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Submissions from 2020

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Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation., Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace Stafford, Vivek Kohar, Leonard D. Shultz, and Michael V. Wiles

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Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils., Vishnu Hosur, Daniel A Skelly, Christopher Francis, Benjamin E. Low, Vivek Kohar, Lisa M. Burzenski, Mansoor M Amiji, Leonard D. Shultz, and Michael V. Wiles

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A Thalamic Orphan Receptor Drives Variability in Short-Term Memory., Kuangfu Hsiao, Chelsea Noble, Wendy Pitman, Nakul Yadav, Suraj Kumar, Gregory R Keele, Andrea Terceros, Matt Kanke, Tara Conniff, Christopher Cheleuitte-Nieves, Ravi Tolwani, Praveen Sethupathy, and Priyamvada Rajasethupathy

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Decoding the mechanisms underlying cell-fate decision-making during stem cell differentiation by random circuit perturbation., Bin Huang, Mingyang Lu, Madeline Galbraith, Herbert Levine, Jose N Onuchic, and Dongya Jia

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FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity., Jonathan J Hubbard, Michal Pyzik, Timo Rath, Lisa K Kozicky, Kine M K Sand, Amit K Gandhi, Algirdas Grevys, Stian Foss, Susan C Menzies, Jonathan N Glickman, Edda Fiebiger, Derry C. Roopenian, Inger Sandlie, Jan Terje Andersen, Laura M Sly, Kristi Baker, and Richard S Blumberg

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Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells., Insoo Hyun, Megan Munsie, Martin F Pera, Nicolas C Rivron, and Janet Rossant

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Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology., Robert Ietswaart, Seda Arat, Amanda X Chen, Saman Farahmand, Bumjun Kim, William DuMouchel, Duncan Armstrong, Alexander Fekete, Jeffrey J Sutherland, and Laszlo Urban

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A novel mouse model expressing human forms for complement receptors CR1 and CR2., Harriet M. Jackson, Kate E Foley, Rita O'Rourke, Timothy M Stearns, Dina Fathalla, B Paul Morgan, and Gareth R Howell

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Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy., Liwei Jiang, Yi-Jun Wang, Jing Zhao, Mayuko Uehara, Qingming Hou, Vivek Kasinath, Takaharu Ichimura, Naima Banouni, Li Dai, Xiaofei Li, Dale L Greiner, Leonard D. Shultz, Xiaolong Zhang, Zhen-Yu Jim Sun, Ian Curtin, Nicholas E Vangos, Zoe C Yeoh, Ezekiel A Geffken, Hyuk-Soo Seo, Ze-Xian Liu, Gregory J Heffron, Khalid Shah, Sirano Dhe-Paganon, and Reza Abdi

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Integrating image caption information into biomedical document classification in support of biocuration., Xiangying Jiang, Pengyuan Li, James A. Kadin, Judith A. Blake, Martin Ringwald, and Hagit Shatkay

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MSIsensor-pro: Fast, Accurate, and Matched-normal-sample-free Detection of Microsatellite Instability., Peng Jia, Xiaofei Yang, Li Guo, Bowen Liu, Jiadong Lin, Hao Liang, Jianyong Sun, Chengsheng Zhang, and Kai Ye

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TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice., Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Laura Bongiovanni, Alain de Bruin, Dennis Beringer, Sanne van Dooremalen, Leonard D. Shultz, Fumihiko Ishikawa, Zsolt Sebestyen, Trudy Straetemans, and Jürgen Kuball

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ABCC4/MRP4 contributes to the aggressiveness of Myc-associated epithelial ovarian cancer., Moonsun Jung, Jixuan Gao, Leanna Cheung, Angelika Bongers, Klaartje Somers, Molly Clifton, Emma E Ramsay, Amanda J Russell, Emanuele Valli, Andrew J Gifford, Joshy George, Catherine J Kennedy, Matthew J Wakefield, Monique Topp, Gwo-Yaw Ho, Clare L Scott, David D Bowtell, Anna deFazio, Murray D Norris, Michelle Haber, and Michelle J Henderson

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STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells., Sascha Kahlfuss, Ulrike Kaufmann, Axel R Concepcion, Lucile Noyer, Dimitrius Raphael, Martin Vaeth, Jun Yang, Priya Pancholi, Mate Maus, James Muller, Lina Kozhaya, Alireza Khodadadi-Jamayran, Zhengxi Sun, Patrick Shaw, Derya Unutmaz, Peter B Stathopulos, Cori Feist, Scott B Cameron, Stuart E Turvey, and Stefan Feske

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Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility., Mridu Kapur, Archan Ganguly, Gabor Nagy, Scott I Adamson, Jeffrey Chuang, Wayne N Frankel, and Susan L Ackerman

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HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis., Guy Karlebach, Peter Hansen, Diogo FT Veiga, Robin Steinhaus, Daniel Danis, Sheng Li, Olga Anczuków, and Peter N Robinson

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Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle., Ataur Katebi, Vivek Kohar, and Mingyang Lu

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Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes., David C Katz, J David Aponte, Wei Liu, Rebecca M Green, Jessica M Mayeux, K Michael Pollard, Daniel Pomp, Steven C. Munger, Stephen A Murray, Charles C Roseman, Christopher J Percival, James Cheverud, Ralph S Marcucio, and Benedikt Hallgrímsson

High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains., Brendan T Keenan, Raymond J Galante, Jie Lian, Petr Simecek, Daniel M. Gatti, Lin Zhang, Diane C Lim, Karen L. Svenson, Gary Churchill, and Allan I Pack

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Decoy exosomes provide protection against bacterial toxins., Matthew D Keller, Krystal L Ching, Feng-Xia Liang, Avantika Dhabaria, Kayan Tam, Beatrix M Ueberheide, Derya Unutmaz, Victor J Torres, and Ken Cadwell

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PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock., Christina M Kelliher, Randy Lambreghts, Qijun Xiang, Christopher L. Baker, Jennifer J Loros, and Jay C Dunlap

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Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation., Eraj Shafiq Khokhar, Sneha Borikar, Elizabeth Eudy, Timothy M Stearns, Kira Young, and Jennifer J. Trowbridge

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Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers., Hoon Kim, Nam-Phuong Nguyen, Kristen Turner, Sihan Wu, Amit D Gujar, Jens Luebeck, Jihe Liu, Viraj Deshpande, Utkrisht Rajkumar, Sandeep Namburi, Samirkumar B Amin, Eunhee Yi, Francesca Menghi, Johannes H Schulte, Anton G Henssen, Howard Y Chang, Christine R Beck, Paul S Mischel, Vineet Bafna, and Roel G W Verhaak

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Automated generation of gene summaries at the Alliance of Genome Resources., Ranjana Kishore, Valerio Arnaboldi, Ceri E Van Slyke, Juancarlos Chan, Robert S Nash, Jose M Urbano, Mary E. Dolan, Stacia R Engel, Mary Shimoyama, Paul W Sternberg, and The Alliance Of Genome Resources

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A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes., Heike Kollmus, Helmut Fuchs, Christoph Lengger, Hamed Haselimashhadi, Molly A. Bogue, Manuela A Östereicher, Marion Horsch, Thure Adler, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Johannes Beckers, Julia Calzada-Wack, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Tanja Klein-Rodewald, Holger Maier, Philipp Mayer-Kuckuk, Gregor Miller, Kristin Moreth, Frauke Neff, Birgit Rathkolb, Ildikó Rácz, Jan Rozman, Nadine Spielmann, Irina Treise, Dirk Busch, Jochen Graw, Thomas Klopstock, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Jeremy Mason, Arturo Torres, Mouse Phenome Database Team, Rudi Balling, Terry Mehaan, Valerie Gailus-Durner, Klaus Schughart, and Martin Hrabě de Angelis

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Systems biology of ferroptosis: A modeling approach., Anna Konstorum, Lia Tesfay, Bibbin T Paul, Frank M Torti, Reinhard Laubenbacher, and Suzy V Torti

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Implications of increased S100β and Tau5 proteins in dystrophic nerves of two mdx mouse models for Duchenne muscular dystrophy., Vidya S Krishnan, Annemieke Aartsma-Rus, Maurice Overzier, Cathleen Lutz, Laurent P. Bogdanik, and Miranda D Grounds

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Long non-coding RNAs in immune regulation and their potential as therapeutic targets., Dinesh Babu Uthaya Kumar and Adam Williams

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Ten simple rules for providing effective bioinformatics research support., Judit Kumuthini, Michael Chimenti, Sven Nahnsen, Alexander Peltzer, Rebone Meraba, Ross McFadyen, Gordon Wells, Deanne Taylor, Mark Maienschein-Cline, Jian-Liang Li, Jyothi Thimmapuram, Radha Murthy-Karuturi, and Lyndon Zass

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Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure., Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G Tolman, Syed Hameed, Yusef Seymens, Eric Dang, Anil K Mandal, Sirisha Senthil, Rohit C Khanna, Meha Kabra, Inderjeet Kaur, Simon W M John, Subhabrata Chakrabarti, and K Saidas Nair

From GWAS Association to Function: Candidate Gene Screening Within Insulin Resistance-Associated Genomic Loci Using a Preadipocyte Differentiation Model., Feria A Ladha, Michael L. Stitzel, and J Travis Hinson

Regulation of meiotic progression by Sertoli-cell androgen signaling., Hailey Larose, Travis Kent, Qianyi Ma, Adrienne Niederriter Shami, Nadia Harerimana, Jun Z Li, Saher Sue Hammoud, and Mary Ann Handel

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Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal., Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L. Baker, Tracy C. McGarr, Christine A Wells, and Martin Pera

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V-SVA: an R Shiny application for detecting and annotating hidden sources of variation in single-cell RNA-seq data., Nathan Lawlor, Eladio J Marquez, Donghyung Lee, and Duygu Ucar

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LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia., Justin H Layer, Michael Christy, Lindsey Placek, Derya Unutmaz, Yan Guo, and Utpal P Davé

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Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis., Nathan Leclair, Mattia Brugiolo, Laura M Urbanski, Shane C Lawson, Ketan Thakar, Marina Yurieva, Joshy George, J Travis Hinson, Albert Cheng, Brenton R Graveley, and Olga Anczuków

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ChIA-PIPE: A fully automated pipeline for comprehensive ChIA-PET data analysis and visualization., Byoungkoo Lee, Jiahui Wang, Liuyang Cai, Minji Kim, Sandeep Namburi, Harianto Tjong, Yuliang Feng, Ping Wang, Zhonghui Tang, Ahmed Abbas, Chia-Lin Wei, Yijun Ruan, and Sheng Li

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Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients., Jihyun Lee, Suzanne D Vernon, Patricia Jeys, Weam Ali, Andrea Campos, Derya Unutmaz, Brayden Yellman, and Lucinda Bateman

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Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A., Se-Jin Lee, Adam Lehar, Yewei Liu, Chi Hai Ly, Quynh-Mai Pham, Michael Michaud, Renata Rydzik, Daniel W Youngstrom, Michael M Shen, Vesa Kaartinen, Emily L Germain-Lee, and Thomas A Rando

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Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight., Se-Jin Lee, Adam Lehar, Jessica U Meir, Christina Koch, Andrew Morgan, Lara E Warren, Renata Rydzik, Daniel W Youngstrom, Harshpreet Chandok, Joshy George, Joseph Gogain, Michael Michaud, Thomas A Stoklasek, Yewei Liu, and Emily L Germain-Lee

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An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation., Andrew M Lerner, Austin J Hepperla, Gregory R Keele, Hashem A Meriesh, Hayretin Yumerefendi, David Restrepo, Seth Zimmerman, James E Bear, Brian Kuhlman, Ian J Davis, and Brian D Strahl

Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity., Zhengzheng S Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E Vancollie, Ximena Ibarra-Soria, Helen V Firth, Debra Rimmington, I Sadaf Farooqi, Christopher J Lelliott, Steven C. Munger, Stephen O'Rahilly, Anne C Ferguson-Smith, Anthony P Coll, and Darren W Logan

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Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice., Fang Li, Ruijuan Xu, Chih-Li Lin, Benjamin E. Low, Louise Cai, Sally Li, Ping Ji, Liqun Huang, Michael V. Wiles, Yusuf A Hannun, Lina M Obeid, Ye Chen, and Cungui Mao

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miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells., Clarice X Lim, Bernett Lee, Olivia Geiger, Christina Passegger, Michaela Beitzinger, Johann Romberger, Anika Stracke, Christoph Högenauer, Anton Stift, Heribert Stoiber, Michael Poidinger, Armin Zebisch, Gunter Meister, Adam Williams, Richard A Flavell, Jorge Henao-Mejia, and Herbert Strobl

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Development and validation of a novel 29-plex Y-STR typing system for forensic application., Min Li, Wei Zhou, Yilun Zhang, Lei Huang, Xinjie Wang, Jun Wu, Meng Meng, Hongran Wang, Chengtao Li, and Yingnan Bian

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A large-scale genome-lipid association map guides lipid identification., Vanessa Linke, Katherine A Overmyer, Ian J Miller, Dain R Brademan, Paul D Hutchins, Edna A Trujillo, Thiru R Reddy, Jason D Russell, Emily M Cushing, Kathryn L Schueler, Donald S Stapleton, Mary E Rabaglia, Mark P Keller, Daniel M Gatti, Gregory R Keele, Duy Pham, Karl W Broman, Gary A Churchill, Alan D Attie, and Joshua J Coon

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Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis., Peishan Li, Mingyang Lu, Jiayuan Shi, Zheng Gong, Li Hua, Qing Li, Bora Lim, Xiang H-F Zhang, Xiaowen Chen, Sheng Li, Leonard D. Shultz, and Guangwen Ren

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Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status., Peishan Li, Mingyang Lu, Jiayuan Shi, Li Hua, Zheng Gong, Qing Li, Leonard D. Shultz, and Guangwen Ren

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Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML., Sheng Li, Xiaowen Chen, Jiahui Wang, Cem Meydan, Jacob L Glass, Alan H Shih, Ruud Delwel, Ross L Levine, Christopher E Mason, and Ari M Melnick

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GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells., thomas lisse, Manju Sharma, Neda Vishlaghi, Sri Ramulu N Pullagura, and Robert E Braun

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GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells., Thomas S Lisse, Manju Sharma, Neda Vishlaghi, Sri Ramulu N Pullagura, and Robert E Braun

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Structure-based discovery of a small-molecule inhibitor of methicillin-resistant, Jie Liu, Lina Kozhaya, Victor J Torres, Derya Unutmaz, and Min Lu

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Addressing the batch effect issue for LC/MS metabolomics data in data preprocessing., Qin Liu, Douglas Walker, Karan Uppal, Zihe Liu, Chunyu Ma, ViLinh Tran, Shuzhao Li, Dean P Jones, and Tianwei Yu

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The Deep Genome Project., K C Kent Lloyd, David J Adams, Gareth Baynam, Arthur L Beaudet, Fatima Bosch, Kym M Boycott, Robert E Braun, Mark Caulfield, Ronald Cohn, Mary E Dickinson, Michael S Dobbie, Ann M Flenniken, Paul Flicek, Sanjeev Galande, Xiang Gao, Anne Grobler, Jason D Heaney, Yann Herault, Martin Hrabě de Angelis, James R Lupski, Stanislas Lyonnet, Ann-Marie Mallon, Fabio Mammano, Calum A MacRae, Roderick McInnes, Colin McKerlie, Terrence F Meehan, Stephen A Murray, Lauryl M J Nutter, Yuichi Obata, Helen Parkinson, Michael S Pepper, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Damian Smedley, Glauco Tocchini-Valentini, David Valle, Chi-Kuang Leo Wang, Sara Wells, Jacqueline K White, Wolfgang Wurst, Ying Xu, and Steve D M Brown

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Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human, Benjamin E. Low, Gregory J. Christianson, Emily Lowell, Wenning Qin, and Michael V. Wiles

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LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding., Huacheng Luo, Qin Yu, Yang Liu, Ming Tang, Mingwei Liang, Dingpeng Zhang, Tsan Sam Xiao, Lizi Wu, Ming Tan, Yijun Ruan, Jörg Bungert, and Jianrong Lu

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Realizing the gains and losses in C9ORF72 ALS/FTD., Cathleen Lutz

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COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice., Cathleen Lutz, Leigh Maher, Charles Lee, and Wonyoung Kang

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Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma., Mayinuer Maitituoheti, Emily Z Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K Singh, Ayush T Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B Amin, Sneha Sharma, Maura Williams, Neha S Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B Axelrad, Nazanin E Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q Chang, Davis R Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, and Kunal Rai

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Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α., Shivani N Mann, Niran Hadad, Molly Nelson Holte, Alicia R Rothman, Roshini Sathiaseelan, Samim Ali Mondal, Martin-Paul Agbaga, Archana Unnikrishnan, Malayannan Subramaniam, John Hawse, Derek M Huffman, Willard M Freeman, and Michael B Stout

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Genomic Medicine Year in Review: 2020., Teri A Manolio, Carol J Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Madison Goldrich, Gail P Jarvik, George A Mensah, Mary V Relling, Dan M Roden, Robb Rowley, Cecelia Tamburro, Marc S Williams, and Eric D Green

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Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation., Olivia J Marola, Stephanie B Syc-Mazurek, Gareth R Howell, and Richard T Libby

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Sexual-dimorphism in human immune system aging., Eladio J Márquez, Cheng-Han Chung, Radu Marches, Robert J Rossi, Djamel Nehar-Belaid, Alper Eroglu, David J Mellert, George A Kuchel, Jacques Banchereau, and Duygu Ucar

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The lethal sex gap: COVID-19., Eladio J Márquez, Jennifer J. Trowbridge, George A Kuchel, Jacques Banchereau, and Duygu Ucar

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Overlapping spectrums: The clinicogenetic commonalities between Charcot-Marie-Tooth and other neurodegenerative diseases., Paige B Martin, Amy N Hicks, Sarah E Holbrook, and Gregory A. Cox

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NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease., Paige B Martin, Yu Kigoshi-Tansho, Roger B Sher, Gianina Ravenscroft, Jennifer E Stauffer, Rajesh Kumar, Ryo Yonashiro, Tina Müller, Christopher Griffith, William Allen, Davut Pehlivan, Tamar Haral, Martin Zenker, Denise Howting, Denny Schanze, Eissa A Faqeih, Naif A M Almontashiri, Reza Maroofian, Henry Houlden, Neda Mazaheri, Hamid Galehdari, Ganka Douglas, Jennifer E Posey, Monique Ryan, James R Lupski, Nigel G Laing, Claudio A P Joazeiro, and Gregory A. Cox

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Nine quick tips for efficient bioinformatics curriculum development and training., Susan McClatchy, Kristin M Bass, Daniel M. Gatti, Adam Moylan, and Gary Churchill

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High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy., Michael A McLellan, Daniel A Skelly, Malathi S I Dona, Galen T Squiers, Gabriella E Farrugia, Taylah L Gaynor, Charles D Cohen, Raghav Pandey, Henry Diep, Antony Vinh, Nadia Rosenthal, and Alexander R Pinto

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Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus., Laura E Mickelsen, William F Flynn, Kristen Springer, Lydia Wilson, Eric J Beltrami, Mohan Bolisetty, Paul Robson, and Alexander C Jackson

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Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4, Ashley A Viehmann Milam, Juliet M Bartleson, Michael D Buck, Chih-Hao Chang, Alexey Sergushichev, David L Donermeyer, Wing Y Lam, Erika L Pearce, Maxim N Artyomov, and Paul M Allen

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Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology., Nikhil Milind, Christoph Preuss, Annat Haber, Guruprasad Ananda, Shubhabrata Mukherjee, Cai John, Sarah Shapley, Benjamin A Logsdon, Paul K Crane, and Gregory W. Carter

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Canagliflozin extends life span in genetically heterogeneous male but not female mice., Richard A Miller, David E Harrison, David B Allison, Molly A. Bogue, Lucas Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej Galecki, W Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin A Javors, Warren C Ladiges, Francesca Macchiarini, James Nelson, Peter C. Reifsnyder, Nadia Rosenthal, Marianna Sadagurski, Adam B Salmon, Daniel L Smith, Jessica M Snyder, David B Lombard, and Randy Strong

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Prognostic gene expression signature for high-grade serous ovarian cancer., J Millstein, T Budden, E L Goode, M S Anglesio, A Talhouk, M P Intermaggio, H S Leong, S Chen, W Elatre, B Gilks, T Nazeran, M Volchek, R C Bentley, C Wang, D S Chiu, S Kommoss, S C Y Leung, J Senz, A Lum, V Chow, H Sudderuddin, R Mackenzie, Joshy George, AOCS Group, S Fereday, J Hendley, N Traficante, H Steed, J M Koziak, M Köbel, I A McNeish, T Goranova, D Ennis, G Macintyre, D Silva De Silva, T Ramón Y Cajal, J García-Donas, S Hernando Polo, G C Rodriguez, K L Cushing-Haugen, H R Harris, C S Greene, R A Zelaya, S Behrens, R T Fortner, P Sinn, E Herpel, J Lester, J Lubiński, O Oszurek, A Tołoczko, C Cybulski, J Menkiszak, C L Pearce, M C Pike, C Tseng, J Alsop, V Rhenius, H Song, M Jimenez-Linan, A M Piskorz, A Gentry-Maharaj, C Karpinskyj, M Widschwendter, N Singh, C J Kennedy, R Sharma, P R Harnett, B Gao, S E Johnatty, R Sayer, J Boros, S J Winham, G L Keeney, S H Kaufmann, M C Larson, H Luk, B Y Hernandez, P J Thompson, L R Wilkens, M E Carney, B Trabert, J Lissowska, L Brinton, M E Sherman, C Bodelon, S Hinsley, L A Lewsley, R Glasspool, S N Banerjee, E A Stronach, P Haluska, I Ray-Coquard, S Mahner, B Winterhoff, D Slamon, D A Levine, L E Kelemen, J Benitez, J Chang-Claude, J Gronwald, A H Wu, U Menon, M T Goodman, J M Schildkraut, N Wentzensen, R Brown, A Berchuck, G Chenevix-Trench, A deFazio, S A Gayther, M J García, M J Henderson, M A Rossing, A Beeghly-Fadiel, P A Fasching, S Orsulic, B Y Karlan, G E Konecny, D G Huntsman, D D Bowtell, J D Brenton, J A Doherty, P D P Pharoah, and S J Ramus

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Differences in Gut Microbiome in Hospitalized Immunocompetent vs. Immunocompromised Children, Including Those With Sickle Cell Disease., Sindhu Mohandas, Vijaya L Soma, Thi Dong Binh Tran, Erica Sodergren, Tresa Ambooken, David L Goldman, George M. Weinstock, and Betsy C Herold

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Gene therapies for axonal neuropathies: Available strategies, successes to date, and what to target next., Kathryn H Morelli, Courtney L Hatton, Scott Q Harper, and Robert W. Burgess

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Molecular estimation of neurodegeneration pseudotime in older brains., Sumit Mukherjee, Laura Heath, Christoph Preuss, Suman Jayadev, Gwenn A Garden, Anna K Greenwood, Solveig K Sieberts, Philip L De Jager, Nilüfer Ertekin-Taner, Gregory W. Carter, Lara M Mangravite, and Benjamin A Logsdon

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The acquisition of positional information across the radial axis of the cochlea., Vidhya Munnamalai and Donna M Fekete

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Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways., Xiang Nan, Jiang Wang, Hao Cheng, Zheng Yin, Jianting Sheng, Bensheng Qiu, Ching C Lau, Jason T Yustein, Hong Zhao, and Stephen T C Wong

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A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities., Ravi S Narayan, Piet Molenaar, Jian Teng, Fleur M G Cornelissen, Irene Roelofs, Renee Menezes, Rogier Dik, Tonny Lagerweij, Yoran Broersma, Naomi Petersen, Jhon Alexander Marin Soto, Eelke Brands, Philip van Kuiken, Maria C Lecca, Kristiaan J Lenos, Sjors G J G In 't Veld, Wessel van Wieringen, Frederick F Lang, Erik Sulman, Roel G W Verhaak, Brigitta G Baumert, Lucas J A Stalpers, Louis Vermeulen, Colin Watts, David Bailey, Ben J Slotman, Rogier Versteeg, David Noske, Peter Sminia, Bakhos A Tannous, Tom Wurdinger, Jan Koster, and Bart A Westerman

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A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T, Rabab Nasrallah, Charlotte J Imianowski, Lara Bossini-Castillo, Francis M Grant, Mikail Dogan, Lindsey Placek, Lina Kozhaya, Paula Kuo, Firas Sadiyah, Sarah K Whiteside, Maxwell R Mumbach, Dafni Glinos, Panagiota Vardaka, Carly E Whyte, Teresa Lozano, Toshitsugu Fujita, Hodaka Fujii, Adrian Liston, Simon Andrews, Adeline Cozzani, Jie Yang, Suman Mitra, Enrico Lugli, Howard Y Chang, Derya Unutmaz, Gosia Trynka, and Rahul Roychoudhuri

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Mapping systemic lupus erythematosus heterogeneity at the single-cell level., Djamel Nehar-Belaid, Seunghee Hong, Radu Marches, Guo Chen, Mohan Bolisetty, Jeanine Baisch, Lynnette Walters, Marilynn Punaro, Robert J Rossi, Cheng-Han Chung, Richie P Huynh, Prashant Singh, William F Flynn, Joy-Ann Tabanor-Gayle, Navya Kuchipudi, Asuncion Mejias, Magalie A Collet, Anna Lisa Lucido, Karolina Palucka, Paul Robson, Santhanam Lakshminarayanan, Octavio Ramilo, Tracey Wright, Virginia Pascual, and Jacques Banchereau

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Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development., Chew Yee Ngan, Chee-Hong Wong, Harianto Tjong, Wenbo Wang, Rachel L Goldfeder, Cindy Choi, Hao He, Liang Gong, Junyan Lin, Barbara Urban, Julianna Chow, Meihong Li, Joanne Lim, Vivek M. Philip, Stephen A. Murray, Haoyi Wang, and Chia-Lin Wei

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Molecular profiling of CNS tumors for the treatment and management of disease., Qian Nie, Meng-Chang Hsiao, Harshpreet Chandok, Shannon Rowe, Matthew Prego, Bridgette Meyers, Gregory Omerza, Andrew N Hesse, Jasmina Uvalic, Melissa Soucy, Daniel Bergeron, Michael Peracchio, Shelbi Burns, Kevin Kelly, Jens Rueter, and Honey V Reddi

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Molecular profiling of gynecologic cancers for treatment and management of disease - demonstrating clinical significance using the AMP/ASCO/CAP guidelines for interpretation and reporting of somatic variants., Qian Nie, Gregory Omerza, Harshpreet Chandok, Matthew Prego, Meng-Chang Hsiao, Bridgette Meyers, Andrew N Hesse, Jasmina Uvalic, Melissa Soucy, Daniel Bergeron, Michael Peracchio, Shelbi Burns, Kevin Kelly, Shannon Rowe, Jens Rueter, and Honey V Reddi

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An intact C-terminal end of albumin is required for its long half-life in humans., Jeannette Nilsen, Esben Trabjerg, Algirdas Grevys, Claudia Azevedo, Stephen O Brennan, Maria Stensland, John J Wilson, Kine Marita Knudsen Sand, Malin Bern, Bjørn Dalhus, Derry C. Roopenian, Inger Sandlie, Kasper Dyrberg Rand, and Jan Terje Andersen

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Deep learning-based cross-classifications reveal conserved spatial behaviors within tumor histological images., Javad Noorbakhsh, Saman Farahmand, Ali Foroughi Pour, Sandeep Namburi, Dennis Caruana, David Rimm, Mohammad Soltanieh-Ha, Kourosh Zarringhalam, and Jeffrey Chuang

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Treating Cancer as an Invasive Species., Javad Noorbakhsh, Zi-Ming Zhao, James C Russell, and Jeffrey H Chuang

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Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD., Adrian L Oblak, Stefania Forner, Paul R Territo, Michael Sasner, Gregory W. Carter, Gareth R Howell, Stacey J Sukoff-Rizzo, Benjamin A Logsdon, Lara M Mangravite, Ali Mortazavi, David Baglietto-Vargas, Kim N Green, Grant R MacGregor, Marcelo A Wood, Andrea J Tenner, Frank M LaFerla, Bruce T Lamb, and The MODEL-AD Consortium

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Novel CTNND2-TERT fusion in a spindle cell liposarcoma., Michael Occidental, Guomiao Shen, Xiaojun Feng, Kelsey Zhu, Kevin Kelly, Qian Nie, Honey V Reddi, Eleftheria Lakiotaki, Nora Athina Viniou, Penelope Korkolopoulou, Konstantinos Linos, and George Jour

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Targeting antioxidant enzymes enhances the therapeutic efficacy of the BCL-X, Yumi Oh, Hae Rim Jung, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Jiwon Kim, Sang Eun Lee, Chang Ohk Sung, Won-Suk Lee, Charles Lee, Charles Lee, and Sung-Yup Cho

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MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas., Barbara Oldrini, Nuria Vaquero-Siguero, Quanhua Mu, Paula Kroon, Ying Zhang, Marcos Galán-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason K Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel G W Verhaak, Raul Rabadan, Tao Jiang, Jiguang Wang, and Massimo Squatrito

Modelling kidney disease using ontology: insights from the Kidney Precision Medicine Project., Edison Ong, Lucy L Wang, Jennifer Schaub, John F O'Toole, Becky Steck, Avi Z Rosenberg, Frederick Dowd, Jens Hansen, Laura Barisoni, Sanjay Jain, Ian H de Boer, M Todd Valerius, Sushrut S Waikar, Christopher Park, Dana C Crawford, Theodore Alexandrov, Christopher R Anderton, Christian Stoeckert, Chunhua Weng, Alexander D Diehl, Christopher J Mungall, Melissa Haendel, Peter N Robinson, Jonathan Himmelfarb, Ravi Iyengar, Matthias Kretzler, Sean Mooney, Yongqun He, and Kidney Precision Medicine Project

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Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation., Daniel Ortmann, Stephanie Brown, Anne M Czechanski, Selcan Aydin, Daniele Muraro, Yuanhua Huang, Rute A Tomaz, Anna Osnato, Giovanni Canu, Brandon T Wesley, Daniel A Skelly, Oliver Stegle, Ted Choi, Gary A Churchill, Christopher L. Baker, Peter J Rugg-Gunn, Steven C. Munger, Laura G Reinholdt, and Ludovic Vallier

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Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia., Andrew R Ouellette, Sarah M Neuner, Logan Dumitrescu, Laura C. Anderson, Daniel M. Gatti, Emily R Mahoney, Jason A. Bubier, Gary Churchill, Luanne L. Peters, Matthew J Huentelman, Jeremy H Herskowitz, Hyun-Sik Yang, Alexandra N Smith, Christiane Reitz, Brian W Kunkle, Charles C White, Philip L De Jager, Julie A Schneider, David A Bennett, Nicholas T Seyfried, Alzheimer's Disease Genetics Consortium, Elissa J Chesler, Niran Hadad, Timothy J Hohman, and Catherine Kaczorowski

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Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitry., William Paden, Kelly Barko, Rachel Puralewski, Kelly M Cahill, Zhiguang Huo, Micah A Shelton, George C Tseng, Ryan W Logan, and Marianne L Seney

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MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics., Zhiqiang Pang, Jasmine Chong, Shuzhao Li, and Jianguo Xia

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Depletion of CLK2 sensitizes glioma stem-like cells to PI3K/mTOR and FGFR inhibitors., Soon Young Park, Sandeep Mittal, Jianwen Dong, Kangjin Jeong, Emmanuel Martinez-Ledesma, Yuji Piao, Sabbir Khan, Verlene Henry, Roel G W Verhaak, Nazanin Majd, Veerakumar Balasubramaniyan, and John F de Groot

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The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing., Sara Parsa, Ana Ortega-Molina, Hsia-Yuan Ying, Man Jiang, Matt Teater, Jiahui Wang, Chunying Zhao, Ed Reznik, Joyce P Pasion, David Kuo, Prathibha Mohan, Shenqiu Wang, Jeannie M Camarillo, Paul M Thomas, Neeraj Jain, Javier Garcia-Bermudez, Byoung-Kyu Cho, Wayne Tam, Neil L Kelleher, Nicholas Socci, Ahmet Dogan, Elisa De Stanchina, Giovanni Ciriello, Michael R Green, Sheng Li, Kivanc Birsoy, Ari M Melnick, and Hans-Guido Wendel

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Proceedings of the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT) Oligodendroglioma Workshop., Marta Penas-Prado, Jing Wu, Daniel P Cahill, Daniel J Brat, Joseph F Costello, Paul G Kluetz, J Gregory Cairncross, Martin van den Bent, Roel G W Verhaak, Orwa Aboud, Peter Burger, Susan M Chang, Christine Cordova, Raymond Y Huang, Lindsay S Rowe, Martin J B Taphoorn, Mark R Gilbert, Terri S Armstrong, and NCI-CONNECT Oligodendr0glioma Worhshop

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Sestrins induce natural killer function in senescent-like CD8, Branca I Pereira, Roel P H De Maeyer, Luciana P Covre, Djamel Nehar-Belaid, Alessio Lanna, Sophie Ward, Radu Marches, Emma S Chambers, Daniel C O Gomes, Natalie E Riddell, Mala K Maini, Vitor H Teixeira, Samuel M Janes, Derek W Gilroy, Anis Larbi, Neil A Mabbott, Duygu Ucar, George A Kuchel, Sian M Henson, Jessica Strid, Jun H Lee, Jacques Banchereau, and Arne N Akbar