Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 2016
Manipulating beta cell regulatory circuitry using CRISPR/Cas9 epigenome editing., Rujia Lian
Heightened human red blood cell survival in genetically and chemically engineered next generation NSG mice., Cedric Lozano
Modulation of the adaptive immune system by cardiac fibroblasts., Maddie Mara
Analysis of the expression pattern of the Egr2-cre driver in the mouse brain during postnatal development., Kiersten Marr
Investigating the effects of sodium channel dysfunction on chemotherapy induced peripheral neuropathy., Carla Martinez
Building regression models for predicting age from human blood epigenomes profiled with the ATAC-seq technology., Gokul Parakulam
Polygenic and Mendelian mechanisms of inherited anemia., Tejal Patwardhan
An exploratory analysis of international mouse phenotyping consortium (IMPC) data., Stephen Price
ADAD2: a new player in RNA granule biology., Cassandra Rios
Survey on variation in epigenetic histone modification across nine inbred mouse strains., Arya Royal
Investigation of the effect of structural variants on RNA secondary structure., Amber Salome
The experimental validation of structural variation candidates produced by the FusorSV algorithm., John E. Sargent
Positional cloning of the genetic mutation and histological analysis of femoral nerve axonal degeneration in the NM4803 mouse mutant., Allen Schroeder
Data integration & analysis of the epigenetics of drug and alcohol dependence: an application of GeneWeaver., Nkima J Stephenson
Alternative splicing: approaching transcriptome complexity in human immune cell subsets., Christina Welch
IGF-1 and healthy aging., Madeline Williams
Predicting differential regulation of cell cycle genes in aging hematopoietic progenitor cells., Zollie Yavarow
Submissions from 2015
Cell cycle and survival status of erythroid precursors in the Nan mouse model., Omorose Aighewi
DSCAM and DSCAML1 molecular mechanisms of self avoidance., Julia Bassell
The effect of repurposed drugs: sertraline, fluoxetine, and cannibidiol on spontaneous seizure activity in fitful mice., Jacqueline Bridges
Elucidating the function of Yap in normal and cancer stem cells in the brain., Xingyao Chen
Examining the antitumor activity of a monoclonal antibody via complement-dependent cytotoxicity in novel NSG mouse model., Julia Clemens
Neuroprotective drug treatment in DBA/2J glaucoma., Kelly Cochran
The influence of the NOD/ShiLtJ genetic background on a mouse model of Alzheimer's disease., Calvin Coffey
Acetyl-L-Carnitine: a potential therapy for alleviation of the neurophysiological effects of Charcot-Marie-Tooth disease type 2D., Meagan Currie
The biological significance of hub genes found by weighted correlation network analysis., Reanna Dona
Exploring the genetic mechanisms of exfoliation syndrome and glaucoma., Annie Gagnon
The role of Hbs1l in the developing brain., Thomas Gallup
Neuroinflammation and early cognitive decline induced by short-term exposure to western diet in C57BL/6J mice., Weronika Grabowska
The role of 3' untranslated region (3'UTR) in Celf4 regulation of target mRNA., Daniel S. Hawkins
A pipeline to discover new genes involved in Cochlear hair cell differentiation., Lawrence Jacobs
Assessment of hepatic insulin signaling in a murine model for Alstrom Syndrome., Ayla Kanber
The challenges of mosaicism., Emily Keator
Identification of gene expression in the murine tissue surrounding tumors in patient derived xenograft mouse models., Adam Lavertu
Gene activation through enhancer epigenetic modifications using Casilio, a three-hybrid CRISPRzyme system., Phoebe Lee
Targeted therapeutic treatment of MLL-rearranged AML based on the cell of origin., Matthew A. Loberg
The effectiveness of CHK2 inhibitors for oocyte survival after induced DNA damage., Julia Loose
Identifying genome signatures of drug response in patient derived xenografts (PDX): a machine learning approach., Jacob Luber
Superimposing gene expression data onto gene interaction data to evaluate molecular networks during mouse development., Dylan Maghini
A novel Cux1 CRISPR-Cas9 knockout system to study mesangial matrix expansion in mouse kidney cells., Demetri Maxim
Examining the role of inhibitory GABAergic neurons in the pathophysiology of Rett Syndrome., Kevin Newhall
Orthologs and isoforms and conservation of function., Daniela Perry
The role of pancreatic Irx3 in the gut-brain axis., Jaye Sudweeks
Discovery of enriched variants for Alzheimer's disease., Carl Vitzthum
Taking a BAT at obesity with Ucp1., Judy A. Yau
Submissions from 2014
Investigation into the immunogenicity of green fluorescence protein as a tool to eliminate populations of cells in vivo., Isaac Aderinto
The effects of histone deacetylase 6 inhibition on a mouse model of Charcot-Marie-Tooth disease type 2D., Opemipo Akerele
The role of the interleukin-2 receptor {gamma} gene in the development and progression of DBA/2J glaucoma., Ricky Anjorin
Development of a human macrophage migration inhibitory factor transgenic NSG mouse model to enhance engraftment of primary human chronic lymphocytic leukemia., Olive Baranowski
The role of telomere length in meiotic DNA recombination., Isabella Beroutsos
Exploring the efficiency of the codon optimized flippase in vivo., George Chen
Mastering the biological clock., Natalie Correa
Does ribosome stalling in the nmf205 mutant brain disrupt proteostasis?, Audrey Crane
PCR-based validation of structural variations predicted by whole genome sequencing using triple negative breast cancer cell lines., Jackson Dalman
Discovering the distinct genetic components contributing to anaplastic thyroid cancer using bioinformatics tools., Erika M. Estrada
Validity of heterozygous Dscam mice model (Mus musculus) for human ASD., Allyson Fulton
LIGER: a platform for Pacbio transcriptome analysis., Nicholas K.S. Grewal
Strain differences in Pavlovian sign-tracking and goal-tracking surveyed among Collaborative Cross founder strains., Lingfeng Hou
An improved approach to model epistatic interactions among multiple genetic variants., Tian-Shun Allan Jiang
The expression of n-Tr20, a CNS-specific tRNA, depends on the presence of the upstream regulatory sequence., Michelle Johnson
Screening and cloning of mouse and human APOBECs., Sarah Judd
Exploring the development of T follicular helper cells and their role in autoimmune disease., Sarah Kate Lane-Reticker
The role of pancretic Irx3 expression in obesity and the gut-brain axis., Yvonne Lei
A model for binding site selectivity of 1ncRNA-chromatin interactions., Ran Liu
Preparing to breathe: a comparison of lung development in chick and mouse., Vania Lopez
iRhom2 regulates shredding of metalloprotease ADAM17 substrate TNF(alpha): implications in inflammatory bowel disease., Paul Macklis
Interrogating activity of C2CD4A/B/VPS13C stretch enhancer constituent sites., Anubhuti Mathur
Sex differences in Pavlovian conditioned approach behavior in Collaborative Cross and diversity outbred founder strains., Kathryn McNaughton
Simmer: the spplication of semantic similarity measures in search result retrieval., Patrick Osterhaus
Improving Cas9 through targeted engineering., Dylan Plaskon
Effect of Dnm1a seizure mutation on protein and RNA expression of genes implicated in epilepsy., Casey Marie Poore
Developing computable models of metabolic processes for the gene ontology., Nikolai Renedo
Voluntary running preserves Apoe expression and reverses neurovascular decline in aged mouse neocortex., Hannah J. Richter
Smarca2 downregulates Ucp1 expression in adipose tissue., Mary E. Sims
Investigating the role of ADAD1 by protein interaction and localization pattern studies., Jamie Lee Solimano
Design and development of a long-term mouse eye organ culture perfusion system., Gregory Stevens
Computational inference of the epigenetic changes inducd by ER stress in pancreatic beta cell line MIN6., Haley Strassner
Genetic mapping of spontaneous musculoskeletal mutations in mouse models: Shultz new mutant., Annie Sullivan
Effect of rapamycin on insulin sensitivity and glucose tolerance in various strains of inbred mice., Austen Te
CRISPR-Cas knockouts of tumor suppressor genes in breast cancer., Jessica Xie
Submissions from 2013
Behavioral aging in diversity outbred mice: disparate phenotypes of inbred and heterogeneous populations, Casey Acklin
Methodology for inferring gene function using phenotype data., Joao A. Ascensao
Inductive influence of dystrophin deficiency on rhabdomyosarcoma (RMS) growth in NRG-Dmdmdx-5cv mice: a novel mouse model to evaluate immune therapies., Chantal Barksdale
The altered expression of CELF4 responsive mRNAs in kindled wild-type mice., Bethany Berry
The role of Kdm5d in regulating meiotic recombination., James Boucher
Genomic DNA sequencing of p53 in normal oviduct, tubal tumor, and high grade serous ovarian cancer., Sophie de Bruijn
Basis of synaptic dysfunction related to Charcot-Marie-Tooth type 2D: investigating active zones., Lauren Budd
QTL mapping of modifiers of junctional epidermolysis bullosa using phenotypically disparate strains B6 and 129X1., Nabig Chaudhry
Mouse modeling of mutational acquisition in human acute myeloid leukemia (AML)., Jennifer Ditano