Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 2023
Enhancing Deep Learning Model Evaluation via Attention Consistency Analysis in Spatial Transcriptomics Data, Dylan Agyemang
The impact of the Y chromosome on the reproductive fitness of male wild-derived mice, Keona Banks
An approach to promoting survival of human microglia in humanized mouse models of Alzheimer's Disease, Lauren Baptiste
Effect of hair cell orientation on mechanotransduction response in the vestibular system, Kayla Bright
Identifying the Genetic Basis of Immune Checkpoint Inhibitor Induced Type 1 Diabetes, Tobias Emge
Contrasting Osteosarcoma and Epithelial Breast Cancer Immune Regulation in Murine Cell Lines, Juliana Fenimore
Comparing Ovarian Reserve Damage Response to Different Sources of Radiation Exposure, Paris Guerrero
Modeling hyperopia in Prss56glcr4 mice: Molecular comparativ analysis with Mfrprd6 and QTL mapping of axial length alterations, Jessica Guzman
Automated Assessment of Feeding Behaviors in Mice Using Machine Vision, Cayson Hamilton
Investigating a Genetically Diverse Mouse Model for Vasculitis, Emma Hendrix
Elucidating Gli3 and Hand2 interactions in the developing mandible, Aria Hossain
Characterization of the Pulmonary Phenotype of a Zfhx4 Mutant Mouse Model During Embryonic Development, Sara Hunstad
Using Modified Bacterial Artificial Chromosomes to Develop Transgenic Mouse Models Containing Human Genes with Disease Causing Mutations, Srilekha Kadimi
Identifying Transcriptomic Signatures to Mediate Causal Effect of Genotype on Alzheimer's Disease, Simran Kaur
Neoteny in Mice: The effects of PDGFRα+ cell depletion during postnatal growth, Raheem Khadour
Characterizing retinal vascular development in New Zealand Obese mice, Julia Klein
Identification of structural variants leading to non-reference gene structure, Grace Koo
Unraveling the Role of Glycolysis-Derived Pyruvate in Modulation of TIM-3 Expression in Cancer, Chloe Ledford
Characterizing de novo variants in the CRISPR-Cas9 edited KOLF2.2J iPSC cell line, Alyssa Lima
Cell Cycle Changes Following TPHP Exposure of Induced Pluripotent Stem Cells, Lacie Low
The Milky Way Project: Multi-omic Clocks of Biological Age and Rates of Aging, Matthew Luchs
The Impact of Zbtb7a and Zbtb7b Loss in Acute Myeloid Leukemia Drug Resistance, Meryl McKenna
The Effect of Genetic Background on Charcot-Marie-Tooth Histopathology in Mice, Lily Moy
Variant Caller Performance on Diverse Strains: Exploring the significance of the reference genome on caller performance, Aleisha Roberts
The role of EPASI, an oxygen-sensing transcription facor, in trophoblast differentiation, Braeden Rose
Cortex-wide In-vivo Two-photon Calcium Imaging Analysis of Mice During Skilled Reaching, Andrea Ruiz D'Argence
Generation of transgenic pluripotent stem cells to overexpress neuronal survival genes against stroke using CRISPR-activation technology, Pilar Saavedra-Weis
Targeting gene fusions as a therapeutic approach in pediatric cancers, Elisa Saint-Denis
Characterization of Glycosylation in a Cancer Model, Elaine Schumacher
Growth kinetics and treatment of pharyngeal carcinoma in immunodeficient mice, Leah Spade
Assessing GPX4 as a Blood-Based Biomarker via a LLM-engaged Gene Prioritization and Characterization Workflow, Bishesh Subba
Plasticity Requirements in IL-to-BLA Circuitry During Extinction Learning, Allison Velie
Exploring Adipose Cellular Heterogeneity in Mice, Gabriella von Dohlen
Modeling the dynamics of BRCA1 promoter methylation relevant to triple-negative breast cancer, Anthony Woodruff
Submissions from 2022
Chromatin Looping Differences between 129S and CAST Mice Regulate Transcriptional Variation, Beatriz Alvarez
Immunomodulatory metabolite production by commensal microbiome bacteria, Christian Badawi
The Effects of Genetic Variation on Acute Myeloid Leukemia Growth in Mice, Dan Bernstein
Investigating Loss of Methylation at the BRCA1 Promoter as a Mechanism of Chemoresistance, Benjamin C. Brim
Quantifying the spatial relationship between PORCN and JAG1 in the Mouse Cochlea, Emily Burt
Role of srGAP3 protein stability in mediating voluntary cocaine abuse in Gridlock'd mutant mice, Elaina Cote
Using Machine-Vision to Quantify Mouse Behavior, Joseph DuPree
Exploring NKT cell and Perforin-mediated regulation of digit tip regeneration in both male and female adult mice, Nina Greeley
Visual Prediction of Mouse Mass using Machine Learning, Malachy Guzman
Morphological analysis of cutaneous T-cell lymphoma unaging using attention-based deep learning, Amaris Huang
Analyzing C12orf65 (MTRFR) Expression in Mutant Mouse Models, Jupiter Kalinowski
Essential function of Slmap in embryonic development and skeletal differentiation, Tess Kelly
The effect of the Arg1956Trp mutation in the IQ3 domain of MYO15A on stereocilia formation and hearing loss, Lilly Krupp
Profiling the transposable element landscape in a new wild mouse resource, Sirohi Kumar
The Expression of ZFHX4 Protein in Developing Mouse Lungs and Lung Adenocarcinoma, Tina Li
Developing and Using an R Package To Identify Causative Variations Driving Gene eQTL, Bryant Luna-Ramos
Molecular Approaches to Increase Stroke Resiliency Using Human Pluripotent Stem Cell- Derived Neurons, Elise MacDonald
Investigation of Metabolic Changes for Early Detection of Alzheimer's Disease, Megan Sherally Mathews
Bxb1-Integrase and Modified Bacterial Artificial Chromosomes as a Tool for Site-Specific Transgenesis of Large Donor DNA into Mouse Models, Thomas Mehaffey
Metabolic Control of T follicular helper cell polarization, Anthony Mendoza
Investigating the role of potential PRDM9 interactors FUS and DEK in recombination hotspot activation., Adel Misherghi
Using the Collaborative Cross to identify putative gamete compatibility genes, Clare Mulcahy
Investigating the Infralimbic-Amygdala Circuit During Fear Extinction Learning, Grace O'Brien
Assessing the Potential Relevance of TMOD1 as a Blood Transcriptional Biomarker, Fuadur Omi
Gene fusion dependence in acute myeloid leukemia Ewing sarcoma, and ependymoma cell lines, Aisha Pasha
Efficacy of a High Fat Diet and L-NAME Combinatory Mouse Model for Heart Failure With Preserved Ejection Fraction, Maggie Peng
Utilizing CRISPR technologies to probe Staphylococcus epidermidis' role in the human skin microbiome, Destiny Porter
Characterization of Spontaneous Sugar Modifications of Proteins, Lily Sabol
Role of Flial Cells in the Arcuate Nucleus of the Hypothalamus in High-Fat Diet Consuming Mice, Hunter Samuel
Investigating the Oocyte DNA Damage Response after Radiation Exposure, Michelle Seeler
Assessment of axonal regeneration in Gjb1/CMT1X mouse model, Alsu Shagieva
Identifying signatures of mutational mechanisms for tandem duplications found in breast cancers, Leila Shepard
The role of Oit3 in embryonic development, Lenka Slamova
Advancing Metabolic Flux Analysis in the Single-Cell Era, Maggi Smart
Single-nucleus Transcriptome Profiling of Cancer-associated Fibroblasts in Glioma, Andreas Stephanou
Weighted learning for long-read DNA sequencing consensus methylation detection, Emma Wade
Optimizing the morphological characterization of single hippocampal neurons using Patch-seq, Annie Williams
The Effects of Heterochromatin Formation on 3-D Genome Contacts in Mouse Embryonic Stem Cells, Brooke Wilson
Submissions from 2021
Employing ChIP-Seq to Identify Novel Genes and Pathways for Congenital Diaphragmatic Hernia (CDH), Syed Ali
Comparison of eQTL Identification when using Single-end or Paired- end RNA-sequencing Data, Sam Ardery
Exploration of the Patient-Derived Xenografts at the Jackson Laboratory, Kara Barnao
Are Genetic Effects on Gene Expression Correlated Within TAD Boundaries?, Alexander Daines
Engineering induced pluripotent stem cells to capture critical mechanisms of dendritic cells activation, Richard Fu
Data Annotation Module for Frictionless Data, Naomie Gao
V225G Mutation Increases Stability of KPNA3 Thereby Contributing to an Age-Dependent Hyperactive Phenotype in C57BL/6J Mice, Ryan Guardado
Evaluating the Role of RFX3 in Kidney Function and Cilial Development in an Alport Syndrome Mouse Model, Isabel Huesa
Characterizing TNF-alpha levels in the context of Dnmt3a-mutant bone marrow, Brandon James
Modifiers of Charcot-Marie-Tooth Disease Type 1A Neuropathy in the Sox10/Egr2 Networ, Leeza Kopaeva
The Effect of Allelic Variation on Genetic Recombination and Oocyte Quality, Priya Kosana
Establishing in vitro mES-RPE cells bearing S28C TIMP3 mutation toidentify mouse models for Age Related Macular Degeneration., English Laserna
Determining the Role of the ELF3 gene in trophoblast cell differentiation. The Jacksons Laboratory Summer Student Program, Abraham Lopez
Comparing Gene Sets by Comparing Gene Enrichmen, Irissa Machetta
In vitro validation of inhibitors targeting TCF-4 and beta catenin interaction in WNT-activated tumors, Cynthia Martucci
Profiling Genomic Diversity in a New Wild Mouse Strain Resource, Gabriel McMillen
Longitudinal investigation of the gut microbiome in a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) cohort, Stefanie Moncayo