The Summer Student Program began in 1924 when University of Maine President C.C. Little (our founder) brought six undergraduates to Mount Desert Island for a summer of biological field studies. The Summer Student Program officially became a part of the Jackson Memorial Laboratory's operation in 1931.

Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.

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Submissions from 2023

 

Plasticity Requirements in IL-to-BLA Circuitry During Extinction Learning, Allison Velie

 

Exploring Adipose Cellular Heterogeneity in Mice, Gabriella von Dohlen

 

Modeling the dynamics of BRCA1 promoter methylation relevant to triple-negative breast cancer, Anthony Woodruff

Submissions from 2022

 

Chromatin Looping Differences between 129S and CAST Mice Regulate Transcriptional Variation, Beatriz Alvarez

 

Immunomodulatory metabolite production by commensal microbiome bacteria, Christian Badawi

 

The Effects of Genetic Variation on Acute Myeloid Leukemia Growth in Mice, Dan Bernstein

 

Investigating Loss of Methylation at the BRCA1 Promoter as a Mechanism of Chemoresistance, Benjamin C. Brim

 

Quantifying the spatial relationship between PORCN and JAG1 in the Mouse Cochlea, Emily Burt

 

Effects of Microglia Depletion on Dendritic Spine Architecture in Genetically Distinct Alzheimer's Disease Mouse Models, Harry Chen

 

Role of srGAP3 protein stability in mediating voluntary cocaine abuse in Gridlock'd mutant mice, Elaina Cote

 

Investigating the endometrial microenvironment via characterization of progenitor-like epithelial cells and fibroblastic response to trophectoderm secretions, Colt Crain

 

Using Machine-Vision to Quantify Mouse Behavior, Joseph DuPree

 

Exploring NKT cell and Perforin-mediated regulation of digit tip regeneration in both male and female adult mice, Nina Greeley

 

Visual Prediction of Mouse Mass using Machine Learning, Malachy Guzman

 

Morphological analysis of cutaneous T-cell lymphoma unaging using attention-based deep learning, Amaris Huang

 

Analyzing C12orf65 (MTRFR) Expression in Mutant Mouse Models, Jupiter Kalinowski

 

Essential function of Slmap in embryonic development and skeletal differentiation, Tess Kelly

 

Individual differences in cognitive resilience to AD are not explained by variation in neurogenesis in the AD-BXDs, Emily Kim

 

Comparative effects of acute inflammatory challenge on hematopoietic stem cell differentiation in mouse models of clonal hematopoiesis., Hanna Kodama

 

The effect of the Arg1956Trp mutation in the IQ3 domain of MYO15A on stereocilia formation and hearing loss, Lilly Krupp

 

Profiling the transposable element landscape in a new wild mouse resource, Sirohi Kumar

 

The Expression of ZFHX4 Protein in Developing Mouse Lungs and Lung Adenocarcinoma, Tina Li

 

Transfer learning of a multitask deep neural network to predict enhancer activity of regulatory variants in the HCT116 cell-line, Frank Liu

 

Developing and Using an R Package To Identify Causative Variations Driving Gene eQTL, Bryant Luna-Ramos

 

Molecular Approaches to Increase Stroke Resiliency Using Human Pluripotent Stem Cell- Derived Neurons, Elise MacDonald

 

Investigation of Metabolic Changes for Early Detection of Alzheimer's Disease, Megan Sherally Mathews

 

Bxb1-Integrase and Modified Bacterial Artificial Chromosomes as a Tool for Site-Specific Transgenesis of Large Donor DNA into Mouse Models, Thomas Mehaffey

 

Metabolic Control of T follicular helper cell polarization, Anthony Mendoza

 

Investigating the role of potential PRDM9 interactors FUS and DEK in recombination hotspot activation., Adel Misherghi

 

Using the Collaborative Cross to identify putative gamete compatibility genes, Clare Mulcahy

 

Investigating the Infralimbic-Amygdala Circuit During Fear Extinction Learning, Grace O'Brien

 

Assessing the Potential Relevance of TMOD1 as a Blood Transcriptional Biomarker, Fuadur Omi

 

Gene fusion dependence in acute myeloid leukemia Ewing sarcoma, and ependymoma cell lines, Aisha Pasha

 

Efficacy of a High Fat Diet and L-NAME Combinatory Mouse Model for Heart Failure With Preserved Ejection Fraction, Maggie Peng

 

Utilizing CRISPR technologies to probe Staphylococcus epidermidis' role in the human skin microbiome, Destiny Porter

 

Characterization of Spontaneous Sugar Modifications of Proteins, Lily Sabol

 

Role of Flial Cells in the Arcuate Nucleus of the Hypothalamus in High-Fat Diet Consuming Mice, Hunter Samuel

 

Investigating the Oocyte DNA Damage Response after Radiation Exposure, Michelle Seeler

 

Assessment of axonal regeneration in Gjb1/CMT1X mouse model, Alsu Shagieva

 

Identifying signatures of mutational mechanisms for tandem duplications found in breast cancers, Leila Shepard

 

The role of Oit3 in embryonic development, Lenka Slamova

 

Advancing Metabolic Flux Analysis in the Single-Cell Era, Maggi Smart

 

Single-nucleus Transcriptome Profiling of Cancer-associated Fibroblasts in Glioma, Andreas Stephanou

 

Weighted learning for long-read DNA sequencing consensus methylation detection, Emma Wade

 

Optimizing the morphological characterization of single hippocampal neurons using Patch-seq, Annie Williams

 

The Effects of Heterochromatin Formation on 3-D Genome Contacts in Mouse Embryonic Stem Cells, Brooke Wilson

Submissions from 2021

 

Employing ChIP-Seq to Identify Novel Genes and Pathways for Congenital Diaphragmatic Hernia (CDH), Syed Ali

 

Comparison of eQTL Identification when using Single-end or Paired- end RNA-sequencing Data, Sam Ardery

 

Exploration of the Patient-Derived Xenografts at the Jackson Laboratory, Kara Barnao

 

Analysis of the interaction of genetic background with DYRK1a inhibition on the proliferation and differentiation of mouse embryonic stem cell-derived Neural Precursor Cell, Nicole Da Costa

 

Are Genetic Effects on Gene Expression Correlated Within TAD Boundaries?, Alexander Daines

 

Engineering induced pluripotent stem cells to capture critical mechanisms of dendritic cells activation, Richard Fu

 

Data Annotation Module for Frictionless Data, Naomie Gao

 

V225G Mutation Increases Stability of KPNA3 Thereby Contributing to an Age-Dependent Hyperactive Phenotype in C57BL/6J Mice, Ryan Guardado

 

Evaluating the Role of RFX3 in Kidney Function and Cilial Development in an Alport Syndrome Mouse Model, Isabel Huesa

 

Characterizing TNF-alpha levels in the context of Dnmt3a-mutant bone marrow, Brandon James

 

Modifiers of Charcot-Marie-Tooth Disease Type 1A Neuropathy in the Sox10/Egr2 Networ, Leeza Kopaeva

 

The Effect of Allelic Variation on Genetic Recombination and Oocyte Quality, Priya Kosana

 

Establishing in vitro mES-RPE cells bearing S28C TIMP3 mutation toidentify mouse models for Age Related Macular Degeneration., English Laserna

 

Determining the Role of the ELF3 gene in trophoblast cell differentiation. The Jacksons Laboratory Summer Student Program, Abraham Lopez

 

Comparing Gene Sets by Comparing Gene Enrichmen, Irissa Machetta

 

In vitro validation of inhibitors targeting TCF-4 and beta catenin interaction in WNT-activated tumors, Cynthia Martucci

 

Profiling Genomic Diversity in a New Wild Mouse Strain Resource, Gabriel McMillen

 

Longitudinal investigation of the gut microbiome in a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) cohort, Stefanie Moncayo

 

Determining the Role of KZFPs in Modulating Chromatin Accessibilityand Gene Expression in Mouse Embryonic Stem Cells, Alex J. Mora Pagán

 

Long-Read Sequencing Identifies Structural Variants That Alter Gene Expression In Diverse Mice, Varun Moser

 

Metabolic regulation of CXCR5 expression in T cells via the kynurenine pathway, Thi-Tina N. Nguyen

 

Uncovering transcriptional changesrelated to cisplatin treatment andmixing of TNBC subclones usingsingle-cell RNA sequencing, Shadae Nicholas

 

Characterizing the C57BL/6J-Ighmbp2C495del mouse strainas a model for the study of SMARD1, Harold Peón Castro

 

Identifying the gut microbe gene products that induce human immune cells to upregulate interferon-gamma production, Veronica Perdomo

 

Benchmarking algorithms to infer chromatininteractions from single-cell ATAC-seq data, Matthew Signorotti

 

Mapping the Symptoms of Alzheimer’s Disease and its Subtypes to Mammalianand Human Phenotype Ontology Terms to Enhance Cross Species Analysis, Sarah Stofel

 

Characterizing Weighted Gene Correlation Network Analysis Module Quantitative Trait Loci Through Local and Distal Expression Quantitative Trait Loci Across Four Tissues in Diversity Outbred Mice, Zoe Vittum

 

Testing the Extent a Chemotherapy is Influenced by Host Genetics, Marianna Ward

 

Multi-species convergent functional genomics analysis of substance usedisorders reveals shared genes in poly-drug use, Bailey E. West

 

Longitudinal Molecular Characterization of Oligodendrogliomas, Gordon Y. Ye

 

An Analysis of the Features and Dynamics of BRCA1 Promoter Methylation in Triple Negative Breast and Ovarian cancer, Angela Zhu

Submissions from 2019

 

Characterization of maternal behavior in CS7BL/6J and DBA12J inbred mouse strains, Pura Arroyo Morales

 

The Effects of Obesity and Genetic Diversity on Adipose TissueAssociated Macrophages, Alan Baez

 

UNBIASED, K-MER BASED ANALYSIS OF DIFFERENTIALLY PRESENT REPETITIVE ELEMENTS BETWEEN MOUSE SPECIES, Caleigh Charlebois

 

m6A mRNA modifications containing alternative exons are dynamically regulated in neurological development, Lily Charpentier

 

Using Deep Learning Neural Networks to Quantify Mouse Gait and Patterns of Social Interaction, Megan Darrell

 

Modeling the Interaction of Genetic Background and DYRKlA during Neurogenesis among Collaborative Cross Founder ESC-Derived Cerebral Organoids, Alyssa Edwards

 

The Exacerbation of Vascular Dysfunction with High-Fat Diet in a Novel Mouse Model of Mixed Dementia, Addie Finch

 

Morphological and Biochemical Effects of a Mntation in an AMD Candidate Gene on RPE Cells, Julia Katherine Mills Alice Fiori

 

Construction of Computational Pipeline to Analyze Differences in Gene Expression in Inbred Mouse Strains, Maria Flores

 

Using a Massively-Parallel Reporter Assay to Evaluate Synthetic Enhancer Sequences Acting with Cell Type Specificity, Natalia Fuentes

 

Network-based prediction of novel genes for congenital diaphragmatic hernia (CDH), Angelina Guerra

 

Development of R pipeline to predict causal variants underlying expression quantitative trait loci., Stephanie Hoyt

 

Use of Bioinformatics Tools to Identify Novel Genes Contributing to Lung Cancer Development, Jonathan Judd

 

Optimization of subcellular protein tracking in hair cells, Anna Kasper

 

Molecular mechanisms of Kat6b in the differentiation of HSCs, Maximo A. Kesselhaut

 

RNA-seq Analysis of Sex Differences in the Striatum Cocaine Response of NOD Mice, Violet Kimble

 

Comparative Analysis of cos+T Cell Function and Immunometabolism in Hybrid Cross Models, Amey Maley

 

Gene Expression in the Hippocampus of Diversity Outbred Mice Reveals Differences Between Sexes, Meredith Mayer

 

SAGED-MM: Web Application for the Comprehensive Analysis of Mouse Models, Joshua Mincer

 

Hippocampal Neuronal Activation during Learning and Memory Processes, Andrea M.C. Mirow

 

Complexities of Comparative Genomics and the Cardiac Fibrillation Phenotype, Cailey Mitchell

 

A Universal Drug Based Approach to Treating Dominant Forms of Charcot-Marie-Tooth Disease, Fahad Nabi

 

Summer Student Report 2019, Blanca Perez