Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.
Submissions from 1995
Towards a targeting construct for Zfy2., Holly J. Lasecki
The validation of a short term assay for the primitive hematopoietic stem cell., Kwame Makini
The effect of beta2m-knockout on homeostatic Ig levels and specific antibody response to antigen., Jessica Niles
To determine the mechanisms by which CSF-1 and LPS regulate the expression of the IL-6 gene on macrophages., Jessica Phelps
Translational control of a maternal transcript, stage-specific embryonic cDNA P., Julia Po
The effect of age on oxygen consumption in mice., R. Wilson Powers
Effect of peritoneal macrophages on IGM production by CD5+ B cells in MEv/MEv mice., Meena H. Rajan
Expression and purification of Dll1 fusion proteins., Nicole Roos
Investigation of an inherited diabetes insipidus in BALB/cByJ mice., Sarah B. Shubert
Mapping a gene responsible for a unique anemia in the mouse., Emily B. Wood
Submissions from 1994
The regulatory sequences of the Tcp-10 genes compared., Robin Ackerman
Immunological characteristics of mice homozygous for severe combined immunodeficiency (scid) and beige (bg) nutations., Gillian L. Beamer
Class 1 deficiency of MRL-B2mo/o lpr/lpr reduces the accumulation of double negative T-cells and autoantibody production., Rebecca L. Blankenburg
Time of expression of Simian Virus 40 T antigen in bone of 501 line mice., Cecilia B. Candia
A study of Hairy Ears (Eh) mouse mutation., Janet I. Crane
Chromosome rearrangement, synteny conservation, and evolution of mammalian genomes., Jason S. Ehrlich
Three zinc finger genes upregulated in human neurons., Sarah K. Gelehrter
Characterization of the stage specific embryonic cDNA clone P (SSEC-P) protein in mouse oocytes., Eden Haverfield
Renewing the MATRIX database., Jeffrey S. Kenney
A recombination-based transgenic mouse model for in vivo germ line mutagenicity detection., Douglas S. Kim
The interactive effects of gonadal steroids and exercise in a genetic model of low bone density., Katherine A. Kovalski
Investigation of multiple erythroid beta-spectrin transcripts in normal and jaundiced murine brain., Benjamin Lee
The development of sequence-tagged sites on the mouse Y chromosome., Andrew S. Little
Pathogenic mechanisms of insulin dependent diabetes mellitus in non-obese diabetic (NOD) mice., Oliver W. Liu
Genetic effect on bone loss during aging: relation to reproductive status in female mice., James Edward Lyles
An investigation of the frequency of back mutations in intestinal crypt stem cells., Michael Lynn
Creating a YAC contig around beta-2 microglobulin on mouse chromosome 2., Julie A. Markwardt
Evaluation of Fgf1 as a candidate gene for the Ter mutation on mouse chromosome 18., Kelley Martin
Analysis of the genetic cross NX129-10 x C57BL/6J for obesity QTLs., Heather A. McAuley
The in vitro Cobblestone Assayelationship to tests for functional hematopoietic stem cells in vivo., Andrew L. Miner
Characterization of ankyrin proteins in normal and mutant mice using domain specific antibodies., Penny J. Moshier
Protocol for isolation of various isoforms of the eythrocyte cytoskeleton protein ankyrin., Louise C. Pyle
Characterization of the Angora mouse mutation., Ruth A. Pyle
The characterization of the dominant hair and ear mutation., Adriana E. Shuster
HDL levels and atherogenesis: a potential role for high density lipoprotein as an antioxident., Kelsey J. Webb
Submissions from 1993
A Comparison of the fertilizing capacity of cryopreserved and fresh spermatozoa collected from different areas of the male reproductive tract of mice., Sonya E. Barrineau
The Adipocyte P2/Uncoupling protein transgene: determining the effects on energy inefficiency., Christopher Marshall Bouton
Targeting of the BxH-2 retrovirus in myeloid leukemogenesis., Annabel Bradford
Effects of different mouse genotypes on sperm cryopreservation: a comparison of motility and abnormal forms in fresh and cryopreserved spermatozoa., Katherine Cardenas
Sequencing of the third endogenous ecotropic proviral insertion site in BxH-2 mice., Deborah Chen
Mechanisms of gallium nitrate modulation of diabetes in NOD mice., Emmie Chen
Linkage of hyperalphalipoproteinemia to the Apo A-1 locus and directing expression of apolipoprotein A 1 to macrophages., Connie Cheung
Patterns of protein tyrosine phosphorylation in motheaten and viable motheaten mice., Trac M. Duong
Proteins associated with alternately spliced ankyrin transcripts., Holly Ann Field
An Endocrinological characterization of Fat and Tubby: possible animal models for human noninsulin-dependant diabetes mellitus., Jason E. Frankel
Studies of two neurological mutations: Moonwalker on chromosome 7, and Stargazer on chromosome 15., Jennifer Gervais
Chromosome mapping by fluorescent in situ hybridization., Charles Harris
Characterization of B-lymphoid tyrosine kinase blk as a candidate gene for identifying the disorganization mutation., Florence Jean-Louis
Genetic predisposition to hypertension and gallstones in the inbred strains of mice., Bhupinder Khanuja
Genetic and dietary factors affecting gallstone formation., Bhupinder S. Khanuja
An analysis of the effects of chemotherapy and a hemoregulatory peptide on primitive hematopoietic stem cells., Carmen Mays
A High resolution genetic map and candidates for a minor histocompatibility gene., Huy Q. Nguyen
High-density lipoprotein levels and obesity in mice: understanding the paradox., Cynthia J. Osterling
Preparation of a targeting construct for the Zfa gene., Haley A. Perlick
Purification of the mouse Y chromosome by reversible mobilization and magnetic in situ hybridization labeling., Sudha Reddy
The Genetic mapping of single-gene phenotypes by linkage analysis with PCR-amplified microsatillites from pooled DNA., Phoebe Scott-Wyard
Purification of mouse chromosome 14 by reversible immobilization and magnetic labeling., Brad Stohr
Timing of fetal loss to murine MPS VII., Colleen Storzek
Obtaining four evenly spaced clones on chrmomsome 17 as the first step to deletion mapping of the t-complex., Marie S. Thearle
Development of spina Bifida in undulated/patch double mutants., Bianca Thomas
High density lipoprotein cholesterol: a study of its effects on aging and lipid peroxidation., Kelsey Jeannine Webb
Submissions from 1992
The chromosomal location of a gene that increases susceptibility to testicular teratomas., Carrie E. Berman
Enrichment of primitive hemopoietic stem cells: preparation of monoclonal antibodies and new approaches., William G. Blum
Regulation of IL-6 gene expression in tumor cells: to identify the serum factor(s) required for IL-1 to activate the cells., Brett Cassidy
A Mouse model used to understand the role of minor histocompatibility antigens in tumor immunity., Stormy Chamberlain
Ovarian granulosa cell tumorigenesis: phase II enzymes and immunohistochemical markers., Siew-Sim Cheah
Development of polycystic kidney disease in mutant mice., Jacob N. Claflin
Analysis of mononuclear cell populations in a new mouse model alopecia areata., Wade R. Cordy
Cloning and indentification of a "novel" oncogene., Peter B. Craig
Cytokine gene expression in cancer and the effects of lipopolysaccharide., Garret Djeu
Influences of Ph on W., Amy E. Dunlop
The Effects of gender and dehydroepiandrosterone-sulfate on the aging immune system., Avery W. Gardiner
Developmental and hormone regulation of B-glucuronidase gene expression in transgenic mice., Randy Goethke
Erythropoiesis and erythrocyte survival in alpha-thalassemic mice., Jennifer M. Greer
The Effects of sodium orthovanadate administration on plasma lipid levels in C57BL/Ks-db/db mice., Julie Harris
Genetic predisposition to hypertension and atherosclerosis: exploration with SWR/J and SJL/J recombinant inbred strains., Bhupinder Khanuja
Intrathymic islet cell transplantation in the NOD mouse: a tolerogenic mechanism?, Daniel E. Krull
Reconstitution of viable motheaten mutant mice with normal hematopoietic progenitor cells., Graciana Lapetina
Computer display of inbreeding dynamics., Victor Lin
Association studies ALP and polymorphisms in the LDL receptor gene., Joyce Meng
CHROmouseSOME: a computer-assisted mouse karyotyping system., Steve L. Philbrick
Genetic factors affecting insulin resistance in DBA/2 and C57BL/Ks mice., S. celeste Posey
Retroviral mutagenesis of murine pre-B cells., Juliet K. Vescio
Submissions from 1991
The Effects of a secondary administration of testosterone on the kinetics of beta-glucuronidase induction., Janet Alter
The Genetic control of parthenogenesis and ovarian teratocarcinogenesis., Gayle Bouchard
Do cyclic AMP response element binding proteins regulate the mitochondrial uncoupling protein gene?, Christopher M.L Bouton
Repopulation in the hematopoietic system- a short term analysis of stem cell dynamics., Ralph J. DiLeone
Characterization of genetic factors for cholesterol gallstone formation in mice., Camille A. Falkner
Characterization of a male sterility mutant caused by the integration of a murine ecotropic leukemia provirus., Charles E. Foulds
The Effects of cryopreservation on the acrosome reaction of mouse spermatozoa., Teca Calcagno Galvao
In vitro growth and maturation of primordial ovarian follicles., Devorah C. Goldman
The Effects of aging on immunological response and oxygen consumption., David C. Gordon
Comparison of alpha thalassemic and wild type erythrocyte survival in wild type hosts., Jennifer M. Greer
The Effects of cryopreservation of mouse sperm on its fertilizability tested by in vitro fertilization., Tobi Groman
Genetic analysis of a mutation causing diverse congenital birth defects., Florence Jean-Louis
The Effects of Ph on W42 and S1., Holly Mason