Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 2012
Analysis of RNA-seq data in fasting of C57BL/6J and C3H/HeJ strains of mice., Lisa Zheng
Submissions from 2011
Visualizing gene expression for lung development., DeUntay Bennett
The regulation of heat shock factor 1 by Akt and phosphatidylinositol 3-kinase., Terry Chen
Visualizing differential expression of RNA isoforms., Robert Costa
Characterizing a novel amyotrophic lateral sclerosis transgenic mouse carrying a human mutation TDP43(A315T)., Chelsea Culbert
The role of developmental processes in interstitial lung diseases., Krystal English
Investigation of factors involved in immunoglobulin homeostatsis., Christy Fitzpatrick
Identifying the causative mutation in high stepper mice., Courtany Hanley
Effect of combined drug therapy and genetic modifiers on hepatosteatosis and fibrosis in a mouse model for Alstrom syndrome., Ryan Hanusek
The search for depression-related genes in diversity outbred mice., Carter Harwood
3D gene clustering according to epigenetic state., Danai Kadzere
The role of ALT mechanism in telomerase-deficient (TERC-/-) mice., Gloria Kahamba
The effects of deprenyl and metformin on the developmental maturation and reproductive senescence in Caenorhabditis elegans., Michelle Kahn
Time-series analysis of neuropathic pain., Lillian Kang
Characterizing polo-like kinases 1, 2, 3 and 4 through G2/MI transition in mouse spermatogenesis., Jesse Karppinen
Characterization of cerebellar phenotype in mice with mutated Rreb1., Danielle L. Keahi
A computational biology analysis of the genetic linkage between adrenal gland weight and anxiety behavioral assays., Sangeetha Kumar
In Vivo imaging of the glioma stem cell and interactions with perivascular niche., Maili Lim
The validation of novel humanized mouse models for biomedical research., Deidre Michaud
MouseMine: a flexible storage and retrieval solution for mouse biological data., Michael O'Keefe
The Role of XRCC2 in immunoglobulin isotype switching., Adeline Oursler
Visualization of position-dependent regulatory sequences., Rani Patel
Using spatial and temporal qualities of gene expression to prioritize autism candidate genes., Danielle Penny
QTL mapping analysis of a diabetic mouse backcross., Lauren Reagin
Molecular characterization of TMHS protein in stereocilia of auditory hair cells., Estee Rubien-Thomas
Inferring genetic interactions in an NZO/NON backcross, a mouse model for obesity linked diabetes., Kavya Sekar
How the nuclear lamina directs three dimensional chromosome organization., Sarah C. Selwyn
Nuclear transport-related mechanisms in neurodegeneration: mouse mutations (R86S and R487G) in nuclear export mediator factor (NEMF) provide a window into human neuromuscular disease pathogenesis., Anastasia Singalevich
Pcnx12 as a potential modifier of Gria4 associated absence seisures, Zak Strassberg
QTL analysis of endoplasmic stress in pancreatic {beta}-cells, Casey Thornton
Fatty Acyl CoA reductase 2 as a target for the prevention of renal function decline., Sarah Tran
The functional evolution of mammalian retrogenes., Anna Vesely
Identification of PRDM-dependent recombination hotspots, Jenny Wang
Discovering new mouse models for neurodegenerative diseases., Natalie Williams
In vivo imaging of neuronal circuit change in mouse models of Amyotrophic Lateral Sclerosis (ALS)., Jennifer Zhu
Submissions from 2010
Data integration and analysis of drug and alcohol dependence related genes: an application of ODE., Amanda Ackovitz
Autism speaks: enhancing MGI's ontologies and annotations to improve autism research., Christopher Carr
The relation of polycomb proteins with 3D structure in the nucleus., Sarah Castor
Deciphering the molecular basis of a mutation in the Ptpn6 gene., William Cheng
Using ontological discovery environment to discover mechanisms of glaucoma in gene expression profiling data., Keith Funkhouser
Finding the genetic mutation causing high levels of circulating plasma triglycerides in HLB505 mouse model., Alexandra Greene
Hearing & genetics: mapping and pathology of mouse mutations causing hearing loss., Allison Hanaford
Localization of DSCAMs and interacting proteins in the developing retina., Lesley Hill
Spatial gene associations in ES cell nuclei., Emily Hollenbeck
Identification of gut microbes associated with human intestinal disease., Ashley B. Hunt
The role of heat shock factor 1 and heat shock protein 72 in Jun N-terminal kinase-mediated cell death., Aiyang Jiang
QGV: a QTL and GWAS results viewing and manipulation tool., Michael C. Jones
Creation of an RNA isoform visualization toolkit., Lukas Jordan
Investigating the role of astrocytes in glaucoma., Keren Katorza
The derivation of embryonic stem cells from a novelmouse modelof amyotrophic lateral sclerosis., Kate Macina
Cellular dynamics of the three to eight-cell mouse embryo., Adriana Martinez-Betancourt
Mapping recombination hotspots in the C57BL/6J-Chr1 PWD/PhJ X C57BL/6J mouse cross to find evidence of genetic regulation., Alison Mehlhorn
Notch signaling in medulloblastoma., Emily E. Miller
Dissecting NKT-dendritic cell interactive control of type-1 diabetes., Rebecca O'Donnell
The importance of microarray data in predicting complex disease phenotypes compared to genotype data in soybeans (Glycine max)., Olutoyosi. Oyelowo
Exploring the effect of a high fat diet on alternative transcript abundance., Nurit Pereg-Azouz
Alternate mRNA processing and cancer: a quantitative microarray study., Weitao Qiang
The genetics of lung development and disease., Jennifer Rodriguez
Investigating neuroprotective therapies in mice with glaucoma., Eden Rouse
Characterizing the molecular features of medulloblastoma subtypes., Brad Rybinski
Characterizing a gene variant that extends lifespan in mice., Paul T. Smith
Using mouse models to investigate the genetic pathways of multiple sclerosis (MS)., India Stewart
Inflammatory cell populations and antigenic proteins in the testis of sertoli cell androgen receptor knockout (SCARKO) mice., Chloe J. Taub
Genetic factors controlling intraocular pressure elevation., Patricia J. Troy
The effect of MK2 and Rock2 on leukemia tumor cells., Alex Zannos
Submissions from 2009
Benefits and barriers of manipulating the iNKT-cell dendritic cell axis for treatment of type-1 diabetes., Shannon T. Bean
Transcriptional effects of Ptgs2 exchange in liver and adipose., Alan Bohn
Characterization of Ccr5 deficiency in the NOD-scid IL2rynull Ccr5null mouse strain., Erica Brown
Protein-protein interactions in the epileptic fitful mouse mutant., Alexandra Buckley
Mapping genes responsible for high HDL levels in ENU-mutagenized C57BL/6J mice., Helen Cha
Comparison of genes and biological processes in conserved and non-conserved gene deserts., Minna Chen
Constructing and optimizing a predictive model for polyadenylation sites in mice., Lauren M. Chircus
7q36 and genome stability: investigating Xrcc2., Eliot Coffey
Immunohistochemical screen for new cell-type specific marker proteins in the murine retina., Kevin Conway
Lupus in a murine model., Mario Robert Crisalli
Finding the single gene mutation responsible for causing tachycardia in an ENU mutant., Amy E. Dalrymple
Characterization of Cre driver lines for neurobiology research., Katelyn DeNegre
The role claudin-3 in blood-testis barrier reorganization., Jing Fan
Improved position-dependent sequence motif characterization and automated transfer for gene prediction., Justin Gardin
Characterization of Unc5d netrin receptor in developing mouse brain and retina., Jude Gonsalves
FcRn : The antibody receptor of the immune system., Yonas Hailu
Development and reconstruction of the neuronal cell types in the cell ontology., Morgan V. Hightshoe
A systems biology approach to the genetic dissection of obesity in a C57BL/6J x C3H/HeJ F2 mouse cross., Justin Huang
Locating Lepr db/9J mutation in female and male mice., Aleah Kenner
Identifying quantitative trait loci for hip axis geometry phenotypes in C57BL/6J X CAST/EiJ inbred mice., Amy Marie Michaud
Elucidating the function of the gene adducing 3 (gamma) in T-cell acute lymphoblastic leukemia., Ceslee D. Montgomery
Genomic instability in hematopoietic stem cells in B6 and BALB mice., Olivia Moody
Development of mouse models for hereditary deafness and gene expression analysis and distribution., Bailey C. Peck
Predicting associations between genes and phenotypes using Bayesian networks., Sheetal Rajagopal
A mouse model for the effects of Tenofovir on vitamin D pathway, calcium homeostasis, and bone mineral density in HIV patients., Jacqueline Rodriguez
Building a cell cycle ontology for mouse based on the Mouse Genome Informatics Database., David Robert Smith
Discovering new mouse models for female reproductive diseases., Mandesa Smith
Investigating sodium channel variants for genetic modifers in epileptic mice.l, Michael Stanley
Discovery of genes that contribute to normal lung development., Isaac St. John
The effect of Pank3 on HDL levels in mice., Lidia Valdes