The Summer Student Program began in 1924 when University of Maine President C.C. Little (our founder) brought six undergraduates to Mount Desert Island for a summer of biological field studies. The Summer Student Program officially became a part of the Jackson Memorial Laboratory's operation in 1931.

Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.


Submissions from 1995

Towards a targeting construct for Zfy2., Holly J. Lasecki

The validation of a short term assay for the primitive hematopoietic stem cell., Kwame Makini

The effect of beta2m-knockout on homeostatic Ig levels and specific antibody response to antigen., Jessica Niles

To determine the mechanisms by which CSF-1 and LPS regulate the expression of the IL-6 gene on macrophages., Jessica Phelps

Translational control of a maternal transcript, stage-specific embryonic cDNA P., Julia Po

The effect of age on oxygen consumption in mice., R. Wilson Powers

Effect of peritoneal macrophages on IGM production by CD5+ B cells in MEv/MEv mice., Meena H. Rajan

Expression and purification of Dll1 fusion proteins., Nicole Roos

Investigation of an inherited diabetes insipidus in BALB/cByJ mice., Sarah B. Shubert

The genetic and physiological characterization of CBA/J-rotund/rotund as compared to CBA/J-db/db and respective slim controls., Ellice Wong

Mapping a gene responsible for a unique anemia in the mouse., Emily B. Wood

Submissions from 1994

The regulatory sequences of the Tcp-10 genes compared., Robin Ackerman

Immunological characteristics of mice homozygous for severe combined immunodeficiency (scid) and beige (bg) nutations., Gillian L. Beamer

Class 1 deficiency of MRL-B2mo/o lpr/lpr reduces the accumulation of double negative T-cells and autoantibody production., Rebecca L. Blankenburg

Time of expression of Simian Virus 40 T antigen in bone of 501 line mice., Cecilia B. Candia

A study of Hairy Ears (Eh) mouse mutation., Janet I. Crane

Chromosome rearrangement, synteny conservation, and evolution of mammalian genomes., Jason S. Ehrlich

Mapping of two new seizure mutations in the mouse: Drunken Chicken on chromosome 4 and nm2013 on chromosome 2., Audrey Fu

Three zinc finger genes upregulated in human neurons., Sarah K. Gelehrter

Characterization of the stage specific embryonic cDNA clone P (SSEC-P) protein in mouse oocytes., Eden Haverfield

Renewing the MATRIX database., Jeffrey S. Kenney

A recombination-based transgenic mouse model for in vivo germ line mutagenicity detection., Douglas S. Kim

The interactive effects of gonadal steroids and exercise in a genetic model of low bone density., Katherine A. Kovalski

Investigation of multiple erythroid beta-spectrin transcripts in normal and jaundiced murine brain., Benjamin Lee

The development of sequence-tagged sites on the mouse Y chromosome., Andrew S. Little

Pathogenic mechanisms of insulin dependent diabetes mellitus in non-obese diabetic (NOD) mice., Oliver W. Liu

Genetic effect on bone loss during aging: relation to reproductive status in female mice., James Edward Lyles

An investigation of the frequency of back mutations in intestinal crypt stem cells., Michael Lynn

Creating a YAC contig around beta-2 microglobulin on mouse chromosome 2., Julie A. Markwardt

Evaluation of Fgf1 as a candidate gene for the Ter mutation on mouse chromosome 18., Kelley Martin

Analysis of the genetic cross NX129-10 x C57BL/6J for obesity QTLs., Heather A. McAuley

The in vitro Cobblestone Assayelationship to tests for functional hematopoietic stem cells in vivo., Andrew L. Miner

Characterization of ankyrin proteins in normal and mutant mice using domain specific antibodies., Penny J. Moshier

Protocol for isolation of various isoforms of the eythrocyte cytoskeleton protein ankyrin., Louise C. Pyle

Characterization of the Angora mouse mutation., Ruth A. Pyle

The characterization of the dominant hair and ear mutation., Adriana E. Shuster

HDL levels and atherogenesis: a potential role for high density lipoprotein as an antioxident., Kelsey J. Webb

Submissions from 1993

A Comparison of the fertilizing capacity of cryopreserved and fresh spermatozoa collected from different areas of the male reproductive tract of mice., Sonya E. Barrineau

The Adipocyte P2/Uncoupling protein transgene: determining the effects on energy inefficiency., Christopher Marshall Bouton

Targeting of the BxH-2 retrovirus in myeloid leukemogenesis., Annabel Bradford

Effects of different mouse genotypes on sperm cryopreservation: a comparison of motility and abnormal forms in fresh and cryopreserved spermatozoa., Katherine Cardenas

Sequencing of the third endogenous ecotropic proviral insertion site in BxH-2 mice., Deborah Chen

Mechanisms of gallium nitrate modulation of diabetes in NOD mice., Emmie Chen

Linkage of hyperalphalipoproteinemia to the Apo A-1 locus and directing expression of apolipoprotein A 1 to macrophages., Connie Cheung

Patterns of protein tyrosine phosphorylation in motheaten and viable motheaten mice., Trac M. Duong

Proteins associated with alternately spliced ankyrin transcripts., Holly Ann Field

An Endocrinological characterization of Fat and Tubby: possible animal models for human noninsulin-dependant diabetes mellitus., Jason E. Frankel

Studies of two neurological mutations: Moonwalker on chromosome 7, and Stargazer on chromosome 15., Jennifer Gervais

Chromosome mapping by fluorescent in situ hybridization., Charles Harris

Characterization of B-lymphoid tyrosine kinase blk as a candidate gene for identifying the disorganization mutation., Florence Jean-Louis

Genetic predisposition to hypertension and gallstones in the inbred strains of mice., Bhupinder Khanuja

Genetic and dietary factors affecting gallstone formation., Bhupinder S. Khanuja

An analysis of the effects of chemotherapy and a hemoregulatory peptide on primitive hematopoietic stem cells., Carmen Mays

A High resolution genetic map and candidates for a minor histocompatibility gene., Huy Q. Nguyen

High-density lipoprotein levels and obesity in mice: understanding the paradox., Cynthia J. Osterling

Preparation of a targeting construct for the Zfa gene., Haley A. Perlick

Purification of the mouse Y chromosome by reversible mobilization and magnetic in situ hybridization labeling., Sudha Reddy

The Genetic mapping of single-gene phenotypes by linkage analysis with PCR-amplified microsatillites from pooled DNA., Phoebe Scott-Wyard

Purification of mouse chromosome 14 by reversible immobilization and magnetic labeling., Brad Stohr

Timing of fetal loss to murine MPS VII., Colleen Storzek

Obtaining four evenly spaced clones on chrmomsome 17 as the first step to deletion mapping of the t-complex., Marie S. Thearle

Development of spina Bifida in undulated/patch double mutants., Bianca Thomas

High density lipoprotein cholesterol: a study of its effects on aging and lipid peroxidation., Kelsey Jeannine Webb

Submissions from 1992

The chromosomal location of a gene that increases susceptibility to testicular teratomas., Carrie E. Berman

Enrichment of primitive hemopoietic stem cells: preparation of monoclonal antibodies and new approaches., William G. Blum

Regulation of IL-6 gene expression in tumor cells: to identify the serum factor(s) required for IL-1 to activate the cells., Brett Cassidy

A Mouse model used to understand the role of minor histocompatibility antigens in tumor immunity., Stormy Chamberlain

Ovarian granulosa cell tumorigenesis: phase II enzymes and immunohistochemical markers., Siew-Sim Cheah

Development of polycystic kidney disease in mutant mice., Jacob N. Claflin

Analysis of mononuclear cell populations in a new mouse model alopecia areata., Wade R. Cordy

Cloning and indentification of a "novel" oncogene., Peter B. Craig

Cytokine gene expression in cancer and the effects of lipopolysaccharide., Garret Djeu

Influences of Ph on W., Amy E. Dunlop

The Effects of gender and dehydroepiandrosterone-sulfate on the aging immune system., Avery W. Gardiner

Developmental and hormone regulation of B-glucuronidase gene expression in transgenic mice., Randy Goethke

Erythropoiesis and erythrocyte survival in alpha-thalassemic mice., Jennifer M. Greer

The Effects of sodium orthovanadate administration on plasma lipid levels in C57BL/Ks-db/db mice., Julie Harris

Genetic predisposition to hypertension and atherosclerosis: exploration with SWR/J and SJL/J recombinant inbred strains., Bhupinder Khanuja

The Effects of high and low fat diets on adipose tissue in genetically growth hormone deficient mice., Josh King

Intrathymic islet cell transplantation in the NOD mouse: a tolerogenic mechanism?, Daniel E. Krull

Reconstitution of viable motheaten mutant mice with normal hematopoietic progenitor cells., Graciana Lapetina

Computer display of inbreeding dynamics., Victor Lin

Association studies ALP and polymorphisms in the LDL receptor gene., Joyce Meng

CHROmouseSOME: a computer-assisted mouse karyotyping system., Steve L. Philbrick

Genetic factors affecting insulin resistance in DBA/2 and C57BL/Ks mice., S. celeste Posey

Retroviral mutagenesis of murine pre-B cells., Juliet K. Vescio

Submissions from 1991

The Effects of a secondary administration of testosterone on the kinetics of beta-glucuronidase induction., Janet Alter

The Genetic control of parthenogenesis and ovarian teratocarcinogenesis., Gayle Bouchard

Do cyclic AMP response element binding proteins regulate the mitochondrial uncoupling protein gene?, Christopher M.L Bouton

Repopulation in the hematopoietic system- a short term analysis of stem cell dynamics., Ralph J. DiLeone

DNA sequence variation in the region upstream from the transcriptional start site of the beta-glucuronidase gene in species exhibiting different androgen induction phenotypes., Laura Drohan

Characterization of genetic factors for cholesterol gallstone formation in mice., Camille A. Falkner

Characterization of a male sterility mutant caused by the integration of a murine ecotropic leukemia provirus., Charles E. Foulds

The Effects of cryopreservation on the acrosome reaction of mouse spermatozoa., Teca Calcagno Galvao

In vitro growth and maturation of primordial ovarian follicles., Devorah C. Goldman

The Effects of aging on immunological response and oxygen consumption., David C. Gordon

Comparison of alpha thalassemic and wild type erythrocyte survival in wild type hosts., Jennifer M. Greer

The Effects of cryopreservation of mouse sperm on its fertilizability tested by in vitro fertilization., Tobi Groman

Genetic analysis of a mutation causing diverse congenital birth defects., Florence Jean-Louis

The Effects of Ph on W42 and S1., Holly Mason