Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 2004
The role of Sf1 in gonadal sex determination in C57BL/6J (B6) mice., Jane Ferguson
Comparison of accelerated versus retarded diabetes in two genetically modified stocks of NOD/Lt mice., Nathan A. Harbacek
The role of growth hormone on aging., Bomopregha A. Julius
Genetic studies of deafness mutations., Hannah L. Kiernes
Assessment of analgesics in mice., Ebony King
Genetics of a mutation that leads to hearing loss., Julie A. Linden
Spontaneous hematological mutations in mice., Gina Luchini
Localization of mitochondria during early development of the mouse embryo., Jacquelyn Masse
Gene identification of the spontaneous Fitfull mutation., Amanda Muscat
Identification of homologous 3'-untranslated region sequences and characterization of conserved regulatory elements., Jill M. Recla
Genetic mutations linked with mouse ear infections., Whitney A. Reid
The normoblastis mutation in mice: investigation of neurological deficits in the nb/nb cerebellum., Jesse Sayers
Bone formation in B6.C3H-9 congenic strain with male specific reduction in bone mineral density (BMD)., Carolyn C. Schook
Bioinformatics search for stem cell regulatory mechanisms., Michael Segal
Detecting helicobacter spp. by fecal PCR analysis., Mihaela Senek
Identifying genetic polymorphisms that contribute to kidney disease., Caitlin Stanton
Roles of cyclin D1 in BCR/ABL signaling., Sarah J. Swerdlow
Positional cloning of a novel neuromuscular mutation., Ashley Phillips Taylor
Mapping obesity genes., Alicia Kim Vose
The genetic analysis of non-alcoholic fatty liver disease., Abby Winterberg
Understanding B10.D2 mice's resistance to diabetogenic IS-CD8+ T cells., Carol Yan
Identifying and mapping the mutant allele for retinal degeneration in nm3448., Jiyang Zhang
Submissions from 2003
Characterization of autoimmune mediated myositis in the NOD.IFNyRbetaTg mouse., Ashley R. Bamman
The nature of alternative polyadenylation sites in yeast., Seema Bhopale
Genetic basis and phenotypic effects of a novel mouse muscular dystrophy and limb developmental mutation., Michael E. Birnbaum
Mrf2 as a candidate gene for atherosclerosis susceptibility in mice., Alisha Biser
Erythroid ankyrin (Ank1) gene expression in C2C12 myoblasts during differentiation in culture: usage of alternative 3' UTRs., Sara A. Bumgardner
Developmental rates predict longevity in genetically heterogeneous mice., Teressa Egeler
Post-doc housing: environmentally friendly solutions to housing and childcare needs on MDI., Emily Eller
Expression of WNT-beta-catenin signaling pathway members in oocytes and preimplantation embryos., Bryce Haac
Bioinformatics of disease., David Haluska
Pathogenesis of alopecia and ulcerative dermatitis in C57BL/6J mice., Jennifer Hayford
Multiparametric evaluation and enumeration of murine hematopoietic stem cells in various strains., Karen Hussein
Investigation of FcRn induction by different stimuli and its importance on the half life of immunoglobulin G., Eda Kapinova
Positional cloning of a novel mouse neuromuscular mutation., Alexandra L. Kieffer
Real-time PCR analysis of gene expression in adipose tissue of obese tubby mice., Stephanie Liu
Gene expression in retinal development., Rebecca C. Lock
Metabolic function in three strains of neonatal diabetic mouse models., Anne MacNeil
Mapping the viral infectivity controller gene conferring resistance to mouse mammary tumor virus infection in I/LnJ mice., Mary Mechetner
The role of gene "Deserts" in chromosome structure., Kelly R. Molloy
Fine mapping of MHC linked gene(s) conferring resistance to IS-CD8+ cell induced diabetes., Ian Monk
Searching QTLs by gene expression: analysis of diabesity., William I. Olver
Identifying bacteria and characterizing pathology of Otitis medica in mice., Adalme Pena
Mapping a gene influencing B cell percentages in blood and spleen cells., Tiffany Pinchinat
Molecular mechanisms of leukemogenesis induced by two human oncogenes: BCR/ABL and TEL/PDGFbetaR in a murine model., Camden Ramsay
Identifying the gene for Hdlq7, a quantitative trait locus the regulates high density lipoprotein cholesterol concentrations in mice., Regina L. Readling
Genetic and phenotypic analysis of Jitterbug (jbg), a novel spontaneous mutation causing deafness and vestibular dysfunction in mice., Katherine W. Saylor
Absence of TNF receptors may decrease diabetic nephropathy., Max Stem
ALMS1: mutational analysis in humans and subcellular localization in TallyHo mice., Vanessa J. Sterling
Capturing age-retarding alleles through selection for longevity., Kathryn L. Stewart
Creation of an online relational database housing human and mouse cancer genes., Andrew J. Sweatt
Positional cloning of the Pintail gene., Edward George Tailfeathers
Software for in silico positional candidate analysis., Brad Witham
Role of the virally encoded gag gene in mouse mammary tumor virus-induced mammary tumors., Annie Zhang
Submissions from 2002
INVESTIGATION OF PHOSPHATIDYLETHANOLAMINE N-METHYL TRANSFERASE EXPRESSION AS A FACTOR IN TYPE II DIABETES., ADEWOLE S. ADAMSON
A study of an atypical small isoform of the cytoskeletal protein ankyrin in the heart., Jennifer Baker
Investigating the biological pathway through which Nr2e3 functions., Joemma Berberich
Mapping of a gene regulating B lymphocyte proportions in mouse peripheral blood., Emily R. Cuthbertson
Defective B cell tolerance mechanisms in the NOD mouse., Joseph William Dombrowsky
Neural stem cells in MRL and CD-1 mice., Nathan Dorr
Quantitative trait locus analysis for cholesterol gallstone susceptibility and phenotypic evaluation of candidate genes using 129S1/SvImJ and CAST/Ei inbred mouse strains., Bethany L. Dumont
Evaluation of pheromonal and hormonal treatments for the synchronization of estrus in mice., Jared J. Eddy
The genetic mapping of a novel mouse muscular dystrophy., Rebecca C. Edgerly
Immunohistological studies of ALMS1 in the mouse: differential expression in obesity mutants., Sarah Eichenberger
The role of growth hormone on development and maturation., Te-Ana Harris
Absence of adhesion molecules ICAM-I and P-selectin accelerates the development of chronic myeloid leukemia induced by BCR/ABL oncogene in mice., Daniel S. Hong
Immunohistochemical characterization of the developing mouse mammary gland., Meggan Hovick
The development of M cells in Peyer's Patches., Tammy Hshieh
Analyzing resistance of B10.D2 mice to insulin-specific diabetogenic CD8+ T cells., Maria Joachim
The transcriptional profile of three mouse chromosomes., Kriten E. Kai
Determining the function of the protein tubby by using the yeast-2-hybrid system., Kristin E. Kalie
Constructing an electronic resource of oncogene information., Charles Kircher
Molecular mechanisms of clozapine-induced hyperglycemia., Kristen Lingley
Gene expression profiles in autoimmune predisposed mice., Lisa L. Ng
Anti-retrovirus immune response and selection of viral variants with distinct pathogenic characteristics., Susannah Parke
Characterization of genes important in preimplantation development., Emily E. Radford
Klebsiella prevention using probiotics., Ricardo Salgado
Mouse mutagenesis database development and mutant characterization of embryonic lethal 15., Carly Satsuma
To oligo or not to oligo? That is the question! Optimizing oligonucleotide arrays using normal and cancerous breast RNA., Julia M. Schmitz
Genetic analysis of the vl mouse., Melissa Spurr
Screening mice for otitis media: assessment of middle ear status in 60 inbred strains of mice., Isaac Tong
Genetic interactions between Jagged1 and Notch1 during embryogenesis., Kate Violette
Finding and testing the candidate genes that determine the high density lipoprotein cholesterol levels in the mouse cross C57BL/6J X NZB/B1NJ., Richard Wagner
Submissions from 2001
The genetic basis of cholelithiasis: a quantitative trait locus (QTL) analysis of CAST/Ei and DBA/2J mouse strains., Laura E. Ayotte
Use of recombinant congenic mouse strains for analysis of diabesity., Victoria Barron
Testing hepatic lipase as a candidate gene for cholesterol gallstone formation in SWR/J and AKR/J inbred strains of mice., Kristin Brubaker
Candidate gene analysis of ALR/Lt. strain's free radical dissipation locus., Thomas Cassidy
Genetic modification of retinal degeneration in tubby mice., Da Chang
Oocyte gene knockouts with a novel technique utilizing BAC's as vectors., Julie Crudele
Optimizing signal amplification in immunohistochemistry and in situ hybridization., Susannah Dickerson
An internship in the Mouse Mutant Resource., Meghan Goff
Gene discovery in the piebald region of mouse chromosome 14., Jackson B. Hewlett
Retroviral recombination and the loss of tumorigenicity., Margaret Hsieh
The effects of hypophysectomy with corticosterone on health span., Elijah Hutchinson
Subclinical infections in immunocompomised mice: a closer look., Lily Johnston
Adapting Lee Silver's book, Mouse Genetics: concepts and applications, for the web., Daniel S. Lawrence
Mechanism of mouse mammary tumor virus neutralization by antibodies produced in I/LnJ mice., Nilah Monnier