Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 1999
Mapping a gene responsible for increased stem cell function in CXB12 mice using the cobblestone in vitro assay., Kristin Walson
Towards understanding the mechanism of the transmembrane receptor Unc5h3 in neuronal migration., Elisabeth Wurtmann
Selection of molecular markers for genetic analysis of developmental rate in C3HxCAST intercross., Chance E. Yohman
Submissions from 1998
Analysis of the genetic cross C57BL/6J x A/J for obesity quantitative trait loci., Kristen M. Belfi
Gene therapy of insulin dependent diabetes mellitus in NOD mice., John J. Bendokas
Chromosomal regions timing the first adult hair cycle in mice., Jason Burwen
Genetic characterization of diabetes in selected female mice from the diabetes protective factor cross., Laura Delbridge
Generating deletions within the mouse t complex., Jessica Dimson
Graphical representations of conserved regions between mouse and human genomes., Margaret Douglass
Toward the positional cloning of a new mouse mutation causing hind limb paralysis and digit abnormalities., Elizabeth A. Good
Investigation of the role of S-AKAP84 in the genetic control of brown adipocyte induction in white adipose tissue., Heather Hammerstedt
Creating a bioinformatics resource: problems and promise., Christina M. Hull
Novel approaches for eliciting transplantation immunity., Anne Jefferson
Documenting the cloning process for gene p48/52., Alice Letcher
The use of microsatelitte mouse markers to study the genetic diversity of beaver and spruce grouse populations on Mount Desert Island., Devin Lueddeke
Mapping genes that regulate volumetric bone mineral density in BXH recombinant inbred strains of mice., Margaret E. McCrann
Mapping the mouse Y chromosome., Bryan B. McQuade
Serial analysis gene expression of a 10.5 day old mouse embryo., Vail Miller
Th1 and Th2 CD4+T cells from NOD mice vary in susceptibility to AICD but do not differentially contribute to autoimmune diabetes., Erin M. Nelli
The effects of thyroid hormone dose on minimal oxygen consumption in mice., Trey Powers
Identification of the mutation in x-spectrin of a new mutant with hemolytic anemia., Amanda N. Roesch
Identification of transcription factors in the mouse 2-cell embryo and analysis of their translational activation., Michael Roopenian
Using ApoA-IMilano gene therapy to protect against atherosclerosis., Corina Rosales
Genetic effects of hyper hematopoietic stem cells., Benjamin H. Schmidt
To test the hypothesis the mEMS88 embryonic (ES) cell line has germline potential., Bobby0Jo Shirley
Production of a deletion panel at the pim-1 locus of the t-complex in mouse chromosome 17., Karen T. Smith
In search of the genes for epilepsy: a fine mapping project., Hilary Stanley
Elimination of autoreactive T cells using ectopically FasL and autoantigen in B cells lacking co-stimulatory molecules., Nathaniel Stetson
A failure of erythropoiesis in Band 3 deficient mice suggests a modifier gene influences red blood cell terminal differentiation., Rebecca A. Swearingen
Obesity in C57BLKS and HRS mice., Pei-Shan Christine Thai
Chromosomal localization of ocular abnormalities in C57BL/6-Trp53 homozygous null mutants., Ludger Tushaus
Environmental initiatives at the Jackson Laboratory., Kristin Vekasi
Expression studies and physical mapping associated with the Piebald Lethal deletion., Stephen J. Warner
The association between hormone deficiency and hearing loss in mice., Dara Zweig
Submissions from 1997
Studies to understand factors influencing glaucoma., Lily M. Belfi
Positional cloning of the Punk Rocker mutation., Christopher Berry
Phenotypic characterization of the spontaneous Piebald Lethal deletion and mapping of the s24Pub deletion., Dennis M. Bissonnette
Effect of age of hematopoietic stem cell activity in vitro in CXB RI mice., Dean Campagna
Mouse colony maintenance and breeding experiments., Rachel E. Cox
Completion of a YAC contig spanning the minor histocompatibility gene H3a., Sonal B. Dave
Alopecia in C57BL/6J female mice., Bethany Dede
Genomic pattern identification., Natalie Mildred Douglas
Creating an information resource on the internet., Jefferson Hobbs
Cataracts., Sara Hurd
Automated mouse shavings disposal., Ryan Johnson
Over-expression of the putative autoantigen GAD65 in beta cells of NOD/Lt transgenic mice., Benjamin M. Lee
Mapping genes and markers with a mouse radiation hybrid panel., Allen P. Lerner
Development of an improved strain of transgenic mice for the preparation of puromycin-resistant embryonic stem (ES) cell feeder layers., Elizabeth R. Linnell
The genetic dtermination of cold-sensitivity in BALB/cByJ mice., Walker MacCormick
A year in bioinformatics., Max McGarr
Using limiting dilution cobblestone area forming cell assays to detect hematopoietic stem cell defects., Genevieve M. Monsees
Genetics tutorial project., Jason Moody
The Molecular characterization of the cold-sensitivity of BALB/cByJ mice., Lauren K. Morges
Mean sperm counts of several inbred strains in PBS and CPA: analysis of total count, motility and cryopreservation effect., Meghan Beth Palmer
Positional cloning of the mdm mutation., Chandrika Rajan
Molecular biology incorporated into the Of Mice and Mendel genetics source., Suzanna Rich
Rostral cerebellar malformation (rcm): further characterization of phenotype and analysis of protein mechanism., Melanie Roberts
Shavings disposal system., Michael Roopenian
Characterization of embryonic brain structure in mice with a genomic deletion leading to aggressive adult behavior., Jennifer Saionz
Using mice as models for human osteoporosis., Jocelyn Sharp
Molecular analysis of a spontaneous anemia mutation in the mouse reveals a premature stop codon in the cytoplasmic domain of the erythrocyte band in gene (Ae1)., Rebecca A. Swearingen
A typical task in bioinformatics., Christopher Tracy
Using genetic tools from the mouse to estimate genetic diversity in the black rhinoseros., Joshua Veatch
Evaluating effects of cyclophosphamide on meiotic recombination in mice., Leah Rosa Weinberg
Studies on gene therapy of autoimmune diabetes in NOD mice., Kristin M. Willcox
Submissions from 1996
An investigation of the antigen presenting function of a new NOD macrophage cell line., Christopher D. Adams
Creation of a targeting vector for the functional mapping of mouse chromosome 17., Edward Cho
Transgenic mice for the preparation of feeder layers in gene targeting., Agnieszka K. Czopik
B2m effects both progression of the B cell lymphoma and the life expectancy in SJL mice., Kohar Der Simonian
The role of GAD65 in insulin-dependent diabetes mellitus causation in NOD/Lt mice., Tiffany N. Flaum
Contributions of B-lymphocytes to the development of pancreatic beta cell autoreactive T lymphocytes in the NOD mouse model of insulin dependent diabetes mellitus., Sara Anne Fleming
A genetic and physical map surrounding the transplantation antigen H3a., Jennifer Hackstt
Isolating 3'exons from the Stargazer region., Sarah Hipkens
The role of Mac-1 and tumor necrosis factor-alpha in the immunopathological changes observed in Motheaten and Viable Motheaten mice., Rachel C. Kidman
Analysis of thrombi and infarctions in erythroid x-spectrin deficient mice., John C. Lee
High resolution mapping of the adrenal lipid depletion gene., Matthew Lerner
Of mice and Mendel: the online genetics tutorial., Meghann Mabon
Computational and statistical modeling of shared haplotypes in QTL mapping., Joshua Pincus
The effects of the LH-RH agonist [Des-Gly10, D-Ala6, Pro-NHet9] on the estrus cycle of the mouse., Myrtland Roberts
A mouse model of human gene therapy for atherosclerosis., Gregory K. Scott
The characterization of high density lipoproteins as an antioxidant in vivo., Eboni Smith
Quantitative trait loci analysis in the inbred strains SM and NZB., Megan A. Staton
The effect of a ketogenic diet on seizure frequency in the EL and SWXL-4 strains of mice., Jason Tarbet
Using mouse genetic tools to study genetic diversity in the African black rhinoceros., Joshua Veatch
Mice, mice, baby!: Generating interactive genetics crosses on the World Wide Web., Katherine E. Wong
Submissions from 1995
Effect of nutritional anti-oxidents on radiation-induced increases in somatic mutations rates., Sky David Agnitti
Investigation of the IL-6 synthesis pathway in murine peripheral blood monocytes., Susanne E. Ahmari
High resolution genetic and YAC-based physical mapping of a transplantation antigen gene on mouse chromosome 2., Heidi J. Auman
A graphical interface for displaying and interacting with strain pedigrees and strain derivation histories., Amar Bajpayee
Function of Idd13 in autoimmune diabetes., Emmie I. Chen
The genetic control of hyperalphalipoproteinemia., Scott R. DuBois
Development of an erythroid beta-spectrin transgenic construct with tissue specific expression., Holly Ann Field
Towards the positional cloning of the fidget (fi) mutation located on mouse chromosome 2., Jennifer Gervais
Studies of autoimmune diabetes in the NOD mouse., Heide M. Girardin
The characterization of tubby (tub) and the mapping of a modifying factor., Johannah Kone
Graphical rendering of homology between the mouse and human genomes., Victor Dragon Ko
Etl2 constructs for transgenic mice., Holger Kranich
The use of chromosome paints in localizing the translocation breakpoint in a mouse model for Down Syndrome., Jeremy Lambert