Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 1991
Gene mapping using PCR and primers of arbitrary nucleotide sequence., Sarah Mutka
Biochemical analysis of minor histocompatibility proteins., Huy Q. Nguyen
Devdritic cell abnormalities in the viable motheaten mutant mouse., Holly Sherburne
Cytokine expression in graft vs. host disease., Tabitha Staley
Molecular analysis of mutant and wildtype canine beta-glucuronidase cDNA., Kimberly E. Stone
Lateralization of function: development of handedness tasks., Nga K. Tang
Development of six genetic eye disorders of the mouse., Jill Tessier
Fetal-specific ankyrin-related proteins and mRNAs in murine erythrocytes., L. Christine Turtzo
The analysis of a transgenic insertion: where's the homozygote?, Frank van Breukelen
Examination of early hematopoietic repopulation., Tracee E. Watkins
The Effects of growth hormone treatment on the body composition of the (lit/lit) mouse., Jacob B. Wills
The Effects of Ph on W42 and S1., Courtney Worcester
Submissions from 1990
Enumeration of minor histocompatibility loci by cytotoxic T cell generation., Sunil Bansal
The Effects of the nurine scid mutation on chromosome recombination and repair. .. Leonard Shultz., Alison Barth
Analysis of blood formation and anemia in embryos carrying the Patch and White-spotting genes., Elizabeth Briggs
Studies characterizing a mouse DHEA sulfotransferaes (Dst) gene and its role in diabetes pathogenesis., Linda M. Call
Quantitation of pneumocystis carinii antigens succeeding anti-Pc immune therapy of scid mice., Eduardo Carrillo
Influence of patch (Ph) upon the fetal blood phenotypes of two white-spotting (W) heterozygotes., Heather Mirth Corbett
The induction of interleukin-6 gene expression in elicited peritoneal macrophages by tumor-derived products., Paul Curthoys
Genetic effects on the change in anti-TNP response with age., Tammy L. Edwards
Isolation and mapping of mouse chromosome a4 anonymous DNA clones., Arleen Gell
A comparison of potential regulatory sequences for the beta-glucuronidase gene in Mus musculus and Mus abotti., Sarah Gillmor
Molecular evolution of the Crya-1 gene in the distal region of the t complex., Jennifer Grenier
Cutaneous dendritic cell populations in the "Flaky-skin Fsn mouse, a mutation resembling psoriasis., Tina Marie Hahn
The interaction of metabolism and aging., Jeffrey M. Heneghan
The expression of EVI-4 in normal tissues of the recombinant inbred BXH-2 mice., Sherry L. Kuchma
The induction of TNF- gene expression in the macrophage cell line P388 D1 by Bh2-1 tumor derived products., Jeffrey Meyerhardt
Molecular comparison of ecotropic murine leukemia viruses isolated from CWD/LeAgl mice., Steven J. Montante
Cytokine mRNA levels in C57BL/6J-lpr/lpr--> +/+ GVH-like syndrome., Jeffrey C. Rathmell
Immunocytochemical localization of tumor necrosis factor- in the lungs of viable motheaten mutant mice., Philip Schaner
Analysis of Hertwig's anemia mutation., Cristan Small
Free radicals in aging: a longitudinal study., Paul Tomlinson
Epidermal kinetics of a murine inherited papulosquamous skin disease resembling psoriasis., Frank van Breukelen
Is the mitochondrial uncoupling protein gene transcribed in white adipose tissue?, Maude White
Submissions from 1989
Generation of a FPS oncogene fusion protein., Jonica Calkins
Chromosomal breakage and repair in severe combined immunodeficient mice., Emma K. Chaput
Scanning electron microscopic evaluation of renal dysfunction in Hairpatches mutant mice., Debbie Chen
Steriodogenesis in adrenocortical dysplasic mutant mice., David Davis
Comparison of binding of mouse insulins I and II to insulin autoantibodies in serum of NOD/Lt mice., Daniel A. Fajardo
Molecular studies of cerecellar development in congenital thyroid deficiency., Brian J. Feinstein
Mapping spontaneous proviral insertions in the germline of the MEV linkage testing stock., Jessica S. Forman
The Replacement of hemopoietic cells in mice with a heritable stem cell defect., Jennifer M. Greer
The Reoccurring anemia following normal bone marrow transplantation in mice: is it an autoimmune response?, Chad Heinzelman
Genetic analysis of the Ds locus: mapping the murine homologues of genes and anonymous DNA markers located on human chromosome 13., Elizabeth L. Hendel
Effect of LH, and FSH on cumulus cell enclosed oocytes maturing in vitro., Daniel S. Johnston
Gastric papillomatous hyperplasia associated with anemia in mutant mice., George A. Kenty
Screening for papillomaviruses in skin tumors induced in Hairless and Rhino mice by a two-stage carcinogenesis protocol., Byron A. Long
The Cytokine network: regulation of marcophage TNF-alpha gene transcription., James M. Malone
The mapping of genes linked to the type II keratin locus Krt-2 on mouse chromosome 15., Anne McBride
Immunological characterization of new mouse mutants., Emily Miyashita
Chromosome evolution in successive tumor transplants of an/an histiocytic sarcoma., Kim-Ngoc Thi Nguyen
Characterization of a cellular hyperplasia in a mutant transgenic mouse., Jenna Roberts
Mapping the murine homologues of genes and anonymous DNA markers flanking the Wilson disease and Hirschsprung disease loci., Marie-Blanche N. Tchetgen
The Role of metabolism, O2 consumption, and free radicals in aging., Paul S. Tomlinson
Towards a physical map of mouse chromosome 14 using irradiated hybrid cells., Robert Q. To
Characterization of LT congenic strains for two genetic traits known to influence teratoma incidence., L. Christine Turtzo
The Genetic effects on the aging of the immune system., Lisa Y. Wang
Submissions from 1988
A structural analysis of the PIM-1 and CRYA-1 genes within the t-complex of wild-derived mice., Lorelee M. Bergmark
Studies into the nature of antigens recognized by cytotoxic T cells using a synthetic peptide., Nancy Chiu
IL-2 expression in tumor bearing mice and after combination therapy., Mary Crosby
The Effects of low level microwave irradiation on mutation in E. Coli., David W. Gatchell
Keratin gene mapping., Jennifer Grancio
Developmental expression of vitamin-A receptor and homeobox containing genes in the mouse., Andrew Hanscom
Spontaneous myoepitheliomas in inbred mice: a histologic, ultrastructural and immunohistochemical study., Christopher A. Hanson
The Effect of pituitary hormones on the senescent thymus,, Laurence E. Isaacs
The Effects of metabolic activity on aging., Pamela D. Mead
Immunological status of leukemia-prone BXH-2 mice., Amy J. Newell
Immune reactions to the tumor in progeny of mice that survived a syngeneic tumor application., Anthony D. Owen
Tissue-specificity and developmental changes in Spl expression., So Young Park
X-linked methylation patterns for use in clonal analysis of developmental defects., Alexandra Pellicena-Palle
Immunoglobulin abnormalities in Mott cell hybridomas., David W. Sehy
Quantitative and qualitative analysis of pneumocystis carinii loads., Kimberly Ann Smirles
Genetic control of androgen metabolism in granulosa cell tumor susceptible mice., Juliet S. Sonkin
Single versus successive events responsible for B lineage tumors in Eu-myc transgenic mice., Rebecca M. Stowe
Genetic control of gamma-interferon inducible MHC class I-like antigen in NOD/Lt mice., Adrian T. Ting
Expression of C/EBP as related to the nutritional and metabolic state of the Balbc/By mouse., Rosalie Truong
Use of fluoresceinated lectins as probes to analyze thymocyte populations from immunodeficient mice., Jennifer Winslow
Submissions from 1987
Enrichment of hematopoietic stem cells in vitro., Sarah Jane Bacon
Repopulation of W/Wv mice with bone marrow cells., Jessica Braun
The effects of growth factors and other growth promoters on mevalonate-depletion arrest of DNA synthesis in Chinese hamster ovary cells., Daniel M. Breitkopf
Mouse type II keratin gene mapping using RI strains., Jennifer L. Cartier
Monoclonal antibody approaches to the study of neuronal cell surfaces., Katherine A. Daly
The developmental control and regulation of the human GPDH gene in transgenic mice., Pamela S. Ganschow
Cellular mechanisms affected by the lymphoproliferation gene., Kirsten Gregor
The effect of replication of reducer activity., Je Young Han
Retrovirus segregation in SJL-lpr mice., Keith Hanson
Establishing the construct validity of the immune response to TNP-KLH as a biomarker of aging., Douglas L. Idelson
A cellular enhancer of retrovirus gene expression in an embryonal carcinoma cell line., Yoko Irie
Genes controlling levels of specific lymphocyte subsets., Kimberly Kaphingst
White blood cell repopulation in irradiated and bone marrow transplanted Hertwigs anemic mice., Alison M. Lehman
The epidermis of bareskin and flaky skin mutant mice: a study of histology and keratin composition., Nina S. Livingston
Mapping the Weaver mutant gene relative to the cEts-2 locus., Tim McNellis
Analysis of trans-acting factors associated with an enhancer active in PCC4.aza 1R EC cells., William J. Morrow
Cell-surface expression of adhesion molecules on strains of immunodeficient mice., Nancy Norris
Characterization of cell surface phenotypes of T cell lines specific for class I and class II H-2a mutant antigens., Anthony D. Owen
Pre-implantation developmental potential of SWR/J oocytes following maintenance of meiotic arrest in vitro., Arlene S. Rapkin
Defective prothymocyte activity in viable motheaten mutant mice., Cheryl A. Skinner
Parthenogenesis and teratocarcinogenesis in the LTXBO mice., Marie-Blanche Tchetgen