Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 2001
A comparison of inositol polyphosphate type II expression in relation to neuronal loss in the weeble mouse., Terri Myers
The genetic mapping of the foot-topper (Ftp) mutation and its modifiers., Jesse J. Mynahan
Genetic analyses of bone strength in inbred strains of mice., Jennifer Mytar
Optimizing detection and sorting of protein secreting cells using GMD and FACs., Kseniya Petrova
Characterization of purkinje cell degeneration in nb/nb mice., Emily Quirion
Characterizing genes important in preimplantation embryo development., Emily E. Radford
Mining for genes important preimplantation embryo development., Emily E. Radford
The mouse phenome project: acoustic startle response and prepulse inhibition., Matthew Reid
Genetically mapping the foot-topper (Ftp) mutation and its modifiers., Amy E. Russell
Phenotyping the chronic proliferative dermatitis (cpdm) mutant mouse., Anne P. Spillane
The chronic proliferative dermatitis locus (cpdm): high resolution mapping., Erin L. Spillane
The role of IFNy in mycobacterium-induced diabetes resistance in the NOD mouse., Brian Stadinski
Endocrine and environmental factors that retard aging in mammals., Dana Swanson
The effect of induced mutations on the B6 background on hematopoietic stem cell surface marker phenotype and hematopoietic stem cell function., Michael TeKippe
The generation of insulin producing, islet type cells from embryonic stem cells., Jessica M. Tierney
Submissions from 2000
Androgen receptor levels in ovarian granulosa cells of granulosa cell tumor susceptible mouse strains., Sudeep Agarwala
Genes supporting neural stem cell population in the adult brain., Rachel L. Allen
Comparing telomere lengths and identifying carriers of trisomy and Sod1 in the Down Syndrome mouse model., Dorothy E. Boles
Yeast two-hybrid analysis of skeletal muscle protein interactions., Catherine Del Vecchio
A novel mechanism of resistance to retroviral infection., Melody G. Duvall
The role of lymphocytes in the organogenesis of Peyer's Patches., Dennis Hsieh
Genetic mapping of a new semi-dominant mouse mutation: Foot-topper (Ftp), Rachel M. Lee
The effects of cryopreservation on the motility of mouse spermatozoa., Andrews Little
The creation of a GAD67 condtional knock-out: a mouse model for the study of insulin dependent diabetes., Peter Madden
Effects of Sod on development in mouse model on Down's Syndrome., Jacki Medin-Ghiraldi
Mapping the insertion site of the Zp3-Cre transgene., Lauren Naliboff
A characterization of myeloid differentiation using flow cytometry., William I. Olver
Design of a knockout construct for an X-linked dynein light chain, P56387, a candidate for primary ciliary dyskinesia., Jill Marie Ricker
Characterization of spontaneous mutants Toothhopper, NM2804, and NM1360., Margaret Samra
The role of the MTHFR gene in cerebellar development., Abigail Shaw
Genetic factors influencing frozen murine spermatozoa viability and function., Michelle A. Theobald
Creation of a bioinformatics resource: designing and implementing a phenotype vocabulary., Kelly E. Tolle
Development of a comparative pathology resource for animal models for human colo-rectal cancer., Pierre Vanden Borre
Characterization of the inferior olive and PNS development in cerebellar deficient folia (cdf) mice. ..SP:Dr. Susan Ackerman. date, Amy B. Vashlishan
Migration and proliferation trends of donor T-lymphocytes in a murine model of minor histocompatibility antigen-induced graft-versus-host disease., Breelyn A. Wilky
Submissions from 1999
Effects of the maternal environment on a mouse model for Down Syndrome., Celia Adelson
Somatic cell genetic mapping of the Ram1 tumor antigen gene., Shreeram Akilesh
Localizing target proteins on mouse tissue samples using mouse monoclonal antibodies., Alecia Ball
Analysis of new Zp3-CRE transgenic lines., Lorraine T. Binns
Bio-informatics, Andrew Borden-Chisholm
Analysis of the Cobblestone assay as an approximation of hematopoietic stem cell function., David Boshko
Mouse / fly homologies on mouse chromosome 2., Douglas A. Calhoun
Gene expression of NZO/HLt mice by Atlas cDNA expression arrays., Kimberly J. Chung
The effects of aging on the telomere length of hematopoietic stem cells in BALB/cByJ and C57BL/6J mice., Paul F. Gugger
Isolation and characterization of a Dynein Light Chain Pseudogene, tctex1PS, of the mouse t complex., Susan E. Habas
Conditional Fas knock-out in pancreatic insulin-producing beta cells., Heather Hartig
A locus responsible for brain development, tailless (Tlx), is proximal to Zfa on mouse chromosome 10 and is located at 28 cM., Mary Catherine Healy
Development of a mouse Trp53 mutation database., Winnie Liang
Effects of cryopreservation on the acrosome and fertilizing ability of mouse spermatozoa., Rita MacCormick
The effects of population size and marker density on power to detect QTL., Genevieve M. Monsees
Genetic analysis of developmental phenotypes in a CASTxC3H intercross., Matthew D. Mrazek
Construction of an retroviral vector containing the Hu APOA-1 Milano gene., Michael A. Newton
The comparative cancer genetics web site., Beto Peliks
CD4 molecules lacking p56lck binding site promote T cell recognition of MHC class I., Stephen Poon
A high-resolution map of the piebald(s) deletion complex on chromosome 14., Jeffrey Roix
Molecular approaches to understanding retinal degenerations., Philip C. Rosenstiel
Examination of dying granule and purkinje cells in harlequin and sticky mutant mice., Marlies Rossman
A comparison of sperm osmotic tolerances between C57BL/6J and B6D2F1., Sarah Rubin
Looking for new alleles in mouse mutants with absence epilepsies., Valeria Smith
Mechanisms of tumorigenesis induced by simple retroviruses., Stephanie Turner
Guidelines for developing staining panels for multi-parametric fluorescent analysis., Kristin Vekasi
Knocking-out the H13 gene., Travis Walls
Mapping a gene responsible for increased stem cell function in CXB12 mice using the cobblestone in vitro assay., Kristin Walson
Towards understanding the mechanism of the transmembrane receptor Unc5h3 in neuronal migration., Elisabeth Wurtmann
Selection of molecular markers for genetic analysis of developmental rate in C3HxCAST intercross., Chance E. Yohman
Submissions from 1998
Analysis of the genetic cross C57BL/6J x A/J for obesity quantitative trait loci., Kristen M. Belfi
Gene therapy of insulin dependent diabetes mellitus in NOD mice., John J. Bendokas
Chromosomal regions timing the first adult hair cycle in mice., Jason Burwen
Genetic characterization of diabetes in selected female mice from the diabetes protective factor cross., Laura Delbridge
Generating deletions within the mouse t complex., Jessica Dimson
Graphical representations of conserved regions between mouse and human genomes., Margaret Douglass
Toward the positional cloning of a new mouse mutation causing hind limb paralysis and digit abnormalities., Elizabeth A. Good
Investigation of the role of S-AKAP84 in the genetic control of brown adipocyte induction in white adipose tissue., Heather Hammerstedt
Creating a bioinformatics resource: problems and promise., Christina M. Hull
Novel approaches for eliciting transplantation immunity., Anne Jefferson
Documenting the cloning process for gene p48/52., Alice Letcher
The use of microsatelitte mouse markers to study the genetic diversity of beaver and spruce grouse populations on Mount Desert Island., Devin Lueddeke
Mapping genes that regulate volumetric bone mineral density in BXH recombinant inbred strains of mice., Margaret E. McCrann
Mapping the mouse Y chromosome., Bryan B. McQuade
Serial analysis gene expression of a 10.5 day old mouse embryo., Vail Miller
Th1 and Th2 CD4+T cells from NOD mice vary in susceptibility to AICD but do not differentially contribute to autoimmune diabetes., Erin M. Nelli
The effects of thyroid hormone dose on minimal oxygen consumption in mice., Trey Powers
Identification of the mutation in x-spectrin of a new mutant with hemolytic anemia., Amanda N. Roesch
Identification of transcription factors in the mouse 2-cell embryo and analysis of their translational activation., Michael Roopenian
Using ApoA-IMilano gene therapy to protect against atherosclerosis., Corina Rosales
Genetic effects of hyper hematopoietic stem cells., Benjamin H. Schmidt
To test the hypothesis the mEMS88 embryonic (ES) cell line has germline potential., Bobby0Jo Shirley
Production of a deletion panel at the pim-1 locus of the t-complex in mouse chromosome 17., Karen T. Smith
In search of the genes for epilepsy: a fine mapping project., Hilary Stanley
Elimination of autoreactive T cells using ectopically FasL and autoantigen in B cells lacking co-stimulatory molecules., Nathaniel Stetson
A failure of erythropoiesis in Band 3 deficient mice suggests a modifier gene influences red blood cell terminal differentiation., Rebecca A. Swearingen
Obesity in C57BLKS and HRS mice., Pei-Shan Christine Thai
Chromosomal localization of ocular abnormalities in C57BL/6-Trp53 homozygous null mutants., Ludger Tushaus
Environmental initiatives at the Jackson Laboratory., Kristin Vekasi
Expression studies and physical mapping associated with the Piebald Lethal deletion., Stephen J. Warner
The association between hormone deficiency and hearing loss in mice., Dara Zweig
Submissions from 1997
Studies to understand factors influencing glaucoma., Lily M. Belfi
Positional cloning of the Punk Rocker mutation., Christopher Berry