Submissions from 2017
An evidence-based evaluation of transferrable skills and job satisfaction for science PhDs., Melanie Sinche, Rebekah L Layton, Patrick D Brandt, Anna B O'Connell, Joshua D Hall, Ashalla M Freeman, Jessica R Harrell, Jeanette Gowen Cook, and Patrick J Brennwald
A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development., V Sivakamasundari, Petra Kraus, Wenjie Sun, Xiaoming Hu, Siew Lan Lim, Shyam Prabhakar, and Thomas Lufkin
Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations., James N Sleigh, John M Dawes, Steven J West, Na Wei, Emily L Spaulding, Adriana Gómez-Martín, Qian Zhang, Robert W. Burgess, M Zameel Cader, Kevin Talbot, Xiang-Lei Yang, David L Bennett, and Giampietro Schiavo
APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo., Elizabeth Snyder, Christopher McCarty, Adrienne Mehalow, Karen L. Svenson, Stephen A. Murray, Ron Korstanje, and Robert E Braun
Testicular adenosine to inosine RNA editing in the mouse is mediated by ADARB1†,‡., Elizabeth M Snyder, Konstantin Licht, and Robert E Braun
Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART)., Joanne E Sordillo, Yanjiao Zhou, Michael J McGeachie, John Ziniti, Nancy Lange, Nancy Laranjo, Jessica R Savage, Vincent Carey, George O'Connor, Megan Sandel, Robert Strunk, Leonard Bacharier, Robert Zeiger, Scott T Weiss, George M. Weinstock, Diane R Gold, and Augusto A Litonjua
Accumulating Evidence for Axonal Translation in Neuronal Homeostasis., Emily L Spaulding and Robert W. Burgess
Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection., Jessica R Spengler, M Kelly Keating, Anita K McElroy, Marko Zivcec, JoAnn D Coleman-McCray, Jessica R Harmon, Brigid C Bollweg, Cynthia S Goldsmith, Éric Bergeron, James G. Keck, Sherif R Zaki, Stuart T Nichol, and Christina F Spiropoulou
Genomes of the Mouse Collaborative Cross., Anuj Srivastava, Andrew P Morgan, Maya L Najarian, Vishal Kumar Sarsani, J Sebastian Sigmon, John R Shorter, Anwica Kashfeen, Rachel C McMullan, Lucy H Williams, Paola Giusti-Rodríguez, Martin T Ferris, Patrick Sullivan, Pablo Hock, Darla R Miller, Timothy A Bell, Leonard McMillan, Gary A. Churchill, and Fernando Pardo-Manuel de Villena
Barriers preventing the adoption of comprehensive cancer genomic profiling in the clinic., Cara M. Statz, Sara E. Patterson, and Susan Mockus
mTOR Inhibitors in Castration-Resistant Prostate Cancer: A Systematic Review., Cara M. Statz, Sara E. Patterson, and Susan Mockus
Behavioral Phenotyping Assays for Genetic Mouse Models of Neurodevelopmental, Neurodegenerative, and Psychiatric Disorders., Stacey J Sukoff Rizzo and Jacqueline N Crawley
Training mouse pathologists: 15 years of workshops on the pathology of mouse models of human disease., John P Sundberg, Kelli Boyd, Harm Hogenesch, Alexander Y Nikitin, Piper M Treuting, and Jerrold M Ward
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program., John P Sundberg, Soheil S Dadras, Kathleen A Silva, Victoria E. Kennedy, Gaven Garland, Stephen A. Murray, Beth A. Sundberg, Paul N Schofield, and C Herbert Pratt
Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity., George L. Sutphin, Grant Backer, Susan Sheehan, Shannon Bean, Caroline Corban, Teresa Liu, Marjolein J Peters, Joyce B J van Meurs, Joanne M Murabito, Andrew D Johnson, and Ron Korstanje
Ancient hybridization and strong adaptation to viruses across African vervet monkey populations., Hannes Svardal, Anna J Jasinska, Cristian Apetrei, Giovanni Coppola, Yu Huang, Christopher A Schmitt, Beatrice Jacquelin, Vasily Ramensky, Michaela Müller-Trutwin, Martin Antonio, George M. Weinstock, J Paul Grobler, Ken Dewar, Richard K Wilson, Trudy R Turner, Wesley C Warren, Nelson B Freimer, and Magnus Nordborg
The Spindle Orientation Machinery Beyond Mitosis: When Cell Specialization Demands Polarization., Abigail L.D. Tadenev and Basile Tarchini
Visualization of RAS/MAPK Signaling In Situ by the Proximity Ligation Assay (PLA)., Zijian Tang and Chengkai Dai
Introduction to Mammalian Genome Special Issue: Genome Editing., Lydia Teboul, Yann Hérault, Cynthia Smith, and Bruce Whitelaw
Phenotyping first-generation genome editing mutants: a new standard?, Lydia Teboul, Stephen A. Murray, and Patrick M Nolan
Chromatin interaction networks revealed unique connectivity patterns of broad H3K4me3 domains and super enhancers in 3D chromatin., Asa Thibodeau, Eladio J Marquez, Dong-Guk Shin, Paola Vera-Licona, and Duygu Ucar
Angiopoietin-1 is required for Schlemm's canal development in mice and humans., Benjamin R Thomson, Tomokazu Souma, Stuart W Tompson, Tuncer Onay, Krishnakumar Kizhatil, Owen M Siggs, Liang Feng, Kristina N Whisenhunt, Tammy L Yanovitch, Luba Kalaydjieva, Dimitar N Azmanov, Simone Finzi, Christine E Tanna, Alex W Hewitt, David A Mackey, Yasmin S Bradfield, Emmanuelle Souzeau, Shari Javadiyan, Janey L Wiggs, Francesca Pasutto, Xiaorong Liu, Simon W M John, Jamie E Craig, Jing Jin, Terri L Young, and Susan E Quaggin
Hearing loss without overt metabolic acidosis in ATP6V1B1 deficient MRL mice, a new genetic model for non-syndromic deafness with enlarged vestibular aqueducts., Cong Tian, Leona H. Gagnon, Chantal M. Longo-Guess, Ron Korstanje, Susan Sheehan, Kevin K Ohlemiller, Angela D Schrader, Jaclynn M Lett, and Kenneth R. Johnson
Modeling the response of a tumor-suppressive network to mitogenic and oncogenic signals., Xinyu Tian, Bo Huang, Xiao-Peng Zhang, Mingyang Lu, Feng Liu, José N Onuchic, and Wei Wang
Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes., Alexander J Titus, Gregory P Way, Kevin C Johnson, and Brock C Christensen
Lung microbiome in human immunodeficiency virus infection., Homer L Twigg, George M. Weinstock, and Kenneth S Knox
Genetic interactions improve models of quantitative traits., Anna L. Tyler and Gregory W. Carter
Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice., Anna L. Tyler, Bo Ji, Daniel M. Gatti, Steven C. Munger, Gary A. Churchill, Karen L. Svenson, and Gregory W. Carter
The chromatin accessibility signature of human immune aging stems from CD8(+) T cells., Duygu Ucar, Eladio J Marquez, Cheng-Han Chung, Radu Marches, Robert J Rossi, Asli Uyar, Te-Chia Wu, Joshy George, Michael L. Stitzel, A Karolina Palucka, George A Kuchel, and Jacques Banchereau
Mutations in TP53, PIK3CA, PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes., Paul A VanderLaan, Deepa Rangachari, Susan Mockus, Vanessa Spotlow, Honey V Reddi, Joan Malcolm, Mark S Huberman, Loren J Joseph, Susumu S Kobayashi, and Daniel B Costa
Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis., Frank J A van Rooij, Rehan Qayyum, Albert V Smith, Yi Zhou, Stella Trompet, Toshiko Tanaka, Margaux F Keller, Li-Ching Chang, Helena Schmidt, Min-Lee Yang, Ming-Huei Chen, James Hayes, Andrew D Johnson, Lisa R Yanek, Christian Mueller, Leslie Lange, James S Floyd, Mohsen Ghanbari, Alan B Zonderman, J Wouter Jukema, Albert Hofman, Cornelia M van Duijn, Karl C Desch, Yasaman Saba, Ayse B Ozel, Beverly M Snively, Jer-Yuarn Wu, Reinhold Schmidt, Myriam Fornage, Robert J Klein, Caroline S Fox, Koichi Matsuda, Naoyuki Kamatani, Philipp S Wild, David J Stott, Ian Ford, P Eline Slagboom, Jaden Yang, Audrey Y Chu, Amy J Lambert, André G Uitterlinden, Oscar H Franco, Edith Hofer, David Ginsburg, Bella Hu, Brendan Keating, Ursula M Schick, Jennifer A Brody, Jun Z Li, Zhao Chen, Tanja Zeller, Jack M Guralnik, Daniel I Chasman, Luanne L. Peters, Michiaki Kubo, Diane M Becker, Jin Li, Gudny Eiriksdottir, Jerome I Rotter, Daniel Levy, Vera Grossmann, Kushang V Patel, Chien-Hsiun Chen, Paul M Ridker, Hua Tang, Lenore J Launer, Kenneth M Rice, Ruifang Li-Gao, Luigi Ferrucci, Michelle K Evans, Avik Choudhuri, Eirini Trompouki, Brian J Abraham, Song Yang, Atsushi Takahashi, Yoichiro Kamatani, Charles Kooperberg, Tamara B Harris, Sun Ha Jee, Josef Coresh, Fuu-Jen Tsai, Dan L Longo, Yuan-Tsong Chen, Janine F Felix, Qiong Yang, Bruce M Psaty, Eric Boerwinkle, Lewis C Becker, Dennis O Mook-Kanamori, James G Wilson, Vilmundur Gudnason, Christopher J O'Donnell, Abbas Dehghan, L Adrienne Cupples, Michael A Nalls, Andrew P Morris, Yukinori Okada, Alexander P Reiner, Leonard I Zon, and Santhi K Ganesh
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes., Arushi Varshney, Laura J Scott, Ryan P Welch, Michael R Erdos, Peter S Chines, Narisu Narisu, Ricardo D'O Albanus, Peter Orchard, Brooke N Wolford, Romy Kursawe, Swarooparani Vadlamudi, Maren E Cannon, John P Didion, John Hensley, Anthony Kirilusha, Lori L Bonnycastle, D Leland Taylor, Richard Watanabe, Karen L Mohlke, Michael Boehnke, Francis S Collins, Stephen C J Parker, and Michael L. Stitzel
A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo., Mohit K Verma, Julia Clemens, Lisa M. Burzenski, Stephen B. Sampson, Michael A Brehm, Dale L Greiner, and Leonard D. Shultz
The role of platelet and endothelial GARP in thrombosis and hemostasis., Elien Vermeersch, Frederik Denorme, Wim Maes, Simon F De Meyer, Karen Vanhoorelbeke, Justin Edwards, Ethan M Shevach, Derya Unutmaz, Hodaka Fujii, Hans Deckmyn, and Claudia Tersteeg
Humanized Mouse Models of Clinical Disease., Nicole C Walsh, Laurie L Kenney, Sonal Jangalwe, Ken-Edwin Aryee, Dale L Greiner, Michael A Brehm, and Leonard D. Shultz
Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage., Hong Wang, Elyse van Spyk, Qiang Liu, Mikhail Geyfman, Michael L Salmans, Vivek Kumar, Alexander Ihler, Ning Li, Joseph S Takahashi, and Bogi Andersen
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment., Qianghu Wang, Baoli Hu, Xin Hu, Hoon Kim, Massimo Squatrito, Lisa Scarpace, Ana C deCarvalho, Sali Lyu, Pengping Li, Yan Li, Floris P Barthel, Hee Jin Cho, Yu-Hsi Lin, Nikunj Satani, Emmanuel Martinez-Ledesma, Siyuan Zheng, Edward Chang, Charles-Etienne Gabriel Sauvé, Adriana Olar, Zheng D Lan, Gaetano Finocchiaro, Joanna J Phillips, Mitchel S Berger, Konrad R Gabrusiewicz, Guocan Wang, Eskil Eskilsson, Jian Hu, Tom Mikkelsen, Ronald A DePinho, Florian Muller, Amy B Heimberger, Erik P Sulman, Do-Hyun Nam, and Roel G W Verhaak
Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy., Qiming Wang, Jeremy Racine, Jeremy Ratiu, Shu Wang, Rachel Ettinger, Clive Wasserfall, Mark A Atkinson, and David V. Serreze
Genomic analyses of primitive, wild and cultivated citrus provide insights into asexual reproduction., Xia Wang, Yuantao Xu, Siqi Zhang, Li Cao, Yue Huang, Junfeng Cheng, Guizhi Wu, Shilin Tian, Chunli Chen, Yan Liu, Huiwen Yu, Xiaoming Yang, Hong Lan, Nan Wang, Lun Wang, Jidi Xu, Xiaolin Jiang, Zongzhou Xie, Meilian Tan, Robert M Larkin, Ling-Ling Chen, Bin-Guang Ma, Yijun Ruan, Xiuxin Deng, and Qiang Xu
Reproducibility of histopathological findings in experimental pathology of the mouse: a sorry tail., Jerrold M Ward, Paul N Schofield, and John P Sundberg
GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma., Pete A. Williams, Catherine E Braine, Nicole E Foxworth, Kelly E Cochran, and Simon W M John
Nicotinamide and WLD(S) Act Together to Prevent Neurodegeneration in Glaucoma., Pete A. Williams, Jeffrey M. Harder, Nicole E Foxworth, Brynn H Cardozo, Kelly E Cochran, and Simon W M John
Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice., Pete A. Williams, Jeffrey M. Harder, Nicole E Foxworth, Kelly E Cochran, Vivek M. Philip, Vittorio Porciatti, Oliver Smithies, and Simon W M John
Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma., Pete A. Williams, Jeffrey M. Harder, and Simon W M John
Neuroinflammation in glaucoma: A new opportunity., Pete A. Williams, Nick Marsh-Armstrong, and Gareth R Howell
Mechanism of tandem duplication formation in BRCA1-mutant cells., Nicholas A Willis, Richard L Frock, Francesca Menghi, Erin E Duffey, Arvind Panday, Virginia Camacho, E Paul Hasty, Edison T Liu, Frederick W Alt, and Ralph Scully
Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy., Raffaella Willmann, Heather Gordish-Dressman, Sarina Meinen, Markus A Rüegg, Qing Yu, Kanneboyina Nagaraju, Ayar Kumar, Mahasweta Girgenrath, Caroline B M Coffey, Vivian Cruz, Pam M Van Ry, Laurent P. Bogdanik, Cathleen Lutz, Anne Rutkowski, and Dean J Burkin
Advances at the intersection of normal brain aging and Alzheimer's disease., Lynda A Wilmott, Sarah M Neuner, Corina Burger, and Catherine Kaczorowski
Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection., Benjamin Y Winer, Tiffany Huang, Benjamin E. Low, Cindy Avery, Mihai-Alexandru Pais, Gabriela Hrebikova, Evelyn Siu, Luis Chiriboga, Michael V. Wiles, and Alexander Ploss
Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer., Jean M Winter, Derek E Gildea, Jonathan P Andreas, Daniel M. Gatti, Kendra A Williams, Minnkyong Lee, Ying Hu, Suiyuan Zhang, James C Mullikin, Tyra G Wolfsberg, Shannon K McDonnell, Zachary C Fogarty, Melissa C Larson, Amy J French, Daniel J Schaid, Stephen N Thibodeau, Gary A Churchill, and Nigel P S Crawford
Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice., Jiang Wei Wu, Christoph Preuss, Shu Pei Wang, Hao Yang, Bo Ji, Gregory W. Carter, Rebecca Gladdy, Gregor Andelfinger, and Grant A Mitchell
Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation., Lijian Yu, Haesook T Kim, Siddha N Kasar, Parul Benien, Wei Du, Kevin Hoang, Andrew Aw, Bethany Tesar, Reina Improgo, Stacey M Fernandes, Saranya Radhakrishnan, Josephine L Klitgaard, Charles Lee, Gad Getz, Sunita R Setlur, and Jennifer R Brown
The Phosphatidylinositol 3-Kinase Pathway as a Potential Therapeutic Target in Bladder Cancer., Shu-Xiong Zeng, Yanjun Zhu, Ai-Hong Ma, Weimin Yu, Hongyong Zhang, Tzu-Yin Lin, Wei Shi, Clifford G Tepper, Paul T Henderson, Susan Airhart, Jian-Ming Guo, Chuan-Liang Xu, Ralph W deVere White, and Chong-Xian Pan
Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements., Cinthya J Zepeda-Mendoza, Jonas Ibn-Salem, Tammy Kammin, David J Harris, Debra Rita, Karen W Gripp, Jennifer J MacKenzie, Andrea Gropman, Brett Graham, Ranad Shaheen, Fowzan S Alkuraya, Campbell K Brasington, Edward J Spence, Diane Masser-Frye, Lynne M Bird, Erica Spiegel, Rebecca L Sparkes, Zehra Ordulu, Michael E Talkowski, Miguel A Andrade-Navarro, Peter N Robinson, and Cynthia C Morton
Array-Based Comparative Genomic Hybridization (aCGH)., Chengsheng Zhang, Eliza Cerveira, Mallory Romanovitch, and Qihui Zhu
The Degeneration and Apoptosis Patterns of Cone Photoreceptors in rd11 Mice., Hua Zhang, Xia Li, Xufeng Dai, Juanjuan Han, Yangyang Zhang, Yan Qi, Ying He, Yan Liu, Bo Chang, and Ji-Jing Pang
Plasma PPi Deficiency Is the Major, but Not the Exclusive, Cause of Ectopic Mineralization in an Abcc6(-/-) Mouse Model of PXE., Jingyi Zhao, Joshua Kingman, John P Sundberg, Jouni Uitto, and Qiaoli Li
Concerted effects of heterogeneous nuclear ribonucleoprotein C1/C2 to control vitamin D-directed gene transcription and RNA splicing in human bone cells., Rui Zhou, Juw Won Park, Rene F Chun, Thomas S Lisse, Alejandro J Garcia, Kathryn Zavala, Jessica L Sea, Zhi-Xiang Lu, Jianzhong Xu, John S Adams, Yi Xing, and Martin Hewison
Microdose-Induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice., Maike Zimmermann, Si-Si Wang, Hongyong Zhang, Tzu-Yin Lin, Michael Malfatti, Kurt Haack, Ted Ognibene, Hongyuan Yang, Susan Airhart, Kenneth W Turteltaub, George D Cimino, Clifford G Tepper, Alexandra Drakaki, Karim Chamie, Ralph de Vere White, Chong-Xian Pan, and Paul T Henderson
Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer., Andrew Zloza, A Karolina Palucka, Lisa M Coussens, Philip J Gotwals, Mark B Headley, Elizabeth M Jaffee, Amanda W Lund, Arlene H Sharpe, Mario Sznol, Derek A Wainwright, Kwok-Kin Wong, and Marcus W Bosenberg