Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 2019
Discovering Signatures of Balancing Selection in Wild Mouse Species, Shaheer Rizwan
A Study of Causal Inference and its Implications in Kinship Correction, Kelsey Robertson
Evaluating Differences in the Growth of Triple-Negative Breast Cancer on Different Genetic Backgrounds, Roberto J. Rodriguez Cartagena
Characterizing genetic control of the 2C state in pluripotent stem cells, Elizabeth Ruark
Epigenetic Inheritance At The Agouti Locus in Mine, Chelsea Schroeder
Modeling transcription factor interaction in biochemically grounded gene regulatory networks, Jainil Shah
Characterization of CFH and the Alternate Complement Pathway in Models for Age Related Macular Degeneration, Hagen (Joki) Wallace
Submissions from 2018
A Computational analysis of cardiac aging using mRNA and protein expression data., Daniel Alfonsetti
Studying the effects of genetic variation on the aminoacyl-tRNA charging pathway using the Diversity Outbred mouse population, Benjamin Allan-Rahill
An Algorithm to Quantitatively Predict Feature-Based Equivalence Between Mouse Inbred Strain Genomes, Rex Asabor
Enhancing Lymph Node Structure in Humanized Mice, Ana Castaner
Transcription factors, their targets, and their role in breast cancer, Jessica Creelman
Understanding the Role of Fibroblasts post-Myocardial Infarction, Maureen Ekwebelem
Inflammasome as an Inflammatory Response to Ocular Hypertension, Annabelle Feist
Characterizing Motor Phenotypes of the Spontaneous Mutant NM5084, Jacqueline Garcia
Development of Parasympathetic Innervation in Aqueous Humor Drainage Structures, Madhumithaq Gautham
Exogenous expression of Scgblcl in understanding its role in cardiac function, Kevin Guerrero
Investigation of the Influence of Nudtl 9 and Dpp 7 Genes on Alzheimer's Disease Progression, Brianna Gurdon
The Effects of AlCF Knock Out on Stressed Mouse Kidneys, Bailey Hixon
Investigating the effects of APOE-£4 on angiogenesis and blood brain barrier integrity in early stages of cerebrovascular development, Larisa Kavetsky
Conservation of Human GWAS Variants in the Mouse Genome, Connor Kean
Rapid Modeling of Developmental Disorders Using CRISPR/ Cas9, Ali Ladha
Pharmacological and Behavioral Characterization of the Reward Pathway in Diverse Mice, Avery Lopez
Stromal regulation of neutrophils during lung metastasis of breast cancer, Sarah Marsden
Identifying the Cause of Decreased Urine pH of Mice on A Caloric Restriction., James Mejia
Identification of Candidate miRNAs as Therapeutic Targets and Biomarkers for Lung Cancer through Differential Expression Analysis, Antonio Mendoza
Framework to Assess Optimal Sequencing Depth Involving Long Noncoding RNAs, Bajram Metjahic
Deciphering Quantitative Phenotypes in Complex Diseases using Gene Co-Expression Modules, Nikhil Milind
Determining the Molecular Mechanisms of Type 1 Diabetes Resistance in Nfkbid Transgenic Non-Obese Diabetic Mice, Anna Quinlan
The Effects of a High-Fat Diet on State-Dependent Activation of the Bed Nucleus of the Stria Terminalis, Katherinne Rabanal
Modeling the Genetic Regulatory Network of Epithelial- Mesenchymal Transition, Dan Ramirez
Developing a Pipeline for Integrating Large Datasets to select candidate Late Onset Alzhei1ner's Disease (LOAD) genes, Sarah Shapley
The Role of STK35 in Germ Cell Development and Fertility, Bailey Shevenell
Identifying genetic interactions related to diabetes using phenotype, Gabriella E. Tenoria
Cell Cycle Profile of Spermatogonial Stem Cells, Diego Trujillo
Lymphocyte Proliferation in response to Cardiomyosin ex vivo, Elias Tzor-Pacheco
Glycine Supplementation in a Mouse Model of Charcot Marie Tooth Type 2D, Kamari Weaver
The Role of TIMP3 Mutation on the Development of Age-Related Macular Degeneration, Nicole Wilkinson
Submissions from 2017
Predicting cancer drug targets using genetic networks., Madelyn Adams
Drivers of pancreatic islet composition., Sadie Allen
Evaluation of concordance of variant to phenotype associations in mouse and human., Cassandra Alvarado
Characterizing sex ratio distortion in the Collaborative Cross., Francesca Barradale
Evaluating machine learning approaches for deciding relevance of ArrayExpress experiments for the Gene Expression Database., Yasmine Boukataya
A reporter system for template bias of meiotic repair in mammals., Emily Bramel
Role of PRDM9 KRAB domain in H3K4 trimethylation at hotspot loci., Naomi Bronkema
Machine learning in the observation of behavioral phenotypes., Gabrielle Cohn
A new GARS mutation, S625L, sensitizes peripheral neurons to degeneration., Donson Cook-Gallardo
Sympathetic innervation of the developing aqueous humor drainage structures., Haelynn Gim
Understanding chemotherapeutic-gene relationships through cross-species analysis., Akeena Harper
Modulation of immune and stromal cells by cancer immunotherapy and chemotherapy in mice., Kevin Hayes
Identification of non-histone protein targets of KMT5A in hematopoietic cells., Teniola Idowu
Genetic drivers of insulin homeostasis., Takanao Ishimura
Mechanistic insights into liposarcoma progression., Ellen Kendall
Identifying addiction related genes through operant sensation seeking in a BXD recombinant inbred panel., Padam Kumar
Understanding the relationship between neuroinflammatory cells and AD-related symptoms through systems genetics., Michelle Kung
Evaluating the therapeutic effect of 2-Deoxy-D-glucose on various cancer models., Nathan Labrie
Characterization of strain specific cardiac macrophage-trophic microenvironments., Kelsey Letson
Examining the role of Dyrkl a in the development and function of inhibitory neurons., Rachel V. Levy
Investigating the role of Rab34 in regulating Hedgehog signaling pathway activity., Amelia Meles
Unbiased profiling of the origin and function of cardiac interstitial cells, Kaesi Morelli
Using gene network analysis to identify novel candidate genes for Congenital Diaphragmatic Hernia (CDH)., Taylar J. Mouton
The genetic mechanism driving risk taking phenotype in BXD recombinant inbred panel., Sartre K. Ndebaneza
Is RNA editing involved in the full recovery of kidneys in Black Bears after hibernation., Selena Neptune-Bear
Research in Action: effectively communicating our translational impact on the JAX.org public website., Grace Niewijk
Assessing Alzheimer's disease phenotypes in a type 2 diabetic mouse model., Bansri Patel
Identifying genetic variation with diet and sex-dependent effects in diversity outbred mice., Douglas Perkins
Modeling the differentiation of induced pluripotent stem cells using single cell RNA sequencing data, Tossapol Pholcharee
Spermatogonial stem cell self-renewal in the mouse, Danielle Smith
Chracterization of the effect of the Mnm(c) modifying allele on a new, CRISPR-based mouse model of SMARD1, Alex Thele
Submissions from 2016
Comparative genomics to determine the genotype responsible for a bacillus subtilis mutant phenotype., Amber Acquaye
Analysis of autoreactive type one diabetes contributory CD8 T-cell frequencies in Nfkbid deficient NOD mice., Jennifer Allocco
Determination of the mutation responsible for tachycardia in ENU mutant strain HLB468., Emma Anderson
The effects of high-fat diets with varied carbohydrate content on the development of diabetes in obese mouse models., Emma Anderson
Determining the genetic framework of hereditary deafness using bioinformatics., Alina K. Andrews
Communicating science at The Jackson Laboratory, Tamsyn Brann
Application of the metabolic inhibitor 2-Deoxy-D-Glucose to treat autoimmune disease in mice., Rachel Burke
From function to dysfunction: gene ontology and cancer., Yoojin Cha
Gene mapping of glaucoma related phenotypes in a forward genetics ENU screen., Sherley Collado-Justiniano
What can the genomics of normal development tell us about disease?, Raphael B. Espinoza
Examining expression of Scgb1c1 in developing and adult murine hearts., Adam Fasman
Tracking spontaneous hair cell regeneration in wildtype mice., Michaela Flonard
Testing the paradigm: cancer gene sets and the hallmarks of cancer., Jesus Roberto Franco
Shedding light on microbial dark matter: reference-based species identification in microbiomes., Nicole Gay
Functional interrogation of human T cell co-stimulatory molecules., Jordana Graveley
Innovating high school genomic education with hands-on and classroom teaching methods., Ashley Greaves
The role of androgen receptor in meiotic progress of male germ cells., Nadia V. Harerimana
Characterization of Crichton mutation leading to age-dependent, behavioral phenotypes., Molly Herman
Establishing a role for the kinesin-8 superfamily member Kif18a during cell migration., Ashley Hudson
Elucidating retinal transcripts correlated with changes in the aging brain of an Alzheimer's mouse model., Julia Huesa
Determining the relationship between spermatogonial stem cells and blood vessels in mouse testis., Yuzhao Hu
Varying non-synonymous/synonymous rate ratios (dN/dS) in TCGA data points to prevalence of Darwinian tumor evolution, Alexander Iyabor Jr.
Tandem duplications affect gene integrity/expression in triple negative breast cancer., Tyler Jackson
Lethality in hspn mutant mice., Se Rin (Julie) Kim
The relationship between the adaptive immune system and aging., Samuel Elliot Krause
Discovering the role of pathogenic BRCA1 mutations in tandem duplicator phenotype development., Conner Lajoie