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Submissions from 2019

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The Global State of the Genetic Counseling Profession., MaryAnn Abacan, Lamia Alsubaie, Kristine Barlow-Stewart, Beppy Caanen, Christophe Cordier, Eliza Courtney, Emeline Davoine, Janice Edwards, Niby J Elackatt, Kate Gardiner, Yue Guan, Lian-Hua Huang, Charlotta Ingvoldstad Malmgren, Sahil Kejriwal, Hyon J Kim, Deborah Lambert, Paulina Araceli Lantigua-Cruz, Juliana M H Lee, Marianne Lodahl, Åshild Lunde, Shelley Macaulay, Ivan Macciocca, Sonia Margarit, Anna Middleton, Ramona Moldovan, Joanne Ngeow, Alexandra J Obregon-Tito, Kelly E Ormond, Milena Paneque, Karen Powell, Kunal Sanghavi, Diana Scotcher, Jenna Scott, Clara Serra Juhé, Shiri Shkedi-Rafid, Tina-Marié Wessels, Sook-Yee Yoon, and Catherine Wicklund

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Quantitative evaluation of ontology design patterns for combining pathology and anatomy ontologies., Sarah M Alghamdi, Beth A. Sundberg, John P Sundberg, Paul N Schofield, and Robert Hoehndorf

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Effects of IGF-1 isoforms on muscle growth and sarcopenia., Francesca Ascenzi, Laura Barberi, Gabriella Dobrowolny, Aline Villa Nova Bacurau, Carmine Nicoletti, Emanuele Rizzuto, Nadia Rosenthal, Bianca Maria Scicchitano, and Antonio Musarò

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Annotation of gene product function from high-throughput studies using the Gene Ontology., Helen Attrill, Pascale Gaudet, Rachael P Huntley, Ruth C Lovering, Stacia R Engel, Sylvain Poux, Kimberly M Van Auken, George Georghiou, Marcus C Chibucos, Tanya Z Berardini, Valerie Wood, Harold J. Drabkin, Petra Fey, Penelope Garmiri, Midori A Harris, Tony Sawford, Leonore Reiser, Rebecca Tauber, Sabrina Toro, and Gene Ontology Consortium

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Tissue-Specific Trans Regulation of the Mouse Epigenome., Christopher L. Baker, Michael Walker, Seda Arat, Guruprasad Ananda, Pavlina Petkova, Natalie Powers, Hui Tian, Catrina Spruce, Bo Ji, Dylan Rausch, Kwangbom Choi, Petko M. Petkov, Gregory W. Carter, and Kenneth Paigen

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The lung microbiome, vitamin D, and the tuberculous granuloma: A balance triangle., María Elvira Balcells, Noemí Yokobori, Bo-Young Hong, John Corbett, and Jorge Cervantes

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Symbiotic organs shaped by distinct modes of genome evolution in cephalopods., Mahdi Belcaid, Giorgio Casaburi, Sarah J McAnulty, Hannah Schmidbaur, Andrea M Suria, Silvia Moriano-Gutierrez, M Sabrina Pankey, Todd H Oakley, Natacha Kremer, Eric J Koch, Andrew J Collins, Hoan Nguyen, Sai H Lek, Irina Goncharenko-Foster, Patrick Minx, Erica Sodergren Weinstock, George M. Weinstock, Daniel S Rokhsar, Margaret McFall-Ngai, Oleg Simakov, Jamie S Foster, and Spencer V Nyholm

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Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance., Jessica A Bertolini, Rebecca Favaro, Yanfen Zhu, Miriam Pagin, Chew Yee Ngan, Chee-Hong Wong, Harianto Tjong, Marit W Vermunt, Ben Martynoga, Cristiana Barone, Jessica Mariani, Marcos Julián Cardozo, Noemi Tabanera, Federico Zambelli, Sara Mercurio, Sergio Ottolenghi, Paul Robson, Menno P Creyghton, Paola Bovolenta, Giulio Pavesi, Francois Guillemot, Silvia K Nicolis, and Chia-Lin Wei

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Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes., Tanmoy Bhattacharyya, Michael Walker, Natalie Powers, Catherine Brunton, Alexander D Fine, Petko M. Petkov, and Mary Ann Handel

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An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology., Raghu Bhushan, Lukas Altinbas, Marten Jäger, Marcin Zaradzki, Daniel Lehmann, Bernd Timmermann, Nicholas P Clayton, Yunxiang Zhu, Klaus Kallenbach, Georgios Kararigas, and Peter N Robinson

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Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression., Michael A Brehm, Laurie L Kenney, Michael V. Wiles, Benjamin E. Low, Roland M Tisch, Lisa M. Burzenski, Christian Mueller, Dale L Greiner, and Leonard D. Shultz

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R/qtl2: Software for Mapping Quantitative Trait Loci with High-Dimensional Data and Multiparent Populations., Karl W Broman, Daniel M Gatti, Petr Simecek, Nicholas A Furlotte, Pjotr Prins, Śaunak Sen, Brian S Yandell, and Gary Churchill

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Cleaning Genotype Data from Diversity Outbred Mice., Karl W Broman, Daniel M. Gatti, Karen L. Svenson, Śaunak Sen, and Gary Churchill

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Curating gene sets: challenges and opportunities for integrative analysis., Jason A. Bubier, David P. Hill, Gaurab Mukherjee, Timothy Reynolds, Erich J Baker, Alexander Berger, Jake Emerson, Judith A. Blake, and Elissa J Chesler

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Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species., Jason A. Bubier, George L Sutphin, Timothy J Reynolds, Ron Korstanje, Axis Fuksman-Kumpa, Erich J Baker, Michael A Langston, and Elissa J Chesler

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Mouse Genome Database (MGD) 2019., Carol J Bult, Judith A. Blake, Cynthia Smith, James A. Kadin, Joel E Richardson, and Mouse Genome Database Group

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A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate., Simone Caielli, Diogo Troggian Veiga, Preetha Balasubramanian, Shruti Athale, Bojana Domic, Elise Murat, Romain Banchereau, Zhaohui Xu, Manjari Chandra, Cheng-Han Chung, Lynnette Walters, Jeanine Baisch, Tracey Wright, Marilynn Punaro, Lorien Nassi, Katie Stewart, Julie Fuller, Duygu Ucar, Hideki Ueno, Joseph Zhou, Jacques Banchereau, and Virginia Pascual

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Sarcomere-Directed Calcium Reporters in Cardiomyocytes., Stuart G Campbell, Yibing Qyang, and J Travis Hinson

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors., Alessandro Carugo, Rosalba Minelli, Luigi Sapio, Melinda Soeung, Federica Carbone, Frederick S Robinson, James Tepper, Ziheng Chen, Sara Lovisa, Maria Svelto, Samirkumar B Amin, Sanjana Srinivasan, Edoardo Del Poggetto, Sara Loponte, Francesca Puca, Prasenjit Dey, Gabriel G Malouf, Xiaoping Su, Liren Li, Dolores Lopez-Terrada, Dinesh Rakheja, Alexander J Lazar, George J Netto, Priya Rao, Alessandro Sgambato, Anirban Maitra, Durga N Tripathi, Cheryl L Walker, Jose A Karam, Timothy P Heffernan, Andrea Viale, Charles W M Roberts, Pavlos Msaouel, Nizar M Tannir, Giulio F Draetta, and Giannicola Genovese

Proliferative Typhlocolitis With Multinucleated Giant Cells: A Nonspecific Enteropathy in Immunodeficient Sentinel Mice., Kerriann M Casey, Amanda L Johnson, Melea N Hunrath, Jenelle K Fraser, Nicole C McCowan, Katherine Wasson, Rosalinda A. Doty, Stephen M Griffey, and Denise M Imai

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Mutations in DNA repair genes are associated with increased neoantigen burden and a distinct immunophenotype in lung squamous cell carcinoma., Young Kwang Chae, Jonathan F Anker, Michael S Oh, Preeti Bais, Sandeep Namburi, Sarita Agte, Francis J Giles, and Jeffrey H Chuang

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Multi-platform discovery of haplotype-resolved structural variation in human genomes., Mark J P Chaisson, Ashley D Sanders, Xuefang Zhao, Ankit Malhotra, David Porubsky, Tobias Rausch, Eugene J Gardner, Oscar L Rodriguez, Li Guo, Ryan L Collins, Xian Fan, Jia Wen, Robert E Handsaker, Susan Fairley, Zev N Kronenberg, Xiangmeng Kong, Fereydoun Hormozdiari, Dillon Lee, Aaron M Wenger, Alex R Hastie, Danny Antaki, Thomas Anantharaman, Peter A Audano, Harrison Brand, Stuart Cantsilieris, Han Cao, Eliza Cerveira, Chong Chen, Xintong Chen, Chen-Shan Chin, Zechen Chong, Nelson T Chuang, Christine C Lambert, Deanna M Church, Laura Clarke, Andrew Farrell, Joey Flores, Timur Galeev, David U Gorkin, Madhusudan Gujral, Victor Guryev, William Haynes Heaton, Jonas Korlach, Sushant Kumar, Jee Young Kwon, Ernest T Lam, Jong Eun Lee, Joyce Lee, Wan-Ping Lee, Sau Peng Lee, Shantao Li, Patrick Marks, Karine Viaud-Martinez, Sascha Meiers, Katherine M Munson, Fabio C P Navarro, Bradley J Nelson, Conor Nodzak, Amina Noor, Sofia Kyriazopoulou-Panagiotopoulou, Andy W C Pang, Yunjiang Qiu, Gabriel Rosanio, Mallory Ryan, Adrian Stütz, Diana C J Spierings, Alistair Ward, AnneMarie E Welch, Ming Xiao, Wei Xu, Chengsheng Zhang, Qihui Zhu, Xiangqun Zheng-Bradley, Ernesto Lowy, Sergei Yakneen, Steven McCarroll, Goo Jun, Li Ding, Chong Lek Koh, Bing Ren, Paul Flicek, Ken Chen, Mark B Gerstein, Pui-Yan Kwok, Peter M Lansdorp, Gabor T Marth, Jonathan Sebat, Xinghua Shi, Ali Bashir, Kai Ye, Scott E Devine, Michael E Talkowski, Ryan E Mills, Tobias Marschall, Jan O Korbel, Evan E Eichler, and Charles Lee

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Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom"., Georgia Charkoftaki, Yewei Wang, Monica McAndrews, Elspeth A Bruford, David C Thompson, Vasilis Vasiliou, and Daniel W Nebert

Liriodendron genome sheds light on angiosperm phylogeny and species-pair differentiation., Jinhui Chen, Zhaodong Hao, Xuanmin Guang, Chenxi Zhao, Pengkai Wang, Liangjiao Xue, Qihui Zhu, Linfeng Yang, Yu Sheng, Yanwei Zhou, Haibin Xu, Hongqing Xie, Xiaofei Long, Jin Zhang, Zhangrong Wang, Mingming Shi, Ye Lu, Siqin Liu, Lanhua Guan, Qianhua Zhu, Liming Yang, Song Ge, Tielong Cheng, Thomas Laux, Qiang Gao, Ye Peng, Na Liu, Sihai Yang, and Jisen Shi

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LISA: Accurate reconstruction of cell trajectory and pseudo-time for massive single cell RNA-seq data., Yang Chen, Yuping Zhang, and Zhengqing Ouyang

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Unstable Genome and Transcriptome Dynamics during Tumor Metastasis Contribute to Therapeutic Heterogeneity in Colorectal Cancers., Sung-Yup Cho, Jeesoo Chae, Deukchae Na, Wonyoung Kang, Ahra Lee, Seoyeon Min, Jinjoo Kang, Boram Choi, Jieun Lee, Chang Ohk Sung, Jeffrey Chuang, Charles Lee, Won-Suk Lee, Hansoo Park, and Jong-Il Kim

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A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations., Rachel Cohn, Ketan Thakar, Andre Lowe, Feria A Ladha, Anthony M Pettinato, Robert Romano, Emily Meredith, Yu-Sheng Chen, Katherine Atamanuk, Bryan D Huey, and J Travis Hinson

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The Gene Ontology Resource: 20 years and still GOing strong., Gene Ontology Consortium

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PDX Finder: A portal for patient-derived tumor xenograft model discovery., Nathalie Conte, Jeremy C Mason, Csaba Halmagyi, Steven Neuhauser, Abayomi Mosaku, Galabina Yordanova, Aikaterini Chatzipli, Dale A. Begley, Debra M Krupke, Helen Parkinson, Terrence F Meehan, and Carol J Bult

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Photoreceptor degeneration in a new Cacna1f mutant mouse model., Xufeng Dai, Shiyi Pang, Jieping Wang, Bernard FitzMaurice, Jijing Pang, and Bo Chang

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Single-Molecule Real-Time (SMRT) Full-Length RNA-Sequencing Reveals Novel and Distinct mRNA Isoforms in Human Bone Marrow Cell Subpopulations., Anne DeslattesMays, Marcel Schmidt, Garrett Graham, Elizabeth Tseng, Primo Baybayan, Robert Sebra, Miloslav Sanda, Jean-Baptiste Mazarati, Anna Riegel, and Anton Wellstein

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Systems genetics of sensation seeking., Price E. Dickson, Tyler A Roy, Kathryn A. McNaughton, Troy Wilcox, Padam Kumar, and Elissa J Chesler

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Significant Strain Variation in the Mutation Spectra of Inbred Laboratory Mice., Beth L Dumont

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Toward Regeneration of the Heart: Bioengineering Strategies for Immunomodulation., Arianna Ferrini, Molly M Stevens, Susanne Sattler, and Nadia Rosenthal

Uncoupling of transcriptomic and cytological differentiation in mouse spermatocytes with impaired meiosis., Alexander D Fine, Robyn L Ball, Yasuhiro Fujiwara, Mary Ann Handel, and Gregory W. Carter

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Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase., Cindy L Fonseca, Heidi L H Malaby, Leslie A Sepaniac, Whitney Martin, Candice Byers, Anne M Czechanski, Dana Messinger, Mary Tang, Ryoma Ohi, Laura G Reinholdt, and Jason Stumpff

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Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus., Matthew H Forsberg, Bardees Foda, David V. Serreze, and Yi-Guang Chen

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Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1., Melissa A Gawron, Mark Duval, Claudia Carbone, Smita Jaiswal, Aaron Wallace, Joseph C Martin, Ann Dauphin, Michael A Brehm, Dale L Greiner, Leonard D. Shultz, Jeremy Luban, and Lisa A Cavacini

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Robust mouse tracking in complex environments using neural networks., Brian Q Geuther, Sean P Deats, Kai J Fox, Stephen A Murray, Robert E Braun, Jacqueline K White, Elissa J Chesler, Cathleen Lutz, and Vivek Kumar

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Ultra-long Read Sequencing for Whole Genomic DNA Analysis., Liang Gong, Chee-Hong Wong, Jennifer Idol, Chew Yee Ngan, and Chia-Lin Wei

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Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis., Leslie O Goodwin, Erik Splinter, Tiffany Leidy-Davis, Rachel Urban, Hao He, Robert E Braun, Elissa J Chesler, Vivek Kumar, Max van Min, Juliet Ndukum, Vivek M. Philip, Laura G Reinholdt, Karen L. Svenson, Jacqueline K White, Michael Sasner, Cathleen Lutz, and Stephen A. Murray

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ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm., Russell A Gould, Hamza Aziz, Courtney E Woods, Manuel Alejandro Seman-Senderos, Elizabeth Sparks, Christoph Preuss, Florian Wünnemann, Djahida Bedja, Cassandra R Moats, Sarah A McClymont, Rebecca Rose, Nara Sobreira, Hua Ling, Gretchen MacCarrick, Ajay Anand Kumar, Ilse Luyckx, Elyssa Cannaerts, Aline Verstraeten, Hanna M Björk, Ann-Cathrin Lehsau, Vinod Jaskula-Ranga, Henrik Lauridsen, Asad A Shah, Christopher L Bennett, Patrick T Ellinor, Honghuang Lin, Eric M Isselbacher, Christian Lacks Lino Cardenas, Jonathan T Butcher, G Chad Hughes, Mark E Lindsay, Luc Mertens, Anders Franco-Cereceda, Judith M A Verhagen, Marja Wessels, Salah A Mohamed, Per Eriksson, Seema Mital, Lut Van Laer, Bart L Loeys, Gregor Andelfinger, Andrew S McCallion, and Harry C Dietz

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Identification of a novel gene regulating amygdala-mediated fear extinction., Ozge Gunduz-Cinar, Emma Brockway, Lauren Lederle, Troy Wilcox, Lindsay R Halladay, Ying Ding, Hyunjung Oh, Erica F Busch, Katie Kaugars, Shaun Flynn, Aaron Limoges, Olena Bukalo, Kathryn P MacPherson, Sophie Masneuf, Courtney Pinard, Etienne Sibille, Elissa J Chesler, and Andrew Holmes

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GOPHER: Generator Of Probes for capture Hi-C Experiments at high Resolution., Peter Hansen, Salaheddine Ali, Hannah Blau, Daniel Danis, Jochen Hecht, Uwe Kornak, Darío G Lupiáñez, Stefan Mundlos, Robin Steinhaus, and Peter N Robinson

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Fibronectin-conjugated thermoresponsive nanobridges generate three dimensional human pluripotent stem cell cultures for differentiation towards the neural lineages., Linda Harkness, Xiaoli Chen, Zhongfan Jia, Anthony M Davies, Michael Monteiro, Peter Gray, and Martin Pera

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Acarbose improves health and lifespan in aging HET3 mice., David E Harrison, Randy Strong, Silvestre Alavez, Clinton M Astle, John DiGiovanni, Elizabeth Fernandez, Kevin Flurkey, Michael Garratt, Jonathan A L Gelfond, Martin A Javors, Moshe Levi, Gordon J Lithgow, Francesca Macchiarini, James F Nelson, Stacey J Sukoff Rizzo, Thomas J Slaga, Timothy M Stearns, John Erby Wilkinson, and Richard A Miller

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Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis., Bo-Young Hong, Takanori Sobue, Linda Choquette, Amanda K Dupuy, Angela Thompson, Joseph A Burleson, Andrew L Salner, Peter K Schauer, Pujan Joshi, Evan Fox, Dong-Guk Shin, George M. Weinstock, Linda D Strausbaugh, Anna Dongari-Bagtzoglou, Douglas E Peterson, and Patricia I Diaz

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Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy., Seunghee Hong, Romain Banchereau, Bat-Sheva L Maslow, Marta M Guerra, Jacob Cardenas, Jeanine Baisch, D Ware Branch, T Flint Porter, Allen Sawitzke, Carl A Laskin, Jill P Buyon, Joan Merrill, Lisa R Sammaritano, Michelle Petri, Elizabeth Gatewood, Alma-Martina Cepika, Marina Ohouo, Gerlinde Obermoser, Esperanza Anguiano, Tae Whan Kim, John Nulsen, Djamel Nehar-Belaid, Derek Blankenship, Jacob Turner, Jacques Banchereau, Jane E Salmon, and Virginia Pascual

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ENU-induced mutant allele of Dnah1, ferf1, causes abnormal sperm behavior and fertilization failure in mice., Jianjun Hu, Carl Lessard, Charles J Longstaff, Marilyn J. O'Brien, Kristina Palmer, Laura G Reinholdt, John J. Eppig, John Schimenti, and Mary Ann Handel

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miR-181a/b downregulation exerts a protective action on mitochondrial disease models., Alessia Indrieri, Sabrina Carrella, Alessia Romano, Alessandra Spaziano, Elena Marrocco, Erika Fernandez-Vizarra, Sara Barbato, Mariateresa Pizzo, Yulia Ezhova, Francesca M Golia, Ludovica Ciampi, Roberta Tammaro, Jorge Henao-Mejia, Adam Williams, Richard A Flavell, Elvira De Leonibus, Massimo Zeviani, Enrico M Surace, Sandro Banfi, and Brunella Franco

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Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells., Philippe Jean, Özge Demet Özçete, Basile Tarchini, and Tobias Moser

Testing the gene expression classification of the EMT spectrum., Dongya Jia, Jason T George, Satyendra C Tripathi, Deepali L Kundnani, Mingyang Lu, Samir M Hanash, José N Onuchic, Mohit Kumar Jolly, and Herbert Levine

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Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways., Dongya Jia, Mingyang Lu, Kwang Hwa Jung, Jun Hyoung Park, Linglin Yu, José N Onuchic, Benny Abraham Kaipparettu, and Herbert Levine

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An effective biomedical document classification scheme in support of biocuration: addressing class imbalance., Xiangying Jiang, Martin Ringwald, Judith A. Blake, Cecilia Arighi, Gongbo Zhang, and Hagit Shatkay

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Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources., Sebastian Köhler, Leigh Carmody, Nicole Vasilevsky, Julius O B Jacobsen, Daniel Danis, Jean-Philippe Gourdine, Michael Gargano, Nomi L Harris, Nicolas Matentzoglu, Julie A McMurry, David Osumi-Sutherland, Valentina Cipriani, James P Balhoff, Tom Conlin, Hannah Blau, Gareth Baynam, Richard Palmer, Dylan Gratian, Hugh Dawkins, Michael Segal, Anna C Jansen, Ahmed Muaz, Willie H Chang, Jenna Bergerson, Stanley J F Laulederkind, Zafer Yüksel, Sergi Beltran, Alexandra F Freeman, Panagiotis I Sergouniotis, Daniel Durkin, Andrea L Storm, Marc Hanauer, Michael Brudno, Susan M. Bello, Murat Sincan, Kayli Rageth, Matthew T Wheeler, Renske Oegema, Halima Lourghi, Maria G Della Rocca, Rachel Thompson, Francisco Castellanos, James Priest, Charlotte Cunningham-Rundles, Ayushi Hegde, Ruth C Lovering, Catherine Hajek, Annie Olry, Luigi Notarangelo, Morgan Similuk, Xingmin A Zhang, David Gómez-Andrés, Hanns Lochmüller, Hélène Dollfus, Sergio Rosenzweig, Shruti Marwaha, Ana Rath, Kathleen Sullivan, Cynthia Smith, Joshua D Milner, Dorothée Leroux, Cornelius F Boerkoel, Amy Klion, Melody C Carter, Tudor Groza, Damian Smedley, Melissa A Haendel, Chris Mungall, and Peter N Robinson

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Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function., Nathan Lawlor, Eladio J Marquez, Peter Orchard, Narisu Narisu, Muhammad Saad Shamim, Asa Thibodeau, Arushi Varshney, Romy Kursawe, Michael R Erdos, Matt Kanke, Huiya Gu, Evgenia Pak, Amalia Dutra, Sheikh Russell, Xingwang Li, Emaly Piecuch, Oscar Junhong Luo, Peter S Chines, Christian Fuchbserger, NIH Intramural Sequencing Center, Praveen Sethupathy, Aviva Presser Aiden, Yijun Ruan, Erez Lieberman Aiden, Francis S Collins, Duygu Ucar, Stephen C J Parker, and Michael L. Stitzel

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Structure and function of the immune system in the spleen., Steven M Lewis, Adam Williams, and Stephanie C Eisenbarth

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Complex Microbiome in Brain Abscess Revealed by Whole-Genome Culture-Independent and Culture-Based Sequencing., Jyun-Hong Lin, Zong-Yen Wu, Liang Gong, Chee-Hong Wong, Wen-Cheng Chao, Chun-Ming Yen, Ching-Ping Wang, Chia-Lin Wei, Yao-Ting Huang, and Po-Yu Liu

Nail abnormalities identified in an ageing study of 30 inbred mouse strains., Sarah C Linn, Allison M Mustonen, Kathleen A Silva, Victoria E. Kennedy, Beth A. Sundberg, Lesley S Bechtold, Sarah Alghamdi, Robert Hoehndorf, Paul N Schofield, and John P Sundberg

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Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6, Qiaoli Li, Jianhe Huang, Anthony B Pinkerton, Jose Luis Millan, Bertrand D van Zelst, Michael A Levine, John P Sundberg, and Jouni Uitto

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Genomic inversions and GOLGA core duplicons underlie disease instability at the 15q25 locus., Flavia A M Maggiolini, Stuart Cantsilieris, Pietro D'Addabbo, Michele Manganelli, Bradley P Coe, Beth L Dumont, Ashley D Sanders, Andy Wing Chun Pang, Mitchell R Vollger, Orazio Palumbo, Pietro Palumbo, Maria Accadia, Massimo Carella, Evan E Eichler, and Francesca Antonacci

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Effects of diet on the childhood gut microbiome and its implications for atopic dermatitis., Mahboobeh Mahdavinia, Heather E Rasmussen, Maresa Botha, Thi Dong Binh Tran, Jolice P Van den Berg, Erica Sodergren Weinstock, Erika Davis, Krista Engen, Claudia Gray, Nonhlanhla Lunjani, Carol Hlela, Nailliw Z Preite, Wisdom Basera, Lelani Hobane, Alexandra Watkins, Phillip Engen, Avumile Mankahla, Ben Gaunt, Facey Thomas, Mary C Tobin, Alan Landay, George M. Weinstock, Ali Keshavarzian, and Michael E Levin

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Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX)., Joan Malcolm, Timothy M Stearns, Susan Airhart, Joel H. Graber, and Carol J Bult

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A Mobile Prenatal Care App to Reduce In-Person Visits: Prospective Controlled Trial., Kathryn I Marko, Nihar Ganju, Jill M Krapf, Nancy D Gaba, James A Brown, Joshua J Benham, Julia Oh, Lorna M Richards, and Andrew C Meltzer

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Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice., Masashi Matsuda, Rintaro Ono, Tomonori Iyoda, Takaho Endo, Makoto Iwasaki, Mariko Tomizawa-Murasawa, Yoriko Saito, Akiko Kaneko, Kanako Shimizu, Daisuke Yamada, Narumi Ogonuki, Takashi Watanabe, Manabu Nakayama, Yoko Koseki, Fuyuko Kezuka-Shiotani, Takanori Hasegawa, Hiromasa Yabe, Shunichi Kato, Atsuo Ogura, Leonard D. Shultz, Osamu Ohara, Masaru Taniguchi, Haruhiko Koseki, Shin-Ichiro Fujii, and Fumihiko Ishikawa

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Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass., Larry D Mesner, Gina M Calabrese, Basel Al-Barghouthi, Daniel M. Gatti, John P Sundberg, Gary A Churchill, Dana A Godfrey, Cheryl L Ackert-Bicknell, and Charles R Farber

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Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons., Laura E Mickelsen, Mohan Bolisetty, Brock R Chimileski, Akie Fujita, Eric J Beltrami, James T Costanzo, Jacob R Naparstek, Paul Robson, and Alexander C Jackson

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Glycine supplementation extends lifespan of male and female mice., Richard A Miller, David E Harrison, Clinton Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G Ryazanov, Jessica Snyder, Timothy M Stearns, Douglas E Vaughan, and Randy Strong

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Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells., Eleni P Mimitou, Anthony Cheng, Antonino Montalbano, Stephanie Hao, Marlon Stoeckius, Mateusz Legut, Timothy Roush, Alberto Herrera, Efthymia Papalexi, Zhengqing Ouyang, Rahul Satija, Neville E Sanjana, Sergei B Koralov, and Peter Smibert

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Genetic variation in thyroid folliculogenesis influences susceptibility to hypothyroidism-induced hearing impairment., Amanda H Mortensen, Qing Fang, Michelle T Fleming, Thomas J Jones, Alexandre Z Daly, Kenneth R. Johnson, and Sally A Camper

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Meeting report: 32nd international mammalian genome conference., Jacob Moskowitz, Lauren Tracey, Samuel Widmayer, and Beth L Dumont

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Identification of a Functional Non-coding Variant in the GABA, Megan K Mulligan, Timothy Abreo, Sarah M Neuner, Cory Parks, Christine E Watkins, M Trevor Houseal, Thomas M Shapaker, Michael Hook, Haiyan Tan, Xusheng Wang, Jesse Ingels, Junmin Peng, Lu Lu, Catherine Kaczorowski, Camron D Bryant, Gregg E Homanics, and Robert W Williams

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The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions., Zoltan Nagy, Timo Vögtle, Mitchell J Geer, Jun Mori, Silke Heising, Giada Di Nunzio, Ralph Gareus, Alexander Tarakhovsky, Arthur Weiss, Benjamin G Neel, Guillaume E Desanti, Alexandra Mazharian, and Yotis A Senis

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Knockdown of heterochromatin protein 1 binding protein 3 recapitulates phenotypic, cellular, and molecular features of aging., Sarah M Neuner, Shengyuan Ding, and Catherine C Kaczorowski

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Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine., Sarah M Neuner, Sarah E Heuer, Matthew J Huentelman, Kristen M S O'Connell, and Catherine C Kaczorowski

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Identification of Pre-symptomatic Gene Signatures That Predict Resilience to Cognitive Decline in the Genetically Diverse AD-BXD Model., Sarah M Neuner, Sarah E Heuer, Ji-Gang Zhang, Vivek M. Philip, and Catherine Kaczorowski

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Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis., Alexandra M Nicaise, Laura J Wagstaff, Cory M Willis, Carolyn Paisie, Harshpreet Chandok, Paul Robson, Valentina Fossati, Anna Williams, and Stephen J Crocker

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Antibiotic collateral sensitivity is contingent on the repeatability of evolution., Daniel Nichol, Joseph Rutter, Christopher Bryant, Andrea M Hujer, Sai Lek, Mark D Adams, Peter Jeavons, Alexander R A Anderson, Robert A Bonomo, and Jacob G Scott

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Hybrid Sterility with Meiotic Metaphase Arrest in Intersubspecific Mouse Crosses., Risako Nishino, Sabrina Petri, Mary Ann Handel, Tetsuo Kunieda, and Yasuhiro Fujiwara

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The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis., Hideyuki Oguro

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Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model., Rintaro Ono, Takashi Watanabe, Eiryo Kawakami, Makoto Iwasaki, Mariko Tomizawa-Murasawa, Masashi Matsuda, Yuho Najima, Shinsuke Takagi, Saera Fujiki, Rumi Sato, Yoshiki Mochizuki, Hisahiro Yoshida, Kaoru Sato, Hiromasa Yabe, Shunichi Kato, Yoriko Saito, Shuichi Taniguchi, Leonard D. Shultz, Osamu Ohara, Masayuki Amagai, Haruhiko Koseki, and Fumihiko Ishikawa

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Utility of the JAX Clinical Knowledgebase in capture and assessment of complex genomic cancer data., Sara E. Patterson, Cara M. Statz, Taofei Yin, and Susan Mockus

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Towards large scale automated cage monitoring - Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique., Karin Pernold, F Iannello, Benjamin E. Low, M Rigamonti, G Rosati, F Scavizzi, J Wang, M Raspa, Michael V. Wiles, and B Ulfhake

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On Finding and Enumerating Maximal and Maximum k-Partite Cliques in k-Partite Graphs, Charles A. Phillips, Kai Wang, Erich J. Baker, Jason A. Bubier, Elissa J Chesler, and Michael A. Langston

Delivery of CRISPR-Cas9 into Mouse Zygotes by Electroporation., Wenning Qin and Haoyi Wang

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Acetate Promotes T Cell Effector Function during Glucose Restriction., Jing Qiu, Matteo Villa, David E Sanin, Michael D Buck, David O'Sullivan, Reagan Ching, Mai Matsushita, Katarzyna M Grzes, Frances Winkler, Chih-Hao Chang, Jonathan D Curtis, Ryan L Kyle, Nikki Van Teijlingen Bakker, Mauro Corrado, Fabian Haessler, Francesca Alfei, Joy Edwards-Hicks, Leonard B Maggi, Dietmar Zehn, Takeshi Egawa, Bertram Bengsch, Ramon I Klein Geltink, Thomas Jenuwein, Edward J Pearce, and Erika L Pearce

Three things every nurse practitioner can do to integrate genetics into practice., E Kate Reed, Therese Ingram, and Emily A Edelman

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Somatic Testing: Implications for Targeted Treatment., E Kate Reed, Linda Steinmark, Diane C Seibert, and Emily A Edelman

Linked-read Sequencing Analysis Reveals Tumor-specific Genome Variation Landscapes in Neurofibromatosis Type 2 (NF2) Patients., Daniel S Roberts, Rahul Maurya, Yuka Takemon, Jeremie Vitte, Liang Gong, Juanjuan Zhao, Chee-Hong Wong, William Slattery, Kevin A Peng, Gregory Lekovic, Marc S Schwartz, Ketan Bulsara, Chew Yee Ngan, Marco Giovannini, and Chia-Lin Wei

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Activin type II receptor signaling in cardiac aging and heart failure., Jason D Roh, Ryan Hobson, Vinita Chaudhari, Pablo Quintero, Ashish Yeri, Mark Benson, Chunyang Xiao, Daniel Zlotoff, Vassilios Bezzerides, Nicholas Houstis, Colin Platt, Federico Damilano, Brian R Lindman, Sammy Elmariah, Michael Biersmith, Se-Jin Lee, Christine E Seidman, Jonathan G Seidman, Robert E Gerszten, Estelle Lach-Trifilieff, David J Glass, and Anthony Rosenzweig

Identification of Genomic and Molecular Traits that Present Therapeutic Vulnerability to HGF-targeted therapy in Glioblastoma., Jason K Sa, Sung Heon Kim, Jin-Ku Lee, Hee Jin Cho, Yong Jae Shin, Hyemi Shin, Harim Koo, Donggeon Kim, Mijeong Lee, Wonyoung Kang, Sung Hee Hong, Jung Yong Kim, Young-Whan Park, Seong-Won Song, Song-Jae Lee, Kyeung Min Joo, and Do-Hyun Nam

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Variable outcomes of human heart attack recapitulated in genetically diverse mice., Ekaterina Salimova, Kristen J Nowak, Ana C Estrada, Milena B Furtado, Elyshia McNamara, Quang Nguyen, Lois Balmer, Christoph Preuss, Jeffrey W Holmes, Mirana Ramialison, Grant Morahan, and Nadia Rosenthal

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CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes., Adam M Sandor, Robin S Lindsay, Nathan Dyjack, Jennifer C Whitesell, Cydney Rios, Brenda J Bradley, Kathryn Haskins, David V. Serreze, Aron M Geurts, Yi-Guang Chen, Max A Seibold, Jordan Jacobelli, and Rachel S Friedman

Family health history and genetic services-the East Baltimore community stakeholder interview project., Kunal Sanghavi, Ivy Moses, DuWade Moses, Adelaide Gordon, Linda Chyr, and Joann Bodurtha

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Cardiac phenotype in mouse models of systemic autoimmunity., Chandan Sanghera, Lok Man Wong, Mona Panahi, Amalia Sintou, Muneer G. Hasham, and Susanne Sattler

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Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis., Diane C Saunders, Marcela Brissova, Neil Phillips, Shristi Shrestha, John T Walker, Radhika Aramandla, Greg Poffenberger, David K Flaherty, Kevin P Weller, Julie Pelletier, Tracy Cooper, Matt T Goff, John Virostko, Alena Shostak, E Danielle Dean, Dale L Greiner, Leonard D. Shultz, Nripesh Prasad, Shawn E Levy, Robert H Carnahan, Chunhua Dai, Jean Sévigny, and Alvin C Powers

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A longitudinal big data approach for precision health., Sophia Miryam Schüssler-Fiorenza Rose, Kévin Contrepois, Kegan J Moneghetti, Wenyu Zhou, Tejaswini Mishra, Samson Mataraso, Orit Dagan-Rosenfeld, Ariel B Ganz, Jessilyn Dunn, Daniel Hornburg, Shannon Rego, Dalia Perelman, Sara Ahadi, M Reza Sailani, Yanjiao Zhou, Shana Leopold, Jieming Chen, Melanie Ashland, Jeffrey W Christle, Monika Avina, Patricia Limcaoco, Camilo Ruiz, Marilyn Tan, Atul J Butte, George M. Weinstock, George M Slavich, Erica Sodergren Weinstock, Tracey L McLaughlin, Francois Haddad, and Michael P Snyder

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Evaluating gene fusions in solid tumors - clinical experience using an RNA based 53 gene next-generation sequencing panel., Pavalan Selvam, Kevin Kelly, Andrew N Hesse, Daniel Spitzer, and Honey V Reddi

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An ontological foundation for ocular phenotypes and rare eye diseases., Panagiotis I Sergouniotis, Emmanuel Maxime, Dorothée Leroux, Annie Olry, Rachel Thompson, Ana Rath, Peter N Robinson, Hélène Dollfus, and ERN-EYE Ontology Study Group

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A large CRISPR-induced bystander mutation causes immune dysregulation., Dimitre R Simeonov, Alexander J Brandt, Alice Y Chan, Jessica T Cortez, Zhongmei Li, Jonathan M Woo, Youjin Lee, Claudia M B Carvalho, Alyssa C Indart, Theodore L Roth, James Zou, Andrew P May, James R Lupski, Mark S Anderson, F William Buaas, Daniel S Rokhsar, and Alexander Marson