Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 2013
Genomic analysis of transcription regulation in drosophila., Jacqueline Duhl
Identifying the gene responsible for a new spontaneous mouse model of neuromuscular disease., Jakub Dziedzic
Design, construction and evaluation of a LEGO Skinner box for educational use., Andrew Gallup
Evaluation of semantic similarity measures as search tools in the Gene Ontology and Mammalian Phenotype Ontology., Daniel Galvez
Molecular dissection of the role of VEGFA in development of Schlemm's canal., Sneha Goswami
Comparison of inference reliability of ovarian cancer purity., Jared Graveley
Identification of candidate gene regulators linking obesity to sleep., Jasmine Johnson
Expression of mammalian U2 snRNA genes., Parixit B. Joshi
Investigating pleiotropic and epistatic effects in the BTBR x C57BL/6 mouse model., Bo Kane
Developmental genotyping and phenotyping of a novel mouse mutant, Olivia Katz
Investigating neurovascular changes in aging and alzheimer's disease., Jake Radell
Electrical stimulation as an alternative method to terminal sperm freeze., Robert Rounds
The role of complement proteins in cancer., Ruchi Shah
Transcriptome analysis of spontaneous and induced lung tumors in mice using RNA Seq., Janaya Shelly
The function of Netrin5 in the development of the mouse nervous system., Liam Sigaud
Discovering pancreatic islet function in an obese mouse model., Chelse-Amoy Steele
Dissection of tumor heterogeneity by the proteotoxic stress response., Xiaochen Sun
Investigating aspartoacylase activity in mouse podocytes through genomic and proteomic analyses., Yuka Takemon
Finding potential new candidate genes for the negative and cognitive symptoms of schizophrenia using mouse phenomics and bioinformatics., Gwenaelle Thomas
Examination of insulin signaling in an Alms1 gene trap mouse model for Alstrom syndrome., Charles Thorpe
Dendritic spine density changes: a correlation with age and behavioral phenotypes., Courtney Vaughn
Identifying differentially expressed genes in sleep deprived mice., Gabriel Vela
Alternative RNA isoform analysis in Adad1tm1Reb mutant testes., He Yang
Two disease models for congenital glycosylation deficiency., Xingjian Zhang
Submissions from 2012
Investigating the genetic connection between autism and epilepsy through the RNA binding protein CELF4., Parirash Abdolhosseini
In vitro removal of the androgen recepto from adult sertoli cells., Jenna Adams
Using bioinformatics to develop genome mapping tools for diabetes., Elizabeth Ann Omoluyi Adesanya
Identification of novel regulators of {beta}h1 and {epsilon}y., Aleena Arakaki
Examining mouse models to determine type 1 diabetes susceptibility candidate genes., Kiana Brown
Discovery of Wisp2 interaction protein., Nahum Buzaglo
Investigation on the effects of a 9bp sequence in Far2 on an increase in mesangial matrix expression., Carlos Diaz
Extraction of ribosome-associated mRNA from motor neurons of the spinal cord and brain., Connor Foster
Identifying PRDM9 binding sites in meiotic recombination hotspots., Gitanjali E. Gnanadesikan
Effects of radiation on the inflammatory response in a mouse model of obesity and diabetes., Hailey Gosnell
Single nucleotide polymorphisms influence outcomes of Lamc2 induced JEB in mice., Fiorella Grandi
Using pleiotropy to model genetic interaction in the B6xC3H F2 intercross and visualization of results., Justin Hendrick
Vascular origins of the Schlemm's canal., Stephen Henrich
The role of XRCC2 in B-cell antibody production to antigen., Maile Hollinger
Identification of a genetic network linking sleep and obesity., Jasmine Johnson
Characterizing gene expression profiles for chronic lymphocytic leukemia samples via RNA-seq., Jean Juang
In vivo functional analyses of DICER cofactor proteins., Lindsey Krening
The role of mammalian HBS1L., Katherine Linder
The effect of Dscam mutations on mouse vision., Gabriela Lopez
Understanding the role of Notch1 in cellular transformation and stem cell maintenance., Madison Luck
The effect of Src homology phosphatase 1(SHP-1) on type 1 diabetes development in NOD mice., Noah V. Lupica
Validation of therapeutic compounds A07 and A09 for the purposes of genetic chemotherapy., John McMichael
Elucidating the role of YAP1 in normal and cancer stem cell differentiation and survival., Rachael McMinimy
The role of p53 in AID-dependent cytotoxicity., Maya Merriweather
Characterization of deprenyl and potential lifespan-extending drugs on lifespan and aging in Caenorhabditis elegans., Sophia Ormond
Identifying novel genes that affect HDL cholesterol levels by verifying and testing point mutations of ENU mutagenized HLB 388/HLB 446 mice., Pooja Potharaju
Integration of the gene unification pipeline into Galaxy., Carlos Reyes
The characterization of an improved murine model for Duchenne muscular dystrophy: the D2.B10-Dmdmdx/J mouse., Allison Saunders
Using mice to understand the metabolic syndrome., Nicole Savignac
The effect of the Spcar3 mutation on meiosis in male mice., Muriel Schwinn
Treemap visualization of enriched gene sets., Timothy Sears
The detection and quantification of the HSF-1 oligomerization in situ by proximity ligation assay (PLA)., Elisha Solowey
Vitamin D pathway polymorphisms and their contribution to the etiology of multiple sclerosis (MS)., India Stewart
TALEN targeting of mouse U2 snRNA genes., Yina Sun
The identification of differentially expressed miRNA in human pulmonary adenocarcinoma tumor progression., Megan Taylor
Identification of QTL and candidate genes underlying sleep., Gabriel Vela
Analysis of time series gene expression following nerve injury., David Wang
The subcellular localization of FMNL2., Tyana Warren
Analysis of RNA-seq data in fasting of C57BL/6J and C3H/HeJ strains of mice., Lisa Zheng
Submissions from 2011
Visualizing gene expression for lung development., DeUntay Bennett
The regulation of heat shock factor 1 by Akt and phosphatidylinositol 3-kinase., Terry Chen
Visualizing differential expression of RNA isoforms., Robert Costa
Characterizing a novel amyotrophic lateral sclerosis transgenic mouse carrying a human mutation TDP43(A315T)., Chelsea Culbert
The role of developmental processes in interstitial lung diseases., Krystal English
Investigation of factors involved in immunoglobulin homeostatsis., Christy Fitzpatrick
Identifying the causative mutation in high stepper mice., Courtany Hanley
Effect of combined drug therapy and genetic modifiers on hepatosteatosis and fibrosis in a mouse model for Alstrom syndrome., Ryan Hanusek
The search for depression-related genes in diversity outbred mice., Carter Harwood
3D gene clustering according to epigenetic state., Danai Kadzere
The role of ALT mechanism in telomerase-deficient (TERC-/-) mice., Gloria Kahamba
The effects of deprenyl and metformin on the developmental maturation and reproductive senescence in Caenorhabditis elegans., Michelle Kahn
Time-series analysis of neuropathic pain., Lillian Kang
Characterizing polo-like kinases 1, 2, 3 and 4 through G2/MI transition in mouse spermatogenesis., Jesse Karppinen
Characterization of cerebellar phenotype in mice with mutated Rreb1., Danielle L. Keahi
A computational biology analysis of the genetic linkage between adrenal gland weight and anxiety behavioral assays., Sangeetha Kumar
In Vivo imaging of the glioma stem cell and interactions with perivascular niche., Maili Lim
The validation of novel humanized mouse models for biomedical research., Deidre Michaud
MouseMine: a flexible storage and retrieval solution for mouse biological data., Michael O'Keefe
The Role of XRCC2 in immunoglobulin isotype switching., Adeline Oursler
Visualization of position-dependent regulatory sequences., Rani Patel
Using spatial and temporal qualities of gene expression to prioritize autism candidate genes., Danielle Penny
QTL mapping analysis of a diabetic mouse backcross., Lauren Reagin
Molecular characterization of TMHS protein in stereocilia of auditory hair cells., Estee Rubien-Thomas
Inferring genetic interactions in an NZO/NON backcross, a mouse model for obesity linked diabetes., Kavya Sekar
How the nuclear lamina directs three dimensional chromosome organization., Sarah C. Selwyn
Nuclear transport-related mechanisms in neurodegeneration: mouse mutations (R86S and R487G) in nuclear export mediator factor (NEMF) provide a window into human neuromuscular disease pathogenesis., Anastasia Singalevich
Pcnx12 as a potential modifier of Gria4 associated absence seisures, Zak Strassberg
QTL analysis of endoplasmic stress in pancreatic {beta}-cells, Casey Thornton
Fatty Acyl CoA reductase 2 as a target for the prevention of renal function decline., Sarah Tran
The functional evolution of mammalian retrogenes., Anna Vesely
Identification of PRDM-dependent recombination hotspots, Jenny Wang
Discovering new mouse models for neurodegenerative diseases., Natalie Williams