Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 2014
The expression of n-Tr20, a CNS-specific tRNA, depends on the presence of the upstream regulatory sequence., Michelle Johnson
Screening and cloning of mouse and human APOBECs., Sarah Judd
Exploring the development of T follicular helper cells and their role in autoimmune disease., Sarah Kate Lane-Reticker
The role of pancretic Irx3 expression in obesity and the gut-brain axis., Yvonne Lei
A model for binding site selectivity of 1ncRNA-chromatin interactions., Ran Liu
Preparing to breathe: a comparison of lung development in chick and mouse., Vania Lopez
iRhom2 regulates shredding of metalloprotease ADAM17 substrate TNF(alpha): implications in inflammatory bowel disease., Paul Macklis
Interrogating activity of C2CD4A/B/VPS13C stretch enhancer constituent sites., Anubhuti Mathur
Sex differences in Pavlovian conditioned approach behavior in Collaborative Cross and diversity outbred founder strains., Kathryn McNaughton
Simmer: the spplication of semantic similarity measures in search result retrieval., Patrick Osterhaus
Improving Cas9 through targeted engineering., Dylan Plaskon
Effect of Dnm1a seizure mutation on protein and RNA expression of genes implicated in epilepsy., Casey Marie Poore
Developing computable models of metabolic processes for the gene ontology., Nikolai Renedo
Voluntary running preserves Apoe expression and reverses neurovascular decline in aged mouse neocortex., Hannah J. Richter
Smarca2 downregulates Ucp1 expression in adipose tissue., Mary E. Sims
Investigating the role of ADAD1 by protein interaction and localization pattern studies., Jamie Lee Solimano
Design and development of a long-term mouse eye organ culture perfusion system., Gregory Stevens
Computational inference of the epigenetic changes inducd by ER stress in pancreatic beta cell line MIN6., Haley Strassner
Genetic mapping of spontaneous musculoskeletal mutations in mouse models: Shultz new mutant., Annie Sullivan
Effect of rapamycin on insulin sensitivity and glucose tolerance in various strains of inbred mice., Austen Te
CRISPR-Cas knockouts of tumor suppressor genes in breast cancer., Jessica Xie
Submissions from 2013
Behavioral aging in diversity outbred mice: disparate phenotypes of inbred and heterogeneous populations, Casey Acklin
Methodology for inferring gene function using phenotype data., Joao A. Ascensao
Inductive influence of dystrophin deficiency on rhabdomyosarcoma (RMS) growth in NRG-Dmdmdx-5cv mice: a novel mouse model to evaluate immune therapies., Chantal Barksdale
The altered expression of CELF4 responsive mRNAs in kindled wild-type mice., Bethany Berry
The role of Kdm5d in regulating meiotic recombination., James Boucher
Genomic DNA sequencing of p53 in normal oviduct, tubal tumor, and high grade serous ovarian cancer., Sophie de Bruijn
Basis of synaptic dysfunction related to Charcot-Marie-Tooth type 2D: investigating active zones., Lauren Budd
QTL mapping of modifiers of junctional epidermolysis bullosa using phenotypically disparate strains B6 and 129X1., Nabig Chaudhry
Mouse modeling of mutational acquisition in human acute myeloid leukemia (AML)., Jennifer Ditano
Genomic analysis of transcription regulation in drosophila., Jacqueline Duhl
Identifying the gene responsible for a new spontaneous mouse model of neuromuscular disease., Jakub Dziedzic
Design, construction and evaluation of a LEGO Skinner box for educational use., Andrew Gallup
Evaluation of semantic similarity measures as search tools in the Gene Ontology and Mammalian Phenotype Ontology., Daniel Galvez
Molecular dissection of the role of VEGFA in development of Schlemm's canal., Sneha Goswami
Comparison of inference reliability of ovarian cancer purity., Jared Graveley
Identification of candidate gene regulators linking obesity to sleep., Jasmine Johnson
Expression of mammalian U2 snRNA genes., Parixit B. Joshi
Investigating pleiotropic and epistatic effects in the BTBR x C57BL/6 mouse model., Bo Kane
Developmental genotyping and phenotyping of a novel mouse mutant, Olivia Katz
Investigating neurovascular changes in aging and alzheimer's disease., Jake Radell
Electrical stimulation as an alternative method to terminal sperm freeze., Robert Rounds
The role of complement proteins in cancer., Ruchi Shah
Transcriptome analysis of spontaneous and induced lung tumors in mice using RNA Seq., Janaya Shelly
The function of Netrin5 in the development of the mouse nervous system., Liam Sigaud
Discovering pancreatic islet function in an obese mouse model., Chelse-Amoy Steele
Dissection of tumor heterogeneity by the proteotoxic stress response., Xiaochen Sun
Investigating aspartoacylase activity in mouse podocytes through genomic and proteomic analyses., Yuka Takemon
Finding potential new candidate genes for the negative and cognitive symptoms of schizophrenia using mouse phenomics and bioinformatics., Gwenaelle Thomas
Examination of insulin signaling in an Alms1 gene trap mouse model for Alstrom syndrome., Charles Thorpe
Dendritic spine density changes: a correlation with age and behavioral phenotypes., Courtney Vaughn
Identifying differentially expressed genes in sleep deprived mice., Gabriel Vela
Alternative RNA isoform analysis in Adad1tm1Reb mutant testes., He Yang
Two disease models for congenital glycosylation deficiency., Xingjian Zhang
Submissions from 2012
Investigating the genetic connection between autism and epilepsy through the RNA binding protein CELF4., Parirash Abdolhosseini
In vitro removal of the androgen recepto from adult sertoli cells., Jenna Adams
Using bioinformatics to develop genome mapping tools for diabetes., Elizabeth Ann Omoluyi Adesanya
Identification of novel regulators of {beta}h1 and {epsilon}y., Aleena Arakaki
Examining mouse models to determine type 1 diabetes susceptibility candidate genes., Kiana Brown
Discovery of Wisp2 interaction protein., Nahum Buzaglo
Investigation on the effects of a 9bp sequence in Far2 on an increase in mesangial matrix expression., Carlos Diaz
Extraction of ribosome-associated mRNA from motor neurons of the spinal cord and brain., Connor Foster
Identifying PRDM9 binding sites in meiotic recombination hotspots., Gitanjali E. Gnanadesikan
Effects of radiation on the inflammatory response in a mouse model of obesity and diabetes., Hailey Gosnell
Single nucleotide polymorphisms influence outcomes of Lamc2 induced JEB in mice., Fiorella Grandi
Using pleiotropy to model genetic interaction in the B6xC3H F2 intercross and visualization of results., Justin Hendrick
Vascular origins of the Schlemm's canal., Stephen Henrich
The role of XRCC2 in B-cell antibody production to antigen., Maile Hollinger
Identification of a genetic network linking sleep and obesity., Jasmine Johnson
Characterizing gene expression profiles for chronic lymphocytic leukemia samples via RNA-seq., Jean Juang
In vivo functional analyses of DICER cofactor proteins., Lindsey Krening
The role of mammalian HBS1L., Katherine Linder
The effect of Dscam mutations on mouse vision., Gabriela Lopez
Understanding the role of Notch1 in cellular transformation and stem cell maintenance., Madison Luck
The effect of Src homology phosphatase 1(SHP-1) on type 1 diabetes development in NOD mice., Noah V. Lupica
Validation of therapeutic compounds A07 and A09 for the purposes of genetic chemotherapy., John McMichael
Elucidating the role of YAP1 in normal and cancer stem cell differentiation and survival., Rachael McMinimy
The role of p53 in AID-dependent cytotoxicity., Maya Merriweather
Characterization of deprenyl and potential lifespan-extending drugs on lifespan and aging in Caenorhabditis elegans., Sophia Ormond
Identifying novel genes that affect HDL cholesterol levels by verifying and testing point mutations of ENU mutagenized HLB 388/HLB 446 mice., Pooja Potharaju
Integration of the gene unification pipeline into Galaxy., Carlos Reyes
The characterization of an improved murine model for Duchenne muscular dystrophy: the D2.B10-Dmdmdx/J mouse., Allison Saunders
Using mice to understand the metabolic syndrome., Nicole Savignac
The effect of the Spcar3 mutation on meiosis in male mice., Muriel Schwinn
Treemap visualization of enriched gene sets., Timothy Sears
The detection and quantification of the HSF-1 oligomerization in situ by proximity ligation assay (PLA)., Elisha Solowey
Vitamin D pathway polymorphisms and their contribution to the etiology of multiple sclerosis (MS)., India Stewart
TALEN targeting of mouse U2 snRNA genes., Yina Sun
The identification of differentially expressed miRNA in human pulmonary adenocarcinoma tumor progression., Megan Taylor
Identification of QTL and candidate genes underlying sleep., Gabriel Vela
Analysis of time series gene expression following nerve injury., David Wang
The subcellular localization of FMNL2., Tyana Warren