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Submissions from 2017

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Combination of IL-10 and IL-2 induces oligoclonal human CD4 T cell expansion during xenogeneic and allogeneic GVHD in humanized mice., Sojan Abraham, Hua Guo, Jang-Gi Choi, Chunting Ye, Midhun Ben Thomas, Nora Ortega, Alok Dwivedi, N Manjunath, Guohua Yi, and Premlata Shankar

Optimization and Control of Agent-Based Models in Biology: A Perspective., G An, B G Fitzpatrick, S Christley, P Federico, A Kanarek, R Miller Neilan, M Oremland, R Salinas, Reinhard Laubenbacher, and S Lenhart

Tutorial on Protein Ontology Resources., Cecilia N Arighi, Harold J. Drabkin, Karen R. Christie, Karen E Ross, and Darren A Natale

An atypical role for the myeloid receptor Mincle in central nervous system injury., Thiruma V Arumugam, Silvia Manzanero, Milena B Furtado, Patrick J Biggins, Yu-Hsuan Hsieh, Mathias Gelderblom, Kelli Pa MacDonald, Ekaterina Salimova, Yu-I Li, Othmar Korn, Deborah Dewar, I Mhairi Macrae, Robert B Ashman, Sung-Chun Tang, Nadia Rosenthal, Marc J Ruitenberg, Tim Magnus, and Christine A Wells

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Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets., Shruti Athale, Romain Banchereau, LuAnn Thompson-Snipes, Yuanyuan Wang, Karolina Palucka, Virginia Pascual, and Jacques Banchereau

How mice are indispensable for understanding obesity and diabetes genetics., Alan D Attie, Gary A Churchill, and Joseph H Nadeau

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Mean vector testing for high-dimensional dependent observations., Deepak Nag Ayyala, Junyong Park, and Anindya Roy

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Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics., Romain Banchereau, Alma-Martina Cepika, Jacques Banchereau, and Virginia Pascual

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Systematic analysis of telomere length and somatic alterations in 31 cancer types., Floris P Barthel, Wei Wei, Ming Tang, Emmanuel Martinez-Ledesma, Xin Hu, Samirkumar B Amin, Kadir C Akdemir, Sahil Seth, Xingzhi Song, Qianghu Wang, Tara Lichtenberg, Jian Hu, Jianhua Zhang, Siyuan Zheng, and Roel G W Verhaak

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Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse., Judith A. Blake, Janan T. Eppig, James A. Kadin, Joel E Richardson, Cynthia Smith, Carol J Bult, and Mouse Genome Database Group

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Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy., Jana Blazkova, Sarthak Gupta, Yudong Liu, Brice Gaudilliere, Edward A Ganio, Christopher R Bolen, Ron Saar-Dover, Gabriela K Fragiadakis, Martin S Angst, Sarfaraz Hasni, Nima Aghaeepour, David Stevenson, Nicole Baldwin, Esperanza Anguiano, Damien Chaussabel, Matthew C Altman, Mariana J Kaplan, Mark M Davis, and David Furman

Respiratory manifestations in 38 patients with Alström syndrome., Caroline Boerwinkle, Jan D Marshall, Joy Bryant, William A Gahl, Kenneth N Olivier, and Meral Gunay-Aygun

GlioVis data portal for visualization and analysis of brain tumor expression datasets., Robert L Bowman, Qianghu Wang, Angel Carro, Roel G W Verhaak, and Massimo Squatrito

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Effects of research complexity and competition on the incidence and growth of coauthorship in biomedicine., Jason Cory Brunson, Xiaoyan Wang, and Reinhard Laubenbacher

Integrative Functional Genomics for Systems Genetics in GeneWeaver.org., Jason A. Bubier, Michael A Langston, Erich J Baker, and Elissa J Chesler

Confined placental mosaicism for 22q11.2 deletion as the etiology for discordant positive NIPT results., M Bunnell, Chengsheng Zhang, Charles Lee, D W Bianchi, and L Wilkins-Haug

Abnormalities in the Structure and Function of Cerebellar Neurons and Neuroglia in the Lc/+ Chimeric Mouse Model of Variable Developmental Purkinje Cell Loss., James Cairns, Doug Swanson, Joanna Yeung, Anna Sinova, Ronny Chan, Praneetha Potluri, Price E. Dickson, Guy Mittleman, and Dan Goldowitz

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Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation., Sonia Caprio, Rachel Perry, and Romy Kursawe

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A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density., Jeremy R. Charette, Sarah E Earp, Brent A Bell, Cheryl L Ackert-Bicknell, Dana A Godfrey, Sujata Rao, Bela Anand-Apte, Patsy M. Nishina, and Neal S Peachey

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Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective., Julia Chifman, Seda Arat, Zhiyong Deng, Erica Lemler, James C Pino, Leonard A Harris, Michael A Kochen, Carlos F Lopez, Steven A Akman, Frank M Torti, Suzy V Torti, and Reinhard Laubenbacher

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High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients., Sung-Yup Cho, Changho Park, Deukchae Na, Jee Yun Han, Jieun Lee, Ok-Kyoung Park, Chengsheng Zhang, Chang Ohk Sung, Hyo Eun Moon, Yona Kim, Jeong Hoon Kim, Jong Jae Kim, Shin Kwang Khang, Do-Hyun Nam, Jung Won Choi, Yeon-Lim Suh, Dong Gyu Kim, Sung Hye Park, Hyewon Youn, Kyuson Yun, Jong-Il Kim, Charles Lee, Sun Ha Paek, and Hansoo Park

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Editorial overview: Characterizing the cancer genome: mechanistic insights and translational opportunities., Olivier Delattre and Carol J Bult

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Cerebellar contribution to higher and lower order rule learning and cognitive flexibility in mice., Price E. Dickson, J Cairns, D Goldowitz, and G Mittleman

Interferon-γ Limits Diabetogenic CD8(+) T-Cell Effector Responses in Type 1 Diabetes., John P Driver, Jeremy Racine, Cheng Ye, Deanna J Lamont, Brittney N Newby, Caroline M. Leeth, Harold D. Chapman, Todd M Brusko, Yi-Guang Chen, Clayton E Mathews, and David V. Serreze

Mouse Genome Informatics (MGI): Resources for Mining Mouse Genetic, Genomic, and Biological Data in Support of Primary and Translational Research., Janan T. Eppig, Cynthia Smith, Judith A. Blake, Martin Ringwald, James A. Kadin, Joel E Richardson, and Carol J Bult

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The mouse Gene Expression Database (GXD): 2017 update., Jacqueline H. Finger, Constance M. Smith, Terry F. Hayamizu, Ingeborg J. McCright, Jingxia Xu, MeiYee Law, David R. Shaw, Richard M. Baldarelli, Jon S Beal, Olin Blodgett, Jeff W Campbell, Lori E. Corbani, Jill R Lewis, Kim L. Forthofer, Pete J. Frost, Sharon C Giannatto, Lucie Hutchins, Dave Miers, Howie Motenko, Kevin R. Stone, Janan T. Eppig, James A. Kadin, Joel E Richardson, and Martin Ringwald

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Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling., Milena B Furtado, Julia C Wilmanns, Anjana Chandran, Joelle Perera, Olivia Hon, Christine Biben, Taylor J Willow, Hieu T Nim, Gurpreet Kaur, Stephanie Simonds, Qizhu Wu, David Willians, Ekaterina Salimova, Nicolas Plachta, James M. Denegre, Stephen A. Murray, Diane Fatkin, Michael Cowley, James T Pearson, David Kaye, Mirana Ramialison, Richard P Harvey, Nadia A Rosenthal, and Mauro W Costa

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Normal behavioral responses to light and darkness and the pupillary light reflex are dependent upon the olivary pretectal nucleus in the diurnal Nile grass rat., Andrew J Gall, Ohanes S Khacherian, Brandi Ledbetter, Sean P Deats, Megan Luck, Laura Smale, Lily Yan, and Antonio A Nunez

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Defining Disease, Diagnosis, and Translational Medicine within a Homeostatic Perturbation Paradigm: The National Institutes of Health Undiagnosed Diseases Program Experience., Timothy Gall, Elise Valkanas, Christofer Bello, Thomas Markello, Christopher Adams, William P Bone, Alexander J Brandt, Jennifer M Brazill, Lynn Carmichael, Mariska Davids, Joie Davis, Zoraida Diaz-Perez, David Draper, Jeremy Elson, Elise D Flynn, Rena Godfrey, Catherine Groden, Cheng-Kang Hsieh, Roxanne Fischer, Gretchen A Golas, Jessica Guzman, Yan Huang, Megan S Kane, Elizabeth Lee, Chong Li, Amanda E Links, Valerie Maduro, May Christine V Malicdan, Fayeza S Malik, Michele Nehrebecky, Joun Park, Paul Pemberton, Katherine Schaffer, Dimitre Simeonov, Murat Sincan, Damian Smedley, Zaheer Valivullah, Colleen Wahl, Nicole Washington, Lynne A Wolfe, Karen Xu, Yi Zhu, William A Gahl, Cynthia J Tifft, Camillo Toro, David R Adams, Miao He, Peter N Robinson, Melissa A Haendel, R Grace Zhai, and Cornelius F Boerkoel

QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment., Daniel Mario Gatti, John E French, and Klaus Schughart

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Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability., Kevin R Gillinder, Melissa D Ilsley, Danitza Nébor, Ravi Sachidanandam, Mathieu Lajoie, Graham W Magor, Michael R Tallack, Timothy Bailey, Michael J Landsberg, Joel P Mackay, Michael W Parker, Luke A Miles, Joel H. Graber, Luanne L. Peters, James J Bieker, and Andrew C Perkins

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Chasing the recipe for a pro-regenerative immune system., James W Godwin, Alexander R Pinto, and Nadia A Rosenthal

Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin., Laura A Gonyar, Mary C Gray, Gregory J. Christianson, Borna Mehrad, and Erik L Hewlett

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Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective., Jeffrey M. Harder, Catherine E. Braine, Pete A. Williams, Xianjun Zhu, Katharine H Macnicoll, Gregory L Sousa, Rebecca A Buchanan, Richard S Smith, Richard T Libby, Gareth R Howell, and Simon W M John

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Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease., Muneer G. Hasham, Nicoleta Baxan, Daniel J Stuckey, Jane Branca, Bryant Perkins, Oliver Dent, Ted Duffy, Tolani S Hameed, Sarah E Stella, Mohammed Bellahcene, Michael D Schneider, Sian E Harding, Nadia Rosenthal, and Susanne Sattler

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Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing., Vishnu Hosur, Lisa M. Burzenski, Timothy M Stearns, Michelle L Farley, John P Sundberg, Michael V. Wiles, and Leonard D. Shultz

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Interrogating the topological robustness of gene regulatory circuits by randomization., Bin Huang, Mingyang Lu, Dongya Jia, Eshel Ben-Jacob, Herbert Levine, and Jose N Onuchic

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SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes., Grace Hwang, Fengyun Sun, Marilyn J. O'Brien, John J. Eppig, Mary Ann Handel, and Philip W Jordan

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Effective biomedical document classification for identifying publications relevant to the mouse Gene Expression Database (GXD)., Xiangying Jiang, Martin Ringwald, Judith A. Blake, and Hagit Shatkay

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Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains., Kenneth R. Johnson, Cong Tian, Leona H. Gagnon, Haiyan Jiang, Dalian Ding, and Richard Salvi

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A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers., MoonSun Jung, Amanda J Russell, Bing Liu, Joshy George, Pei Yan Liu, Tao Liu, Anna DeFazio, David D L Bowtell, André Oberthuer, Wendy B London, Jamie I Fletcher, Michelle Haber, Murray D Norris, and Michelle J Henderson

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Cardiac regeneration: All work and no repair?, Teresa Kennedy-Lydon and Nadia Rosenthal

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Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating., Stacey L Kirkpatrick, Lisa R Goldberg, Neema Yazdani, R Keith Babbs, Jiayi Wu, Eric R Reed, David F Jenkins, Amanda F Bolgioni, Kelsey I Landaverde, Kimberly P Luttik, Karen S Mitchell, Vivek Kumar, W Evan Johnson, Megan K Mulligan, Pietro Cottone, and Camron D Bryant

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The Human Phenotype Ontology in 2017., Sebastian Köhler, Nicole A Vasilevsky, Mark Engelstad, Erin Foster, Julie McMurry, Ségolène Aymé, Gareth Baynam, Susan M. Bello, Cornelius F Boerkoel, Kym M Boycott, Michael Brudno, Orion J Buske, Patrick F Chinnery, Valentina Cipriani, Laureen E Connell, Hugh J S Dawkins, Laura E DeMare, Andrew D Devereau, Bert B A de Vries, Helen V Firth, Kathleen Freson, Daniel Greene, Ada Hamosh, Ingo Helbig, Courtney Hum, Johanna A Jähn, Roger James, Roland Krause, Stanley J F Laulederkind, Hanns Lochmüller, Gholson J Lyon, Soichi Ogishima, Annie Olry, Willem H Ouwehand, Nikolas Pontikos, Ana Rath, Franz Schaefer, Richard H Scott, Michael Segal, Panagiotis I Sergouniotis, Richard Sever, Cynthia L Smith, Volker Straub, Rachel Thompson, Catherine Turner, Ernest Turro, Marijcke W M Veltman, Tom Vulliamy, Jing Yu, Julie von Ziegenweidt, Andreas Zankl, Stephan Züchner, Tomasz Zemojtel, Julius O B Jacobsen, Tudor Groza, Damian Smedley, Christopher J Mungall, Melissa Haendel, and Peter N Robinson

Isolation of Methicillin-resistant Staphylococcus aureus and Multidrug-resistant Elizabethkingia meningoseptica From Neonates Within Minutes of Birth., Brenda A Kwambana-Adams, Claire S Laxton, Ebenezer Foster-Nyarko, Claire S Laxton, George M. Weinstock, and Martin Antonio

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Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes., Nathan Lawlor, Joshy George, Mohan Bolisetty, Romy Kursawe, Lili Sun, V Sivakamasundari, Ina Kycia, Paul Robson, and Michael L. Stitzel

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Genomics of Islet (Dys)function and Type 2 Diabetes., Nathan Lawlor, Shubham Khetan, Duygu Ucar, and Michael L. Stitzel

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MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice., Benjamin P Lee, Ivana Burić, Anupriya George-Pandeth, Kevin Flurkey, David E Harrison, Rong Yuan, Luanne L. Peters, George A Kuchel, David Melzer, and Lorna W Harries

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mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors., Jungmin Lee, Brad Dykstra, Joel A Spencer, Laurie L Kenney, Dale L Greiner, Leonard D. Shultz, Michael A Brehm, Charles P Lin, Robert Sackstein, and Derrick J Rossi

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Glioma: experimental models and reality., Krissie Lenting, Roel G W Verhaak, Mark Ter Laan, Pieter Wesseling, and William Leenders

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Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors., Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan, Kok Hao Chen, Jolene Jie Lin Goh, Say Li Kong, Clarinda Chua, Lim Kiat Hon, Wah Siew Tan, Mark Wong, Paul Jongjoon Choi, Lawrence J K Wee, Axel M Hillmer, Iain Beehuat Tan, Paul Robson, and Shyam Prabhakar

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice., Bixuan Lin, Ashley E Ciecko, Erin MacKinney, David V. Serreze, and Yi-Guang Chen

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Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum., Qiaoli Li, Joshua Kingman, Koen van de Wetering, Sami Tannouri, John P Sundberg, and Jouni Uitto

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IKKα regulates human keratinocyte migration through surveillance of the redox environment., Thomas S lisse and Sandra Rieger

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Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition., Edison T Liu, Ewelina Bolcun-Filas, David S Grass, Cathleen Lutz, Stephen A Murray, Leonard D. Shultz, and Nadia Rosenthal

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CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells., Xiaojuan Liu, Yongping Zhang, Chen Cheng, Albert Cheng, Xingying Zhang, Na Li, Changqing Xia, Xiaofei Wei, Xiang Liu, and Haoyi Wang

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Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions., Xingwang Li, Oscar Junhong Luo, Ping Wang, Meizhen Zheng, Danjuan Wang, Emaly Piecuch, Jacqueline Jufen Zhu, Simon Zhongyuan Tian, Zhonghui Tang, Guoliang Li, and Yijun Ruan

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ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis., Zhaomin Li, Peng Zhang, Aimin Yan, Zhengyu Guo, Yuguang Ban, Jin Li, Shi Chen, Hui Yang, Yongzheng He, Jianping Li, Ying Guo, Wen Zhang, Ehsan Hajiramezanali, Huangda An, Darlene Fajardo, J William Harbour, Yijun Ruan, Stephen D Nimer, Peng Yu, Xi Chen, Mingjiang Xu, and Feng-Chun Yang

Genome-wide enrichment of damaging de novo variants in patients with isolated and complex congenital diaphragmatic hernia., Mauro Longoni, Frances A High, Hongjian Qi, Maliackal P Joy, Regis Hila, Caroline M Coletti, Julia Wynn, Maria Loscertales, Linshan Shan, Carol J Bult, Jay M Wilson, Yufeng Shen, Wendy K Chung, and Patricia K Donahoe

A license to cure?, Cathleen Lutz

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Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research., Teri A Manolio, Douglas M Fowler, Lea M Starita, Melissa A Haendel, Daniel G MacArthur, Leslie G Biesecker, Elizabeth Worthey, Rex L Chisholm, Eric D Green, Howard J Jacob, Howard L McLeod, Dan Roden, Laura Lyman Rodriguez, Marc S Williams, Gregory M Cooper, Nancy J Cox, Gail E Herman, Stephen Kingsmore, Cecilia Lo, Cathleen Lutz, Calum A MacRae, Robert L Nussbaum, Jose M Ordovas, Erin M Ramos, Peter N Robinson, Wendy S Rubinstein, Christine Seidman, Barbara E Stranger, Haoyi Wang, Monte Westerfield, and Carol J Bult

Cre-loxP-Mediated Recombination: General Principles and Experimental Considerations., Michael A McLellan, Nadia A Rosenthal, and Alexander R Pinto

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Downregulation of miR-33a-5p in Hepatocellular Carcinoma: A Possible Mechanism for Chemotherapy Resistance., Wei Meng, Yan Tai, Hui Zhao, Binsheng Fu, Tong Zhang, Wei Liu, Hua Li, Yang Yang, Qi Zhang, Yuliang Feng, and Guihua Chen

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Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice., Paul H Miller, Gabrielle Rabu, Margarita MacAldaz, David J H F Knapp, Alice M S Cheung, Kiran Dhillon, Naoto Nakamichi, Philip A Beer, Leonard D. Shultz, R Keith Humphries, and Connie J Eaves

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Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes., Kathryn H. Morelli, Kevin L. Seburn, David G. Schroeder, Emily L Spaulding, Louise A. Dionne, Gregory A. Cox, and Robert W. Burgess

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Structural Variation Shapes the Landscape of Recombination in Mouse., Andrew P Morgan, Daniel M. Gatti, Maya L Najarian, Thomas M Keane, Raymond J Galante, Allan I Pack, Richard Mott, Gary A. Churchill, and Fernando Pardo-Manuel de Villena

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The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species., Christopher J Mungall, Julie A McMurry, Sebastian Köhler, James P Balhoff, Charles Borromeo, Matthew Brush, Seth Carbon, Tom Conlin, Nathan Dunn, Mark Engelstad, Erin Foster, J P Gourdine, Julius O B Jacobsen, Dan Keith, Bryan Laraway, Suzanna E Lewis, Jeremy NguyenXuan, Kent Shefchek, Nicole Vasilevsky, Zhou Yuan, Nicole Washington, Harry Hochheiser, Tudor Groza, Damian Smedley, Peter N Robinson, and Melissa A Haendel

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Protein Ontology (PRO): enhancing and scaling up the representation of protein entities., Darren A Natale, Cecilia N Arighi, Judith A. Blake, Jonathan Bona, Chuming Chen, Sheng-Chih Chen, Karen R. Christie, Julie Cowart, Peter D'Eustachio, Alexander D Diehl, Harold J. Drabkin, William D Duncan, Hongzhan Huang, Jia Ren, Karen Ross, Alan Ruttenberg, Veronica Shamovsky, Barry Smith, Qinghua Wang, Jian Zhang, Abdelrahman El-Sayed, and Cathy H Wu

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Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice., João Luís Neto, Jong-Min Lee, Ali Afridi, Tammy Gillis, Jolene R Guide, Stephani Dempsey, Brenda Lager, Isabel Alonso, Vanessa C Wheeler, and Ricardo Mouro Pinto

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Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis., Masayuki Nigo, Lorena Diaz, Lina P Carvajal, Truc T Tran, Rafael Rios, Diana Panesso, Juan D Garavito, William R Miller, Audrey Wanger, George M. Weinstock, Jose M Munita, Cesar A Arias, and Henry F Chambers

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Combinatorial Ranking of Gene Sets to Predict Disease Relapse: The Retinoic Acid Pathway in Early Prostate Cancer., Hieu T Nim, Milena B Furtado, Mirana Ramialison, and Sarah E Boyd

Systems Genetic Analysis in GeneNetwork.org., Clarissa C Parker, Price E. Dickson, Vivek M. Philip, Mary Thomas, and Elissa J Chesler

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PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis., Emil D Parvanov, Hui Tian, Timothy Billings, Ruth L. Saxl, Catrina Spruce, Rakesh Aithal, Lumir Krejci, Kenneth Paigen, and Petko M. Petkov

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L1Base 2: more retrotransposition-active LINE-1s, more mammalian genomes., Tobias Penzkofer, Marten Jäger, Marek Figlerowicz, Richard Badge, Stefan Mundlos, Peter N Robinson, and Tomasz Zemojtel

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Embryogenesis in a dish., Martin Pera

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Human embryo research and the 14-day rule., Martin Pera

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SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland., Emilia Peuhu, Riina Kaukonen, Martina Lerche, Markku Saari, Camilo Guzmán, Pia Rantakari, Nicola De Franceschi, Anni Wärri, Maria Georgiadou, Guillaume Jacquemet, Elina Mattila, Reetta Virtakoivu, Yuming Liu, Youmna Attieh, Kathleen A Silva, Timo Betz, John P Sundberg, Marko Salmi, Marie-Ange Deugnier, Kevin W Eliceiri, and Johanna Ivaska

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Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development., Antanas Planutis, Li Xue, Cecelia D Trainor, Mohan Dangeti, Kevin Gillinder, Miroslawa Siatecka, Danitza Nébor, Luanne L. Peters, Andrew C Perkins, and James J Bieker

Alopecia areata., C Herbert Pratt, Lloyd E King, Andrew G Messenger, Angela M Christiano, and John P Sundberg

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Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ., C Herbert Pratt, Christopher S Potter, Raoul V Kuiper, Son Yong Karst, Soheil S Dadras, Derry C. Roopenian, and John P Sundberg

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Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury., Michal Pyzik, Timo Rath, Timothy T Kuo, Sanda Win, Kristi Baker, Jonathan J Hubbard, Rosa Grenha, Amit Gandhi, Thomas D Krämer, Adam R Mezo, Zachary S Taylor, Kevin McDonnell, Vicki Nienaber, Jan Terje Andersen, Atsushi Mizoguchi, Laurence Blumberg, Shalaka Purohit, Susan D Jones, Gregory J. Christianson, Wayne I Lencer, Inger Sandlie, Neil Kaplowitz, Derry C. Roopenian, and Richard S Blumberg

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Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes., Jeremy Ratiu, Jeremy Racine, Muneer G. Hasham, Qiming Wang, Jane Branca, Harold D Chapman, Jing Zhu, Nina M. Donghia, Vivek M. Philip, William H. Schott, Clive Wasserfall, Mark A Atkinson, Kevin D Mills, Caroline M Leeth, and David V. Serreze

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Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death., Vera D Rinaldi, Kristin Hsieh, Robert Munroe, Ewelina Bolcun-Filas, and John C Schimenti

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Finger stick blood collection for gene expression profiling and storage of tempus blood RNA tubes., Darawan Rinchai, Esperanza Anguiano, Phuong Nguyen, and Damien Chaussabel

Once doesn't count: Phenotype-driven gene hunting in cohorts., Peter N Robinson

SVEP1 plays a crucial role in epidermal differentiation., Liat Samuelov, Qiaoli Li, Ron Bochner, Nicole A Najor, Lauren Albrecht, Natalia Malchin, Tomer Goldsmith, Meital Grafi-Cohen, Dan Vodo, Gilad Fainberg, Benjamin Meilik, Ilan Goldberg, Emily Warshauer, Tova Rogers, Sarah Edie, Akemi Ishida-Yamamoto, Lisa M. Burzenski, Noam Erez, Stephen A Murray, Alan D Irvine, Leonard D. Shultz, Kathleen J Green, Jouni Uitto, Eli Sprecher, and Ofer Sarig

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Validation of Metagenomic Next-Generation Sequencing Tests for Universal Pathogen Detection., Robert Schlaberg, Charles Y Chiu, Steve Miller, Gary W Procop, and George M. Weinstock

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Imbalance-Aware Machine Learning for Predicting Rare and Common Disease-Associated Non-Coding Variants., Max Schubach, Matteo Re, Peter N Robinson, and Giorgio Valentini

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Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis., Kerstin Seidel, Pauline Marangoni, Cynthia Tang, Bahar Houshmand, Wen Du, Richard L Maas, Stephen A Murray, Michael C Oldham, and Ophir D Klein

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Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross., John R Shorter, Fanny Odet, David L Aylor, Wenqi Pan, Chia-Yu Kao, Chen-Ping Fu, Andrew P Morgan, Seth Greenstein, Timothy A Bell, Alicia M Stevans, Ryan W Feathers, Sunny Patel, Sarah E Cates, Ginger D Shaw, Darla R Miller, Elissa J Chesler, Leonard McMillian, Deborah A O'Brien, and Fernando Pardo-Manuel de Villena

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A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development., V Sivakamasundari, Petra Kraus, Wenjie Sun, Xiaoming Hu, Siew Lan Lim, Shyam Prabhakar, and Thomas Lufkin

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Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations., James N Sleigh, John M Dawes, Steven J West, Na Wei, Emily L Spaulding, Adriana Gómez-Martín, Qian Zhang, Robert W. Burgess, M Zameel Cader, Kevin Talbot, Xiang-Lei Yang, David L Bennett, and Giampietro Schiavo

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APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo., Elizabeth Snyder, Christopher McCarty, Adrienne Mehalow, Karen L. Svenson, Stephen A. Murray, Ron Korstanje, and Robert E Braun

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Testicular adenosine to inosine RNA editing in the mouse is mediated by ADARB1†,‡., Elizabeth M Snyder, Konstantin Licht, and Robert E Braun

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Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART)., Joanne E Sordillo, Yanjiao Zhou, Michael J McGeachie, John Ziniti, Nancy Lange, Nancy Laranjo, Jessica R Savage, Vincent Carey, George O'Connor, Megan Sandel, Robert Strunk, Leonard Bacharier, Robert Zeiger, Scott T Weiss, George M. Weinstock, Diane R Gold, and Augusto A Litonjua

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Genomes of the Mouse Collaborative Cross., Anuj Srivastava, Andrew P Morgan, Maya L Najarian, Vishal Kumar Sarsani, J Sebastian Sigmon, John R Shorter, Anwica Kashfeen, Rachel C McMullan, Lucy H Williams, Paola Giusti-Rodríguez, Martin T Ferris, Patrick Sullivan, Pablo Hock, Darla R Miller, Timothy A Bell, Leonard McMillan, Gary A. Churchill, and Fernando Pardo-Manuel de Villena

Barriers preventing the adoption of comprehensive cancer genomic profiling in the clinic., Cara M. Statz, Sara E. Patterson, and Susan Mockus

mTOR Inhibitors in Castration-Resistant Prostate Cancer: A Systematic Review., Cara M. Statz, Sara E. Patterson, and Susan Mockus

Behavioral Phenotyping Assays for Genetic Mouse Models of Neurodevelopmental, Neurodegenerative, and Psychiatric Disorders., Stacey J Sukoff Rizzo and Jacqueline N Crawley

Training mouse pathologists: 15 years of workshops on the pathology of mouse models of human disease., John P Sundberg, Kelli Boyd, Harm Hogenesch, Alexander Y Nikitin, Piper M Treuting, and Jerrold M Ward