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Submissions from 2017

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Combination of IL-10 and IL-2 induces oligoclonal human CD4 T cell expansion during xenogeneic and allogeneic GVHD in humanized mice., Sojan Abraham, Hua Guo, Jang-Gi Choi, Chunting Ye, Midhun Ben Thomas, Nora Ortega, Alok Dwivedi, N Manjunath, Guohua Yi, and Premlata Shankar

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Age exacerbates abnormal protein expression in a mouse model of Down syndrome., Md Mahiuddin Ahmed, Aaron Block, Suhong Tong, Muriel T. Davisson, and Katheleen J Gardiner

Navigating the Cancer Transcriptome by Decoding Divergent Oncogenic States., Samirkumar B Amin and Roel G W Verhaak

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Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications., Peter W Andrews, Uri Ben-David, Nissim Benvenisty, Peter Coffey, Kevin Eggan, Barbara B. Knowles, Andras Nagy, Martin Pera, Benjamin Reubinoff, Peter J Rugg-Gunn, and Glyn N Stacey

Optimization and Control of Agent-Based Models in Biology: A Perspective., G An, B G Fitzpatrick, S Christley, P Federico, A Kanarek, R Miller Neilan, M Oremland, R Salinas, Reinhard Laubenbacher, and S Lenhart

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Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014., Rocío Arellano-Llamas, Luis Alfaro-Ruiz, Cristian Arriaga Canon, Ivan Imaz Rosshandler, Alfredo Cruz-Lagunas, Joaquín Zúñiga, Rosa Rebollar Vega, Christopher W Wong, Sebastian Maurer-Stroh, Sandra Romero Córdoba, Edison T Liu, Alfredo Hidalgo-Miranda, and Joel A Vázquez-Pérez

Tutorial on Protein Ontology Resources., Cecilia N Arighi, Harold J. Drabkin, Karen R. Christie, Karen E Ross, and Darren A Natale

An atypical role for the myeloid receptor Mincle in central nervous system injury., Thiruma V Arumugam, Silvia Manzanero, Milena B Furtado, Patrick J Biggins, Yu-Hsuan Hsieh, Mathias Gelderblom, Kelli Pa MacDonald, Ekaterina Salimova, Yu-I Li, Othmar Korn, Deborah Dewar, I Mhairi Macrae, Robert B Ashman, Sung-Chun Tang, Nadia Rosenthal, Marc J Ruitenberg, Tim Magnus, and Christine A Wells

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Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets., Shruti Athale, Romain Banchereau, LuAnn Thompson-Snipes, Yuanyuan Wang, Karolina Palucka, Virginia Pascual, and Jacques Banchereau

How mice are indispensable for understanding obesity and diabetes genetics., Alan D Attie, Gary A Churchill, and Joseph H Nadeau

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Mean vector testing for high-dimensional dependent observations., Deepak Nag Ayyala, Junyong Park, and Anindya Roy

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CloudNeo: A cloud pipeline for identifying patient-specific tumor neoantigens., Preeti Bais, Sandeep Namburi, Daniel M. Gatti, Xinyu Zhang, and Jeffrey Chuang

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Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics., Romain Banchereau, Alma-Martina Cepika, Jacques Banchereau, and Virginia Pascual

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Systematic analysis of telomere length and somatic alterations in 31 cancer types., Floris P Barthel, Wei Wei, Ming Tang, Emmanuel Martinez-Ledesma, Xin Hu, Samirkumar B Amin, Kadir C Akdemir, Sahil Seth, Xingzhi Song, Qianghu Wang, Tara Lichtenberg, Jian Hu, Jianhua Zhang, Siyuan Zheng, and Roel G W Verhaak

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Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses., Jenna M Bartley, Xin Zhou, George A Kuchel, George M. Weinstock, and Laura Haynes

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Iron addiction: a novel therapeutic target in ovarian cancer., D Basuli, L Tesfay, Z Deng, B Paul, Y Yamamoto, Gang Ning, W Xian, F McKeon, M Lynch, C P Crum, P Hegde, M Brewer, X Wang, L D Miller, N Dyment, F M Torti, and S V Torti

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Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma., Narendra Bharathy, Matthew N Svalina, Teagan P Settelmeyer, Megan M Cleary, Noah E Berlow, Susan D Airhart, Sunny Xiang, James Keck, James B Hayden, Jack F Shern, Atiya Mansoor, Melvin Lathara, Ganapati Srinivasa, David M Langenau, and Charles Keller

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Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse., Judith A. Blake, Janan T. Eppig, James A. Kadin, Joel E Richardson, Cynthia Smith, Carol J Bult, and Mouse Genome Database Group

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Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy., Jana Blazkova, Sarthak Gupta, Yudong Liu, Brice Gaudilliere, Edward A Ganio, Christopher R Bolen, Ron Saar-Dover, Gabriela K Fragiadakis, Martin S Angst, Sarfaraz Hasni, Nima Aghaeepour, David Stevenson, Nicole Baldwin, Esperanza Anguiano, Damien Chaussabel, Matthew C Altman, Mariana J Kaplan, Mark M Davis, and David Furman

Respiratory manifestations in 38 patients with Alström syndrome., Caroline Boerwinkle, Jan D Marshall, Joy Bryant, William A Gahl, Kenneth N Olivier, and Meral Gunay-Aygun

Review of CO₂ as a Euthanasia Agent for Laboratory Rats and Mice., Gregory P Boivin, Debra L Hickman, Michelle A Creamer-Hente, Kathleen R Pritchett-Corning, and Natalie A Bratcher

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Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency., Florie Borel, Qiushi Tang, Gwladys Gernoux, Cynthia Greer, Ziqiong Wang, Adi Barzel, Mark A Kay, Leonard D. Shultz, Dale L Greiner, Terence R Flotte, Michael A Brehm, and Christian Mueller

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Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea., Robert M Bowers, Nikos C Kyrpides, Ramunas Stepanauskas, Miranda Harmon-Smith, Devin Doud, T B K Reddy, Frederik Schulz, Jessica Jarett, Adam R Rivers, Emiley A Eloe-Fadrosh, Susannah G Tringe, Natalia N Ivanova, Alex Copeland, Alicia Clum, Eric D Becraft, Rex R Malmstrom, Bruce Birren, Mircea Podar, Peer Bork, George M. Weinstock, George M Garrity, Jeremy A Dodsworth, Shibu Yooseph, Granger Sutton, Frank O Glöckner, Jack A Gilbert, William C Nelson, Steven J Hallam, Sean P Jungbluth, Thijs J G Ettema, Scott Tighe, Konstantinos T Konstantinidis, Wen-Tso Liu, Brett J Baker, Thomas Rattei, Jonathan A Eisen, Brian Hedlund, Katherine D McMahon, Noah Fierer, Rob Knight, Rob Finn, Guy Cochrane, Ilene Karsch-Mizrachi, Gene W Tyson, Christian Rinke, Alla Lapidus, Folker Meyer, Pelin Yilmaz, Donovan H Parks, A M Eren, Lynn Schriml, Jillian F Banfield, Philip Hugenholtz, and Tanja Woyke

GlioVis data portal for visualization and analysis of brain tumor expression datasets., Robert L Bowman, Qianghu Wang, Angel Carro, Roel G W Verhaak, and Massimo Squatrito

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International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases., Kym M Boycott, Ana Rath, Jessica X Chong, Taila Hartley, Fowzan S Alkuraya, Gareth Baynam, Anthony J Brookes, Michael Brudno, Angel Carracedo, Johan T den Dunnen, Stephanie O M Dyke, Xavier Estivill, Jack Goldblatt, Catherine Gonthier, Stephen C Groft, Ivo Gut, Ada Hamosh, Philip Hieter, Sophie Höhn, Matthew E Hurles, Petra Kaufmann, Bartha M Knoppers, Jeffrey P Krischer, Milan Macek, Gert Matthijs, Annie Olry, Samantha Parker, Justin Paschall, Anthony A Philippakis, Heidi L Rehm, Peter N Robinson, Pak-Chung Sham, Rumen Stefanov, Domenica Taruscio, Divya Unni, Megan R Vanstone, Feng Zhang, Han Brunner, Michael J Bamshad, and Hanns Lochmüller

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Characteristics of cardiomyopathy in Alström syndrome: Prospective single-center data on 38 patients., Alessandra Brofferio, Vandana Sachdev, Hwaida Hannoush, Jan D. Marshall, Juergen K. Naggert, Stanislav Sidenko, Anna Noreuil, Arlene Sirajuddin, Joy Bryant, Joan C Han, Andrew E Arai, William A Gahl, and Meral Gunay-Aygun

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Effects of research complexity and competition on the incidence and growth of coauthorship in biomedicine., Jason Cory Brunson, Xiaoyan Wang, and Reinhard Laubenbacher

Integrative Functional Genomics for Systems Genetics in GeneWeaver.org., Jason A. Bubier, Michael A Langston, Erich J Baker, and Elissa J Chesler

Confined placental mosaicism for 22q11.2 deletion as the etiology for discordant positive NIPT results., M Bunnell, Chengsheng Zhang, Charles Lee, D W Bianchi, and L Wilkins-Haug

Abnormalities in the Structure and Function of Cerebellar Neurons and Neuroglia in the Lc/+ Chimeric Mouse Model of Variable Developmental Purkinje Cell Loss., James Cairns, Doug Swanson, Joanna Yeung, Anna Sinova, Ronny Chan, Praneetha Potluri, Price E. Dickson, Guy Mittleman, and Dan Goldowitz

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Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation., Sonia Caprio, Rachel Perry, and Romy Kursawe

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Assessing the potential for raw meat to influence human colonization with Staphylococcus aureus., Margaret Carrel, Chang Zhao, Dipendra Thapaliya, Patrick Bitterman, Ashley E Kates, Blake M Hanson, and Tara C Smith

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A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis., Alma-Martina Cepika, Romain Banchereau, Elodie Segura, Marina Ohouo, Brandi Cantarel, Kristina Goller, Victoria Cantrell, Emily Ruchaud, Elizabeth Gatewood, Phuong Nguyen, Jinghua Gu, Esperanza Anguiano, Sandra Zurawski, Jeanine M Baisch, Marilynn Punaro, Nicole Baldwin, Gerlinde Obermoser, Karolina Palucka, Jacques Banchereau, Sebastian Amigorena, and Virginia Pascual

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A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density., Jeremy R. Charette, Sarah E Earp, Brent A Bell, Cheryl L Ackert-Bicknell, Dana A Godfrey, Sujata Rao, Bela Anand-Apte, Patsy M. Nishina, and Neal S Peachey

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Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective., Julia Chifman, Seda Arat, Zhiyong Deng, Erica Lemler, James C Pino, Leonard A Harris, Michael A Kochen, Carlos F Lopez, Steven A Akman, Frank M Torti, Suzy V Torti, and Reinhard Laubenbacher

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A Novel Combination Treatment Targeting BCL-XL and MCL1 for KRAS/BRAF-mutated and BCL2L1-amplified Colorectal Cancers., Sung-Yup Cho, Jee Yun Han, Deukchae Na, Wonyoung Kang, Ahra Lee, Jooyoung Kim, Jieun Lee, Seoyeon Min, Jinjoo Kang, Jeesoo Chae, Jong-Il Kim, Hansoo Park, Won-Suk Lee, and Charles Lee

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High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients., Sung-Yup Cho, Changho Park, Deukchae Na, Jee Yun Han, Jieun Lee, Ok-Kyoung Park, Chengsheng Zhang, Chang Ohk Sung, Hyo Eun Moon, Yona Kim, Jeong Hoon Kim, Jong Jae Kim, Shin Kwang Khang, Do-Hyun Nam, Jung Won Choi, Yeon-Lim Suh, Dong Gyu Kim, Sung Hye Park, Hyewon Youn, Kyuson Yun, Jong-Il Kim, Charles Lee, Sun Ha Paek, and Hansoo Park

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S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma., Kin-Hoe Chow, Hee Jung Park, Joshy George, Keiko Yamamoto, Andrew D Gallup, Joel H. Graber, Yuanxin Chen, Wen Jiang, Dennis A Steindler, Eric G Neilson, Betty Y S Kim, and Kyuson Yun

The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity., Catrina Cropano, Nicola Santoro, Leif Groop, Chiara Dalla Man, Claudio Cobelli, Alfonso Galderisi, Romy Kursawe, Bridget Pierpont, Martina Goffredo, and Sonia Caprio

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Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling., Chunhua Dai, Yan Hang, Alena Shostak, Greg Poffenberger, Nathaniel Hart, Nripesh Prasad, Neil Phillips, Shawn E Levy, Dale L Greiner, Leonard D. Shultz, Rita Bottino, Seung K Kim, and Alvin C Powers

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Editorial overview: Characterizing the cancer genome: mechanistic insights and translational opportunities., Olivier Delattre and Carol J Bult

QTL and systems genetics analysis of mouse grooming and behavioral responses to novelty in an open field., A Delprato, M-P Algéo, B Bonheur, Jason A. Bubier, L Lu, R W Williams, Elissa J Chesler, and W E Crusio

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Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob., Lisa K Denzin, Aly A Khan, Francesca Virdis, Jessica Wilks, Melissa Kane, Helen A Beilinson, Stanislav Dikiy, Laure K Case, Derry C. Roopenian, Michele Witkowski, Alexander V Chervonsky, and Tatyana V Golovkina

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Cerebellar contribution to higher and lower order rule learning and cognitive flexibility in mice., Price E. Dickson, J Cairns, D Goldowitz, and G Mittleman

Spectral-domain optical coherence tomography findings in Alström syndrome., Gad Dotan, Vikas Khetan, Jan D Marshall, Elizabeth Affel, Denise Armiger-George, Juergen K. Naggert, Gayle B. Collin, and Alex V Levin

Interferon-γ Limits Diabetogenic CD8(+) T-Cell Effector Responses in Type 1 Diabetes., John P Driver, Jeremy Racine, Cheng Ye, Deanna J Lamont, Brittney N Newby, Caroline M. Leeth, Harold D. Chapman, Todd M Brusko, Yi-Guang Chen, Clayton E Mathews, and David V. Serreze

Expression and function of ABCG2 and XIAP in glioblastomas., Ivette F Emery, Archana Gopalan, Stephanie Wood, Kin-Hoe Chow, Chiara Battelli, Joshy George, Hagen Blaszyk, Jeffrey Florman, and Kyuson Yun

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Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological Knowledgebase for the Laboratory Mouse., Janan T. Eppig

Mouse Genome Informatics (MGI): Resources for Mining Mouse Genetic, Genomic, and Biological Data in Support of Primary and Translational Research., Janan T. Eppig, Cynthia Smith, Judith A. Blake, Martin Ringwald, James A. Kadin, Joel E Richardson, and Carol J Bult

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EIF1AX and NRAS Mutations Co-occur and Cooperate in Low-Grade Serous Ovarian Carcinomas., Dariush Etemadmoghadam, Walid J Azar, Ying Lei, Tania Moujaber, Dale W Garsed, Catherine J Kennedy, Sian Fereday, Chris Mitchell, Yoke-Eng Chiew, Joy Hendley, Raghwa Sharma, Paul R Harnett, Jason Li, Elizabeth L Christie, Ann-Marie Patch, Joshy George, George Au-Yeung, Gisela Mir Arnau, Timothy P Holloway, Timothy Semple, John V Pearson, Nicola Waddell, Sean M Grimmond, Martin Köbel, Helen Rizos, Ivan B Lomakin, David D L Bowtell, and Anna deFazio

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Antibiotic-associated Manipulation of the Gut Microbiota and Phenotypic Restoration in NOD Mice., James R Fahey, Bonnie L. Lyons, Haiyan L Olekszak, Anthony J Mourino, Jeremy Ratiu, Jeremy Racine, Harold D Chapman, David V. Serreze, Dina L Baker, and N Ken Hendrix

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The mouse Gene Expression Database (GXD): 2017 update., Jacqueline H. Finger, Constance M. Smith, Terry F. Hayamizu, Ingeborg J. McCright, Jingxia Xu, MeiYee Law, David R. Shaw, Richard M. Baldarelli, Jon S Beal, Olin Blodgett, Jeff W Campbell, Lori E. Corbani, Jill R Lewis, Kim L. Forthofer, Pete J. Frost, Sharon C Giannatto, Lucie Hutchins, Dave Miers, Howie Motenko, Kevin R. Stone, Janan T. Eppig, James A. Kadin, Joel E Richardson, and Martin Ringwald

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HIV-Infected Children Have Elevated Levels of PD-1+ Memory CD4 T Cells With Low Proliferative Capacity and High Inflammatory Cytokine Effector Functions., Julia Foldi, Lina Kozhaya, Bret McCarty, Mussa Mwamzuka, Fatma Marshed, Tiina Ilmet, Max Kilberg, Adam Kravietz, Aabid Ahmed, William Borkowsky, Derya Unutmaz, and Alka Khaitan

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EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids., Elvira Forte, Isotta Chimenti, Paolo Rosa, Francesco Angelini, Francesca Pagano, Antonella Calogero, Alessandro Giacomello, and Elisa Messina

Properties and Immune Function of Cardiac Fibroblasts., Milena B Furtado and Muneer G. Hasham

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Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling., Milena B Furtado, Julia C Wilmanns, Anjana Chandran, Joelle Perera, Olivia Hon, Christine Biben, Taylor J Willow, Hieu T Nim, Gurpreet Kaur, Stephanie Simonds, Qizhu Wu, David Willians, Ekaterina Salimova, Nicolas Plachta, James M. Denegre, Stephen A. Murray, Diane Fatkin, Michael Cowley, James T Pearson, David Kaye, Mirana Ramialison, Richard P Harvey, Nadia A Rosenthal, and Mauro W Costa

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Normal behavioral responses to light and darkness and the pupillary light reflex are dependent upon the olivary pretectal nucleus in the diurnal Nile grass rat., Andrew J Gall, Ohanes S Khacherian, Brandi Ledbetter, Sean P Deats, Megan Luck, Laura Smale, Lily Yan, and Antonio A Nunez

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Defining Disease, Diagnosis, and Translational Medicine within a Homeostatic Perturbation Paradigm: The National Institutes of Health Undiagnosed Diseases Program Experience., Timothy Gall, Elise Valkanas, Christofer Bello, Thomas Markello, Christopher Adams, William P Bone, Alexander J Brandt, Jennifer M Brazill, Lynn Carmichael, Mariska Davids, Joie Davis, Zoraida Diaz-Perez, David Draper, Jeremy Elson, Elise D Flynn, Rena Godfrey, Catherine Groden, Cheng-Kang Hsieh, Roxanne Fischer, Gretchen A Golas, Jessica Guzman, Yan Huang, Megan S Kane, Elizabeth Lee, Chong Li, Amanda E Links, Valerie Maduro, May Christine V Malicdan, Fayeza S Malik, Michele Nehrebecky, Joun Park, Paul Pemberton, Katherine Schaffer, Dimitre Simeonov, Murat Sincan, Damian Smedley, Zaheer Valivullah, Colleen Wahl, Nicole Washington, Lynne A Wolfe, Karen Xu, Yi Zhu, William A Gahl, Cynthia J Tifft, Camillo Toro, David R Adams, Miao He, Peter N Robinson, Melissa A Haendel, R Grace Zhai, and Cornelius F Boerkoel

QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment., Daniel Mario Gatti, John E French, and Klaus Schughart

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Biometric and structural ocular manifestations of Marfan syndrome., Petra Gehle, Barbara Goergen, Daniel Pilger, Peter Ruokonen, Peter N Robinson, and Daniel J Salchow

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Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability., Kevin R Gillinder, Melissa D Ilsley, Danitza Nébor, Ravi Sachidanandam, Mathieu Lajoie, Graham W Magor, Michael R Tallack, Timothy Bailey, Michael J Landsberg, Joel P Mackay, Michael W Parker, Luke A Miles, Joel H. Graber, Luanne L. Peters, James J Bieker, and Andrew C Perkins

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Chasing the recipe for a pro-regenerative immune system., James W Godwin, Alexander R Pinto, and Nadia A Rosenthal

Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin., Laura A Gonyar, Mary C Gray, Gregory J. Christianson, Borna Mehrad, and Erik L Hewlett

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Targeting interferon-alpha to dendritic cells enhances a CD8(+) T cell response to a human CD40-targeted cancer vaccine., John P Graham, Pierre Authie, A Karolina Palucka, and Gerard Zurawski

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Genome-wide DNA methylation profiling reveals cancer-associated changes within early colonic neoplasia., M P Hanley, M A Hahn, A X Li, X Wu, Jianan Lin, J Wang, A H Choi, Zhengqing Ouyang, Y Fong, G P Pfeifer, T J Devers, and D W Rosenberg

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Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective., Jeffrey M. Harder, Catherine E. Braine, Pete A. Williams, Xianjun Zhu, Katharine H Macnicoll, Gregory L Sousa, Rebecca A Buchanan, Richard S Smith, Richard T Libby, Gareth R Howell, and Simon W M John

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Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease., Muneer G. Hasham, Nicoleta Baxan, Daniel J Stuckey, Jane Branca, Bryant Perkins, Oliver Dent, Ted Duffy, Tolani S Hameed, Sarah E Stella, Mohammed Bellahcene, Michael D Schneider, Sian E Harding, Nadia Rosenthal, and Susanne Sattler

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Genetic and epigenetic heterogeneity and the impact on cancer relapse., Ciaran Hassan, Ebrahim Afshinnekoo, Sheng Li, Shixiu Wu, and Christopher E Mason

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Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing., Vishnu Hosur, Lisa M. Burzenski, Timothy M Stearns, Michelle L Farley, John P Sundberg, Michael V. Wiles, and Leonard D. Shultz

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Development of Humanized Mice in the Age of Genome Editing., Vishnu Hosur, Benjamin E. Low, Cindy Avery, Leonard D. Shultz, and Michael V. Wiles

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Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis., Vishnu Hosur, Benjamin E. Low, Leonard D. Shultz, and Michael V. Wiles

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Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease., Vishnu Hosur, Bonnie L. Lyons, Lisa M. Burzenski, and Leonard D. Shultz

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PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer., Jessie Hao-Ru Hsu, Benjamin Hubbell-Engler, Guillaume Adelmant, Jialiang Huang, Cailin E Joyce, Francisca Vazquez, Barbara A Weir, Philip Montgomery, Aviad Tsherniak, Andrew O Giacomelli, Jennifer A Perry, Jennifer J. Trowbridge, Yuko Fujiwara, Glenn S Cowley, Huafeng Xie, Woojin Kim, Carl D Novina, William C Hahn, Jarrod A Marto, and Stuart H Orkin

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Interrogating the topological robustness of gene regulatory circuits by randomization., Bin Huang, Mingyang Lu, Dongya Jia, Eshel Ben-Jacob, Herbert Levine, and Jose N Onuchic

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Revisiting the Warnock rule., J Benjamin Hurlbut, Insoo Hyun, Aaron D Levine, Robin Lovell-Badge, Jeantine E Lunshof, Kirstin R W Matthews, Peter Mills, Alison Murdoch, Martin Pera, Christopher Thomas Scott, Juliet Tizzard, Mary Warnock, Magdalena Zernicka-Goetz, Qi Zhou, and Laurie Zoloth

Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma., Xin Hu, Emmanuel Martinez-Ledesma, Siyuan Zheng, Hoon Kim, Floris P Barthel, Tao Jiang, Kenneth R Hess, and Roel G W Verhaak

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SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes., Grace Hwang, Fengyun Sun, Marilyn J. O'Brien, John J. Eppig, Mary Ann Handel, and Philip W Jordan

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Generating CRISPR mouse models: challenges and solutions., Rudolf Jaenisch and David S Grass

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Effective biomedical document classification for identifying publications relevant to the mouse Gene Expression Database (GXD)., Xiangying Jiang, Martin Ringwald, Judith A. Blake, and Hagit Shatkay

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Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains., Kenneth R. Johnson, Cong Tian, Leona H. Gagnon, Haiyan Jiang, Dalian Ding, and Richard Salvi

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A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers., MoonSun Jung, Amanda J Russell, Bing Liu, Joshy George, Pei Yan Liu, Tao Liu, Anna DeFazio, David D L Bowtell, André Oberthuer, Wendy B London, Jamie I Fletcher, Michelle Haber, Murray D Norris, and Michelle J Henderson

The influence of canalization on the robustness of Boolean networks, C Kadelka, J Kuipers, and Reinhard Laubenbacher

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Prevalence of sexual dimorphism in mammalian phenotypic traits., Natasha A Karp, Jeremy Mason, Arthur L Beaudet, Yoav Benjamini, Lynette Bower, Robert E Braun, Steve D M Brown, Elissa J Chesler, Mary E Dickinson, Ann M Flenniken, Helmut Fuchs, Martin Hrabe de Angelis, Xiang Gao, Shiying Guo, Simon Greenaway, Ruth Heller, Yann Herault, Monica J Justice, Natalja Kurbatova, Christopher J Lelliott, K C Kent Lloyd, Ann-Marie Mallon, Judith E Mank, Hiroshi Masuya, Colin McKerlie, Terrence F Meehan, Richard F Mott, Stephen A. Murray, Helen Parkinson, Ramiro Ramirez-Solis, Luis Santos, John R Seavitt, Damian Smedley, Tania Sorg, Anneliese O Speak, Karen P Steel, Karen L. Svenson, Shigeharu Wakana, David West, Sara Wells, Henrik Westerberg, Shay Yaacoby, and Jacqueline K White

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Modeling of Patient-Derived Xenografts in Colorectal Cancer., Anastasia Katsiampoura, Kanwal Raghav, Zhi-Qin Jiang, David G Menter, Andreas Varkaris, Maria P Morelli, Shanequa Manuel, Ji Wu, Alexey V Sorokin, Bahar Salimian Rizi, Christopher Bristow, Feng Tian, Susan Airhart, Mingshan Cheng, Bradley M Broom, Jeffrey Morris, Michael J Overman, Garth Powis, and Scott Kopetz

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Cardiac regeneration: All work and no repair?, Teresa Kennedy-Lydon and Nadia Rosenthal

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Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells., Jung-Hyun Kim, Andreas Kurtz, Bao-Zhu Yuan, Fanyi Zeng, Geoff Lomax, Jeanne F Loring, Jeremy Crook, Ji Hyeon Ju, Laura Clarke, Maneesha S Inamdar, Martin Pera, Meri T Firpo, Michael Sheldon, Nafees Rahman, Orla O'Shea, Patricia Pranke, Qi Zhou, Rosario Isasi, Ruttachuk Rungsiwiwut, Shin Kawamata, Steve Oh, Tenneille Ludwig, Tohru Masui, Thomas J Novak, Tsuneo Takahashi, Wataru Fujibuchi, Soo Kyung Koo, and Glyn N Stacey

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Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating., Stacey L Kirkpatrick, Lisa R Goldberg, Neema Yazdani, R Keith Babbs, Jiayi Wu, Eric R Reed, David F Jenkins, Amanda F Bolgioni, Kelsey I Landaverde, Kimberly P Luttik, Karen S Mitchell, Vivek Kumar, W Evan Johnson, Megan K Mulligan, Pietro Cottone, and Camron D Bryant

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Naming CRISPR alleles: endonuclease-mediated mutation nomenclature across species., Michelle N Knowlton and Cynthia L Smith

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The Human Phenotype Ontology in 2017., Sebastian Köhler, Nicole A Vasilevsky, Mark Engelstad, Erin Foster, Julie McMurry, Ségolène Aymé, Gareth Baynam, Susan M. Bello, Cornelius F Boerkoel, Kym M Boycott, Michael Brudno, Orion J Buske, Patrick F Chinnery, Valentina Cipriani, Laureen E Connell, Hugh J S Dawkins, Laura E DeMare, Andrew D Devereau, Bert B A de Vries, Helen V Firth, Kathleen Freson, Daniel Greene, Ada Hamosh, Ingo Helbig, Courtney Hum, Johanna A Jähn, Roger James, Roland Krause, Stanley J F Laulederkind, Hanns Lochmüller, Gholson J Lyon, Soichi Ogishima, Annie Olry, Willem H Ouwehand, Nikolas Pontikos, Ana Rath, Franz Schaefer, Richard H Scott, Michael Segal, Panagiotis I Sergouniotis, Richard Sever, Cynthia L Smith, Volker Straub, Rachel Thompson, Catherine Turner, Ernest Turro, Marijcke W M Veltman, Tom Vulliamy, Jing Yu, Julie von Ziegenweidt, Andreas Zankl, Stephan Züchner, Tomasz Zemojtel, Julius O B Jacobsen, Tudor Groza, Damian Smedley, Christopher J Mungall, Melissa Haendel, and Peter N Robinson

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Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics., Nigel G Kooreman, Patricia E de Almeida, Jonathan P Stack, Raman V Nelakanti, Sebastian Diecke, Ning-Yi Shao, Rutger-Jan Swijnenburg, Veronica Sanchez-Freire, Elena Matsa, Chun Liu, Andrew J Connolly, Jaap F Hamming, Paul H A Quax, Michael A Brehm, Dale L Greiner, Leonard D. Shultz, and Joseph C Wu

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Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature., Ron Korstanje, Jennifer L Ryan, Holly S Savage, Bonnie L. Lyons, Kevin G Kane, and Stacey J Sukoff Rizzo

Using Vascular Landmarks to Orient 3D Optical Coherence Tomography Images of the Mouse Eye., Mark P. Krebs

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Mouse models of human ocular disease for translational research., Mark P. Krebs, Gayle B. Collin, Wanda L. Hicks, Minzhong Yu, Jeremy R. Charette, Lan Ying Shi, Jieping Wang, Juergen K. Naggert, Neal S Peachey, and Patsy M. Nishina

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The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer., Debra M. Krupke, Dale A. Begley, John P Sundberg, Joel E Richardson, Steven B Neuhauser, and Carol J Bult

Isolation of Methicillin-resistant Staphylococcus aureus and Multidrug-resistant Elizabethkingia meningoseptica From Neonates Within Minutes of Birth., Brenda A Kwambana-Adams, Claire S Laxton, Ebenezer Foster-Nyarko, Claire S Laxton, George M. Weinstock, and Martin Antonio

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Rapid replacement by non-vaccine pneumococcal serotypes may mitigate the impact of the pneumococcal conjugate vaccine on nasopharyngeal bacterial ecology., Brenda Kwambana-Adams, Blake M Hanson, Archibald Worwui, Schadrac Agbla, Ebenezer Foster-Nyarko, Fatima Ceesay, Chinelo Ebruke, Uzochukwu Egere, Yanjiao Zhou, Maze Ndukum, Erica Sodergren Weinstock, Michael Barer, Richard Adegbola, George M. Weinstock, and Martin Antonio

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Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes., Nathan Lawlor, Joshy George, Mohan Bolisetty, Romy Kursawe, Lili Sun, V Sivakamasundari, Ina Kycia, Paul Robson, and Michael L. Stitzel

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Genomics of Islet (Dys)function and Type 2 Diabetes., Nathan Lawlor, Shubham Khetan, Duygu Ucar, and Michael L. Stitzel

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Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts., Nathan Lawlor, Ahrim Youn, Romy Kursawe, Duygu Ucar, and Michael L. Stitzel

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MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice., Benjamin P Lee, Ivana Burić, Anupriya George-Pandeth, Kevin Flurkey, David E Harrison, Rong Yuan, Luanne L. Peters, George A Kuchel, David Melzer, and Lorna W Harries