Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 1997
Phenotypic characterization of the spontaneous Piebald Lethal deletion and mapping of the s24Pub deletion., Dennis M. Bissonnette
Effect of age of hematopoietic stem cell activity in vitro in CXB RI mice., Dean Campagna
Mouse colony maintenance and breeding experiments., Rachel E. Cox
Completion of a YAC contig spanning the minor histocompatibility gene H3a., Sonal B. Dave
Alopecia in C57BL/6J female mice., Bethany Dede
Genomic pattern identification., Natalie Mildred Douglas
Creating an information resource on the internet., Jefferson Hobbs
Cataracts., Sara Hurd
Automated mouse shavings disposal., Ryan Johnson
Over-expression of the putative autoantigen GAD65 in beta cells of NOD/Lt transgenic mice., Benjamin M. Lee
Mapping genes and markers with a mouse radiation hybrid panel., Allen P. Lerner
Development of an improved strain of transgenic mice for the preparation of puromycin-resistant embryonic stem (ES) cell feeder layers., Elizabeth R. Linnell
The genetic dtermination of cold-sensitivity in BALB/cByJ mice., Walker MacCormick
A year in bioinformatics., Max McGarr
Using limiting dilution cobblestone area forming cell assays to detect hematopoietic stem cell defects., Genevieve M. Monsees
Genetics tutorial project., Jason Moody
The Molecular characterization of the cold-sensitivity of BALB/cByJ mice., Lauren K. Morges
Mean sperm counts of several inbred strains in PBS and CPA: analysis of total count, motility and cryopreservation effect., Meghan Beth Palmer
Positional cloning of the mdm mutation., Chandrika Rajan
Molecular biology incorporated into the Of Mice and Mendel genetics source., Suzanna Rich
Rostral cerebellar malformation (rcm): further characterization of phenotype and analysis of protein mechanism., Melanie Roberts
Shavings disposal system., Michael Roopenian
Characterization of embryonic brain structure in mice with a genomic deletion leading to aggressive adult behavior., Jennifer Saionz
Using mice as models for human osteoporosis., Jocelyn Sharp
Molecular analysis of a spontaneous anemia mutation in the mouse reveals a premature stop codon in the cytoplasmic domain of the erythrocyte band in gene (Ae1)., Rebecca A. Swearingen
A typical task in bioinformatics., Christopher Tracy
Using genetic tools from the mouse to estimate genetic diversity in the black rhinoseros., Joshua Veatch
Evaluating effects of cyclophosphamide on meiotic recombination in mice., Leah Rosa Weinberg
Studies on gene therapy of autoimmune diabetes in NOD mice., Kristin M. Willcox
Submissions from 1996
An investigation of the antigen presenting function of a new NOD macrophage cell line., Christopher D. Adams
Creation of a targeting vector for the functional mapping of mouse chromosome 17., Edward Cho
Transgenic mice for the preparation of feeder layers in gene targeting., Agnieszka K. Czopik
B2m effects both progression of the B cell lymphoma and the life expectancy in SJL mice., Kohar Der Simonian
The role of GAD65 in insulin-dependent diabetes mellitus causation in NOD/Lt mice., Tiffany N. Flaum
Contributions of B-lymphocytes to the development of pancreatic beta cell autoreactive T lymphocytes in the NOD mouse model of insulin dependent diabetes mellitus., Sara Anne Fleming
A genetic and physical map surrounding the transplantation antigen H3a., Jennifer Hackstt
Isolating 3'exons from the Stargazer region., Sarah Hipkens
The role of Mac-1 and tumor necrosis factor-alpha in the immunopathological changes observed in Motheaten and Viable Motheaten mice., Rachel C. Kidman
Analysis of thrombi and infarctions in erythroid x-spectrin deficient mice., John C. Lee
High resolution mapping of the adrenal lipid depletion gene., Matthew Lerner
Of mice and Mendel: the online genetics tutorial., Meghann Mabon
Computational and statistical modeling of shared haplotypes in QTL mapping., Joshua Pincus
The effects of the LH-RH agonist [Des-Gly10, D-Ala6, Pro-NHet9] on the estrus cycle of the mouse., Myrtland Roberts
A mouse model of human gene therapy for atherosclerosis., Gregory K. Scott
The characterization of high density lipoproteins as an antioxidant in vivo., Eboni Smith
Quantitative trait loci analysis in the inbred strains SM and NZB., Megan A. Staton
The effect of a ketogenic diet on seizure frequency in the EL and SWXL-4 strains of mice., Jason Tarbet
Using mouse genetic tools to study genetic diversity in the African black rhinoceros., Joshua Veatch
Mice, mice, baby!: Generating interactive genetics crosses on the World Wide Web., Katherine E. Wong
Submissions from 1995
Effect of nutritional anti-oxidents on radiation-induced increases in somatic mutations rates., Sky David Agnitti
Investigation of the IL-6 synthesis pathway in murine peripheral blood monocytes., Susanne E. Ahmari
High resolution genetic and YAC-based physical mapping of a transplantation antigen gene on mouse chromosome 2., Heidi J. Auman
A graphical interface for displaying and interacting with strain pedigrees and strain derivation histories., Amar Bajpayee
Function of Idd13 in autoimmune diabetes., Emmie I. Chen
The genetic control of hyperalphalipoproteinemia., Scott R. DuBois
Development of an erythroid beta-spectrin transgenic construct with tissue specific expression., Holly Ann Field
Towards the positional cloning of the fidget (fi) mutation located on mouse chromosome 2., Jennifer Gervais
Studies of autoimmune diabetes in the NOD mouse., Heide M. Girardin
The characterization of tubby (tub) and the mapping of a modifying factor., Johannah Kone
Graphical rendering of homology between the mouse and human genomes., Victor Dragon Ko
Etl2 constructs for transgenic mice., Holger Kranich
The use of chromosome paints in localizing the translocation breakpoint in a mouse model for Down Syndrome., Jeremy Lambert
Towards a targeting construct for Zfy2., Holly J. Lasecki
The validation of a short term assay for the primitive hematopoietic stem cell., Kwame Makini
The effect of beta2m-knockout on homeostatic Ig levels and specific antibody response to antigen., Jessica Niles
To determine the mechanisms by which CSF-1 and LPS regulate the expression of the IL-6 gene on macrophages., Jessica Phelps
Translational control of a maternal transcript, stage-specific embryonic cDNA P., Julia Po
The effect of age on oxygen consumption in mice., R. Wilson Powers
Effect of peritoneal macrophages on IGM production by CD5+ B cells in MEv/MEv mice., Meena H. Rajan
Expression and purification of Dll1 fusion proteins., Nicole Roos
Investigation of an inherited diabetes insipidus in BALB/cByJ mice., Sarah B. Shubert
Mapping a gene responsible for a unique anemia in the mouse., Emily B. Wood
Submissions from 1994
The regulatory sequences of the Tcp-10 genes compared., Robin Ackerman
Immunological characteristics of mice homozygous for severe combined immunodeficiency (scid) and beige (bg) nutations., Gillian L. Beamer
Class 1 deficiency of MRL-B2mo/o lpr/lpr reduces the accumulation of double negative T-cells and autoantibody production., Rebecca L. Blankenburg
Time of expression of Simian Virus 40 T antigen in bone of 501 line mice., Cecilia B. Candia
A study of Hairy Ears (Eh) mouse mutation., Janet I. Crane
Chromosome rearrangement, synteny conservation, and evolution of mammalian genomes., Jason S. Ehrlich
Three zinc finger genes upregulated in human neurons., Sarah K. Gelehrter
Characterization of the stage specific embryonic cDNA clone P (SSEC-P) protein in mouse oocytes., Eden Haverfield
Renewing the MATRIX database., Jeffrey S. Kenney
A recombination-based transgenic mouse model for in vivo germ line mutagenicity detection., Douglas S. Kim
The interactive effects of gonadal steroids and exercise in a genetic model of low bone density., Katherine A. Kovalski
Investigation of multiple erythroid beta-spectrin transcripts in normal and jaundiced murine brain., Benjamin Lee
The development of sequence-tagged sites on the mouse Y chromosome., Andrew S. Little
Pathogenic mechanisms of insulin dependent diabetes mellitus in non-obese diabetic (NOD) mice., Oliver W. Liu
Genetic effect on bone loss during aging: relation to reproductive status in female mice., James Edward Lyles
An investigation of the frequency of back mutations in intestinal crypt stem cells., Michael Lynn
Creating a YAC contig around beta-2 microglobulin on mouse chromosome 2., Julie A. Markwardt
Evaluation of Fgf1 as a candidate gene for the Ter mutation on mouse chromosome 18., Kelley Martin
Analysis of the genetic cross NX129-10 x C57BL/6J for obesity QTLs., Heather A. McAuley
The in vitro Cobblestone Assayelationship to tests for functional hematopoietic stem cells in vivo., Andrew L. Miner
Characterization of ankyrin proteins in normal and mutant mice using domain specific antibodies., Penny J. Moshier
Protocol for isolation of various isoforms of the eythrocyte cytoskeleton protein ankyrin., Louise C. Pyle
Characterization of the Angora mouse mutation., Ruth A. Pyle
The characterization of the dominant hair and ear mutation., Adriana E. Shuster