The Summer Student Program began in 1924 when University of Maine President C.C. Little (our founder) brought six undergraduates to Mount Desert Island for a summer of biological field studies. The Summer Student Program officially became a part of the Jackson Memorial Laboratory's operation in 1931.

Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.


Submissions from 2021

Determining the Role of KZFPs in Modulating Chromatin Accessibilityand Gene Expression in Mouse Embryonic Stem Cells, Alex J. Mora Pagán

Long-Read Sequencing Identifies Structural Variants That Alter Gene Expression In Diverse Mice, Varun Moser

Metabolic regulation of CXCR5 expression in T cells via the kynurenine pathway, Thi-Tina N. Nguyen

Uncovering transcriptional changesrelated to cisplatin treatment andmixing of TNBC subclones usingsingle-cell RNA sequencing, Shadae Nicholas

Characterizing the C57BL/6J-Ighmbp2C495del mouse strainas a model for the study of SMARD1, Harold Peón Castro

Identifying the gut microbe gene products that induce human immune cells to upregulate interferon-gamma production, Veronica Perdomo

Benchmarking algorithms to infer chromatininteractions from single-cell ATAC-seq data, Matthew Signorotti

Mapping the Symptoms of Alzheimer’s Disease and its Subtypes to Mammalianand Human Phenotype Ontology Terms to Enhance Cross Species Analysis, Sarah Stofel

Characterizing Weighted Gene Correlation Network Analysis Module Quantitative Trait Loci Through Local and Distal Expression Quantitative Trait Loci Across Four Tissues in Diversity Outbred Mice, Zoe Vittum

Testing the Extent a Chemotherapy is Influenced by Host Genetics, Marianna Ward

Multi-species convergent functional genomics analysis of substance usedisorders reveals shared genes in poly-drug use, Bailey E. West

Longitudinal Molecular Characterization of Oligodendrogliomas, Gordon Y. Ye

An Analysis of the Features and Dynamics of BRCA1 Promoter Methylation in Triple Negative Breast and Ovarian cancer, Angela Zhu

Submissions from 2019

Characterization of maternal behavior in CS7BL/6J and DBA12J inbred mouse strains, Pura Arroyo Morales

The Effects of Obesity and Genetic Diversity on Adipose TissueAssociated Macrophages, Alan Baez


m6A mRNA modifications containing alternative exons are dynamically regulated in neurological development, Lily Charpentier

Using Deep Learning Neural Networks to Quantify Mouse Gait and Patterns of Social Interaction, Megan Darrell

Modeling the Interaction of Genetic Background and DYRKlA during Neurogenesis among Collaborative Cross Founder ESC-Derived Cerebral Organoids, Alyssa Edwards

The Exacerbation of Vascular Dysfunction with High-Fat Diet in a Novel Mouse Model of Mixed Dementia, Addie Finch

Morphological and Biochemical Effects of a Mntation in an AMD Candidate Gene on RPE Cells, Julia Katherine Mills Alice Fiori

Construction of Computational Pipeline to Analyze Differences in Gene Expression in Inbred Mouse Strains, Maria Flores

Using a Massively-Parallel Reporter Assay to Evaluate Synthetic Enhancer Sequences Acting with Cell Type Specificity, Natalia Fuentes

Network-based prediction of novel genes for congenital diaphragmatic hernia (CDH), Angelina Guerra

Development of R pipeline to predict causal variants underlying expression quantitative trait loci., Stephanie Hoyt

Use of Bioinformatics Tools to Identify Novel Genes Contributing to Lung Cancer Development, Jonathan Judd

Optimization of subcellular protein tracking in hair cells, Anna Kasper

Molecular mechanisms of Kat6b in the differentiation of HSCs, Maximo A. Kesselhaut

RNA-seq Analysis of Sex Differences in the Striatum Cocaine Response of NOD Mice, Violet Kimble

Comparative Analysis of cos+T Cell Function and Immunometabolism in Hybrid Cross Models, Amey Maley

Gene Expression in the Hippocampus of Diversity Outbred Mice Reveals Differences Between Sexes, Meredith Mayer

SAGED-MM: Web Application for the Comprehensive Analysis of Mouse Models, Joshua Mincer

Hippocampal Neuronal Activation during Learning and Memory Processes, Andrea M.C. Mirow

Complexities of Comparative Genomics and the Cardiac Fibrillation Phenotype, Cailey Mitchell

A Universal Drug Based Approach to Treating Dominant Forms of Charcot-Marie-Tooth Disease, Fahad Nabi

Summer Student Report 2019, Blanca Perez

Discovering Signatures of Balancing Selection in Wild Mouse Species, Shaheer Rizwan

A Study of Causal Inference and its Implications in Kinship Correction, Kelsey Robertson

Evaluating Differences in the Growth of Triple-Negative Breast Cancer on Different Genetic Backgrounds, Roberto J. Rodriguez Cartagena

Characterizing genetic control of the 2C state in pluripotent stem cells, Elizabeth Ruark

Epigenetic Inheritance At The Agouti Locus in Mine, Chelsea Schroeder

Modeling transcription factor interaction in biochemically grounded gene regulatory networks, Jainil Shah

Characterization of CFH and the Alternate Complement Pathway in Models for Age Related Macular Degeneration, Hagen (Joki) Wallace

Submissions from 2018

A Computational analysis of cardiac aging using mRNA and protein expression data., Daniel Alfonsetti

Studying the effects of genetic variation on the aminoacyl-tRNA charging pathway using the Diversity Outbred mouse population, Benjamin Allan-Rahill

An Algorithm to Quantitatively Predict Feature-Based Equivalence Between Mouse Inbred Strain Genomes, Rex Asabor

Enhancing Lymph Node Structure in Humanized Mice, Ana Castaner

Transcription factors, their targets, and their role in breast cancer, Jessica Creelman

Understanding the Role of Fibroblasts post-Myocardial Infarction, Maureen Ekwebelem

Inflammasome as an Inflammatory Response to Ocular Hypertension, Annabelle Feist

Characterizing Motor Phenotypes of the Spontaneous Mutant NM5084, Jacqueline Garcia

Development of Parasympathetic Innervation in Aqueous Humor Drainage Structures, Madhumithaq Gautham

Exogenous expression of Scgblcl in understanding its role in cardiac function, Kevin Guerrero

Investigation of the Influence of Nudtl 9 and Dpp 7 Genes on Alzheimer's Disease Progression, Brianna Gurdon

The Effects of AlCF Knock Out on Stressed Mouse Kidneys, Bailey Hixon

Investigating the effects of APOE-£4 on angiogenesis and blood brain barrier integrity in early stages of cerebrovascular development, Larisa Kavetsky

Conservation of Human GWAS Variants in the Mouse Genome, Connor Kean

Rapid Modeling of Developmental Disorders Using CRISPR/ Cas9, Ali Ladha

Pharmacological and Behavioral Characterization of the Reward Pathway in Diverse Mice, Avery Lopez

Stromal regulation of neutrophils during lung metastasis of breast cancer, Sarah Marsden

Identifying the Cause of Decreased Urine pH of Mice on A Caloric Restriction., James Mejia

Identification of Candidate miRNAs as Therapeutic Targets and Biomarkers for Lung Cancer through Differential Expression Analysis, Antonio Mendoza

Framework to Assess Optimal Sequencing Depth Involving Long Noncoding RNAs, Bajram Metjahic

Deciphering Quantitative Phenotypes in Complex Diseases using Gene Co-Expression Modules, Nikhil Milind

Determining the Molecular Mechanisms of Type 1 Diabetes Resistance in Nfkbid Transgenic Non-Obese Diabetic Mice, Anna Quinlan

The Effects of a High-Fat Diet on State-Dependent Activation of the Bed Nucleus of the Stria Terminalis, Katherinne Rabanal

Modeling the Genetic Regulatory Network of Epithelial- Mesenchymal Transition, Dan Ramirez

Developing a Pipeline for Integrating Large Datasets to select candidate Late Onset Alzhei1ner's Disease (LOAD) genes, Sarah Shapley

The Role of STK35 in Germ Cell Development and Fertility, Bailey Shevenell

Identifying genetic interactions related to diabetes using phenotype, Gabriella E. Tenoria

Cell Cycle Profile of Spermatogonial Stem Cells, Diego Trujillo

Lymphocyte Proliferation in response to Cardiomyosin ex vivo, Elias Tzor-Pacheco

Glycine Supplementation in a Mouse Model of Charcot Marie Tooth Type 2D, Kamari Weaver

The Role of TIMP3 Mutation on the Development of Age-Related Macular Degeneration, Nicole Wilkinson

Submissions from 2017

Predicting cancer drug targets using genetic networks., Madelyn Adams

Drivers of pancreatic islet composition., Sadie Allen

Evaluation of concordance of variant to phenotype associations in mouse and human., Cassandra Alvarado

Characterizing sex ratio distortion in the Collaborative Cross., Francesca Barradale

Evaluating machine learning approaches for deciding relevance of ArrayExpress experiments for the Gene Expression Database., Yasmine Boukataya

A reporter system for template bias of meiotic repair in mammals., Emily Bramel

Role of PRDM9 KRAB domain in H3K4 trimethylation at hotspot loci., Naomi Bronkema

Machine learning in the observation of behavioral phenotypes., Gabrielle Cohn

A new GARS mutation, S625L, sensitizes peripheral neurons to degeneration., Donson Cook-Gallardo

Sympathetic innervation of the developing aqueous humor drainage structures., Haelynn Gim

Understanding chemotherapeutic-gene relationships through cross-species analysis., Akeena Harper

Modulation of immune and stromal cells by cancer immunotherapy and chemotherapy in mice., Kevin Hayes

Identification of non-histone protein targets of KMT5A in hematopoietic cells., Teniola Idowu

Genetic drivers of insulin homeostasis., Takanao Ishimura

Mechanistic insights into liposarcoma progression., Ellen Kendall

Identifying addiction related genes through operant sensation seeking in a BXD recombinant inbred panel., Padam Kumar

Understanding the relationship between neuroinflammatory cells and AD-related symptoms through systems genetics., Michelle Kung

Evaluating the therapeutic effect of 2-Deoxy-D-glucose on various cancer models., Nathan Labrie

Characterization of strain specific cardiac macrophage-trophic microenvironments., Kelsey Letson

Examining the role of Dyrkl a in the development and function of inhibitory neurons., Rachel V. Levy

Investigating the role of Rab34 in regulating Hedgehog signaling pathway activity., Amelia Meles

Unbiased profiling of the origin and function of cardiac interstitial cells, Kaesi Morelli

Using gene network analysis to identify novel candidate genes for Congenital Diaphragmatic Hernia (CDH)., Taylar J. Mouton

The genetic mechanism driving risk taking phenotype in BXD recombinant inbred panel., Sartre K. Ndebaneza

Is RNA editing involved in the full recovery of kidneys in Black Bears after hibernation., Selena Neptune-Bear

Research in Action: effectively communicating our translational impact on the public website., Grace Niewijk