Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 1989
Scanning electron microscopic evaluation of renal dysfunction in Hairpatches mutant mice., Debbie Chen
Steriodogenesis in adrenocortical dysplasic mutant mice., David Davis
Comparison of binding of mouse insulins I and II to insulin autoantibodies in serum of NOD/Lt mice., Daniel A. Fajardo
Molecular studies of cerecellar development in congenital thyroid deficiency., Brian J. Feinstein
Mapping spontaneous proviral insertions in the germline of the MEV linkage testing stock., Jessica S. Forman
The Replacement of hemopoietic cells in mice with a heritable stem cell defect., Jennifer M. Greer
The Reoccurring anemia following normal bone marrow transplantation in mice: is it an autoimmune response?, Chad Heinzelman
Genetic analysis of the Ds locus: mapping the murine homologues of genes and anonymous DNA markers located on human chromosome 13., Elizabeth L. Hendel
Effect of LH, and FSH on cumulus cell enclosed oocytes maturing in vitro., Daniel S. Johnston
Gastric papillomatous hyperplasia associated with anemia in mutant mice., George A. Kenty
Screening for papillomaviruses in skin tumors induced in Hairless and Rhino mice by a two-stage carcinogenesis protocol., Byron A. Long
The Cytokine network: regulation of marcophage TNF-alpha gene transcription., James M. Malone
The mapping of genes linked to the type II keratin locus Krt-2 on mouse chromosome 15., Anne McBride
Immunological characterization of new mouse mutants., Emily Miyashita
Chromosome evolution in successive tumor transplants of an/an histiocytic sarcoma., Kim-Ngoc Thi Nguyen
Characterization of a cellular hyperplasia in a mutant transgenic mouse., Jenna Roberts
Mapping the murine homologues of genes and anonymous DNA markers flanking the Wilson disease and Hirschsprung disease loci., Marie-Blanche N. Tchetgen
The Role of metabolism, O2 consumption, and free radicals in aging., Paul S. Tomlinson
Towards a physical map of mouse chromosome 14 using irradiated hybrid cells., Robert Q. To
Characterization of LT congenic strains for two genetic traits known to influence teratoma incidence., L. Christine Turtzo
The Genetic effects on the aging of the immune system., Lisa Y. Wang
Submissions from 1988
A structural analysis of the PIM-1 and CRYA-1 genes within the t-complex of wild-derived mice., Lorelee M. Bergmark
Studies into the nature of antigens recognized by cytotoxic T cells using a synthetic peptide., Nancy Chiu
IL-2 expression in tumor bearing mice and after combination therapy., Mary Crosby
The Effects of low level microwave irradiation on mutation in E. Coli., David W. Gatchell
Keratin gene mapping., Jennifer Grancio
Developmental expression of vitamin-A receptor and homeobox containing genes in the mouse., Andrew Hanscom
Spontaneous myoepitheliomas in inbred mice: a histologic, ultrastructural and immunohistochemical study., Christopher A. Hanson
The Effect of pituitary hormones on the senescent thymus,, Laurence E. Isaacs
The Effects of metabolic activity on aging., Pamela D. Mead
Immunological status of leukemia-prone BXH-2 mice., Amy J. Newell
Immune reactions to the tumor in progeny of mice that survived a syngeneic tumor application., Anthony D. Owen
Tissue-specificity and developmental changes in Spl expression., So Young Park
X-linked methylation patterns for use in clonal analysis of developmental defects., Alexandra Pellicena-Palle
Immunoglobulin abnormalities in Mott cell hybridomas., David W. Sehy
Quantitative and qualitative analysis of pneumocystis carinii loads., Kimberly Ann Smirles
Genetic control of androgen metabolism in granulosa cell tumor susceptible mice., Juliet S. Sonkin
Single versus successive events responsible for B lineage tumors in Eu-myc transgenic mice., Rebecca M. Stowe
Genetic control of gamma-interferon inducible MHC class I-like antigen in NOD/Lt mice., Adrian T. Ting
Expression of C/EBP as related to the nutritional and metabolic state of the Balbc/By mouse., Rosalie Truong
Use of fluoresceinated lectins as probes to analyze thymocyte populations from immunodeficient mice., Jennifer Winslow
Submissions from 1987
Enrichment of hematopoietic stem cells in vitro., Sarah Jane Bacon
Repopulation of W/Wv mice with bone marrow cells., Jessica Braun
The effects of growth factors and other growth promoters on mevalonate-depletion arrest of DNA synthesis in Chinese hamster ovary cells., Daniel M. Breitkopf
Mouse type II keratin gene mapping using RI strains., Jennifer L. Cartier
Monoclonal antibody approaches to the study of neuronal cell surfaces., Katherine A. Daly
The developmental control and regulation of the human GPDH gene in transgenic mice., Pamela S. Ganschow
Cellular mechanisms affected by the lymphoproliferation gene., Kirsten Gregor
The effect of replication of reducer activity., Je Young Han
Retrovirus segregation in SJL-lpr mice., Keith Hanson
Establishing the construct validity of the immune response to TNP-KLH as a biomarker of aging., Douglas L. Idelson
A cellular enhancer of retrovirus gene expression in an embryonal carcinoma cell line., Yoko Irie
Genes controlling levels of specific lymphocyte subsets., Kimberly Kaphingst
White blood cell repopulation in irradiated and bone marrow transplanted Hertwigs anemic mice., Alison M. Lehman
The epidermis of bareskin and flaky skin mutant mice: a study of histology and keratin composition., Nina S. Livingston
Mapping the Weaver mutant gene relative to the cEts-2 locus., Tim McNellis
Analysis of trans-acting factors associated with an enhancer active in PCC4.aza 1R EC cells., William J. Morrow
Cell-surface expression of adhesion molecules on strains of immunodeficient mice., Nancy Norris
Characterization of cell surface phenotypes of T cell lines specific for class I and class II H-2a mutant antigens., Anthony D. Owen
Pre-implantation developmental potential of SWR/J oocytes following maintenance of meiotic arrest in vitro., Arlene S. Rapkin
Defective prothymocyte activity in viable motheaten mutant mice., Cheryl A. Skinner
Parthenogenesis and teratocarcinogenesis in the LTXBO mice., Marie-Blanche Tchetgen
Identification of histocompatibility loci in newly derived congenic stocks and backcrossed inversion stocks., Linda Tienli Wu
Submissions from 1986
Interaction of proteins with a reducer sequence., Joon Ahn
The role of T helper cells in immune responses against minor and major histocompatibility antigens., Michelle M. Allen
Analysis of African green monkey reducer specificity., Laura Donatella Attardi
I. A correlation of reproductive aging, biological markers and longevity. II. Tail collagen denaturation in recombinant inbred strain for C57BL/6J and BALB/cByJ mice., Stephen C. Bryant
Analysis of H-2 mutants with monoclonal antibodies., Michael P. Bukowski
The nature of the loss of meiotic products in males heterozygous for paracentric inversions., Domenica Carrier
Searches for histocompatibility loci and their linkages using inversion congenics., Donenica Carrier
Specific chromosomal defects in histocytic sarcoma from Hertwig's anemic mice., Mark Carter
Karyotyping of embryonal carcinoma cells., Nancy Fan
Methods for the maximum production of hybridoma antibodies., Sharon L. Flom
Transplantation of bone marrow via placental microinjection to study hemoglobin switching., C. Daniel Frisbie
Methylation of the promoter region of glycerol-3-phosphate dehydrogenase., P. Suzanne Jacks
Southern blot analysis using a photoactivated biotin labelled DNA probe., Jane Libbey
Correlation of glycosylated hemoglobin with collagen aging in mice., Aaron Todd Miller
The effects of superovulation on the development of embryos in culture., Lori S. Newman
Tyrosine hydroxylase maps to murine chromosome 7 within a linkage group conserved in mouse and man., Mark M. Niemann
Thymic homing defects in viable motheaten mutant mice., Glenn Paradis
Gene mapping of 59kDa and 67kDa epidermal keratins., Anthony R. Picarello
Mitotic recombination in the H-2 antigen loss variants., Marie-Blanche N. Tchetgen
Analysis of glycerol-3-phosphate dehydrogenase null mutant., Gillian L. Weiss
Molecular cloning of the platelet fibronectin receptor site., Heather Wilson
The use of ovarian teratomas to construct a meiotic linkage map of chromosome 17 of the house mouse., Hana Yaari
The significance of lymphokines in the immunological function of the DBA/2HA and BXSB mice., Christine Yang
Chromatin determinants of epidermal keratinization., Laura Lee Zenzius
Submissions from 1985
Il-1 production by peritoneal macrophages of tumor- bearing mice., Lorna R. Blanco
Comparison of mouse embryo genotypes in response to cryopreservation protocols., Jessica Boklan
Cryopreservation of hemopoietic stem cells., Jonathan M. Chen
Characterization of DNA sequences in the promoter region of human glycerol-3-phosphate dehydrogenase., Warren Chou
Retrovirus and oncogene expression in normal and tumor tissues of BXH-2 mice., E. Anne Dopson
Analysis of a possible silencer sequence in an African green monkey genomic segment., Barbara L. Hirsch
Diet- and cold-induced thermogenesis in the brown adipose tissue of normal and genetically obese (ob/ob) mice., Robert P. Hoyt
Thermogenesis in the brown adipose tissue of normal (Lean) and genetically obese (ob/ob) mice., Robert P. Hoyt
Genetic analysis of susceptibility to multiple low dose streptozotocin-induced diabetes in two BALB/C sublines., Rebecca A. Lawton