathy, Michael A Sellarole, Nicholas G Tolman, Wilhelmine N de Vries, Richard Smith, and Simon W M John

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Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice., Yuho Najima, Mariko Tomizawa-Murasawa, Yoriko Saito, Takashi Watanabe, Rintaro Ono, Toshiki Ochi, Nahoko Suzuki, Hiroshi Fujiwara, Osamu Ohara, Leonard D. Shultz, Masaki Yasukawa, and Fumihiko Ishikawa

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Effects of Walnut Consumption on Colon Carcinogenesis and Microbial Community Structure., Masako Nakanishi, Yanfei Chen, Veneta Qendro, Shingo Miyamoto, Erica Sodergren Weinstock, George M. Weinstock, and Daniel W Rosenberg

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Health and population effects of rare gene knockouts in adult humans with related parents., Vagheesh M Narasimhan, Karen A Hunt, Dan Mason, Christopher L. Baker, Konrad J Karczewski, Michael R Barnes, Anthony H Barnett, Chris Bates, Srikanth Bellary, Nicholas A Bockett, Kristina Giorda, Christopher J Griffiths, Harry Hemingway, Zhilong Jia, M Ann Kelly, Hajrah A Khawaja, Monkol Lek, Shane McCarthy, Rosie McEachan, Anne O'Donnell-Luria, Kenneth Paigen, Constantinos A Parisinos, Eamonn Sheridan, Laura Southgate, Louise Tee, Mark Thomas, Yali Xue, Michael Schnall-Levin, Petko M. Petkov, Chris Tyler-Smith, Eamonn R Maher, Richard C Trembath, Daniel G MacArthur, John Wright, Richard Durbin, and David A van Heel

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A Cross-Species Analysis of Animal Models for the Investigation of Preterm Birth Mechanisms., Brian W Nielsen, Elizabeth A Bonney, Bradley D Pearce, Leah Rae Donahue, and Indra Neil Sarkar

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Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse., Thomas Nolte, Patricia Brander-Weber, Charles Dangler, Ulrich Deschl, Michael R Elwell, Peter Greaves, Richard Hailey, Michael W Leach, Arun R Pandiri, Arlin Rogers, Cynthia C Shackelford, Andrew Spencer, Takuji Tanaka, and Jerrold M Ward

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Temporal Stability of the Human Skin Microbiome., Julia Oh, Allyson L Byrd, Morgan Park, NISC Compartive Sequencing Program, Heidi H Kong, and Julia A Segre

Application of Mouse Models to Research in Hearing and Balance., Kevin K Ohlemiller, Sherri M Jones, and Kenneth R. Johnson

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Toward more predictive genetic mouse models of Alzheimer's disease., Kristen D Onos, Stacey J. Sukoff Rizzo, Gareth R Howell, and Michael Sasner

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A computational model of invasive aspergillosis in the lung and the role of iron., Matthew Oremland, Kathryn R Michels, Alexandra M Bettina, Chris Lawrence, Borna Mehrad, and Reinhard Laubenbacher

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C9orf72 is required for proper macrophage and microglial function in mice., J G O'Rourke, Laurent P. Bogdanik, A Yáñez, D Lall, A J Wolf, A K M G Muhammad, R Ho, S Carmona, J P Vit, J Zarrow, K J Kim, S Bell, M B Harms, T M Miller, C A Dangler, D M Underhill, H S Goodridge, Cathleen Lutz, and R H Baloh

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Effects of Varied Housing Density on a Hybrid Mouse Strain Followed for 20 Months., Beverly Paigen, Joanne M Currer, and Karen L. Svenson

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Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology., Kristina Palmer, Heather Fairfield, Suhaib Borgeia, Michelle Curtain, Mohamed G Hassan, Louise A. Dionne, Son Yong Karst, Harold Coombs, Roderick T Bronson, Laura G Reinholdt, David E. Bergstrom, Leah Rae Donahue, Timothy C Cox, and Stephen A Murray

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The Basis of Oncoimmunology., A. Karolina Palucka and Lisa M Coussens

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Diversity and collaboration for effective immunotherapy., Karolina Palucka and Jacques Banchereau

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The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies., Sara E. Patterson, Rangjiao Liu, Cara M. Statz, Daniel Durkin, Anuradha Lakshminarayana, and Susan M. Mockus

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Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics., Weijie Peng, Derya Unutmaz, and Ibrahim T Ozbolat

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ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope., Andrew C Phillips, Erwin R Boghaert, Kedar S Vaidya, Michael J Mitten, Suzanne Norvell, Hugh D Falls, Peter J DeVries, Dong Cheng, Jonathan A Meulbroek, Fritz G Buchanan, Laura M McKay, Neal C Goodwin, and Edward B Reilly

Revisiting Cardiac Cellular Composition., Alexander R Pinto, Alexei Ilinykh, Malina J Ivey, Jill T Kuwabara, Michelle L D'Antoni, Ryan Debuque, Anjana Chandran, Lina Wang, Komal Arora, Nadia A Rosenthal, and Michelle D Tallquist

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Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling., Jonathan M Pitt, Simon Blankley, Krzysztof Potempa, Christine M Graham, Lucia Moreira-Teixeira, Finlay W McNab, Ashleigh Howes, Evangelos Stavropoulos, Virginia Pascual, Jacques Banchereau, Damien Chaussabel, and Anne O'Garra

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Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated cristae by mitofilin down-regulation concomitant to MICOS clustering., Lydie Plecitá-Hlavatá, Hana Engstová, Lukáš Alán, Tomáš Špaček, Andrea Dlasková, Katarína Smolková, Jitka Špačková, Jan Tauber, Vendula Strádalová, Jan Malínský, Mark Lessard, Joerg Bewersdorf, and Petr Ježek

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The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo., Natalie R Powers, Emil D Parvanov, Christopher L. Baker, Michael Walker, Petko M. Petkov, and Kenneth Paigen

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Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences., G David Poznik, Yali Xue, Fernando L Mendez, Thomas F Willems, Andrea Massaia, Melissa A Wilson Sayres, Qasim Ayub, Shane A McCarthy, Apurva Narechania, Seva Kashin, Yuan Chen, Ruby Banerjee, Juan L Rodriguez-Flores, Maria Cerezo, Haojing Shao, Melissa Gymrek, Ankit Malhotra, Sandra Louzada, Rob Desalle, Graham R S Ritchie, Eliza Cerveira, Tomas W Fitzgerald, Erik Garrison, Anthony Marcketta, David Mittelman, Mallory Romanovitch, Chengsheng Zhang, Xiangqun Zheng-Bradley, Gonçalo R Abecasis, Steven A McCarroll, Paul Flicek, Peter A Underhill, Lachlan Coin, Daniel R Zerbino, Fengtang Yang, Charles Lee, Laura Clarke, Adam Auton, Yaniv Erlich, Robert E Handsaker, Carlos D Bustamante, and Chris Tyler-Smith

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Gnaq(M1J): An ENU-Induced Mutant Allele Affecting Pigmentation in the Mouse., C Herbert Pratt, Louise A. Dionne, Heather Fairfield, Soheil S Dadras, Christopher S Potter, and John P Sundberg

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Spontaneous partial loss of the OT-I transgene., Gretchen Harms Pritchard, Eric W Cross, Marjorie Strobel, Stephen C Jameson, Ross M Kedl, Kristin A Hogquist, and Christopher A Hunter

Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains., A H Putman, A R Wolen, J L Harenza, R K Yordanova, B T Webb, Elissa J Chesler, and M F Miles

Generating Mouse Models Using CRISPR-Cas9-Mediated Genome Editing., Wenning Qin, Peter Kutny, Richard S. Maser, Stephanie L. Dion, Jeffrey D Lamont, Yingfan Zhang, Greggory A Perry, and Haoyi Wang

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Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes., Peter C. Reifsnyder, Kevin Flurkey, Austen Te, and David E Harrison

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Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs., Isis Ricaño-Ponce, Daria V Zhernakova, Patrick Deelen, Oscar Junhong Luo, Xingwang Li, Aaron Isaacs, Juha Karjalainen, Jennifer Di Tommaso, Zuzanna Agnieszka Borek, Maria M Zorro, Javier Gutierrez-Achury, Andre G Uitterlinden, Albert Hofman, Joyce van Meurs, Mihai G Netea, Iris H Jonkers, Sebo Withoff, Cornelia M van Duijn, Yang Li, Yijun Ruan, Lude Franke, Cisca Wijmenga, and Vinod Kumar

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The Human Vaccines Project: A roadmap for cancer vaccine development., Pedro Romero, Jacques Banchereau, Nina Bhardwaj, Mark Cockett, Mary L Disis, Glenn Dranoff, Eli Gilboa, Scott A Hammond, Robert Hershberg, Alan J Korman, Pia Kvistborg, Cornelis Melief, Ira Mellman, Karolina Palucka, Irina Redchenko, Harlan Robins, Federica Sallusto, Theodore Schenkelberg, Stephen Schoenberger, Jeffrey Sosman, Özlem Türeci, Benoît Van den Eynde, Wayne Koff, and George Coukos

Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies., Derry C. Roopenian, Gregory J. Christianson, Gabriele Proetzel, and Thomas J. Sproule

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Regenerative medicine: today's discoveries informing the future of medical practice., Nadia Rosenthal and Stephen Badylak

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Addressing intra-tumoral heterogeneity and therapy resistance., Brad Rybinski and Kyuson Yun

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Household air pollution and the lung microbiome of healthy adults in Malawi: a cross-sectional study., Jamie Rylance, Anstead Kankwatira, David E Nelson, Evelyn Toh, Richard B Day, Huaiying Lin, Xiang Gao, Qunfeng Dong, Erica Sodergren Weinstock, George M. Weinstock, Robert S Heyderman, Homer L Twigg, and Stephen B Gordon

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Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity., Nicole T M Saksens, Mark P. Krebs, Frederieke E Schoenmaker-Koller, Wanda L. Hicks, Minzhong Yu, Lanying Shi, Lucy B. Rowe, Gayle B. Collin, Jeremy R. Charette, Stef J Letteboer, Kornelia Neveling, Tamara W van Moorsel, Sleiman Abu-Ltaif, Elfride De Baere, Sophie Walraedt, Sandro Banfi, Francesca Simonelli, Frans P M Cremers, Camiel J F Boon, Ronald Roepman, Bart P Leroy, Neal S Peachey, Carel B Hoyng, Patsy M. Nishina, and Anneke I den Hollander

Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition., Hélène Salmon, Juliana Idoyaga, Adeeb Rahman, Marylène Leboeuf, Romain Remark, Stefan Jordan, Maria Casanova-Acebes, Makhzuna Khudoynazarova, Judith Agudo, Navpreet Tung, Svetoslav Chakarov, Christina Rivera, Brandon Hogstad, Marcus Bosenberg, Daigo Hashimoto, Sacha Gnjatic, Nina Bhardwaj, Karolina Palucka, Brian D Brown, Joshua Brody, Florent Ginhoux, and Miriam Merad