Submissions from 2017
Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells., Jung-Hyun Kim, Andreas Kurtz, Bao-Zhu Yuan, Fanyi Zeng, Geoff Lomax, Jeanne F Loring, Jeremy Crook, Ji Hyeon Ju, Laura Clarke, Maneesha S Inamdar, Martin Pera, Meri T Firpo, Michael Sheldon, Nafees Rahman, Orla O'Shea, Patricia Pranke, Qi Zhou, Rosario Isasi, Ruttachuk Rungsiwiwut, Shin Kawamata, Steve Oh, Tenneille Ludwig, Tohru Masui, Thomas J Novak, Tsuneo Takahashi, Wataru Fujibuchi, Soo Kyung Koo, and Glyn N Stacey
Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating., Stacey L Kirkpatrick, Lisa R Goldberg, Neema Yazdani, R Keith Babbs, Jiayi Wu, Eric R Reed, David F Jenkins, Amanda F Bolgioni, Kelsey I Landaverde, Kimberly P Luttik, Karen S Mitchell, Vivek Kumar, W Evan Johnson, Megan K Mulligan, Pietro Cottone, and Camron D Bryant
Naming CRISPR alleles: endonuclease-mediated mutation nomenclature across species., Michelle N Knowlton and Cynthia L Smith
The Human Phenotype Ontology in 2017., Sebastian Köhler, Nicole A Vasilevsky, Mark Engelstad, Erin Foster, Julie McMurry, Ségolène Aymé, Gareth Baynam, Susan M. Bello, Cornelius F Boerkoel, Kym M Boycott, Michael Brudno, Orion J Buske, Patrick F Chinnery, Valentina Cipriani, Laureen E Connell, Hugh J S Dawkins, Laura E DeMare, Andrew D Devereau, Bert B A de Vries, Helen V Firth, Kathleen Freson, Daniel Greene, Ada Hamosh, Ingo Helbig, Courtney Hum, Johanna A Jähn, Roger James, Roland Krause, Stanley J F Laulederkind, Hanns Lochmüller, Gholson J Lyon, Soichi Ogishima, Annie Olry, Willem H Ouwehand, Nikolas Pontikos, Ana Rath, Franz Schaefer, Richard H Scott, Michael Segal, Panagiotis I Sergouniotis, Richard Sever, Cynthia L Smith, Volker Straub, Rachel Thompson, Catherine Turner, Ernest Turro, Marijcke W M Veltman, Tom Vulliamy, Jing Yu, Julie von Ziegenweidt, Andreas Zankl, Stephan Züchner, Tomasz Zemojtel, Julius O B Jacobsen, Tudor Groza, Damian Smedley, Christopher J Mungall, Melissa Haendel, and Peter N Robinson
Addressing current challenges in cancer immunotherapy with mathematical and computational modelling., Anna Konstorum, Anthony T Vella, Adam J Adler, and Reinhard Laubenbacher
Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics., Nigel G Kooreman, Patricia E de Almeida, Jonathan P Stack, Raman V Nelakanti, Sebastian Diecke, Ning-Yi Shao, Rutger-Jan Swijnenburg, Veronica Sanchez-Freire, Elena Matsa, Chun Liu, Andrew J Connolly, Jaap F Hamming, Paul H A Quax, Michael A Brehm, Dale L Greiner, Leonard D. Shultz, and Joseph C Wu
Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature., Ron Korstanje, Jennifer L Ryan, Holly S Savage, Bonnie L. Lyons, Kevin G Kane, and Stacey J Sukoff Rizzo
Using Vascular Landmarks to Orient 3D Optical Coherence Tomography Images of the Mouse Eye., Mark P. Krebs
Mouse models of human ocular disease for translational research., Mark P. Krebs, Gayle B. Collin, Wanda L. Hicks, Minzhong Yu, Jeremy R. Charette, Lan Ying Shi, Jieping Wang, Juergen K. Naggert, Neal S Peachey, and Patsy M. Nishina
Migratory CD11b+ conventional dendritic cells induce T follicular helper cell-dependent antibody responses., Jayendra Kumar Krishnaswamy, Uthaman Gowthaman, Biyan Zhang, Johan Mattsson, Louis Szeponik, Dong Liu, Renee Wu, Theresa White, Samuele Calabro, Lan Xu, Magalie A Collet, Marina Yurieva, Samuel Alsén, Per Fogelstrand, Anne Walter, William R Heath, Scott N Mueller, Ulf Yrlid, Adam Williams, and Stephanie C Eisenbarth
The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer., Debra M. Krupke, Dale A. Begley, John P Sundberg, Joel E Richardson, Steven B Neuhauser, and Carol J Bult
Isolation of Methicillin-resistant Staphylococcus aureus and Multidrug-resistant Elizabethkingia meningoseptica From Neonates Within Minutes of Birth., Brenda A Kwambana-Adams, Claire S Laxton, Ebenezer Foster-Nyarko, Claire S Laxton, George M. Weinstock, and Martin Antonio
Rapid replacement by non-vaccine pneumococcal serotypes may mitigate the impact of the pneumococcal conjugate vaccine on nasopharyngeal bacterial ecology., Brenda Kwambana-Adams, Blake M Hanson, Archibald Worwui, Schadrac Agbla, Ebenezer Foster-Nyarko, Fatima Ceesay, Chinelo Ebruke, Uzochukwu Egere, Yanjiao Zhou, Maze Ndukum, Erica Sodergren Weinstock, Michael Barer, Richard Adegbola, George M. Weinstock, and Martin Antonio
Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes., Nathan Lawlor, Joshy George, Mohan Bolisetty, Romy Kursawe, Lili Sun, V Sivakamasundari, Ina Kycia, Paul Robson, and Michael L. Stitzel
Genomics of Islet (Dys)function and Type 2 Diabetes., Nathan Lawlor, Shubham Khetan, Duygu Ucar, and Michael L. Stitzel
Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts., Nathan Lawlor, Ahrim Youn, Romy Kursawe, Duygu Ucar, and Michael L. Stitzel
MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice., Benjamin P Lee, Ivana Burić, Anupriya George-Pandeth, Kevin Flurkey, David E Harrison, Rong Yuan, Luanne L. Peters, George A Kuchel, David Melzer, and Lorna W Harries
mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors., Jungmin Lee, Brad Dykstra, Joel A Spencer, Laurie L Kenney, Dale L Greiner, Leonard D. Shultz, Michael A Brehm, Charles P Lin, Robert Sackstein, and Derrick J Rossi
An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos., Wenqing Jean Lee, Sumantra Chatterjee, Sook Peng Yap, Siew Lan Lim, Xing Xing, Petra Kraus, Wenjie Sun, Xiaoming Hu, V Sivakamasundari, Hsiao Yun Chan, Prasanna R Kolatkar, Shyam Prabhakar, and Thomas Lufkin
Glioma: experimental models and reality., Krissie Lenting, Roel G W Verhaak, Mark Ter Laan, Pieter Wesseling, and William Leenders
MultiDCoX: Multi-factor analysis of differential co-expression., Herty Liany, Jagath C Rajapakse, and Radha Krishna Murthy Karuturi
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors., Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan, Kok Hao Chen, Jolene Jie Lin Goh, Say Li Kong, Clarinda Chua, Lim Kiat Hon, Wah Siew Tan, Mark Wong, Paul Jongjoon Choi, Lawrence J K Wee, Axel M Hillmer, Iain Beehuat Tan, Paul Robson, and Shyam Prabhakar
Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice., Bixuan Lin, Ashley E Ciecko, Erin MacKinney, David V. Serreze, and Yi-Guang Chen
Auditory and otologic profile of Alström syndrome: Comprehensive single center data on 38 patients., Spencer Lindsey, Carmen Brewer, Olga Stakhovskaya, Hung Jeffrey Kim, Chris Zalewski, Joy Bryant, Kelly A King, Juergen K. Naggert, William A Gahl, Jan D Marshall, and Meral Gunay-Aygun
STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus., Peng Li, Suman Mitra, Rosanne Spolski, Jangsuk Oh, Wei Liao, Zhonghui Tang, Fei Mo, Xingwang Li, Erin E West, Daniel Gromer, Jian-Xin Lin, Chengyu Liu, Yijun Ruan, and Warren J Leonard
Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum., Qiaoli Li, Joshua Kingman, Koen van de Wetering, Sami Tannouri, John P Sundberg, and Jouni Uitto
IKKα regulates human keratinocyte migration through surveillance of the redox environment., Thomas S lisse and Sandra Rieger
Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition., Edison T Liu, Ewelina Bolcun-Filas, David S Grass, Cathleen Lutz, Stephen A Murray, Leonard D. Shultz, and Nadia Rosenthal
Genome-Wide Analysis of Protein-Coding Variants in Leprosy., Hong Liu, Zhenzhen Wang, Yi Li, Gongqi Yu, Xi'an Fu, Chuan Wang, Wenting Liu, Yongxiang Yu, Fangfang Bao, Astrid Irwanto, Jian Liu, Tongsheng Chu, Anand Kumar Andiappan, Sebastian Maurer-Stroh, Vachiranee Limviphuvadh, Honglei Wang, Zihao Mi, Yonghu Sun, Lele Sun, Ling Wang, Chaolong Wang, Jiabao You, Jinghui Li, Jia Nee Foo, Herty Liany, Wee Yang Meah, Guiye Niu, Zhenhua Yue, Qing Zhao, Na Wang, Meiwen Yu, Wenjun Yu, Xiujun Cheng, Chiea Chuen Khor, Kar Seng Sim, Tin Aung, Ningli Wang, Deyun Wang, Li Shi, Yong Ning, Zhongyi Zheng, Rongde Yang, Jinlan Li, Jun Yang, Liangbin Yan, Jianping Shen, Guocheng Zhang, Shumin Chen, Jianjun Liu, and Furen Zhang
CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells., Xiaojuan Liu, Yongping Zhang, Chen Cheng, Albert Cheng, Xingying Zhang, Na Li, Changqing Xia, Xiaofei Wei, Xiang Liu, and Haoyi Wang
The complex genetics of hypoplastic left heart syndrome., Xiaoqin Liu, Hisato Yagi, Shazina Saeed, Abha S Bais, George C Gabriel, Zhaohan Chen, Kevin A Peterson, You Li, Molly C Schwartz, William T Reynolds, Manush Saydmohammed, Brian Gibbs, Yijen Wu, William Devine, Bishwanath Chatterjee, Nikolai T Klena, Dennis Kostka, Karen L de Mesy Bentley, Madhavi K Ganapathiraju, Phillip Dexheimer, Linda Leatherbury, Omar Khalifa, Anchit Bhagat, Maliha Zahid, William Pu, Simon Watkins, Paul Grossfeld, Stephen A. Murray, George A Porter, Michael Tsang, Lisa J Martin, D Woodrow Benson, Bruce J Aronow, and Cecilia W Lo
Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions., Xingwang Li, Oscar Junhong Luo, Ping Wang, Meizhen Zheng, Danjuan Wang, Emaly Piecuch, Jacqueline Jufen Zhu, Simon Zhongyuan Tian, Zhonghui Tang, Guoliang Li, and Yijun Ruan
ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis., Zhaomin Li, Peng Zhang, Aimin Yan, Zhengyu Guo, Yuguang Ban, Jin Li, Shi Chen, Hui Yang, Yongzheng He, Jianping Li, Ying Guo, Wen Zhang, Ehsan Hajiramezanali, Huangda An, Darlene Fajardo, J William Harbour, Yijun Ruan, Stephen D Nimer, Peng Yu, Xi Chen, Mingjiang Xu, and Feng-Chun Yang
Genome-wide enrichment of damaging de novo variants in patients with isolated and complex congenital diaphragmatic hernia., Mauro Longoni, Frances A High, Hongjian Qi, Maliackal P Joy, Regis Hila, Caroline M Coletti, Julia Wynn, Maria Loscertales, Linshan Shan, Carol J Bult, Jay M Wilson, Yufeng Shen, Wendy K Chung, and Patricia K Donahoe
Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer., Hengyu Lu, Nicole Villafane, Turgut Dogruluk, Caitlin L Grzeskowiak, Kathleen Kong, Yiu Huen Tsang, Oksana Zagorodna, Angeliki Pantazi, Lixing Yang, Nicholas J Neill, Young Won Kim, Chad J Creighton, Roel G W Verhaak, Gordon B Mills, Peter J Park, Raju Kucherlapati, and Kenneth L Scott
A license to cure?, Cathleen Lutz
Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research., Teri A Manolio, Douglas M Fowler, Lea M Starita, Melissa A Haendel, Daniel G MacArthur, Leslie G Biesecker, Elizabeth Worthey, Rex L Chisholm, Eric D Green, Howard J Jacob, Howard L McLeod, Dan Roden, Laura Lyman Rodriguez, Marc S Williams, Gregory M Cooper, Nancy J Cox, Gail E Herman, Stephen Kingsmore, Cecilia Lo, Cathleen Lutz, Calum A MacRae, Robert L Nussbaum, Jose M Ordovas, Erin M Ramos, Peter N Robinson, Wendy S Rubinstein, Christine Seidman, Barbara E Stranger, Haoyi Wang, Monte Westerfield, and Carol J Bult
Canine Brachycephaly Is Associated with a Retrotransposon-Mediated Missplicing of SMOC2., Thomas W Marchant, Edward J Johnson, Lynn McTeir, Craig I Johnson, Adam Gow, Tiziana Liuti, Dana Kuehn, Karen L. Svenson, Mairead L Bermingham, Michaela Drögemüller, Marc Nussbaumer, Megan G Davey, David J Argyle, Roger M Powell, Sérgio Guilherme, Johann Lang, Gert Ter Haar, Tosso Leeb, Tobias Schwarz, Richard J Mellanby, Dylan N Clements, and Jeffrey J Schoenebeck
Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease., Elisabeth A Marnik, Xulong Wang, Thomas J. Sproule, Giljun Park, Gregory J. Christianson, Sarah Kate Lane-Reticker, Shweta Jain, Ted Duffy, Hongsheng Wang, Gregory W. Carter, Herbert C Morse, and Derry C. Roopenian
KLF6 depletion promotes NF-κB signaling in glioblastoma., A P Masilamani, R Ferrarese, E Kling, N K Thudi, Hoon Kim, D M Scholtens, F Dai, M Hadler, T Unterkircher, L Platania, A Weyerbrock, M Prinz, G Y Gillespie, G R Harsh Iv, M Bredel, and M S Carro
Cre-loxP-Mediated Recombination: General Principles and Experimental Considerations., Michael A McLellan, Nadia A Rosenthal, and Alexander R Pinto
PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models., Terrence F Meehan, Nathalie Conte, Theodore Goldstein, Giorgio Inghirami, Mark A Murakami, Sebastian Brabetz, Zhiping Gu, Jeffrey A Wiser, Patrick Dunn, Dale A. Begley, Debra M. Krupke, Andrea Bertotti, Alejandra Bruna, Matthew H Brush, Annette T Byrne, Carlos Caldas, Amanda L Christie, Dominic A Clark, Heidi Dowst, Jonathan R Dry, James H Doroshow, Olivier Duchamp, Yvonne A Evrard, Stephane Ferretti, Kristopher K Frese, Neal C Goodwin, Danielle Greenawalt, Melissa A Haendel, Els Hermans, Peter J Houghton, Jos Jonkers, Kristel Kemper, Tin O Khor, Michael T Lewis, K C Kent Lloyd, Jeremy Mason, Enzo Medico, Steven B Neuhauser, James M Olson, Daniel S Peeper, Oscar M Rueda, Je Kyung Seong, Livio Trusolino, Emilie Vinolo, Robert J Wechsler-Reya, David M Weinstock, Alana Welm, S John Weroha, Frédéric Amant, Stefan M Pfister, Marcel Kool, Helen Parkinson, Atul J Butte, and Carol J Bult
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium., Terrence F Meehan, Nathalie Conte, David B West, Julius O Jacobsen, Jeremy Mason, Jonathan Warren, Chao-Kung Chen, Ilinca Tudose, Mike Relac, Peter Matthews, Natasha Karp, Luis Santos, Tanja Fiegel, Natalie Ring, Henrik Westerberg, Simon Greenaway, Duncan Sneddon, Hugh Morgan, Gemma F Codner, Michelle E Stewart, James Brown, Neil Horner, Melissa Haendel, Nicole Washington, Christopher J Mungall, Corey L Reynolds, Juan Gallegos, Valerie Gailus-Durner, Tania Sorg, Guillaume Pavlovic, Lynette R Bower, Mark Moore, Iva Morse, Xiang Gao, Glauco P Tocchini-Valentini, Yuichi Obata, Soo Young Cho, Je Kyung Seong, John Seavitt, Arthur L Beaudet, Mary E Dickinson, Yann Herault, Wolfgang Wurst, Martin Hrabe de Angelis, K C Kent Lloyd, Ann M Flenniken, Lauryl M J Nutter, Susan Newbigging, Colin McKerlie, Monica J Justice, Stephen A. Murray, Karen L. Svenson, Robert E Braun, Jacqueline K White, Allan Bradley, Paul Flicek, Sara Wells, William C Skarnes, David J Adams, Helen Parkinson, Ann-Marie Mallon, Steve D M Brown, and Damian Smedley
Downregulation of miR-33a-5p in Hepatocellular Carcinoma: A Possible Mechanism for Chemotherapy Resistance., Wei Meng, Yan Tai, Hui Zhao, Binsheng Fu, Tong Zhang, Wei Liu, Hua Li, Yang Yang, Qi Zhang, Yuliang Feng, and Guihua Chen
Analysis of BMAA enantiomers in cycads, cyanobacteria, and mammals: in vivo formation and toxicity of D-BMAA., J S Metcalf, Doug Lobner, Sandra Anne Banack, Gregory A. Cox, Peter B Nunn, Peter B Wyatt, and Paul Alan Cox
Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice., Paul H Miller, Gabrielle Rabu, Margarita MacAldaz, David J H F Knapp, Alice M S Cheung, Kiran Dhillon, Naoto Nakamichi, Philip A Beer, Leonard D. Shultz, R Keith Humphries, and Connie J Eaves
Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes., Kathryn H. Morelli, Kevin L. Seburn, David G. Schroeder, Emily L Spaulding, Louise A. Dionne, Gregory A. Cox, and Robert W. Burgess
Structural Variation Shapes the Landscape of Recombination in Mouse., Andrew P Morgan, Daniel M. Gatti, Maya L Najarian, Thomas M Keane, Raymond J Galante, Allan I Pack, Richard Mott, Gary A. Churchill, and Fernando Pardo-Manuel de Villena
Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA., Walter K Mowel, Sam J McCright, Jonathan J Kotzin, Magalie A Collet, Asli Uyar, Xin Chen, Alexandra DeLaney, Sean P Spencer, Anthony T Virtue, EnJun Yang, Alejandro Villarino, Makoto Kurachi, Margaret C Dunagin, Gretchen Harms Pritchard, Judith Stein, Cynthia Hughes, Diogo Fonseca-Pereira, Henrique Veiga-Fernandes, Arjun Raj, Taku Kambayashi, Igor E Brodsky, John J O'Shea, E John Wherry, Loyal A Goff, John L Rinn, Adam Williams, Richard A Flavell, and Jorge Henao-Mejia
The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species., Christopher J Mungall, Julie A McMurry, Sebastian Köhler, James P Balhoff, Charles Borromeo, Matthew Brush, Seth Carbon, Tom Conlin, Nathan Dunn, Mark Engelstad, Erin Foster, J P Gourdine, Julius O B Jacobsen, Dan Keith, Bryan Laraway, Suzanna E Lewis, Jeremy NguyenXuan, Kent Shefchek, Nicole Vasilevsky, Zhou Yuan, Nicole Washington, Harry Hochheiser, Tudor Groza, Damian Smedley, Peter N Robinson, and Melissa A Haendel
NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model., Nancy L Nadon, Randy Strong, Richard A Miller, and David E Harrison
Protein Ontology (PRO): enhancing and scaling up the representation of protein entities., Darren A Natale, Cecilia N Arighi, Judith A. Blake, Jonathan Bona, Chuming Chen, Sheng-Chih Chen, Karen R. Christie, Julie Cowart, Peter D'Eustachio, Alexander D Diehl, Harold J. Drabkin, William D Duncan, Hongzhan Huang, Jia Ren, Karen Ross, Alan Ruttenberg, Veronica Shamovsky, Barry Smith, Qinghua Wang, Jian Zhang, Abdelrahman El-Sayed, and Cathy H Wu
Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice., João Luís Neto, Jong-Min Lee, Ali Afridi, Tammy Gillis, Jolene R Guide, Stephani Dempsey, Brenda Lager, Isabel Alonso, Vanessa C Wheeler, and Ricardo Mouro Pinto
Atopy as a Modifier of the Relationships Between Endotoxin Exposure and Symptoms Among Laboratory Animal Workers., Ashley N Newton, Meghan Davis, Kirsten Koehler, Wayne Shreffler, Sharon Ahluwalia, Nervana Metwali, Peter S Thorne, Beverly J Paigen, and Elizabeth C Matsui
Isolation and 3D expansion of multipotent Sox9+ mouse lung progenitors., Massimo Nichane, Asif Javed, V Sivakamasundari, Monisha Ganesan, Lay Teng Ang, Petra Kraus, Thomas Lufkin, Kyle M Loh, and Bing Lim
Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis., Masayuki Nigo, Lorena Diaz, Lina P Carvajal, Truc T Tran, Rafael Rios, Diana Panesso, Juan D Garavito, William R Miller, Audrey Wanger, George M. Weinstock, Jose M Munita, Cesar A Arias, and Henry F Chambers
Combinatorial Ranking of Gene Sets to Predict Disease Relapse: The Retinoic Acid Pathway in Early Prostate Cancer., Hieu T Nim, Milena B Furtado, Mirana Ramialison, and Sarah E Boyd
Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures., Javad Noorbakhsh and Jeffrey H Chuang
Prediction of Human Phenotype Ontology terms by means of hierarchical ensemble methods., Marco Notaro, Max Schubach, Peter N Robinson, and Giorgio Valentini
27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy., Hideyuki Oguro, Jeffrey G McDonald, Zhiyu Zhao, Michihisa Umetani, Philip W Shaul, and Sean J Morrison
PAF promotes stemness and radioresistance of glioma stem cells., Derrick Sek Tong Ong, Baoli Hu, Yan Wing Ho, Charles-Etienne Gabriel Sauvé, Christopher A Bristow, Qianghu Wang, Asha S Multani, Peiwen Chen, Luigi Nezi, Shan Jiang, Claire Elizabeth Gorman, Marta Moreno Monasterio, Dimpy Koul, Matteo Marchesini, Simona Colla, Eun-Jung Jin, Erik P Sulman, Denise J Spring, Wai-Kwan Alfred Yung, Roel G W Verhaak, Lynda Chin, Y Alan Wang, and Ronald A DePinho
Systems Genetic Analysis in GeneNetwork.org., Clarissa C Parker, Price E. Dickson, Vivek M. Philip, Mary Thomas, and Elissa J Chesler
PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis., Emil D Parvanov, Hui Tian, Timothy Billings, Ruth L. Saxl, Catrina Spruce, Rakesh Aithal, Lumir Krejci, Kenneth Paigen, and Petko M. Petkov
ARHGAP29 Mutation Is Associated with Abnormal Oral Epithelial Adhesions., B J Paul, Kristina Palmer, J C Sharp, C Herbert Pratt, Stephen A Murray, and M Dunnwald
A missense mutation in Grm6 reduces but does not eliminate mGluR6 expression or rod depolarizing bipolar cell function., Neal S Peachey, Nazarul Hasan, Bernie Fitzmaurice, Samantha Burrill, Gobinda Pangeni, Son Yong Karst, Laura G Reinholdt, Melissa L. Berry, Marjorie Strobel, Ronald G Gregg, Maureen A McCall, and Bo Chang
Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy., Yanyan Peng, Deepali N Shinde, C Alexander Valencia, Jun-Song Mo, Jill Rosenfeld, Megan Truitt Cho, Adam Chamberlin, Zhuo Li, Jie Liu, Baoheng Gui, Rachel Brockhage, Alice Basinger, Brenda Alvarez-Leon, Peter Heydemann, Pilar L Magoulas, Andrea M Lewis, Fernando Scaglia, Solange Gril, Shuk Ching Chong, Matthew Bower, Kristin G Monaghan, Rebecca Willaert, Maria-Renee Plona, Rich Dineen, Francisca Milan, George Hoganson, Zoe Powis, Katherine L Helbig, Jennifer Keller-Ramey, Belinda S. Harris, Laura C. Anderson, Stacey J Sukoff Rizzo, Julie Kaylor, Jiani Chen, Min-Xin Guan, Elizabeth Sellars, Steven P Sparagana, James B Gibson, Laura G Reinholdt, Sha Tang, and Taosheng Huang
L1Base 2: more retrotransposition-active LINE-1s, more mammalian genomes., Tobias Penzkofer, Marten Jäger, Marek Figlerowicz, Richard Badge, Stefan Mundlos, Peter N Robinson, and Tomasz Zemojtel
Embryogenesis in a dish., Martin Pera
Human embryo research and the 14-day rule., Martin Pera
Community characteristics of the gut microbiomes of competitive cyclists., Lauren M Petersen, Eddy J Bautista, Hoan Nguyen, Blake M Hanson, Lei Chen, Sai H Lek, Erica Sodergren Weinstock, and George M. Weinstock
CRISPRtools: a flexible computational platform for performing CRISPR/Cas9 experiments in the mouse., Kevin A Peterson, Glen L Beane, Leslie Goodwin, Peter Kutny, Laura G Reinholdt, and Stephen A. Murray
SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland., Emilia Peuhu, Riina Kaukonen, Martina Lerche, Markku Saari, Camilo Guzmán, Pia Rantakari, Nicola De Franceschi, Anni Wärri, Maria Georgiadou, Guillaume Jacquemet, Elina Mattila, Reetta Virtakoivu, Yuming Liu, Youmna Attieh, Kathleen A Silva, Timo Betz, John P Sundberg, Marko Salmi, Marie-Ange Deugnier, Kevin W Eliceiri, and Johanna Ivaska
Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice., Emilia Peuhu, Siiri I Salomaa, Nicola De Franceschi, Christopher S Potter, John P Sundberg, and Jeroen Pouwels
A change of heart: a transforming view of cardiac function., Alexander R Pinto
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development., Antanas Planutis, Li Xue, Cecelia D Trainor, Mohan Dangeti, Kevin Gillinder, Miroslawa Siatecka, Danitza Nébor, Luanne L. Peters, Andrew C Perkins, and James J Bieker
Loss of FAS/FASL signalling does not reduce apoptosis in Sharpin null mice., Christopher S Potter, Kathleen A Silva, Victoria E. Kennedy, Timothy M Stearns, Harm HogenEsch, and John P Sundberg
Genetic variance is associated with susceptibility for cigarette smoke-induced DAMP release in mice., Simon D Pouwels, Alen Faiz, Lisette E den Boef, Reneé Gras, Maarten van den Berge, H Marike Boezen, Ron Korstanje, Nick H T Ten Hacken, Antoon J M van Oosterhout, Irene H Heijink, and Martijn C Nawijn
Alopecia areata., C Herbert Pratt, Lloyd E King, Andrew G Messenger, Angela M Christiano, and John P Sundberg
Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ., C Herbert Pratt, Christopher S Potter, Raoul V Kuiper, Son Yong Karst, Soheil S Dadras, Derry C. Roopenian, and John P Sundberg
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury., Michal Pyzik, Timo Rath, Timothy T Kuo, Sanda Win, Kristi Baker, Jonathan J Hubbard, Rosa Grenha, Amit Gandhi, Thomas D Krämer, Adam R Mezo, Zachary S Taylor, Kevin McDonnell, Vicki Nienaber, Jan Terje Andersen, Atsushi Mizoguchi, Laurence Blumberg, Shalaka Purohit, Susan D Jones, Gregory J. Christianson, Wayne I Lencer, Inger Sandlie, Neil Kaplowitz, Derry C. Roopenian, and Richard S Blumberg
EphB4/EphrinB2 therapeutics in Rhabdomyosarcoma., Matthew E Randolph, Megan M Cleary, Zia Bajwa, Matthew N Svalina, Michael C Young, Atiya Mansoor, Pali Kaur, Carol J Bult, Martin W Goros, Joel E Michalek, Sunny Xiang, James G. Keck, Valery Krasnoperov, Parkash Gill, and Charles Keller
Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes., Jeremy Ratiu, Jeremy Racine, Muneer G. Hasham, Qiming Wang, Jane Branca, Harold D Chapman, Jing Zhu, Nina M. Donghia, Vivek M. Philip, William H. Schott, Clive Wasserfall, Mark A Atkinson, Kevin D Mills, Caroline M Leeth, and David V. Serreze
The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure., Vera D Rinaldi, Ewelina Bolcun-Filas, Hiroshi Kogo, Hiroki Kurahashi, and John C Schimenti
Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death., Vera D Rinaldi, Kristin Hsieh, Robert Munroe, Ewelina Bolcun-Filas, and John C Schimenti
Finger stick blood collection for gene expression profiling and storage of tempus blood RNA tubes., Darawan Rinchai, Esperanza Anguiano, Phuong Nguyen, and Damien Chaussabel
Once doesn't count: Phenotype-driven gene hunting in cohorts., Peter N Robinson
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus., Tamara S Roman, Maren E Cannon, Swarooparani Vadlamudi, Martin L Buchkovich, Brooke N Wolford, Ryan P Welch, Mario A Morken, Grace J Kwon, Arushi Varshney, Romy Kursawe, Ying Wu, Anne U Jackson, Michael R Erdos, Johanna Kuusisto, Markku Laakso, Laura J Scott, Michael Boehnke, Francis S Collins, Stephen C J Parker, Michael L. Stitzel, and Karen L Mohlke
The Gene Ontology of eukaryotic cilia and flagella., Paola Roncaglia, Teunis J P van Dam, Karen R. Christie, Lora Nacheva, Grischa Toedt, Martijn A Huynen, Rachael P Huntley, Toby J Gibson, and Jane Lomax
A Guardian of the Heartbeat., Nadia Rosenthal
Evolutionarily Conserved Principles Predict 3D Chromatin Organization., M Jordan Rowley, Michael H Nichols, Xiaowen Lyu, Masami Ando-Kuri, I Sarahi M Rivera, Karen Hermetz, Ping Wang, Yijun Ruan, and Victor G Corces
Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways., Yoriko Saito, Yoshiki Mochizuki, Ikuko Ogahara, Takashi Watanabe, Leah Hogdal, Shinsuke Takagi, Kaori Sato, Akiko Kaneko, Hiroshi Kajita, Naoyuki Uchida, Takehiro Fukami, Leonard D. Shultz, Shuichi Taniguchi, Osamu Ohara, Anthony G Letai, and Fumihiko Ishikawa
SVEP1 plays a crucial role in epidermal differentiation., Liat Samuelov, Qiaoli Li, Ron Bochner, Nicole A Najor, Lauren Albrecht, Natalia Malchin, Tomer Goldsmith, Meital Grafi-Cohen, Dan Vodo, Gilad Fainberg, Benjamin Meilik, Ilan Goldberg, Emily Warshauer, Tova Rogers, Sarah Edie, Akemi Ishida-Yamamoto, Lisa M. Burzenski, Noam Erez, Stephen A Murray, Alan D Irvine, Leonard D. Shultz, Kathleen J Green, Jouni Uitto, Eli Sprecher, and Ofer Sarig
The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?, Susanne Sattler, Paul Fairchild, Fiona M Watt, Nadia Rosenthal, and Sian E Harding
Validation of Metagenomic Next-Generation Sequencing Tests for Universal Pathogen Detection., Robert Schlaberg, Charles Y Chiu, Steve Miller, Gary W Procop, and George M. Weinstock
Imbalance-Aware Machine Learning for Predicting Rare and Common Disease-Associated Non-Coding Variants., Max Schubach, Matteo Re, Peter N Robinson, and Giorgio Valentini
Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis., Kerstin Seidel, Pauline Marangoni, Cynthia Tang, Bahar Houshmand, Wen Du, Richard L Maas, Stephen A Murray, Michael C Oldham, and Ophir D Klein
Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross., John R Shorter, Fanny Odet, David L Aylor, Wenqi Pan, Chia-Yu Kao, Chen-Ping Fu, Andrew P Morgan, Seth Greenstein, Timothy A Bell, Alicia M Stevans, Ryan W Feathers, Sunny Patel, Sarah E Cates, Ginger D Shaw, Darla R Miller, Elissa J Chesler, Leonard McMillian, Deborah A O'Brien, and Fernando Pardo-Manuel de Villena
Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles., Kimberly Siletti, Basile Tarchini, and A J Hudspeth
Constitutive resistance to viral infection in human CD141+ dendritic cells., Aymeric Silvin, Chun I. Yu, Xavier Lahaye, Francesco Imperatore, Jean-Baptiste Brault, Sylvain Cardinaud, Christian Becker, Wing-Hong Kwan, Cecile Conrad, Mathieu Maurin, Christel Goudot, Santy Marques-Ladeira, Yuanyuan Wang, Virginia Pascual, Esperanza Anguiano, Randy A. Albrecht, Matteo Iannacone, Adolfo Garcia-Sastre, Bruno Goud, Marc Dalod, Arnaud Moris, Meriam Merad, A. Karolina Palucka, and Nicholas Manel
High-Resolution Maps of Mouse Reference Populations., Petr Simecek, Jiri Forejt, Robert W Williams, Toshihiko Shiroishi, Toyoyuki Takada, Lu Lu, Thomas E Johnson, Beth Bennett, Christian F Deschepper, Marie-Pier Scott-Boyer, Fernando Pardo-Manuel de Villena, and Gary A Churchill