Submissions from 2020
Know Your Model: Microbiota & phenotypes., Michelle N Perry, Susan M. Bello, and Cynthia Smith
Know Your Model: Recombinase-expressing mice., Michelle N Perry, Susan M. Bello, and Cynthia Smith
Know Your Model: Why mouse inbred strain contribution matters., Michelle N Perry, Susan M. Bello, and Cynthia Smith
parSMURF, a high-performance computing tool for the genome-wide detection of pathogenic variants., Alessandro Petrini, Marco Mesiti, Max Schubach, Marco Frasca, Daniel Danis, Matteo Re, Giuliano Grossi, Luca Cappelletti, Tiziana Castrignanò, Peter N Robinson, and Giorgio Valentini
Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human, Anthony M Pettinato, Feria A Ladha, David J Mellert, Nicholas Legere, Rachel Cohn, Robert Romano, Ketan Thakar, Yu-Sheng Chen, and J Travis Hinson
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma., Joseph R Podojil, Alexander P Glaser, Dylan Baker, Elise T Courtois, Damiano Fantini, Yanni Yu, Valerie Eaton, Santhosh Sivajothi, Mingyi Chiang, Arighno Das, Kimberly A McLaughlin, Paul Robson, Stephen D Miller, and Joshua J Meeks
The contribution of microRNA-mediated regulation to short- and long-term gene expression predictability., Russell Posner and Reinhard Laubenbacher
Sexual dimorphism in the meiotic requirement for PRDM9: A mammalian evolutionary safeguard., Natalie Powers, Beth L Dumont, Chihiro Emori, Raman Akinyanju Lawal, Catherine Brunton, Kenneth Paigen, Mary Ann Handel, Ewelina Bolcun-Filas, Petko M. Petkov, and Tanmoy Bhattacharyya
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease., Christoph Preuss, Ravi S Pandey, Erin Piazza, Alexander D Fine, Asli Uyar, Thanneer Perumal, Dylan Garceau, Kevin P Kotredes, Harriet M. Williams, Lara M Mangravite, Bruce T Lamb, Adrian L Oblak, Gareth R Howell, Michael Sasner, Benjamin A Logsdon, MODEL-AD Consortium, and Gregory W. Carter
Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors., Lin Qi, Mari Kogiso, Yuchen Du, Huiyuan Zhang, Frank K Braun, Yulun Huang, Wan-Yee Teo, Holly Lindsay, Sibo Zhao, Patricia Baxter, Xiumei Zhao, Litian Yu, Zhigang Liu, Xingding Zhang, Jack Mf Su, Adekunle Adesina, Jianhua Yang, Murali Chintagumpala, Laszlo Perlaky, Chris Tsz-Kwong Man, Ching C Lau, and Xiao-Nan Li
T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue., Jeremy Racine, Harry Chapman, Rosalinda A. Doty, Brynn Cairns, Timothy J Hines, Abigail L D Tadenev, Laura C. Anderson, Torrian L Green, Meaghan E Dyer, Janine M Wotton, Zoë Bichler, Jacqueline K White, Rachel Ettinger, Robert W. Burgess, and David V. Serreze
Toward Modeling Context-Specific EMT Regulatory Networks Using Temporal Single Cell RNA-Seq Data., Daniel Ramirez, Vivek Kohar, and Mingyang Lu
Inter-Strain Epigenomic Profiling Reveals a Candidate IAP Master Copy in C3H Mice., Rita Rebollo, Mariana Galvão-Ferrarini, Liane Gagnier, Ying Zhang, Ardian Ferraj, Christine R Beck, Matthew C Lorincz, and Dixie L Mager
Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice., Sambra D Redick, Linda Leehy, Ann R Rittenhouse, David M Blodgett, Alan G Derr, Alper Kucukural, Manuel G Garber, Leonard D. Shultz, Dale L Greiner, Jennifer P Wang, David M Harlan, Rita Bortell, and Agata Jurczyk
Spinal motor neuron loss occurs through a p53-and-p21-independent mechanism in the Smn, Emily J Reedich, Martin Kalski, Nicholas Armijo, Gregory A. Cox, and Christine J DiDonato
Differential Effects of Rapamycin on Glucose Metabolism in Nine Inbred Strains., Peter C. Reifsnyder, Austen Te, and David E Harrison
Definition of erythroid cell-positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection., Darawan Rinchai, Matthew C Altman, Oceane Konza, Signe Hässler, Federica Martina, Mohammed Toufiq, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Karolina Palucka, Asuncion Mejias, Octavio Ramilo, Davide Bedognetti, Encarnita Mariotti-Ferrandiz, David Klatzmann, and Damien Chaussabel
Ontologies, knowledge representation, and machine learning for translational research: recent contributions, Peter N Robinson and Melissa A. Haendel
Interpretable Clinical Genomics with a Likelihood Ratio Paradigm., Peter N Robinson, Vida Ravanmehr, Julius O B Jacobsen, Daniel Danis, Xingmin Aaron Zhang, Leigh Carmody, Michael Gargano, Courtney L Thaxton, UNC Biocuration Core, Guy Karlebach, Justin Reese, Manuel Holtgrewe, Sebastian Köhler, Julie A McMurry, Melissa A Haendel, and Damian Smedley
Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant., Ray F. Robledo, Steven L. Ciciotte, Joel H Graber, Yue Zhao, Amy J Lambert, Babette Gwynn, Nathaniel J Maki, Elena C Brindley, Emily Hartman, Lionel Blanc, and Luanne L. Peters
Characterisation of ST25 NDM-1-producing Acinetobacter spp. strains leading the increase in NDM-1 emergence in Argentina., Deja Rodgers, Fernando Pasteran, Manuel Calderon, Sara Jaber, German M Traglia, Ezequiel Albornoz, Alejandra Corso, Alejandro J Vila, Robert A Bonomo, Mark D Adams, and María Soledad Ramírez
Improving Characterization of Understudied Human Microbiomes Using Targeted Phylogenetics., Bruce A Rosa, Kathie Mihindukulasuriya, Kymberlie Hallsworth-Pepin, Aye Wollam, John Martin, Caroline Snowden, William Michael Dunne, George M. Weinstock, C A Burnham, and Makedonka Mitreva
TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis., Wojciech Rosikiewicz, Xiaowen Chen, Pilar M Dominguez, Hussein Ghamlouch, Said Aoufouchi, Olivier A Bernard, Ari Melnick, and Sheng Li
PATHBIO: an international training program for precision mouse phenotyping., Jesus Ruberte, Paul N Schofield, Cord Brakebusch, Peter Vogel, Yann Herault, Guillem Gracia, Colin McKerlie, Martin Hrabĕ de Angelis, Michael Hagn, and John P Sundberg
The case for open science: rare diseases., Yaffa R Rubinstein, Peter N Robinson, William A Gahl, Paul Avillach, Gareth Baynam, Helene Cederroth, Rebecca M Goodwin, Stephen C Groft, Mats G Hansson, Nomi L Harris, Vojtech Huser, Deborah Mascalzoni, Julie A McMurry, Matthew Might, Christoffer Nellaker, Barend Mons, Dina N Paltoo, Jonathan Pevsner, Manuel Posada, Alison P Rockett-Frase, Marco Roos, Tamar B Rubinstein, Domenica Taruscio, Esther van Enckevort, and Melissa A Haendel
Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice., Yoriko Saito, Leonard D. Shultz, and Fumihiko Ishikawa
Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma., Jason K Sa, Nakho Chang, Hye Won Lee, Hee Jin Cho, Michele Ceccarelli, Luigi Cerulo, Jinlong Yin, Sung Soo Kim, Francesca P Caruso, Mijeong Lee, Donggeon Kim, Young Taek Oh, Yeri Lee, Nam-Gu Her, Byeongkwi Min, Hye-Jin Kim, Da Eun Jeong, Hye-Mi Kim, Hyunho Kim, Seok Chung, Hyun Goo Woo, Jeongwu Lee, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Jinho Kim, Woong-Yang Park, Qianghu Wang, Erik P Sulman, Amy B Heimberger, Michael Lim, Jong Bae Park, Antonio Iavarone, Roel G W Verhaak, and Do-Hyun Nam
Mechanisms of T-Cell Exhaustion in Pancreatic Cancer., Didem Saka, Muazzez Gökalp, Betül Piyade, Nedim Can Cevik, Elif Arik Sever, Derya Unutmaz, Güralp O Ceyhan, Ihsan Ekin Demir, and Hande Asimgil
A supervised learning framework for chromatin loop detection in genome-wide contact maps., Tarik J Salameh, Xiaotao Wang, Fan Song, Bo Zhang, Sage M Wright, Chachrit Khunsriraksakul, Yijun Ruan, and Feng Yue
Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis., Jennifer M SanMiguel, Kira Young, and Jennifer J. Trowbridge
Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B., Gauthier Schang, Luisina Ongaro, Hailey Schultz, Ying Wang, Xiang Zhou, Emilie Brûlé, Ulrich Boehm, Se-Jin Lee, and Daniel J Bernard
Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine., Sarah A Schoenrock, Padam Kumar, Alexander Gómez-A, Price E. Dickson, Sam-Moon Kim, Lauren Bailey, Sofia Neira, Kyle D Riker, Joseph Farrington, Christiann H Gaines, Saad Khan, Troy D Wilcox, Tyler A. Roy, Michael R Leonardo, Ashley A Olson, Leona H. Gagnon, Vivek M. Philip, William Valdar, Fernando Pardo-Manuel de Villena, James D Jentsch, Ryan W Logan, Colleen A McClung, Donita L Robinson, Elissa J Chesler, and Lisa M Tarantino
Mutation Yield of a Custom 212-Gene Next-Generation Sequencing Panel for Solid Tumors: Clinical Experience of the First 260 Cases Tested Using the JAX ActionSeq™ Assay., Pavalan Selvam, Meng-Chang Hsiao, Gregory Omerza, Daniel Bergeron, Shannon Rowe, Jasmina Uvalic, Melissa Soucy, Michael Peracchio, Shelbi Burns, Bridgette Meyers, Matthew Prego, Qian Nie, Guruprasad Ananda, Harshpreet Chandok, Kevin Kelly, Andrew N Hesse, and Honey V Reddi
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation., Melanie R Shapiro, Wen-I Yeh, Joshua R Longfield, John Gallagher, Caridad M Infante, Sarah Wellford, Amanda L Posgai, Mark A Atkinson, Martha Campbell-Thompson, Scott M Lieberman, David V. Serreze, Aron M Geurts, Yi-Guang Chen, and Todd M Brusko
The Monarch Initiative in 2019: an integrative data and analytic platform connecting phenotypes to genotypes across species., Kent A Shefchek, Nomi L Harris, Michael Gargano, Nicolas Matentzoglu, Deepak Unni, Matthew Brush, Daniel Keith, Tom Conlin, Nicole Vasilevsky, Xingmin Aaron Zhang, James P Balhoff, Larry Babb, Susan M. Bello, Hannah Blau, Yvonne Bradford, Seth Carbon, Leigh Carmody, Lauren E Chan, Valentina Cipriani, Alayne Cuzick, Maria D Rocca, Nathan Dunn, Shahim Essaid, Petra Fey, Chris Grove, Jean-Phillipe Gourdine, Ada Hamosh, Midori Harris, Ingo Helbig, Maureen Hoatlin, Marcin Joachimiak, Simon Jupp, Kenneth B Lett, Suzanna E Lewis, Craig McNamara, Zoë M Pendlington, Clare Pilgrim, Tim Putman, Vida Ravanmehr, Justin Reese, Erin Riggs, Sofia Robb, Paola Roncaglia, James Seager, Erik Segerdell, Morgan Similuk, Andrea L Storm, Courtney Thaxon, Anne Thessen, Julius O B Jacobsen, Julie A McMurry, Tudor Groza, Sebastian Köhler, Damian Smedley, Peter N Robinson, Christopher J Mungall, Melissa A Haendel, Monica C Munoz-Torres, and David Osumi-Sutherland
Association of CNVs with methylation variation., Xinghua Shi, Saranya Radhakrishnan, Jia Wen, Jin Yun Chen, Junjie Chen, Brianna Ashlyn Lam, Ryan E Mills, Barbara E Stranger, Charles Lee, and Sunita R Setlur
Reduced GABAergic Neuron Excitability, Altered Synaptic Connectivity, and Seizures in a KCNT1 Gain-of-Function Mouse Model of Childhood Epilepsy., Amy N Shore, Sophie Colombo, William F Tobin, Sabrina Petri, Erin R Cullen, Soledad Dominguez, Christopher D Bostick, Michael A Beaumont, Damian Williams, Dion Khodagholy, Mu Yang, Cathleen M Lutz, Yueqing Peng, Jennifer N Gelinas, David B Goldstein, Michael J Boland, Wayne N Frankel, and Matthew C Weston
Content and Performance of the MiniMUGA Genotyping Array, a New Tool To Improve Rigor and Reproducibility in Mouse Research., John Sebastian Sigmon, Matthew W Blanchard, Ralph S Baric, Timothy A Bell, Jennifer Brennan, Gudrun A Brockmann, A Wesley Burks, J Mauro Calabrese, Kathleen M Caron, Richard E Cheney, Dominic Ciavatta, Frank Conlon, David B Darr, James Faber, Craig Franklin, Timothy R Gershon, Lisa Gralinski, Bin Gu, Christiann H Gaines, Robert S Hagan, Ernest G Heimsath, Mark T Heise, Pablo Hock, Folami Ideraabdullah, J Charles Jennette, Tal Kafri, Anwica Kashfeen, Mike Kulis, Vivek Kumar, Colton Linnertz, Alessandra Livraghi-Butrico, K C Kent Lloyd, Cathleen Lutz, Rachel M Lynch, Terry Magnuson, Glenn K Matsushima, Rachel McMullan, Darla R Miller, Karen L Mohlke, Sheryl S Moy, Caroline Murphy, Maya Najarian, Lori O'Brien, Abraham A Palmer, Benjamin D Philpot, Scott H Randell, Laura G Reinholdt, Yuyu Ren, Steve Rockwood, Allison R Rogala, Avani Saraswatula, Christopher M Sassetti, Jonathan C Schisler, Sarah A Schoenrock, Ginger D Shaw, John R Shorter, Clare M Smith, Celine L St Pierre, Lisa M Tarantino, David W Threadgill, William Valdar, Barbara J Vilen, Keegan Wardwell, Jason K Whitmire, Lucy Williams, Mark J Zylka, Martin T Ferris, Leonard McMillan, and Fernando Pardo-Manuel de Villena
SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia., Joanna R Sinnakannu, Kian Leong Lee, Shanshan Cheng, Jia Li, Mengge Yu, Siew Peng Tan, Clara Chong Hui Ong, Huihua Li, Hein Than, Olga Anczuków, Adrian R Krainer, Xavier Roca, Steven G Rozen, Jabed Iqbal, Henry Yang, Charles Chuah, and Sin Tiong Ong
Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies and Myocardial Immune-Complexes During Heart Failure in Rodents and Humans., Amalia Sintou, Catherine Mansfield, Alma Iacob, Rasheda A Chowdhury, Salomon Narodden, Stephen M Rothery, Robert Podovei, Jose L Sanchez-Alonso, Elisa Ferraro, Pamela Swiatlowska, Sian E Harding, Sanjay Prasad, Nadia Rosenthal, Julia Gorelik, and Susanne Sattler
Mapping the Effects of Genetic Variation on Chromatin State and Gene Expression Reveals Loci That Control Ground State Pluripotency., Daniel A Skelly, Anne M Czechanski, Candice Byers, Selcan Aydin, Catrina Spruce, Chris Olivier, Kwangbom Choi, Daniel M Gatti, Narayanan Raghupathy, Gregory R Keele, Alexander Stanton, Matthew J Vincent, Stephanie L. Dion, Ian Greenstein, Matthew Pankratz, Devin K Porter, Whitney Martin, Callan O'Connor, Wenning Qin, Alison H Harrill, Ted Choi, Gary Churchill, Steven C. Munger, Christopher L. Baker, and Laura G Reinholdt
Integrated analysis of the molecular pathogenesis of FDXR-associated disease., Jesse D Slone, Li Yang, Yanyan Peng, Luis F Queme, Belinda S. Harris, Stacey J Sukoff Rizzo, Torrian Green, Jennifer L Ryan, Michael P Jankowski, Laura G Reinholdt, and Taosheng Huang
GXD's RNA-Seq and Microarray Experiment Search: using curated metadata to reliably find mouse expression studies of interest., Constance M. Smith, James W Godwin, Richard M. Baldarelli, Jonathan S Beal, Olin Blodgett, Sharon C Giannatto, Joel E Richardson, and Martin Ringwald
ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility., Elizabeth Snyder, Lauren Chukrallah, Kelly Seltzer, Leslie Goodwin, and Robert E Braun
Molecular Biology and Evolution of Cancer: From Discovery to Action., Jason A Somarelli, Heather Gardner, Vincent L Cannataro, Ella F Gunady, Amy M Boddy, Norman A Johnson, Jeffrey Nicholas Fisk, Stephen G Gaffney, Jeffrey Chuang, Sheng Li, Francesca D Ciccarelli, Anna R Panchenko, Kate Megquier, Sudhir Kumar, Alex Dornburg, James DeGregori, and Jeffrey P Townsend
Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients., Daniel Spakowicz, Shaoke Lou, Brian Barron, Jose L Gomez, Tianxiao Li, Qing Liu, Nicole Grant, Xiting Yan, Rebecca Hoyd, George M. Weinstock, Geoffrey L Chupp, and Mark Gerstein
A Universal, Genomewide GuideFinder for CRISPR/Cas9 Targeting in Microbial Genomes., Michelle Spoto, Changhui Guan, Elizabeth Fleming, and Julia Oh
HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots., Catrina Spruce, Sibongakonke Dlamini, Guruprasad Ananda, Naomi Bronkema, Hui Tian, Kenneth Paigen, Gregory W. Carter, and Christopher L. Baker
Pervasive and CpG-dependent promoter-like characteristics of transcribed enhancers., Robin Steinhaus, Tonatiuh Gonzalez, Dominik Seelow, and Peter N Robinson
Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer., C Allison Stewart, Carl M Gay, Yuanxin Xi, Santhosh Sivajothi, V Sivakamasundari, Junya Fujimoto, Mohan Bolisetty, Patrice M Hartsfield, Veerakumar Balasubramaniyan, Milind D Chalishazar, Cesar Moran, Neda Kalhor, John Stewart, Hai Tran, Stephen G Swisher, Jack A Roth, Jianjun Zhang, John de Groot, Bonnie Glisson, Trudy G Oliver, John V Heymach, Ignacio Wistuba, Paul Robson, Jing Wang, and Lauren Averett Byers
Innovations, challenges, and minimal information for standardization of humanized mice., Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl-Dimiter Bissig, Brian Soper, Terrence Meeham, Li-Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb-Parsy, Johannes Sam, Amar Deep Sharma, Andreas Trumpp, Livio Trusolino, Carol J Bult, and Leonard D. Shultz
Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects., Randy Strong, Richard A Miller, Molly A. Bogue, Elizabeth Fernandez, Martin A Javors, Sergiy Libert, Paul Anthony Marinez, Michael P Murphy, Nicolas Musi, James F Nelson, Michael Petrascheck, Peter C. Reifsnyder, Arlan Richardson, Adam B Salmon, Francesca Macchiarini, and David E Harrison
Mass Cytometry Defines Virus-Specific CD4 + T Cells in Influenza Vaccination, Priyanka B Subrahmanyam, Tyson H Holmes, Dongxia Lin, Laura F Su, Gerlinde Obermoser, Jacques Banchereau, Virginia Pascual, Adolfo García-Sastre, Randy A Albrecht, Karolina Palucka, Mark M Davis, and Holden T Maecker
GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone., Joonho Suh, Na-Kyung Kim, Seung-Hoon Lee, Je-Hyun Eom, Youngkyun Lee, Joo-Cheol Park, Kyung Mi Woo, Jeong-Hwa Baek, Jung-Eun Kim, Hyun-Mo Ryoo, Se-Jin Lee, and Yun-Sil Lee
Improving preclinical to clinical translation in Alzheimer's disease research., Stacey J Sukoff Rizzo, Andi Masters, Kristen D. Onos, Sara Quinney, Michael Sasner, Adrian Oblak, Bruce T Lamb, Paul R Territo, and MODEL-AD Consortium
Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy., Jeremy M Sullivan, William W Motley, Janel O Johnson, William H Aisenberg, Katherine L Marshall, Katy Es Barwick, Lingling Kong, Jennifer S Huh, Pamela C Saavedra-Rivera, Meriel M McEntagart, Marie-Helene Marion, Lucy A Hicklin, Hamid Modarres, Emma L Baple, Mohamed H Farah, Aamir Zuberi, Cathleen Lutz, Rachelle Gaudet, Bryan J Traynor, Andrew H Crosby, and Charlotte J Sumner
Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice., John P Sundberg, C Herbert Pratt, Leslie P. Goodwin, Kathleen A Silva, Victoria E. Kennedy, Christopher S Potter, Anisa Dunham, Beth A. Sundberg, and Harm HogenEsch
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density., Anna L Swan, Christine Schütt, Jan Rozman, Maria Del Mar Muñiz Moreno, Stefan Brandmaier, Michelle Simon, Stefanie Leuchtenberger, Mark Griffiths, Robert Brommage, Piia Keskivali-Bond, Harald Grallert, Thomas Werner, Raffaele Teperino, Lore Becker, Gregor Miller, Ala Moshiri, John R Seavitt, Derek D Cissell, Terrence F Meehan, Elif F Acar, Christopher J Lelliott, Ann M Flenniken, Marie-France Champy, Tania Sorg, Abdel Ayadi, Robert E Braun, Heather Cater, Mary E Dickinson, Paul Flicek, Juan Gallegos, Elena J Ghirardello, Jason D Heaney, Sylvie Jacquot, Connor Lally, John G Logan, Lydia Teboul, Jeremy Mason, Nadine Spielmann, Colin McKerlie, Stephen A. Murray, Lauryl M J Nutter, Kristian F Odfalk, Helen Parkinson, Jan Prochazka, Corey L Reynolds, Mohammed Selloum, Frantisek Spoutil, Karen L. Svenson, Taylor S Vales, Sara E Wells, Jacqueline K White, Radislav Sedlacek, Wolfgang Wurst, Kent K C Lloyd, Peter I Croucher, Helmut Fuchs, Graham R Williams, Duncan Bassett, Valerie Gailus-Durner, Yann Herault, Ann-Marie Mallon, Steve D M Brown, Philipp Mayer-Kuckuk, Martin Hrabe de Angelis, and IMPC Consortium
The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP., Flora Szeri, Stefan Lundkvist, Sylvia Donnelly, Udo F H Engelke, Kyu Rhee, Charlene J Williams, John P Sundberg, Ron A Wevers, Ryan E Tomlinson, Robert S Jansen, and Koen van de Wetering
Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)., Aline Talhouk, Joshy George, Chen Wang, Timothy Budden, Tuan Zea Tan, Derek S Chiu, Stefan Kommoss, Huei San Leong, Stephanie Chen, Maria P Intermaggio, Blake Gilks, Tayyebeh M Nazeran, Mila Volchek, Wafaa Elatre, Rex C Bentley, Janine Senz, Amy Lum, Veronica Chow, Hanwei Sudderuddin, Robertson Mackenzie, Samuel C Y Leong, Geyi Liu, Dustin Johnson, Billy Chen, Aocs Group, Jennifer Alsop, Susana N Banerjee, Sabine Behrens, Clara Bodelon, Alison H Brand, Louise Brinton, Michael E Carney, Yoke-Eng Chiew, Kara L Cushing-Haugen, Cezary Cybulski, Darren Ennis, Sian Fereday, Renée T Fortner, Jesús García-Donas, Aleksandra Gentry-Maharaj, Rosalind Glasspool, Teodora Goranova, Casey S Greene, Paul Haluska, Holly R Harris, Joy Hendley, Brenda Y Hernandez, Esther Herpel, Mercedes Jimenez-Linan, Chloe Karpinskyj, Scott H Kaufmann, Gary L Keeney, Catherine J Kennedy, Martin Köbel, Jennifer M Koziak, Melissa C Larson, Jenny Lester, Liz-Anne Lewsley, Jolanta Lissowska, Jan Lubiński, Hugh Luk, Geoff Macintyre, Sven Mahner, Iain A McNeish, Janusz Menkiszak, Nikilyn Nevins, Ana Osorio, Oleg Oszurek, José Palacios, Samantha Hinsley, Celeste L Pearce, Malcolm C Pike, Anna M Piskorz, Isabelle Ray-Coquard, Valerie Rhenius, Cristina Rodriguez-Antona, Raghwa Sharma, Mark E Sherman, Dilrini De Silva, Naveena Singh, Peter Sinn, Dennis Slamon, Honglin Song, Helen Steed, Euan A Stronach, Pamela J Thompson, Aleksandra Tołoczko, Britton Trabert, Nadia Traficante, Chiu-Chen Tseng, Martin Widschwendter, Lynne R Wilkens, Stacey J Winham, Boris Winterhoff, Alicia Beeghly-Fadiel, Javier Benitez, Andrew Berchuck, James D Brenton, Robert Brown, Jenny Chang-Claude, Georgia Chenevix-Trench, Anna deFazio, Peter A Fasching, María J García, Simon A Gayther, Marc T Goodman, Jacek Gronwald, Michelle J Henderson, Beth Y Karlan, Linda E Kelemen, Usha Menon, Sandra Orsulic, Paul D P Pharoah, Nicolas Wentzensen, Anna H Wu, Joellen M Schildkraut, Mary Anne Rossing, Gottfried E Konecny, David G Huntsman, Ruby Yun-Ju Huang, Ellen L Goode, Susan J Ramus, Jennifer A Doherty, David D Bowtell, and Michael S Anglesio
A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency, Dana M Talsness, Katie G Owings, Emily Coelho, Gaelle Mercenne, John M Pleinis, Raghavendran Partha, Kevin A Hope, Aamir Zuberi, Nathan L Clark, Cathleen Lutz, Aylin R Rodan, and Clement Y Chow
Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data., Jovan Tanevski, Thin Nguyen, Buu Truong, Nikos Karaiskos, Mehmet Eren Ahsen, Xinyu Zhang, Chang Shu, Ke Xu, Xiaoyu Liang, Ying Hu, Hoang Vv Pham, Li Xiaomei, Thuc D Le, Adi L Tarca, Gaurav Bhatti, Roberto Romero, Nestoras Karathanasis, Phillipe Loher, Yang Chen, Zhengqing Ouyang, Disheng Mao, Yuping Zhang, Maryam Zand, Jianhua Ruan, Christoph Hafemeister, Peng Qiu, Duc Tran, Tin Nguyen, Attila Gabor, Thomas Yu, Justin Guinney, Enrico Glaab, Roland Krause, Peter Banda, DREAM SCTC Consortium, Gustavo Stolovitzky, Nikolaus Rajewsky, Julio Saez-Rodriguez, and Pablo Meyer
GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis., Markus Terrey, Scott I Adamson, Alana L Gibson, Tianda Deng, Ryuta Ishimura, Jeffrey Chuang, and Susan L Ackerman
TBX1 is required for normal stria vascularis and semicircular canal development., Cong Tian and Kenneth R. Johnson
Deciphering functional redundancy in the human microbiome., Liang Tian, Xu-Wen Wang, Ang-Kun Wu, Yuhang Fan, Jonathan Friedman, Amber Dahlin, Matthew K Waldor, George M. Weinstock, Scott T Weiss, and Yang-Yu Liu
Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice., James R Tribble, Jeffrey M. Harder, Pete A Williams, and Simon W M John
A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei., Jaishree Tripathi, Charis-Patricia Segeritz, Gareth Griffiths, Wendy Bushell, Ludovic Vallier, William C Skarnes, Maria M Mota, and Oliver Billker
A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei., Jaishree Tripathi, Charis-Patricia Segeritz, Gareth Griffiths, Wendy Bushell, Ludovic Vallier, William C Skarnes, Maria M Mota, and Oliver Billker
Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization., Paweł Trzaskoma, Błażej Ruszczycki, Byoungkoo Lee, Katarzyna K Pels, Katarzyna Krawczyk, Grzegorz Bokota, Andrzej A Szczepankiewicz, Jesse Aaron, Agnieszka Walczak, Małgorzata A Śliwińska, Adriana Magalska, Michal Kadlof, Artur Wolny, Zofia Parteka, Sebastian Arabasz, Magdalena Kiss-Arabasz, Dariusz Plewczyński, Yijun Ruan, and Grzegorz M Wilczyński
Genetic Interactions Affect Lung Function in Patients with Systemic Sclerosis., Anna L. Tyler, J Matthew Mahoney, and Gregory W. Carter
Nomenclature: Naming Your Gene-Modified Mouse., Alicia Valenzuela
Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma., Rachael A Vaubel, Shulan Tian, Dioval Remonde, Mark A Schroeder, Ann C Mladek, Gaspar J Kitange, Alissa Caron, Thomas M Kollmeyer, Rebecca Grove, Sen Peng, Brett L Carlson, Daniel J Ma, Gobinda Sarkar, Lisa Evers, Paul A Decker, Huihuang Yan, Harshil D Dhruv, Michael E Berens, Qianghu Wang, Bianca M Marin, Eric W Klee, Andrea Califano, Daniel H LaChance, Jeanette E Eckel-Passow, Roel G W Verhaak, Erik P Sulman, Terry C Burns, Fredrick B Meyer, Brian P O'Neill, Nhan L Tran, Caterina Giannini, Robert B Jenkins, Ian F Parney, and Jann N Sarkaria
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D., Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B Prasad, Olof Asplund, Amanda Bennett, Michael Boehnke, Andrew A Brown, Michael R Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K Iyengar, Paul Johnson, Ulrika Krus, Patrick E MacDonald, Anubha Mahajan, Jocelyn E Manning Fox, Narisu Narisu, Vibe Nylander, Peter Orchard, Nikolay Oskolkov, Nikolaos I Panousis, Anthony Payne, Michael L. Stitzel, Swarooparani Vadlamudi, Ryan Welch, Francis S Collins, Karen L Mohlke, Anna L Gloyn, Laura J Scott, Emmanouil T Dermitzakis, Leif Groop, Stephen C J Parker, and Mark I McCarthy
A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer., Alex H Wagner, Brian Walsh, Georgia Mayfield, David Tamborero, Dmitriy Sonkin, Kilannin Krysiak, Jordi Deu-Pons, Ryan P Duren, Jianjiong Gao, Julie McMurry, Sara E. Patterson, Catherine Del Vecchio Fitz, Beth A Pitel, Ozman U Sezerman, Kyle Ellrott, Jeremy L Warner, Damian T Rieke, Tero Aittokallio, Ethan Cerami, Deborah I Ritter, Lynn M Schriml, Robert R Freimuth, Melissa Haendel, Gordana Raca, Subha Madhavan, Michael Baudis, Jacques S Beckmann, Rodrigo Dienstmann, Debyani Chakravarty, Xuan Shirley Li, Susan Mockus, Olivier Elemento, Nikolaus Schultz, Nuria Lopez-Bigas, Mark Lawler, Jeremy Goecks, Malachi Griffith, Obi L Griffith, and Adam A Margolin
Transplanting cells from old but not young donors causes physical dysfunction in older recipients., Binsheng Wang, Zukai Liu, Vicky P Chen, Lichao Wang, Christina L Inman, Yueying Zhou, Chun Guo, Tamar Tchkonia, David W Rowe, George A Kuchel, Paul Robson, James L Kirkland, and Ming Xu
Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia., Ping Wang, Zhonghui Tang, Byoungkoo Lee, Jacqueline Jufen Zhu, Liuyang Cai, Przemyslaw Szalaj, Simon Zhongyuan Tian, Meizhen Zheng, Dariusz Plewczynski, Xiaoan Ruan, Edison T Liu, Chia-Lin Wei, and Yijun Ruan
Predicting the early risk of ophthalmopathy in Graves' disease patients using TCR repertoire., Yue Wang, Yufeng Liu, Xiaofei Yang, Hui Guo, Jiadong Lin, Jinkui Yang, Mingqian He, Jingya Wang, Xiaomei Liu, Tingting Shi, Liping Wu, Chengsheng Zhang, Kai Ye, and Bingyin Shi
Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models., Ying-Wooi Wan, Rami Al-Ouran, Carl G Mangleburg, Thanneer M Perumal, Tom V Lee, Katherine Allison, Vivek Swarup, Cory C Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M Neuner, Catherine Kaczorowski, Vivek M. Philip, Gareth R Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L Dawson, Ted M Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K Sieberts, Larsson Omberg, Kristen D Dang, James A Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J Ebert, David C Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Gregory W. Carter, David A Collier, Todd E Golde, Allan I Levey, David A Bennett, Karol Estrada, T Matthew Townsend, Bin Zhang, Eric Schadt, Philip L De Jager, Nathan D Price, Nilüfer Ertekin-Taner, Zhandong Liu, Joshua M Shulman, Lara M Mangravite, and Benjamin A Logsdon
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions., Patrick Y Wen, Michael Weller, Eudocia Quant Lee, Brian M Alexander, Jill S Barnholtz-Sloan, Floris P Barthel, Tracy T Batchelor, Ranjit S Bindra, Susan M Chang, E Antonio Chiocca, Timothy F Cloughesy, John F DeGroot, Evanthia Galanis, Mark R Gilbert, Monika E Hegi, Craig Horbinski, Raymond Y Huang, Andrew B Lassman, Emilie Le Rhun, Michael Lim, Minesh P Mehta, Ingo K Mellinghoff, Giuseppe Minniti, David Nathanson, Michael Platten, Matthias Preusser, Patrick Roth, Marc Sanson, David Schiff, Susan C Short, Martin J B Taphoorn, Joerg-Christian Tonn, Jonathan Tsang, Roel G W Verhaak, Andreas von Deimling, Wolfgang Wick, Gelareh Zadeh, David A Reardon, Kenneth D Aldape, and Martin J van den Bent
New hints towards a precision medicine strategy for IDH wild-type glioblastoma., K White, K Connor, J Clerkin, B M Murphy, M Salvucci, A C O'Farrell, M Rehm, D O'Brien, J H M Prehn, S P Niclou, M L M Lamfers, M Verreault, A Idbaih, Roel G W Verhaak, A Golebiewska, and A T Byrne
Age and Genetic Background Modify Hybrid Male Sterility in House Mice., Samuel J Widmayer, Mary Ann Handel, and David L Aylor
Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue., Owen M Wilkins, Kevin C Johnson, E Andres Houseman, Jessica E King, Carmen J Marsit, and Brock C Christensen
Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age., Cory M Willis, Alexandra M Nicaise, Ernesto R Bongarzone, Maria Givogri, Cory R Reiter, Olivia Heintz, Evan R Jellison, Pearl A Sutter, Gregg TeHennepe, Guruprasad Ananda, Anthony T Vella, and Stephen J Crocker
3D-GNOME 2.0: a three-dimensional genome modeling engine for predicting structural variation-driven alterations of chromatin spatial structure in the human genome., Michal Wlasnowolski, Michal Sadowski, Tymon Czarnota, Karolina Jodkowska, Przemyslaw Szalaj, Zhonghui Tang, Yijun Ruan, and Dariusz Plewczynski
Term Matrix: a novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns., Valerie Wood, Seth Carbon, Midori A Harris, Antonia Lock, Stacia R Engel, David P. Hill, Kimberly Van Auken, Helen Attrill, Marc Feuermann, Pascale Gaudet, Ruth C Lovering, Sylvain Poux, Kim M Rutherford, and Christopher J Mungall
Machine learning-based automated phenotyping of inflammatory nocifensive behavior in mice., Janine M Wotton, Emma Peterson, Laura C. Anderson, Stephen A. Murray, Robert E Braun, Elissa J Chesler, Jacqueline K White, and Vivek Kumar
Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice., Charles B Wright, Hironori Uehara, Younghee Kim, Tetsuhiro Yasuma, Reo Yasuma, Shuichiro Hirahara, Ryan D Makin, Ivana Apicella, Felipe Pereira, Yosuke Nagasaka, Siddharth Narendran, Shinichi Fukuda, Romulo Albuquerque, Benjamin J Fowler, Ana Bastos-Carvalho, Philippe Georgel, Izuho Hatada, Bo Chang, Nagaraj Kerur, Balamurali K Ambati, Jayakrishna Ambati, and Bradley D Gelfand
Decreased pancreatic acinar cell number in type 1 diabetes., Jordan J Wright, Diane C Saunders, Chunhua Dai, Greg Poffenberger, Brynn Cairns, David V. Serreze, David M Harlan, Rita Bottino, Marcela Brissova, and Alvin C Powers
Loss of ADAMTS19 causes progressive non-syndromic heart valve disease., Florian Wünnemann, Asaf Ta-Shma, Christoph Preuss, Severine Leclerc, Patrick Piet van Vliet, Andrea Oneglia, Maryse Thibeault, Emily Nordquist, Joy Lincoln, Franka Scharfenberg, Christoph Becker-Pauly, Philipp Hofmann, Kirstin Hoff, Enrique Audain, Hans-Heiner Kramer, Wojciech Makalowski, Amiram Nir, Sebastian S Gerety, Matthew Hurles, Johanna Comes, Anne Fournier, Hanna Osinska, Jeffrey Robins, Michel Pucéat, Orly Elpeleg, Marc-Phillip Hitz, and Gregor Andelfinger
EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma., Shaofang Wu, Feng Gao, Siyuan Zheng, Chen Zhang, Emmanuel Martinez-Ledesma, Ravesanker Ezhilarasan, Jie Ding, Xiaolong Li, Ningping Feng, Asha Multani, Erik P Sulman, Roel G W Verhaak, John F de Groot, Tim P Heffernan, W K Alfred Yung, and Dimpy Koul
Effort-related decision making in humanized COMT mice: Effects of Val, Jen-Hau Yang, Rose E Presby, Suzanne Cayer, Renee A Rotolo, Peter A Perrino, R Holly Fitch, Merce Correa, Elissa J Chesler, and John D Salamone
CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice., Cheng Ye, Benjamin E. Low, Michael V. Wiles, Todd M Brusko, David V. Serreze, and John P Driver
A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome., Chunting Ye, Hongyuan Yang, Mingshan Cheng, Leonard D. Shultz, Dale L Greiner, Michael A Brehm, and James G. Keck
GlyGen: Computational and Informatics Resources for Glycoscience., William S York, Raja Mazumder, Rene Ranzinger, Nathan Edwards, Robel Kahsay, Kiyoko F Aoki-Kinoshita, Matthew P Campbell, Richard D Cummings, Ten Feizi, Maria Martin, Darren A Natale, Nicolle H Packer, Robert J Woods, Gaurav Agarwal, Sena Arpinar, Sanath Bhat, Judith A. Blake, Leyla Jael Garcia Castro, Brian Fochtman, Jeffrey Gildersleeve, Radoslav Goldman, Xavier Holmes, Vinamra Jain, Sujeet Kulkarni, Rupali Mahadik, Akul Mehta, Reza Mousavi, Sandeep Nakarakommula, Rahi Navelkar, Nagarajan Pattabiraman, Michael J Pierce, Karen Ross, Preethi Vasudev, Jeet Vora, Tatiana Williamson, and Wenjin Zhang
Diverse dystonin gene mutations cause distinct patterns of, Nozomu Yoshioka, Yudai Kabata, Momona Kuriyama, Norihisa Bizen, Li Zhou, Dang M Tran, Masato Yano, Atsushi Yoshiki, Tatsuo Ushiki, Thomas J. Sproule, Riichiro Abe, and Hirohide Takebayashi
Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice., Dahea You, Lascelles E Lyn-Cook, Daniel M Gatti, Natalie Bell, Philip R Mayeux, Laura P James, William B Mattes, Gary J Larson, and Alison H Harrill
Heritable genetic background alters survival and phenotype of Mll-AF9-induced leukemias., Kira Young, Matthew A Loberg, Elizabeth Eudy, Logan S Schwartz, Kristina D Mujica, and Jennifer J. Trowbridge
Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice., Rong Yuan, C J M Musters, Yun Zhu, Tracy R Evans, Yujie Sun, Elissa J Chesler, Luanne L. Peters, David E Harrison, and Andrzej Bartke
Techniques for the generation of humanized mouse models for immuno-oncology., Chun I. Yu, Florentina Marches, Te-Chia Wu, Jan Martinek, and Karolina Palucka
100 Years of evolving gene-disease complexities and scientific debutants., Saman Zeeshan, Ruoyun Xiong, Bruce T Liang, and Zeeshan Ahmed