Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 1985
A biochemical analysis of immunoglobulins of viable motheaten mice., Margaret M. McCormack
The effect of geneotype on survival of pre-implantation embryos after ethanol exposure., Elizabeth D. Morgan
Sperm fertility in in vitro fertilization, and chemotaxic interaction between sperm and oocyte., Eric D. Newman
Hemizygosity for cell surface antigens in aging heterozygous murine somatic cells., Nguyen Thi Kin-Anh
Differentiation in mouse myeloid leukemic cells by phorbolesters and lipopolysacharide., Stephanie L. Niznik
Effect of steroid containing diets on cytochrome P450 and hormone sensitive lipase in normal and diabetes mutant mice., Helen Kay Pike
Analysis of cellular sequences flanking intergrated SV40 promoter in embryonal carcinoma cells., Edward Webster Seidel
The measurement of total body fat in living mice by the absorption of cyclopropane., Natalka Antonia Slabyj
The selection of H-2 antigen loss variants from cells which are heterozygous for the t6 chromosome., Daria V. Smith
The strain distribution patterns of genetic markers in recombinant inbred strains that differ in the incidence of spontaneous ovarian teratomas., Michelle R. Stewart
Mechanisms of pulmonary injury in gamma-irradiated recipients of "motheaten" bone marrow., Katherine S. Ullman
HMG protein activatiion of the uncoupling protein gene in brown fat., Michael D. Yanuck
Regulation of gene expression via HMG proteins., Michael D. Yanuck
Submissions from 1984
A comparison of splenocyte populations in C57BL/KsJ db/db (diabetic) and db/+ (normal) mice., Diane R. Blake
The influence of aging on tumor growth., Lawrence S. Bluth
Linkage of an actin-like locus to beta-2-microglobulin on chromosome 2 of the house mouse., Jeffrey L. Crosby
Murine stem cell proliferation and differentiation in vivo and in vitro., Peter Flax
Expression of terminal deoxynucleotidyl transferase and thymus homing capacity of bone marrow cells from viable motheaten mice., Tracy Elizabeth Giordano
Chromatographic analysis or urinary compounds in SWR RI line mice with spontaneous ovarian tumorgenesis of the granulose., Timothy Gormley
The production of intergeneric chimeras from two rodent species., Lora J. Hagemann
Control of virus and oncogene expression in cell cultures of leukemic BXH-2 mice., Paula A. Kataryniak
Selection and characterization of cell lines with reduced and amplified class I H-2 antigen expression and selection for F1 hybrid tumors that survive in homozygous parental mice., Jennifer R. Lederman
Mechanisms involved during amplification of T cell immune responses during tumor rejection., Ann J. Lewis
Epidermal growth factor and insulin binding to liver and ovarian tissue membranes from normal and ovarian tumor- bearing mice., Halina Luszcynska
A genetic analysis of a mouse liver cDNA clone., Heather B. McDonald
The interaction between islet cells and macrophages in vitro., Tracy L. Prosser
Syngeneic and ellogeneic tumor survival in young versus old mice., Elizabeth B. Safran
Dehydroepiandrosterone (DHEA) and lipogenesis., Priscilla W. Sheldon
Spatial abilities in mice selected for differing degrees of cerebral lateralization., Susan E. Snyder
Determination of the effect of injected urethan and of the ter gene on primordial germ cell numbers and incidence of testiculat teratomas., Roger F. Widmann
Submissions from 1983
The effects of age, severe bleeding, and repopulation on erythrocyte lifespans., Tal S. Benschar
The effects of dehydroxyepiandrosteron on the mouse cell line bh2-1., David W. Emery
Assaying for immunodominance effects in skin grafts., Matthew J. Footer
A genetic analysis of 7S RNA sequences in the mouse., Kerin T. Gibbons
The characterization of growth factor independent mutant cell lines., Nina J. Karnovsky
H-2 associated natural resistance to normal bone marrow cells., Amy Kiesche
The effects of melanocyte stimulating hormone on the induction of tyrosinase isozymes in C57BL/6J-Ay/a mice., Carol Lee Leonard
Identification and mapping of the glycerol-3-phosphate dehydrogenase structural genes., Christopher Roland Montanaro
The effect of beta-hydroxyetiocholanolone on streptozotocin induced diabetes in mice., Audra A. Noel
Applications of cognitive maps in mice., Andrew L. Osborn
A new lymphokine from autoimmune viable motheaten mice that promotes B cell differentiation., Deborah H. Paine
Alpha thalassemic mice: identification of fetuses and analysis of gonads and breeding performances., Kathryn A. Pelletier
Hematopoietic stem cell function in viable motheaten mice., K. Kelly Petrison
Characterization of mutant growth factor independent cell lines., Stephanie B. Rubin
Mechanisms of recognition of littermates in mice., Tara Tayyabkhan
Mouse sn-glycerol-3-phosphate dehydrogenase levels and their relationship to hybridizable GPDH mRNA,, Lori A. Wagner
Cyclic nucleotide changes in response to BMF., Phillip L. Wagner
Submissions from 1982
Effect of multiple chromosomal aberrations on fertility in Mus musculus., Roni J. Bollag
The characterization of MOPC 104E cell line., Erie Chao
The biochemical characterization of salivary proteins of inbred mice., Karen M. Davidson
The effect of in vitro culture of mouse pancreatic islets on the prolonation of graft survival in diabetic isogenic and allogenic hosts., Robert F. Davis
The effects of four levels of stress and two diets on the incidence and severity of cardiac calcinosis in DBA/2J mice., Alison K. Hall
Phosphofructokinase and the diabetes/obesity syndrome., Patricia A. Hebert
Regional vasculature in the normal and the tumor bearing muscle of the mouse., Abigail M. Hirschhorn
The development of autoimmunity in viable motheaten mice., Kathleen A. Kaiser
Mechanisms of growth arrest at a unique R (restriction) point in phenotypically normal mouse cell lines., Claire J. Kim
Effects of the PIV caging system on body weight of C57BL/6J male mice., Norma J. LaJoie
Dolichol metabolism in mouse L cell fibroblasts., Paul B. Laub
Immunohistochemical staining for thyrotropin releasing hormone in mouse hypothalamus., Christine A. Lisciotto
Immunological responsiveness of murine strains with single-locus mutations inducing lymphoproliferation and autoimmunity., Amy Mortensen
Chromosome breakage and DNA repair defects in the wasted mutant: a possible model for ataxia telangiectasia., Maureen A. O'Leary
In vitro and in vivo development of preimplantation stage embryos from DBA/2J mice., Abigail Shefer
Control of collagen expression during growth and development., Lisa Stewart
Effect of aging on blood pressure in autoimmune mice., Samuel Ming-Hsien Wu
Submissions from 1981
Pathogenetic significance of renal immune complexes in C57BL/KsJ db/db mice., Barry K. Abramson
The effects of oxygenated derivatives of cholesterol on the differentiation of MELC., Cynthia A. Bayer
Preliminary studies leading toward the cloning of the spectrin gene in the mouse., David M. Bodine
The sensitivity of restriction point specific growth control to hormones., Marian R. Bouchard
Effects of stress on varying population densities of DBA/2J mice., Brenda Jean Dexter
Levels of ECTO-5'-nucleotidase in the motheaten mouse, an immunodeficient mutant., Caroline M. Haas
The effect of ethanol on HTU tumors in murine models., Monique Hagopian
Use of 6050 teratocarcinoma cells to measure local immunity in the uterus., Denise Gayle Hemmings
Association of chromosomal aberrations in specified strains of mice to those seen in described human diseases., Sharon M. Kelley
Voluntary exercise as a biomarker of physiological age., Joseph H. LaCasce
Graft-versus-host reactions mediated by spleen cells from LLC mice having spontaneously-occirring amyloidosis., Jessica Liu
Genotypic differences in response to gonadotropin administration., David Mace
An enzyme-linked immunosorbent assay (ELISA) for autoantibodies to double-stranded DNA (ds-DNA) in C3H/HeJ-gld/gld mice., Glynda V. Maxam
Cage population density: its effect on the physiology of the mouse., Noelle E. Muggli
A proposed general purpose macro facility., Doris R. Nagel
The induction and treatment of amyloidosis in mice., Ilene Richman
The H-2 haplotype of strains TF/GnLe and Ttf/t6+ mice as determined through skin grafting., Stephen J. Roy
Spatial performance in mice selectively bred for variation in lateralization., Constance E. Ruhl
Molecular weight determination of the oxysterol binding protein using the Waters I250 protein column., Stephen P. Scherr
Ophthalmological abnormalities in the laboratory mouse., Lorraine Scott
The feasibility of using leukaemia cells labelled with fluorescein isothiocyanate in the study of H-2 associated natural resistance., Natalie Antonia Slabyj
The effects of manipulating sex hormone levels of neonatal mice on tail posture., Vicki Stone
The effects of insulin on cell proliferation and collagen expression in primary avian tendon cell cultures., Erica Whittaker
Use of dimetridazole in eradication of murine spironucleus muris., Nora E. Wineland
Nuclear uptake of protein-bound oxygenated sterol., David A. Zarkower
Submissions from 1980
The effects of cold stress on the diabetic and obese mutants., Nancy K. Anderson
The effects of host infiltrate on the growth characteristics of a tumor., Alan Attardo
Karyotyping studies in the Mexican axolotl, Ambystoma mexicanum., Benjamin I. Broder
The effects of heat shock on teratocarcinogenesis in genital ridges., Eric A. Chan
The effect of air deprivation on mice kept in the pressurized individually ventilated caging system., Amanda R. Clements
The effects of atmospheric pressure, relative humidity, physical stress, and body position on the intraocular pressure in rabbits., David S. Coco
Mitotic crossing over in triple inversion heterozygous embryos and regenerating adult inversion heterozygous liver: a more acurate sperm preparation technique., Elizabeth W. Cravey
The development and mutant gene effects of thyroid function in the mouse., Lisa A. Cresswell
The role, in tumorigenesis, of antibodies directed against RNA tumor viruses., Deborah Deinzer
The effects of temperature and 2,4-dinitrophenol on non-shivering thermogenesis in diabetic (db/db) and in obese (ob/ob) mutant mice., Paul Edgecomb