*All publications, press releases or other documents about research resulting from the use of any of JAX Nathan Shock Center Cores are required to acknowledge support from the Nathan Shock Center by citing the grant number. In addition, these published materials must comply with NIH Public Access Policy and be assigned a PMCID.
Citation language for Nathan Shock Center publications: “Research reported in this [publication/press release] was supported by the National Institute on Aging of the National Institutes of Health under award number P30 AG038070. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.” If the publication or press release was supported by more than one grant, please reference all relevant grant numbers.
Submissions from 2025
Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer., Brittany Lynn Angarola, Siddhartha Sharma, Neerja Katiyar, Hyeon Gu Kang, Djamel Nehar-Belaid, SungHee Park, Rachel Gott, Giray N Eryilmaz, Mark A LaBarge, Karolina Palucka, Jeffrey Chuang, Ron Korstanje, Duygu Ucar, and Olga Anczuków
ML-UrineQuant: A machine learning program for identifying and quantifying mouse urine on absorbent paper., Warren G Hill, Bryce MacIver, Gary Churchill, Mariana G DeOliveira, Mark L Zeidel, and Marcelo Cicconet
Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice., Lev Litichevskiy, Maya Considine, Jasleen Gill, Vasuprada Shandar, Timothy O Cox, Hélène C Descamps, Kevin M Wright, Kevin R Amses, Lenka Dohnalová, Megan J Liou, Monika Tetlak, Mario R Galindo-Fiallos, Andrea C Wong, Patrick Lundgren, Junwon Kim, Giulia T Uhr, Ryan J Rahman, Sydney Mason, Carter Merenstein, Frederic D Bushman, Anil Raj, Fiona Harding, Zhenghao Chen, G V Prateek, Martin Mullis, Andrew Deighan, Laura Robinson, Ceylan Tanes, Kyle Bittinger, Meenakshi Chakraborty, Ami S Bhatt, Hongzhe Li, Ian Barnett, Emily R Davenport, Karl W Broman, Maayan Levy, Robert L Cohen, David Botstein, Adam Freund, Andrea Di Francesco, Gary Churchill, Mingyao Li, and Christoph A Thaiss
The impact of co-housing on murine aging studies., Alison Luciano and Gary Churchill
Analysis of lifespan across diversity outbred mouse studies identifies multiple longevity-associated loci., Martin N Mullis, Kevin M Wright, Anil Raj, Daniel M Gatti, Peter C. Reifsnyder, Kevin Flurkey, Jonathan R Archer, Laura Robinson, Andrea Di Francesco, Karen L. Svenson, Ron Korstanje, David E Harrison, J Graham Ruby, and Gary Churchill
Arginine metabolism is a biomarker of red blood cell and human aging., Julie A Reisz, Eric J Earley, Travis Nemkov, Alicia Key, Daniel Stephenson, Gregory R Keele, Monika Dzieciatkowska, Steven L Spitalnik, Eldad A Hod, Steven Kleinman, Nareg H Roubinian, Mark T Gladwin, Kirk C Hansen, Philip J Norris, Michael P Busch, James C Zimring, Gary Churchill, Grier P Page, and Angelo D'Alessandro
Machine vision-based frailty assessment for genetically diverse mice., Gautam S Sabnis, Gary Churchill, and Vivek Kumar
Machine vision-based frailty assessment for genetically diverse mice., Gautam S Sabnis, Gary Churchill, and Vivek Kumar
Submissions from 2024
WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration., Alyssa M Coulter, Valerie Cortés, Corey J Theodore, Rachel E Cianciolo, Ron Korstanje, and Kenneth G Campellone
Cross-sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice., Cody M Cousineau, Kaelin Loftus, Gary Churchill, and Dave Bridges
Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models., Beth L Dumont, Daniel Mario Gatti, Mallory A Ballinger, Dana Lin, Megan Phifer-Rixey, Michael J Sheehan, Taichi A Suzuki, Lydia K Wooldridge, Hilda Opoku Frempong, Raman Akinyanju Lawal, Gary Churchill, Cathleen Lutz, Nadia Rosenthal, Jacqueline K White, and Michael W Nachman
Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice., Daniel Mario Gatti, Anna L. Tyler, J Matthew Mahoney, Gary Churchill, Bulent Yener, Deniz Koyuncu, Metin N Gurcan, Mk Khalid Niazi, Thomas Tavolara, Adam Gower, Denise Dayao, Emily McGlone, Melanie L Ginese, Aubrey Specht, Anas Alsharaydeh, Philipe A Tessier, Sherry L Kurtz, Karen L Elkins, Igor Kramnik, and Gillian Beamer
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used., David E Harrison, Randy Strong, Peter C. Reifsnyder, Nadia Rosenthal, Ron Korstanje, Elizabeth Fernandez, Kevin Flurkey, Brett C Ginsburg, Meredith D Murrell, Martin A Javors, Marisa Lopez-Cruzan, James F Nelson, Bradley J Willcox, Richard Allsopp, David M Watumull, David G Watumull, Gino Cortopassi, James L Kirkland, Tamar Tchkonia, Young Geun Choi, Matthew J Yousefzadeh, Paul D Robbins, James R Mitchell, Murat Acar, Ethan A Sarnoski, Michael R Bene, Adam Salmon, Navasuja Kumar, and Richard A Miller
3-Hydroxyanthranilic Acid Delays Paralysis in, Bradford T Hull, Kayla M Miller, Caroline Corban, Grant Backer, Susan Sheehan, Ron Korstanje, and George L. Sutphin
Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics., Rebecca L Koch, James B Stanton, Susan McClatchy, Gary Churchill, Steven W Craig, Darian N Williams, Mallory E Johns, Kylah R Chase, Dana L Thiesfeldt, Jessica C Flynt, and Robert Pazdro
Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice., Alison Luciano, Laura Robinson, Gaven Garland, Bonnie Lyons, Ron Korstanje, Andrea Di Francesco, and Gary Churchill
Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin., Richard A Miller, David E Harrison, Gino A Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G Geisler, Brett C Ginsburg, Melissa L Han, Catherine C Kaczorowski, Navasuja Kumar, Scott F Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R Mitchell, James F Nelson, Peter C. Reifsnyder, Adam B Salmon, Ron Korstanje, Nadia Rosenthal, and Randy Strong
Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro., Travis Nemkov, Alicia Key, Daniel Stephenson, Eric J Earley, Gregory R Keele, Ariel Hay, Pascal Amireault, Madeleine Casimir, Michaël Dussiot, Monika Dzieciatkowska, Julie A Reisz, Xutao Deng, Mars Stone, Steve Kleinman, Steven L Spitalnik, Kirk C Hansen, Philip J Norris, Gary Churchill, Michael P Busch, Nareg Roubinian, Grier P Page, James C Zimring, Arduino Arduini, and Angelo D'Alessandro
Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes., Travis Nemkov, Daniel Stephenson, Eric J Earley, Gregory R Keele, Ariel Hay, Alicia Key, Zachary B Haiman, Christopher Erickson, Monika Dzieciatkowska, Julie A Reisz, Amy Moore, Mars Stone, Xutao Deng, Steven Kleinman, Steven L Spitalnik, Eldad A Hod, Krystalyn E Hudson, Kirk C Hansen, Bernhard O Palsson, Gary Churchill, Nareg Roubinian, Philip J Norris, Michael P Busch, James C Zimring, Grier P Page, and Angelo D'Alessandro
Unraveling the genetics of arsenic toxicity with cellular morphology QTL., Callan O'Connor, Gregory R Keele, Whitney Martin, Tim J Stodola, Daniel M Gatti, Brian Hoffmann, Ron Korstanje, Gary Churchill, and Laura G Reinholdt
Quantitative trait loci mapping provides insights into the genetic regulation of dendritic cell numbers in mouse tissues., Thiago Y Oliveira, Julia Merkenschlager, Thomas Eisenreich, Juliana Bortolatto, Kai-Hui Yao, Daniel M Gatti, Gary Churchill, Michel C Nussenzweig, and Gaëlle Breton
Improving the predictive power of mouse models., Martin Pera, Andrew S Greene, Lon Cardon, Gregory W. Carter, Elissa J Chesler, Gary Churchill, Vivek Kumar, Cathleen Lutz, Steven C. Munger, Stephen A Murray, Kristen M S O'Connell, Laura G Reinholdt, and Nadia Rosenthal
Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging., Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A Miller, David E Harrison, John R Strong, Mitchell B Schaffler, and Shoshana Yakar
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice., Sher Bahadur Poudel, Ryan R Ruff, Gozde Yildirim, Richard A Miller, David E Harrison, Randy Strong, Thorsten Kirsch, and Shoshana Yakar
A machine learning approach for quantifying age-related histological changes in the mouse kidney., Susan Sheehan, Seamus Mawe, Mandy Chen, Jenna Klug, Warren Ladiges, Ron Korstanje, and J Matthew Mahoney
Effects of a Global Rab27a Null Mutation on Murine PVAT and Cardiovascular Function, Ashley Soucy, Christian Potts, Abigail Kaija, Anne Harrington, Marissa McGilvrey, George L. Sutphin, Ron Korstanje, Benjamin Tero, Jacob Seeker, Ilka Pinz, Calvin Vary, Larisa Ryzhova, and Lucy Liaw
Genetic drivers of age-related changes in urinary magnesium excretion., Wouter H van Megen, Jeroen H F de Baaij, Gary Churchill, Olivier Devuyst, Joost G J Hoenderop, and Ron Korstanje
Submissions from 2023
Challenges and opportunities for modeling aging and cancer., Olga Anczuków, Susan Airhart, Jeffrey Chuang, Lisa M Coussens, George A Kuchel, Ron Korstanje, Sheng Li, Anna Lisa Lucido, Sandra S McAllister, Katerina Politi, Kornelia Polyak, Timothy Ratliff, Guangwen Ren, Jennifer J. Trowbridge, Duygu Ucar, and Karolina Palucka
Genetic dissection of the pluripotent proteome through multi-omics data integration., Selcan Aydin, Duy T Pham, Tian Zhang, Gregory R Keele, Daniel A Skelly, Joao A Paulo, Matthew Pankratz, Ted Choi, Steven P Gygi, Laura G Reinholdt, Christopher L. Baker, Gary Churchill, and Steven C. Munger
Aging and urinary control: Alterations in the brain-bladder axis., Cara C Hardy and Ron Korstanje
Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging., Emin Onur Karakaslar, Neerja Katiyar, Muneer G. Hasham, Ahrim Youn, Siddhartha Sharma, Cheng-Han Chung, Radu Marches, Ron Korstanje, Jacques Banchereau, and Duygu Ucar
Global and tissue-specific aging effects on murine proteomes., Gregory R Keele, Ji-Gang Zhang, John Szpyt, Ron Korstanje, Steven P Gygi, Gary Churchill, and Devin K Schweppe
Chow diet in mouse aging studies: nothing regular about it., Jennifer Lee, Chloe Purello, Sarah L Booth, Brian Bennett, Christopher D Wiley, and Ron Korstanje
Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin., Tara R Price, Donnie S Stapleton, Kathryn L Schueler, Marie K Norris, Brian W Parks, Brian S Yandell, Gary Churchill, William L Holland, Mark P Keller, and Alan D Attie
Submissions from 2022
The impact of genetic background on mouse models of kidney disease., Rei Bufi and Ron Korstanje
A Bayesian model selection approach to mediation analysis., Wesley L Crouse, Gregory R Keele, Madeleine S Gastonguay, Gary Churchill, and William Valdar
A microbiome-dependent gut-brain pathway regulates motivation for exercise., Lenka Dohnalová, Patrick Lundgren, Jamie R E Carty, Nitsan Goldstein, Sebastian L Wenski, Pakjira Nanudorn, Sirinthra Thiengmag, Kuei-Pin Huang, Lev Litichevskiy, Hélène C Descamps, Karthikeyani Chellappa, Ana Glassman, Susanne Kessler, Jihee Kim, Timothy O Cox, Oxana Dmitrieva-Posocco, Andrea C Wong, Erik L Allman, Soumita Ghosh, Nitika Sharma, Kasturi Sengupta, Belinda Cornes, Nitai Dean, Gary Churchill, Tejvir S Khurana, Mark A Sellmyer, Garret A FitzGerald, Andrew D Patterson, Joseph A Baur, Amber L Alhadeff, Eric J N Helfrich, Maayan Levy, J Nicholas Betley, and Christoph A Thaiss
Genome-wide transcript and protein analysis highlights the role of protein homeostasis in the aging mouse heart., Isabela Gerdes Gyuricza, Joel M Chick, Gregory R Keele, Andrew Deighan, Steven C. Munger, Ron Korstanje, Steven P Gygi, and Gary Churchill
A machine-vision-based frailty index for mice., Leinani E. Hession, Gautam S Sabnis, Gary Churchill, and Vivek Kumar
Life-long dietary restrictions have negligible or damaging effects on late-life cognitive performance: A key role for genetics in outcomes., Andrew R Ouellette, Niran Hadad, Andrew Deighan, Laura Robinson, Kristen M S O'Connell, Adam Freund, Gary Churchill, and Catherine Kaczorowski
Adding gene transcripts into genomic prediction improves accuracy and reveals sampling time dependence., Bruno C Perez, Marco C A M Bink, Karen L. Svenson, Gary Churchill, and Mario P L Calus
Prediction performance of linear models and gradient boosting machine on complex phenotypes in outbred mice., Bruno C Perez, Marco C A M Bink, Karen L. Svenson, Gary Churchill, and Mario P L Calus
Sequencing and assembling bear genomes: the bare necessities., Courtney Willey and Ron Korstanje
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology., Haopeng Xiao, Luiz H M Bozi, Yizhi Sun, Christopher L Riley, Vivek M. Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L Mills, Margo P Emont, Wenfei Sun, Anita Reddy, Ryan Garrity, Jiani Long, Tobias Becher, Laura Potano Vitas, Dina Laznik-Bogoslavski, Martha Ordonez, Xinyue Liu, Xiong Chen, Yun Wang, Weihai Liu, Nhien Tran, Yitong Liu, Yang Zhang, Aaron M Cypess, Andrew P White, Yuchen He, Rebecca Deng, Heiko Schöder, Joao A Paulo, Mark P Jedrychowski, Alexander S Banks, Yu-Hua Tseng, Paul Cohen, Linus T Tsai, Evan D Rosen, Samuel Klein, Maria Chondronikola, Fiona E McAllister, Nick Van Bruggen, Edward L Huttlin, Bruce M Spiegelman, Gary Churchill, Steven P Gygi, and Edward T Chouchani
Submissions from 2021
Regulation of protein abundance in genetically diverse mouse populations., Gregory R Keele, Tian Zhang, Duy T. Pham, Matthew J Vincent, Timothy A Bell, Pablo Hock, Ginger D Shaw, Joao A Paulo, Steven C. Munger, Fernando Pardo-Manuel de Villena, Martin T Ferris, Steven P Gygi, and Gary Churchill
The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging., Ron Korstanje, Luanne L. Peters, Laura Robinson, Stephen D Krasinski, and Gary Churchill
Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney., Yuka Takemon, Joel M Chick, Isabela Gerdes Gyuricza, Daniel A Skelly, Olivier Devuyst, Steven P Gygi, Gary Churchill, and Ron Korstanje
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging., Kira Young, Elizabeth Eudy, Rebecca Bell, Matthew A Loberg, Timothy M Stearns, Devyani Sharma, Lars Velten, Simon Haas, Marie-Dominique Filippi, and Jennifer J. Trowbridge
Submissions from 2020
Rapamycin rejuvenates oral health in aging mice., Jonathan Y An, Kristopher A Kerns, Andrew R Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, and Matt Kaeberlein
Using Genetic and Species Diversity to Tackle Kidney Disease., Michael R Garrett and Ron Korstanje
circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan., Shahnaz Haque, Ryan M Ames, Karen Moore, Luke C Pilling, Luanne L. Peters, Stefania Bandinelli, Luigi Ferrucci, and Lorna W Harries
Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation., Eraj Shafiq Khokhar, Sneha Borikar, Elizabeth Eudy, Timothy M Stearns, Kira Young, and Jennifer J. Trowbridge
Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia., Andrew R Ouellette, Sarah M Neuner, Logan Dumitrescu, Laura C. Anderson, Daniel M. Gatti, Emily R Mahoney, Jason A. Bubier, Gary Churchill, Luanne L. Peters, Matthew J Huentelman, Jeremy H Herskowitz, Hyun-Sik Yang, Alexandra N Smith, Christiane Reitz, Brian W Kunkle, Charles C White, Philip L De Jager, Julie A Schneider, David A Bennett, Nicholas T Seyfried, Alzheimer's Disease Genetics Consortium, Elissa J Chesler, Niran Hadad, Timothy J Hohman, and Catherine Kaczorowski
Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice., Rong Yuan, C J M Musters, Yun Zhu, Tracy R Evans, Yujie Sun, Elissa J Chesler, Luanne L. Peters, David E Harrison, and Andrzej Bartke
Submissions from 2019
Quantitative evaluation of ontology design patterns for combining pathology and anatomy ontologies., Sarah M Alghamdi, Beth A. Sundberg, John P Sundberg, Paul N Schofield, and Robert Hoehndorf
Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species., Jason A. Bubier, George L Sutphin, Timothy J Reynolds, Ron Korstanje, Axis Fuksman-Kumpa, Erich J Baker, Michael A Langston, and Elissa J Chesler
Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis., Matthew A Loberg, Rebecca K Bell, Leslie Goodwin, Elizabeth Eudy, Linde A Miles, Jennifer M SanMiguel, Kira Young, David E. Bergstrom, Ross L Levine, Rebekka K Schneider, and Jennifer J. Trowbridge
Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass., Larry D Mesner, Gina M Calabrese, Basel Al-Barghouthi, Daniel M. Gatti, John P Sundberg, Gary A Churchill, Dana A Godfrey, Cheryl L Ackert-Bicknell, and Charles R Farber
Submissions from 2018
FAR2 is Associated with Kidney Disease in Mice and Humans., Grant Backer, Sean Eddy, Susan Sheehan, Yuka Takemon, Anna Reznichenko, Holly S Savage, Matthias Kretzler, and Ron Korstanje
A multi-tissue full lifespan epigenetic clock for mice., Michael J Thompson, Karolina Chwiałkowska, Liudmilla Rubbi, Aldons J Lusis, Richard C Davis, Anuj Srivastava, Ron Korstanje, Gary A Churchill, Steve Horvath, and Matteo Pellegrini
Submissions from 2017
MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice., Benjamin P Lee, Ivana Burić, Anupriya George-Pandeth, Kevin Flurkey, David E Harrison, Rong Yuan, Luanne L. Peters, George A Kuchel, David Melzer, and Lorna W Harries
Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity., George L. Sutphin, Grant Backer, Susan Sheehan, Shannon Bean, Caroline Corban, Teresa Liu, Marjolein J Peters, Joyce B J van Meurs, Joanne M Murabito, Andrew D Johnson, and Ron Korstanje
Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice., Anna L. Tyler, Bo Ji, Daniel M. Gatti, Steven C. Munger, Gary A. Churchill, Karen L. Svenson, and Gregory W. Carter
Submissions from 2016
Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span., Molly A. Bogue, Luanne L. Peters, Beverly J Paigen, Ron Korstanje, Rong Yuan, Cheryl Ackert-Bicknell, Stephen C. Grubb, Gary A. Churchill, and Elissa J Chesler
Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria., Ron Korstanje, Konstantin Deutsch, Patricia Bolanos-Palmieri, Nils Hanke, Patricia Schroder, Lynne Staggs, Jan H Bräsen, Ian S D Roberts, Susan Sheehan, Holly S Savage, Hermann Haller, and Mario Schiffer
Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans., Benjamin P Lee, Luke C Pilling, Florence Emond, Kevin Flurkey, David E Harrison, Rong Yuan, Luanne L. Peters, George A Kuchel, Luigi Ferrucci, David Melzer, and Lorna W Harries
WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning., George L. Sutphin, J Matthew Mahoney, Keith Sheppard, David O Walton, and Ron Korstanje
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging., Kira Young, Sneha Borikar, Rebecca Bell, Lauren Kuffler, Vivek M. Philip, and Jennifer J. Trowbridge
Submissions from 2015
Aging research using mouse models., Cheryl L. Ackert-Bicknell, Laura C. Anderson, Susan Sheehan, Warren G. Hill, Bo Chang, Gary A. Churchill, Elissa J. Chesler, Ron Korstanje, and Luanne L. Peters
Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database., Molly A. Bogue, Gary Churchill, and Elissa J. Chesler
A roadmap for the genetic analysis of renal aging., Gerda A Noordmans, Jan-Luuk Hillebrands, Harry van Goor, and Ron Korstanje
The Role of Platelet-Activating Factor in Mesangial Pathophysiology., Anna Reznichenko and Ron Korstanje
Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1., Rong Yuan, Daniel Mario Gatti, Rebecca Krier, Ethan Malay, David Schultz, Luanne L. Peters, Gary A. Churchill, David E. Harrison, and Beverly Paigen
Submissions from 2014
Quantitative trait locus mapping methods for diversity outbred mice., Daniel Mario Gatti, Karen L. Svenson, Andrey Shabalin, Long-Yang Wu, William Valdar, Petr Simecek, Neal Goodwin, Riyan Cheng, Daniel Pomp, Abraham Palmer, Elissa J. Chesler, Karl W Broman, and Gary Churchill
Alterations in thin filament length during postnatal skeletal muscle development and aging in mice., David S Gokhin, Emily A Dubuc, Kendra Q Lian, Luanne L. Peters, and Velia M Fowler
Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice., Yuan Huang, Christina R Caputo, Gerda A Noordmans, Saleh Yazdani, Luiz Henrique Monteiro, Jaap van den Born, Harry van Goor, Peter Heeringa, Ron Korstanje, and Jan-Luuk Hillebrands
Variation and Genetic Control of Gene Expression in Primary Immunocytes across Inbred Mouse Strains., Sara Mostafavi, Adriana Ortiz-Lopez, Molly A. Bogue, Kimie Hattori, Cristina Pop, Daphne Koller, Diane Mathis, Christophe Benoist, David A Blair, Michael L Dustin, Susan A Shinton, Richard R Hardy, Tal Shay, Aviv Regev, Nadia Cohen, Patrick Brennan, Michael Brenner, Francis Kim, Tata Nageswara Rao, Amy Wagers, Tracy Heng, Jeffrey Ericson, Katherine Rothamel, Adriana Ortiz-Lopez, Diane Mathis, Christophe Benoist, Taras Kreslavsky, Anne Fletcher, Kutlu Elpek, Angelique Bellemare-Pelletier, Deepali Malhotra, Shannon Turley, Jennifer Miller, Brian Brown, Miriam Merad, Emmanuel L Gautier, Claudia Jakubzick, Gwendalyn J Randolph, Paul Monach, Adam J Best, Jamie Knell, Ananda Goldrath, Vladimir Jojic, Daphne Koller, David Laidlaw, Jim Collins, Roi Gazit, Derrick J Rossi, Nidhi Malhotra, Katelyn Sylvia, Joonsoo Kang, Natalie A Bezman, Joseph C Sun, Gundula Min-Oo, Charlie C Kim, and Lewis L Lanier
Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice., Gerda A Noordmans, Yuan Huang, Holly S. Savage, Marcory C R F van Dijk, Gert Schaart, Marius A van den Bergh Weerman, Peter Heeringa, Jan-Luuk Hillebrands, Ron Korstanje, and Harry van Goor
Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait., Weiqun Yu, Cheryl L. Ackert-Bicknell, John D Larigakis, Bryce MacIver, William D Steers, Gary Churchill, Warren G Hill, and Mark L Zeidel
Submissions from 2013
High-precision genetic mapping of behavioral traits in the diversity outbred mouse population., R W Logan, Ray F. Robledo, Jill M. Recla, Vivek M. Philip, Jason A. Bubier, Jeremy Jay, C Harwood, Troy Wilcox, Dan M. Gatti, Carol J. Bult, Gary A. Churchill, and Elissa J. Chesler
Genetic analysis of mesangial matrix expansion in aging mice and identification of far2 as a candidate gene., Gerda A Noordmans, Christina R Caputo, Yuan Huang, Susan M Sheehan, Marian Bulthuis, Peter Heeringa, Jan-Luuk Hillebrands, Harry van Goor, and Ron Korstanje
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice., Randy Strong, Richard A Miller, Clinton M. Astle, Joseph A Baur, Rafael de Cabo, Elizabeth Fernandez, Wen Guo, Martin Javors, James L Kirkland, James F Nelson, David A Sinclair, Bruce Teter, David Williams, Nurulain Zaveri, Nancy L Nadon, and David E. Harrison
Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain., Rong Yuan, Kevin Flurkey, Qingying Meng, Clinton M Astle, and David E. Harrison
Submissions from 2012
How the evolutionary theory of aging can guide us in the search for aging genes., Kevin Flurkey and Rong Yuan
Primary neoplasms of bones in mice: retrospective study and review of literature., A M Kavirayani, J P Sundberg, and O Foreman
A Novel Animal Model for Pseudoxanthoma Elasticum: The KK/HlJ Mouse., Qiaoli Li, Annerose Berndt, Haitao Guo, John P Sundberg, and Jouni Uitto
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals., Joanne M Murabito, Rong Yuan, and Kathryn L Lunetta
Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice., Paul N Schofield, Peter Vogel, Georgios V Gkoutos, and John P Sundberg
Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains., Rong Yuan, Qingying Meng, Jaya Nautiyal, Kevin Flurkey, Shirng-Wern Tsaih, Rebecca Krier, Malcolm G Parker, David E Harrison, and Beverly Paigen
Submissions from 2011
Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress., Laureanne Pilar E Lorenzo, Haiyan Chen, Kristen E Shatynski, Sarah Clark, Rong Yuan, David E Harrison, Paul J Yarowsky, and Mark S Williams
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice., R A. Miller, D E. Harrison, C M. Astle, J A. Baur, K Flurkey, M A. Javors, J F. Nelson, C J. Orihuela, S Pletcher, and al et
New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models., Paul N Schofield, John P Sundberg, Robert Hoehndorf, and Georgios V Gkoutos
Rhabdomyosarcomas in aging A/J mice., R B. Sher, G A. Cox, K D. Mills, and J P. Sundberg
Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation., A P. Sinke, C Caputo, S W. Tsaih, R Yuan, D Ren, P M. Deen, and R Korstanje
NPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm development., J Won, de Evsikova Marin, R S. Smith, W L. Hicks, M M. Edwards, Guess C. Longo, T Li, J K. Naggert, and P M. Nishina
Mice as a mammalian model for research on the genetics of aging., R Yuan, L L. Peters, and B Paigen
Submissions from 2010
Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice., K Flurkey, C M. Astle, and D E. Harrison
Pathbase and the MPATH ontology. Community resources for mouse histopathology., P N. Schofield, M Gruenberger, and J P. Sundberg
Submissions from 2009
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels., Rong Yuan, Shirng-Wern Tsaih, Stefka B Petkova, Caralina Marin de Evsikova, Shuqin Xing, Michael A Marion, Molly A Bogue, Kevin D. Mills, Luanne L Peters, Carol J Bult, Clifford J Rosen, John P Sundberg, David E Harrison, Gary A Churchill, and Beverly Paigen