Submissions from 2025
Clonal dynamics and somatic evolution of haematopoiesis in mouse., Chiraag D Kapadia, Nicholas Williams, Kevin J Dawson, Caroline Watson, Matthew J Yousefzadeh, Duy Le, Kudzai Nyamondo, Sreeya Kodavali, Alex Cagan, Sarah Waldvogel, Xiaoyan Zhang, Josephine De La Fuente, Daniel Leongamornlert, Emily Mitchell, Marcus A Florez, Krzysztof Sosnowski, Rogelio Aguilar, Alejandra Martell, Anna Guzman, David E Harrison, Laura J Niedernhofer, Katherine Y King, Peter J Campbell, Jamie Blundell, Margaret A Goodell, and Jyoti Nangalia
The impact of co-housing on murine aging studies., Alison Luciano and Gary Churchill
Analysis of lifespan across diversity outbred mouse studies identifies multiple longevity-associated loci., Martin N Mullis, Kevin M Wright, Anil Raj, Daniel M Gatti, Peter C. Reifsnyder, Kevin Flurkey, Jonathan R Archer, Laura Robinson, Andrea Di Francesco, Karen L. Svenson, Ron Korstanje, David E Harrison, J Graham Ruby, and Gary Churchill
Submissions from 2024
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used., David E Harrison, Randy Strong, Peter C. Reifsnyder, Nadia Rosenthal, Ron Korstanje, Elizabeth Fernandez, Kevin Flurkey, Brett C Ginsburg, Meredith D Murrell, Martin A Javors, Marisa Lopez-Cruzan, James F Nelson, Bradley J Willcox, Richard Allsopp, David M Watumull, David G Watumull, Gino Cortopassi, James L Kirkland, Tamar Tchkonia, Young Geun Choi, Matthew J Yousefzadeh, Paul D Robbins, James R Mitchell, Murat Acar, Ethan A Sarnoski, Michael R Bene, Adam Salmon, Navasuja Kumar, and Richard A Miller
Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin., Richard A Miller, David E Harrison, Gino A Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G Geisler, Brett C Ginsburg, Melissa L Han, Catherine C Kaczorowski, Navasuja Kumar, Scott F Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R Mitchell, James F Nelson, Peter C. Reifsnyder, Adam B Salmon, Ron Korstanje, Nadia Rosenthal, and Randy Strong
Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging., Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A Miller, David E Harrison, John R Strong, Mitchell B Schaffler, and Shoshana Yakar
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice., Sher Bahadur Poudel, Ryan R Ruff, Gozde Yildirim, Richard A Miller, David E Harrison, Randy Strong, Thorsten Kirsch, and Shoshana Yakar
A machine learning approach for quantifying age-related histological changes in the mouse kidney., Susan Sheehan, Seamus Mawe, Mandy Chen, Jenna Klug, Warren Ladiges, Ron Korstanje, and J Matthew Mahoney
Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice., Jake W Willows, Zahra Alshahal, Naeemah M Story, Michele J Alves, Pablo Vidal, Hallie Harris, Rochelle Rodrigo, Kristin I Stanford, Juan Peng, Peter C. Reifsnyder, David E Harrison, W David Arnold, and Kristy L Townsend
Submissions from 2023
Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice., Jessica M Snyder, Kerriann M Casey, Andrzej Galecki, David E Harrison, Hashan Jayarathne, Navasuja Kumar, Francesca Macchiarini, Nadia Rosenthal, Marianna Sadagurski, Adam B Salmon, Randy Strong, Richard A Miller, and Warren Ladiges
Long-term effects of canagliflozin treatment on the skeleton of aged UM-HET3 mice., Gozde Yildirim, Edmara T P Bergamo, Sher Bahadur Poudel, Ryan R Ruff, Manisha Dixit, Bin Hu, Dindo Q Mijares, Lukasz Witek, Carolyn Chlebek, David E Harrison, Randy Strong, Richard A Miller, Warren Ladiges, Timothy G Bromage, Clifford J Rosen, and Shoshana Yakar
Submissions from 2022
Sex- and age-dependent genetics of longevity in a heterogeneous mouse population., Maroun Bou Sleiman, Suheeta Roy, Arwen W Gao, Marie C Sadler, Giacomo V G von Alvensleben, Hao Li, Saunak Sen, David E Harrison, James F Nelson, Randy Strong, Richard A Miller, Zoltán Kutalik, Robert W Williams, and Johan Auwerx
Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice, Peter C. Reifsnyder, Kevin Flurkey, Rosalinda A. Doty, Nigel A. Calcutt, Robert A. Koza, and David E Harrison
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice., Randy Strong, Richard A Miller, Catherine J Cheng, James F Nelson, Jonathan Gelfond, Shailaja Kesaraju Allani, Vivian Diaz, Angela Olsen Dorigatti, Jonathan Dorigatti, Elizabeth Fernandez, Andrzej Galecki, Brett Ginsburg, Karyn L Hamilton, Martin A Javors, Kerry Kornfeld, Matt Kaeberlein, Suja Kumar, David B Lombard, Marisa Lopez-Cruzan, Benjamin F Miller, Peter Rabinovitch, Peter C. Reifsnyder, Nadia Rosenthal, Molly A. Bogue, Adam B Salmon, Yousin Suh, Eric Verdin, Herbert Weissbach, John Newman, Francesca Maccchiarini, and David E. Harrison
Submissions from 2021
17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex., David E Harrison, Randy Strong, Peter C. Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Marisa Lopez-Cruzan, Francesca Macchiarini, James F Nelson, Alessandro Bitto, Amy L Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M Stearns, Molly A. Bogue, and Richard A Miller
Submissions from 2020
Canagliflozin extends life span in genetically heterogeneous male but not female mice., Richard A Miller, David E Harrison, David B Allison, Molly A. Bogue, Lucas Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej Galecki, W Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin A Javors, Warren C Ladiges, Francesca Macchiarini, James Nelson, Peter C. Reifsnyder, Nadia Rosenthal, Marianna Sadagurski, Adam B Salmon, Daniel L Smith, Jessica M Snyder, David B Lombard, and Randy Strong
Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects., Randy Strong, Richard A Miller, Molly A. Bogue, Elizabeth Fernandez, Martin A Javors, Sergiy Libert, Paul Anthony Marinez, Michael P Murphy, Nicolas Musi, James F Nelson, Michael Petrascheck, Peter C. Reifsnyder, Arlan Richardson, Adam B Salmon, Francesca Macchiarini, and David E Harrison
Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice., Rong Yuan, C J M Musters, Yun Zhu, Tracy R Evans, Yujie Sun, Elissa J Chesler, Luanne L. Peters, David E Harrison, and Andrzej Bartke
Submissions from 2019
Acarbose improves health and lifespan in aging HET3 mice., David E Harrison, Randy Strong, Silvestre Alavez, Clinton M Astle, John DiGiovanni, Elizabeth Fernandez, Kevin Flurkey, Michael Garratt, Jonathan A L Gelfond, Martin A Javors, Moshe Levi, Gordon J Lithgow, Francesca Macchiarini, James F Nelson, Stacey J Sukoff Rizzo, Thomas J Slaga, Timothy M Stearns, John Erby Wilkinson, and Richard A Miller
Glycine supplementation extends lifespan of male and female mice., Richard A Miller, David E Harrison, Clinton Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G Ryazanov, Jessica Snyder, Timothy M Stearns, Douglas E Vaughan, and Randy Strong
Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice., Byron J Smith, Richard A Miller, Aaron C Ericsson, David E Harrison, Randy Strong, and Thomas M Schmidt
Submissions from 2018
Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr, Peter C. Reifsnyder, Sergey Ryzhov, Kevin Flurkey, Rea P Anunciado-Koza, Ian Mills, David E Harrison, and Robert A Koza
Submissions from 2017
MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice., Benjamin P Lee, Ivana Burić, Anupriya George-Pandeth, Kevin Flurkey, David E Harrison, Rong Yuan, Luanne L. Peters, George A Kuchel, David Melzer, and Lorna W Harries
NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model., Nancy L Nadon, Randy Strong, Richard A Miller, and David E Harrison
Submissions from 2016
Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans., Benjamin P Lee, Luke C Pilling, Florence Emond, Kevin Flurkey, David E Harrison, Rong Yuan, Luanne L. Peters, George A Kuchel, Luigi Ferrucci, David Melzer, and Lorna W Harries
Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes., Peter C. Reifsnyder, Kevin Flurkey, Austen Te, and David E Harrison
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer., Randy Strong, Richard A Miller, Adam Antebi, Clinton M Astle, Molly A. Bogue, Martin S Denzel, Elizabeth Fernandez, Kevin Flurkey, Karyn L Hamilton, Dudley W Lamming, Martin A Javors, João Pedro de Magalhães, Paul Anthony Martinez, Joe M McCord, Benjamin F Miller, Michael Müller, James F Nelson, Juliet Ndukum, G Ed Rainger, Arlan Richardson, David M Sabatini, Adam B Salmon, James W Simpkins, Wilma T Steegenga, Nancy L Nadon, and David E Harrison
Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice., Airlia C S Thompson, Matthew D Bruss, John C Price, Cyrus F Khambatta, William E Holmes, Marc Colangelo, Marcy Dalidd, Lindsay S Roberts, Clinton M Astle, David E Harrison, and Marc K Hellerstein
Submissions from 2015
Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain., Huan Gong, Hong Qian, Robin Ertl, Clinton M. Astle, Gang G Wang, David E. Harrison, and Xiangru Xu
Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1., Rong Yuan, Daniel Mario Gatti, Rebecca Krier, Ethan Malay, David Schultz, Luanne L. Peters, Gary A. Churchill, David E. Harrison, and Beverly Paigen
Submissions from 2014
Genetically diverse mice are novel and valuable models of age-associated susceptibility to Mycobacterium tuberculosis., David E. Harrison, Clinton M. Astle, M Khalid Khan Niazi, Samuel Major, and Gillian L Beamer
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males., David E. Harrison, Randy Strong, David B Allison, Bruce N Ames, Clinton M. Astle, Hani Atamna, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Nancy L Nadon, James F Nelson, Scott Pletcher, James W Simpkins, Daniel Smith, J Erby Wilkinson, and Richard A Miller
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction., Richard A Miller, David E. Harrison, Clinton M. Astle, Elizabeth Fernandez, Kevin Flurkey, Melissa Han, Martin A Javors, Xinna Li, Nancy L Nadon, James F Nelson, Scott Pletcher, Adam B Salmon, Zelton Dave Sharp, Sabrina Van Roekel, Lynn Winkleman, and Randy Strong
Rapamycin Ameliorates Nephropathy despite Elevating Hyperglycemia in a Polygenic Mouse Model of Type 2 Diabetes, NONcNZO10/LtJ., Peter C. Reifsnyder, Rosalinda A. Doty, and David E. Harrison
Submissions from 2013
Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive., Dudley W Lamming, Lan Ye, Clinton M. Astle, Joseph A Baur, David M Sabatini, and David E. Harrison
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice., Randy Strong, Richard A Miller, Clinton M. Astle, Joseph A Baur, Rafael de Cabo, Elizabeth Fernandez, Wen Guo, Martin Javors, James L Kirkland, James F Nelson, David A Sinclair, Bruce Teter, David Williams, Nurulain Zaveri, Nancy L Nadon, and David E. Harrison
Submissions from 2011
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice., R A. Miller, D E. Harrison, C M. Astle, J A. Baur, K Flurkey, M A. Javors, J F. Nelson, C J. Orihuela, S Pletcher, and al et
Submissions from 2010
Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice., K Flurkey, C M. Astle, and D E. Harrison
Submissions from 2009
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice., D E. Harrison, R Strong, Z D. Sharp, J F. Nelson, C M. Astle, K Flurkey, N L. Nadon, M A. Javors, E Fernandez, and al et
Submissions from 2008
Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated., R P. Ertl, J Chen, C M. Astle, T M. Duffy, and D E. Harrison
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice., R Strong, R A. Miller, C M. Astle, R A. Floyd, K Flurkey, K L. Hensley, M A. Javors, C Leeuwenburgh, J F. Nelson, and E Ongini
Submissions from 2007
An Aging Interventions Testing Program: study design and interim report., R A. Miller, D E. Harrison, C M. Astle, R A. Floyd, K Flurkey, K L. Hensley, M A. Javors, C Leeuwenburgh, J F. Nelson, E Ongini, N L. Nadon, H R. Warner, and R Strong
Submissions from 2006
Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size., R Yuan, K Flurkey, Aelst Bouma Van, W Zhang, B King, S Austad, R A. Miller, and D E. Harrison