Submissions from 2023
Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration., Navdeep Gogna, Lillian F Hyde, Gayle B. Collin, Lisa Stone, Jurgen K Naggert, and Patsy M. Nishina
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis., Zheng Gong, Qing Li, Jiayuan Shi, Peishan Li, Li Hua, Leonard D. Shultz, and Guangwen Ren
Reduction of Paraoxonase Expression Followed by Inactivation across Independent Semiaquatic Mammals Suggests Stepwise Path to Pseudogenization., Allie M Graham, Jerrica M Jamison, Marisol Bustos, Charlotte Cournoyer, Alexa Michaels, Jason S Presnell, Rebecca Richter, Daniel E Crocker, Ari Fustukjian, Margaret E Hunter, Lorrie D Rea, Judit Marsillach, Clement E Furlong, Wynn K Meyer, and Nathan L Clark
Term-BLAST-like alignment tool for concept recognition in noisy clinical texts., Tudor Groza, Honghan Wu, Marcel E Dinger, Daniel Danis, Coleman Hilton, Anita Bagley, Jon R Davids, Ling Luo, Zhiyong Lu, and Peter N Robinson
Spatial mapping of cellular senescence: emerging challenges and opportunities., Aditi U Gurkar, Akos A Gerencser, Ana L Mora, Andrew C Nelson, Anru R Zhang, Anthony B Lagnado, Archibald Enninful, Christopher Benz, David Furman, Delphine Beaulieu, Diana Jurk, Elizabeth L Thompson, Fei Wu, Fernanda Rodriguez, Grant Barthel, Hao Chen, Hemali Phatnani, Indra Heckenbach, Jeffrey Chuang, Jeremy Horrell, Joana Petrescu, Jonathan K Alder, Jun Hee Lee, Laura J Niedernhofer, Manoj Kumar, Melanie Königshoff, Marta Bueno, Miiko Sokka, Morten Scheibye-Knudsen, Nicola Neretti, Oliver Eickelberg, Peter D Adams, Qianjiang Hu, Quan Zhu, Rebecca A Porritt, Runze Dong, Samuel Peters, Stella Victorelli, Thomas Pengo, Timur Khaliullin, Vidyani Suryadevara, Xiaonan Fu, Ziv Bar-Joseph, Zhicheng Ji, and João F Passos
Assembly of 43 human Y chromosomes reveals extensive complexity and variation., Pille Hallast, Peter Ebert, Mark Loftus, Feyza Yilmaz, Peter A Audano, Glennis A Logsdon, Marc Jan Bonder, Weichen Zhou, Wolfram Höps, Kwondo Kim, Chong Li, Savannah J Hoyt, Philip C Dishuck, David Porubsky, Fotios Tsetsos, Jee Young Kwon, Qihui Zhu, Katherine M Munson, Patrick Hasenfeld, William T Harvey, Alexandra P Lewis, Jennifer Kordosky, Kendra Hoekzema, Human Genome Structural Variation Consortium (HGSVC), Rachel J O'Neill, Jan O Korbel, Chris Tyler-Smith, Evan E Eichler, Xinghua Shi, Christine R Beck, Tobias Marschall, Miriam K Konkel, and Charles Lee
Aging and urinary control: Alterations in the brain-bladder axis., Cara C Hardy and Ron Korstanje
Cyfip2 allelic variation in C57BL/6J and C57BL/6NJ mice alters free-choice ethanol drinking but not binge-like drinking or wheel-running activity., Matthew C Hartmann, Walter D McCulley, Sarah E Holbrook, Megan M Haney, Caitlin G Smith, Vivek Kumar, and Alan M Rosenwasser
Biochemical pathways represented by Gene Ontology-Causal Activity Models identify distinct phenotypes resulting from mutations in pathways., David P. Hill, Harold J. Drabkin, Cynthia Smith, Kimberly M Van Auken, and Peter D'Eustachio
A developmental approach to diversifying neuroscience through effective mentorship practices: perspectives on cross-identity mentorship and a critical call to action., Tanisha G Hill-Jarrett, Rowena Ng, Carlos Cardenas-Iniguez, Jemima Akinsanya, Ismary Blanco, Johnathan M Borland, James S Brown, Tameka Clemons, Adriana K Cushnie, Jacqueline Garcia, Brianna George, Cera W Hassinan, Timothy J Hines, Dan Landayan, Taylor A McCorkle, Katherine R Meckel, Mariajose Metcalfe, Samantha A Montoya, Deborah K Rose, and Desmond R Warren
A Novel ENU-Induced, Timothy J Hines, Janice Bailey, Hedi Liu, Anyonya R Guntur, Kevin L. Seburn, Samia L Pratt, Jonathan R Funke, Lisa M Tarantino, and Robert W. Burgess
Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats., Thu Hong-Le, Wesley L Crouse, Gregory R Keele, Katie Holl, Osborne Seshie, Michael Tschannen, Ann Craddock, Swapan K Das, Alexandria M Szalanczy, Bailey McDonald, Michael Grzybowski, Jason Klotz, Neeraj K Sharma, Aron M Geurts, Chia-Chi Chuang Key, Gregory Hawkins, William Valdar, Richard Mott, and Leah C Solberg Woods
Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits., Sanjarbek Hudaiberdiev, D Leland Taylor, Wei Song, Narisu Narisu, Redwan M Bhuiyan, Henry J Taylor, Xuming Tang, Tingfen Yan, Amy J Swift, Lori L Bonnycastle, Diamante Consortium, Shuibing Chen, Michael L. Stitzel, Michael R Erdos, Ivan Ovcharenko, and Francis S Collins
Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study., Ryan W Huey, Aakash Tushar Shah, Honey V Reddi, Priyadarsini Dasari, James T Topham, Hyunsoo Hwang, Nishat Dhillon, Anneleis Willett, Brandon G Smaglo, Jeannelyn S Estrella, Asif Rashid, Aurelio Matamoros, Michael J Overman, Linda Choquette, Greg Omerza, Kevin Kelly, Xuemei Wang, Jonathan M Loree, Jens Rueter, Gauri R Varadhachary, and Kanwal Raghav
In vivo activity of the dual SYK/FLT3 inhibitor TAK-659 against pediatric acute lymphoblastic leukemia xenografts., Keira Hughes, Kathryn Evans, Eric J Earley, Christopher M Smith, Stephen W Erickson, Timothy M Stearns, Vivek M. Philip, Steven Neuhauser, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly A Teicher, Malcolm A Smith, and Richard B Lock
Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome., Cheyenne D Hurst, Amy R Dunn, Eric B Dammer, Duc M Duong, Sarah M Shapley, Nicholas T Seyfried, Catherine Kaczorowski, and Erik C B Johnson
Distinct roles of estrone and estradiol in endothelial colony-forming cells., Alicia Ivory and Andrew S Greene
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)., Sanjay Jain, Liming Pei, Jeffrey M Spraggins, Michael Angelo, James P Carson, Nils Gehlenborg, Fiona Ginty, Joana P Gonçalves, James S Hagood, John W Hickey, Neil L Kelleher, Louise C Laurent, Shin Lin, Yiing Lin, Huiping Liu, Alexandra Naba, Ernesto S Nakayasu, Wei-Jun Qian, Andrea Radtke, Paul Robson, Brent R Stockwell, Raf Van de Plas, Ioannis S Vlachos, Mowei Zhou, Katy Börner, and Michael P Snyder
A multi-lab experimental assessment reveals that replicability can be improved by using empirical estimates of genotype-by-lab interaction., Iman Jaljuli, Neri Kafkafi, Eliezer Giladi, Ilan Golani, Illana Gozes, Elissa J Chesler, Molly A. Bogue, and Yoav Benjamini
Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults., Paniz Jasbi, Janko Nikolich-Žugich, Jeffrey Patterson, Kenneth S Knox, Yan Jin, George M. Weinstock, Patricia Smith, Homer L Twigg, and Haiwei Gu
Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development., Cayla E Jewett, Bailey L McCurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura G Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, and Chad G Pearson
Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model., Bei Jia, Chenchen Zhao, Kentaro Minagawa, Hiroko Shike, David F Claxton, W Christopher Ehmann, Witold B Rybka, Shin Mineishi, Ming Wang, Todd D Schell, K Sandeep Prabhu, Robert F Paulson, Yi Zhang, Leonard D. Shultz, and Hong Zheng
The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear., Shihai Jia, Evan M Ratzan, Ellison J Goodrich, Raisa Abrar, Luke Heiland, Basile Tarchini, and Michael R Deans
Phenotypic trait variation in the North American Tragopogon allopolyploid complex., Ingrid E Jordon-Thaden, Jonathan P Spoelhof, Lyderson Facio Viccini, Joseph Combs, Francisco Gomez, Imari Walker, Douglas E Soltis, and Pamela S Soltis
Clathrin light chain-conjugated drug delivery for cancer., Sungwook Jung, Liwei Jiang, Jing Zhao, Leonard D. Shultz, Dale L Greiner, Munhyung Bae, Xiaofei Li, Farideh Ordikhani, Rui Kuai, John Joseph, Vivek Kasinath, David R Elmaleh, and Reza Abdi
Candidate signatures of positive selection for environmental adaptation in indigenous African cattle: A review., Sumaya Kambal, Abdulfatai Tijjani, Sabah A E Ibrahim, Mohamed-Khair A Ahmed, Joram M Mwacharo, and Olivier Hanotte
Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging., Emin Onur Karakaslar, Neerja Katiyar, Muneer G. Hasham, Ahrim Youn, Siddhartha Sharma, Cheng-Han Chung, Radu Marches, Ron Korstanje, Jacques Banchereau, and Duygu Ucar
An expectation-maximization framework for comprehensive prediction of isoform-specific functions., Guy Karlebach, Leigh Carmody, Jagadish Chandrabose Sundaramurthi, Elena Casiraghi, Peter Hansen, Justin Reese, Christopher J Mungall, Giorgio Valentini, and Peter N Robinson
Aon: a service to augment Alliance Genome Resource data with additional species., Sophie K Kearney, Alexander Berger, and Erich Baker
Global and tissue-specific aging effects on murine proteomes., Gregory R Keele, Ji-Gang Zhang, John Szpyt, Ron Korstanje, Steven P Gygi, Gary Churchill, and Devin K Schweppe
Associations between HLA class II alleles and IgE sensitization to allergens in the Qatar Biobank cohort, Taushif Khan, Isabella Marie Ledoux, Ferdousey Aziz, Fatima Al Ali, Evonne Chin-Smith, Manar Ata, Mohammed Yousuf Karim, and Nico Mar
Evaluation of tarsal injuries in C57BL/6J male mice., Brenda Kick, Laura C. Anderson, Rosalinda A. Doty, Christine Wooley, Meaghan E Dyer, Torrian L Green, Veronica Knickerbocker, Zoe Brown, Samantha Loeber, Janine M Wotton, Bonnie L. Lyons, Linda L Waterman, and Zoë Bichler
Inference of Admixture Origins in Indigenous African Cattle., Kwondo Kim, Donghee Kim, Olivier Hanotte, Charles Lee, Heebal Kim, and Choongwon Jeong
Diffuse alveolar hemorrhage in children with interstitial lung disease: Determine etiologies!, Katrin Knoflach, Christina Katharina Rapp, Nicolaus Schwerk, Julia Carlens, Martin Wetzke, Nagehan Emiralioğlu, Nural Kiper, Astrid Madsen Ring, Frederik Buchvald, Effrosyni Manali, Spyros Papiris, Simone Reu-Hofer, Matthias Kappler, Alexandra Schieber, Elias Seidl, Florian Gothe, Peter N Robinson, and Matthias Griese
Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia., Katherine Knorr, Jahan Rahman, Caroline Erickson, Eric Wang, Mara Monetti, Zhuoning Li, Juliana Ortiz-Pacheco, Andrew Jones, Sydney X Lu, Robert F Stanley, Maria Baez, Nina Fox, Cynthia Castro, Alessandra E Marino, Caroline Jiang, Alex Penson, Simon J Hogg, Xiaoli Mi, Hideaki Nakajima, Hiroyoshi Kunimoto, Koutarou Nishimura, Daichi Inoue, Benjamin Greenbaum, David Knorr, Jeffrey Ravetch, and Omar Abdel-Wahab
High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight., Austin C Korgan, Klausen Oliveira-Abreu, Wei Wei, Sophie L A Martin, Zoey J D Bridges, José Henrique Leal-Cardoso, Catherine Kaczorowski, and Kristen M S O'Connell
A genome-wide CRISPR activation screen identifies, Dinesh B Uthaya Kumar, Marina Yurieva, Jessica D S Grassmann, Lina Kozhaya, Caleb Dante McBride, Derya Unutmaz, and Adam Williams
Canine as a Comparative and Translational Model for Human Mammary Tumor., Jee Young Kwon, Nicholas Moskwa, Wonyoung Kang, Timothy M Fan, and Charles Lee
GA4GH Phenopackets: A Practical Introduction., Markus S Ladewig, Julius O B Jacobsen, Alex H Wagner, Daniel Danis, Baha El Kassaby, Michael Gargano, Tudor Groza, Michael Baudis, Robin Steinhaus, Dominik Seelow, Nikolaos E Bechrakis, Christopher J Mungall, Paul N Schofield, Olivier Elemento, Lindsay Smith, Julie A McMurry, Monica Munoz-Torres, Melissa A Haendel, and Peter N Robinson
Focused ultrasound-mediated brain genome editing., Yeh-Hsing Lao, Robin Ji, Joyce K Zhou, Kathy J. Snow, Nancy Kwon, Ethan Saville, Siyu He, Shradha Chauhan, Chun-Wei Chi, Malika S Datta, Hairong Zhang, Chai Hoon Quek, S Sarah Cai, Mingqiang Li, Yaned Gaitan, Lawrence Bechtel, Shih-Ying Wu, Cathleen Lutz, Raju Tomer, Stephen A. Murray, Alejandro Chavez, Elisa E Konofagou, and Kam W Leong
Myocardial Biomechanics and the Consequent Differentially Expressed Genes of the Left Atrial Ligation Chick Embryonic Model of Hypoplastic Left Heart Syndrome., S Samaneh Lashkarinia, Wei Xuan Chan, Efthymios Motakis, Sheldon Ho, Hummaira Banu Siddiqui, Mervenur Coban, Bortecine Sevgin, Kerem Pekkan, and Choon Hwai Yap
Aberrant RNA Splicing and Therapeutic Reprogramming in Cancer, Nathan Leclair, Brittany Lynn Angarola, and Olga Anczuków
Compendium-Wide Analysis of Pseudomonas aeruginosa Core and Accessory Genes Reveals Transcriptional Patterns across Strains PAO1 and PA14., Alexandra J Lee, Georgia Doing, Samuel L Neff, Taylor Reiter, Deborah A Hogan, and Casey S Greene
Chow diet in mouse aging studies: nothing regular about it., Jennifer Lee, Chloe Purello, Sarah L Booth, Brian Bennett, Christopher D Wiley, and Ron Korstanje
Myostatin: A Skeletal Muscle Chalone., Se-Jin Lee
Challenges and Future Prospects of Targeting Myostatin/Activin A Signaling to Treat Diseases of Muscle Loss and Metabolic Dysfunction., Se-Jin Lee, Shalender Bhasin, Lloyd Klickstein, Venkatesh Krishnan, and Daniel Rooks
Lipid alternations in the plasma of COVID-19 patients with various clinical presentations., Xiao Liang, Xin Qi, Jin Yang, Xiaorui Wang, Hongyu Qin, Fang Hu, Han Bai, Yixin Li, Chengsheng Zhang, and Bingyin Shi
The RSNA Cervical Spine Fracture CT Dataset., Hui Ming Lin, Errol Colak, Tyler Richards, Felipe C Kitamura, Luciano M Prevedello, Jason Talbott, Robyn L Ball, Ekim Gumeler, Kristen W Yeom, Mohammad Hamghalam, Amber L Simpson, Jasna Strika, Deniz Bulja, Salita Angkurawaranon, Almudena Pérez-Lara, María Isabel Gómez-Alonso, Johanna Ortiz Jiménez, Jacob J Peoples, Meng Law, Hakan Dogan, Emre Altinmakas, Ayda Youssef, Yasser Mahfouz, Jayashree Kalpathy-Cramer, Adam E Flanders, and RSNA-ASSR-ASNRAnnotatorsandtheDataset Curation Contributors
Inferring the Cancer Cellular Epigenome Heterogeneity via DNA Methylation Patterns., Sheng Li
Trackable and scalable LC-MS metabolomics data processing using asari., Shuzhao Li, Amnah Siddiqa, Maheshwor Thapa, Yuanye Chi, and Shujian Zheng
Generalized Tree Structure to Annotate Untargeted Metabolomics and Stable Isotope Tracing Data., Shuzhao Li and Shujian Zheng
A signature of five 7-methylguanosine-related genes is a prognostic marker for lung squamous cell carcinoma., Wensheng Liu, Ying Wang, Paola Ulivi, Simona Tavolari, Syed A A Rizvi, Enrico Capobianco, Alfons Navarro, and Yongjun Zhang
Robustness of single-cell RNA-seq for identifying differentially expressed genes., Yong Liu, Jing Huang, Rajan Pandey, Pengyuan Liu, Bhavika Therani, Qiongzi Qiu, Sridhar Rao, Aron M Geurts, Allen W Cowley, Andrew S Greene, and Mingyu Liang
Simultaneous multifunctional transcriptome engineering by CRISPR RNA scaffold., Zukai Liu, Nathaniel L. Jillette, Paul Robson, and Albert Cheng
Adaptive Sentinel Testing in Workplace for COVID-19 Pandemic., Yi Li, Mandy Chen, Joshy George, Edison Liu, and Radha Krishna Murthy Karuturi
OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity., Adriana Lofrano-Porto, Sidney Alcântara Pereira, Andrew Dauber, Jordana Cb Bloom, Audrey N Fontes, Naomi Asimow, Olívia Laquis de Moraes, Petra Ariadne T Araujo, Ana Paula Abreu, Michael H Guo, Silviene Fabiana De Oliveira, Han Liu, Charles Lee, Wendy Kuohung, Michella S Coelho, Rona S Carroll, Rulang Jiang, and Ursula B Kaiser
ISSCR standards for the use of human stem cells in basic research., Tenneille E Ludwig, Peter W Andrews, Ivana Barbaric, Nissim Benvenisty, Anita Bhattacharyya, Jeremy M Crook, Laurence M Daheron, Jonathan S Draper, Lyn E Healy, Meritxell Huch, Maneesha S Inamdar, Kim B Jensen, Andreas Kurtz, Madeline A Lancaster, Prisca Liberali, Matthias P Lutolf, Christine L Mummery, Martin Pera, Yoji Sato, Noriko Shimasaki, Austin G Smith, Jihwan Song, Claudia Spits, Glyn Stacey, Christine A Wells, Tongbiao Zhao, and Jack T Mosher
Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus., Jens Luebeck, Alvin Wei Tian Ng, Patricia C Galipeau, Xiaohong Li, Carissa A Sanchez, Annalise C Katz-Summercorn, Hoon Kim, Sriganesh Jammula, Yudou He, Scott M Lippman, Roel G W Verhaak, Carlo C Maley, Ludmil B Alexandrov, Brian J Reid, Rebecca C Fitzgerald, Thomas G Paulson, Howard Y Chang, Sihan Wu, Vineet Bafna, and Paul S Mischel
Exon-intron boundary inhibits m, Zhiyuan Luo, Qilian Ma, Shan Sun, Ningning Li, Hongfeng Wang, Zheng Ying, and Shengdong Ke
The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4., Alana Luzzio, Sarah Edie, Kristina Palmer, L Brianna Caddle, Rachel Urban, Leslie Goodwin, Ian C Welsh, Laura G Reinholdt, David E. Bergstrom, Timothy C Cox, Leah Rae Donahue, and Stephen A. Murray
New insight into the causes, consequences, and correction of hematopoietic stem cell aging., Els Mansell, Dawn S Lin, Stephen J Loughran, Michael D Milsom, and Jennifer J. Trowbridge
Genomic characterization of an esthesioneuroblastoma with spinal metastases: illustrative case., Bianca M Marin, Nathan K Leclair, Erica Shen, Avery Buehler, Upendra P Hegde, Qian Wu, Kevin Becker, Lei Li, Seth Brown, Leo J Wolansky, Hilary Onyiuke, David Choi, and Ketan R Bulsara
Sex and molecular differences in cardiovascular parameters at peak influenza disease in mice., Brigitte E Martin, Erin B Taylor, Esinam M Attipoe, Wenjie Wu, David E Stec, Kurt C Showmaker, and Michael R Garrett
Clinically relevant mouse models of Charcot-Marie-Tooth type 2S., Paige B Martin, Sarah E Holbrook, Amy N Hicks, Timothy J Hines, Laurent P. Bogdanik, Robert W. Burgess, and Gregory A. Cox
The case for standardizing gene nomenclature in vertebrates., Fiona M McCarthy, Tamsin E M Jones, Anne E Kwitek, Cynthia Smith, Peter D Vize, Monte Westerfield, and Elspeth A Bruford
Africa-specific human genetic variation near CHD1L associates with HIV-1 load., Paul J McLaren, Immacolata Porreca, Gennaro Iaconis, Hoi Ping Mok, Subhankar Mukhopadhyay, Emre Karakoc, Sara Cristinelli, Cristina Pomilla, István Bartha, Christian W Thorball, Riley H Tough, Paolo Angelino, Cher S Kiar, Tommy Carstensen, Segun Fatumo, Tarryn Porter, Isobel Jarvis, William C Skarnes, Andrew Bassett, Marianne K DeGorter, Mohana Prasad Sathya Moorthy, Jeffrey F Tuff, Eun-Young Kim, Miriam Walter, Lacy M Simons, Arman Bashirova, Susan Buchbinder, Mary Carrington, Andrea Cossarizza, Andrea De Luca, James J Goedert, David B Goldstein, David W Haas, Joshua T Herbeck, Eric O Johnson, Pontiano Kaleebu, William Kilembe, Gregory D Kirk, Neeltje A Kootstra, Alex H Kral, Olivier Lambotte, Ma Luo, Simon Mallal, Javier Martinez-Picado, Laurence Meyer, José M Miro, Pravi Moodley, Ayesha A Motala, James I Mullins, Kireem Nam, Niels Obel, Fraser Pirie, Francis A Plummer, Guido Poli, Matthew A Price, Andri Rauch, Ioannis Theodorou, Alexandra Trkola, Bruce D Walker, Cheryl A Winkler, Jean-François Zagury, Stephen B Montgomery, Angela Ciuffi, Judd F Hultquist, Steven M Wolinsky, Gordon Dougan, Andrew M L Lever, Deepti Gurdasani, Harriet Groom, Manjinder S Sandhu, and Jacques Fellay
Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins., Jeanette M Metzger, Yuyuan Wang, Samuel S Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie, Dongdong Li, Yi Zhao, Matthew T Flowers, Heather A Simmons, Subhojit Roy, Krishanu Saha, Jon E Levine, Marina E Emborg, and Shaoqin Gong
Spindle assembly checkpoint insensitivity allows meiosis-II despite chromosomal defects in aged eggs., Aleksandar I Mihajlović, Candice Byers, Laura G Reinholdt, and Greg FitzHarris
Combination Organelle Mitochondrial Endoplasmic Reticulum Therapy (COMET) for Multidrug Resistant Breast Cancer., Lara Scheherazade Milane, Saket Dolare, Guangwen Ren, and Mansoor Amiji
HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis., Jayna J Mistry, Kristian Bowles, and Stuart A Rushworth
In Vivo Imaging of Bone Marrow Long-Chain Fatty Acid Uptake., Jayna J Mistry and Stuart A Rushworth
Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay., Kousuke Mouri, Hannah B Dewey, Rodrigo Castro, Daniel Berenzy, Susan Kales, and Ryan Tewhey
High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos., Patience Mukashyaka, Pooja A Kumar, David J Mellert, Shadae Nicholas, Javad Noorbakhsh, Mattia Brugiolo, Elise T Courtois, Olga Anczuków, Edison Liu, and Jeffrey Chuang
An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response., George Murray, Jason A. Bubier, Oraya Zinder, Belinda S. Harris, James Clark, Mia-Cara Christopher, Courtany Hanley, Harianto Tjong, Meihong Li, Chew Yee Ngan, Laura G Reinholdt, Robert W. Burgess, and Abigail L D Tadenev
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022., Nikita Narayan Naik, Bharadwaja Vadloori, Suresh Poosala, Pratima Srivastava, Sandra Coecke, Adrian Smith, Aysha Akhtar, Clive Roper, Sridhar Radhakrishnan, Balaji Bhyravbhatla, Madhujit Damle, Venkat Koushik Pulla, Johannes Hackethal, Reyk Horland, Albert P Li, Falguni Pati, Manu Smriti Singh, Paola Occhetta, Rohit Bisht, Prajakta Dandekar, Krishna Bhagavatula, Dasja Pajkrt, Michael Johnson, Tilo Weber, John Huang, Lisiena Hysenaj, Banerjee Mallar, Bhat Ramray, Santosh Dixit, Shreekanth Joshi, and Mandar Kulkarni
Papillary thyroid cancer immune phenotypes via tumor-infiltrating lymphocyte spatial analysis., Myungwoo Nam, Woojung Yang, Hye Sung Kim, Jewel Park, Gahee Park, Sukjun Kim, Sanghoon Song, Chan-Young Ock, Victor G Wang, Jeffrey Chuang, and Young Kwang Chae
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS., Djamel Nehar-Belaid, Mark Sokolowski, Sathyabaarathi Ravichandran, Jacques Banchereau, Damien Chaussabel, and Duygu Ucar
Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8, and Their Binding Proteins Follistatin and Follistatin-Like Protein-3 With Dementia and Cognition., Anne B Newman, Sheena Patel, Jorge R Kizer, Se-Jin Lee, Shalinder Bhasin, Peggy Cawthon, Nathan LeBrasseur, Russel P Tracy, Peter Ganz, and Steven R Cummings
Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations., Nima Nouri, Raquel Giacomelli Cao, Eleonora Bunsow, Djamel Nehar-Belaid, Radu Marches, Zhaohui Xu, Bennett Smith, Santtu Heinonen, Sara Mertz, Amy Leber, Gaby Smits, Fiona van der Klis, Asunción Mejías, Jacques Banchereau, Virginia Pascual, and Octavio Ramilo
Generation of four gene-edited human induced pluripotent stem cell lines with mutations in the ATM gene to model Ataxia-Telangiectasia., Wasifa Nurieva, Elena Ivanova, Sanabel Chehab, Parth Singh, Marina Reichlmeir, Karoly Szuhai, Georg W J Auburger, William C Skarnes, and Zoltán Ivics
Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice., Manuela A Oestereicher, Janine M Wotton, Shinya Ayabe, Ghina Bou About, Tsz Kwan Cheng, Jae-Hoon Choi, Dave Clary, Emily M Dew, Lahcen Elfertak, Alain Guimond, Hamed Haseli Mashhadi, Jason D Heaney, Lois Kelsey, Piia Keskivali-Bond, Federico Lopez Gomez, Susan Marschall, Michael McFarland, Hamid Meziane, Violeta Munoz Fuentes, Ki-Hoan Nam, Zuzana Nichtová, Dale Pimm, Lynette Bower, Jan Prochazka, Jan Rozman, Luis Santos, Michelle Stewart, Nobuhiko Tanaka, Christopher S Ward, Amelia M Willett, Robert Wilson, Robert E Braun, Mary E Dickinson, Ann M Flenniken, Yann Herault, K C Kent Lloyd, Ann-Marie Mallon, Colin McKerlie, Stephen A. Murray, Lauryl M J Nutter, Radislav Sedlacek, Je Kyung Seong, Tania Sorg, Masaru Tamura, Sara Wells, Elida Schneltzer, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Jacqueline K White, and Nadine Spielmann
Reduction in GABAB on glia induce Alzheimer's disease related changes., Amanda M Leisgang Osse, Ravi S Pandey, Ryan A Wirt, Andrew A Ortiz, Arnold Salazar, Michael Kimmich, Erin N Toledano Strom, Adrian Oblak, Bruce Lamb, James M Hyman, Gregory W. Carter, and Jefferson Kinney
Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease., Ravi S Pandey, Kevin P Kotredes, Michael Sasner, Gareth R Howell, and Gregory W. Carter
Seven days in the life cycle of Homo sapiens., Martin Pera
Transcriptomic responses in the blood and sputum of cigarette smokers compared to e-cigarette vapers., Mario F Perez, Marina Yurieva, Spandana Poddutoori, Eric M Mortensen, Laura E Crotty Alexander, and Adam Williams
PDCM Finder: an open global research platform for patient-derived cancer models., Zinaida Perova, Mauricio Martinez, Tushar Mandloi, Federico Lopez Gomez, Csaba Halmagyi, Alex Follette, Jeremy Mason, Steven Neuhauser, Dale A. Begley, Debra M Krupke, Carol J Bult, Helen Parkinson, and Tudor Groza
Whole genome analysis for 163 gRNAs in Cas9-edited mice reveals minimal off-target activity., Kevin A Peterson, Sam Khalouei, Nour Hanafi, Joshua A Wood, Denise G Lanza, Lauri G Lintott, Brandon J Willis, John R Seavitt, Robert E Braun, Mary E Dickinson, Jacqueline K White, K C Kent Lloyd, Jason D Heaney, Stephen A. Murray, Arun Ramani, and Lauryl M J Nutter
PLS3 missense variants affecting the actin-binding domains cause X-linked congenital diaphragmatic hernia and body-wall defects., Florence Petit, Mauro Longoni, Julie Wells, Richard S. Maser, Eric L Bogenschutz, Matthew J Dysart, Hannah T M Contreras, Frederic Frénois, Barbara R Pober, Robin D Clark, Philip F Giampietro, Hilger H Ropers, Hao Hu, Maria Loscertales, Richard Wagner, Xingbin Ai, Harrison Brand, Anne-Sophie Jourdain, Marie-Ange Delrue, Brigitte Gilbert-Dussardier, Louise Devisme, Boris Keren, David J McCulley, Lu Qiao, Rebecca Hernan, Julia Wynn, Tiana M Scott, Daniel G Calame, Zeynep Coban-Akdemir, Patricia Hernandez, Andres Hernandez-Garcia, Hagith Yonath, James R Lupski, Yufeng Shen, Wendy K Chung, Daryl A Scott, Carol J Bult, Patricia K Donahoe, and Frances A High
Gene expression genetics of the striatum of Diversity Outbred mice., Vivek M. Philip, Haoxi Chai, Michael C Saul, Price E Dickson, Jason A. Bubier, and Elissa J Chesler
A comparison of DNA sequencing and gene expression profiling to assist tissue of origin diagnosis in cancer of unknown primary., Atara Posner, Owen Wj Prall, Tharani Sivakumaran, Dariush Etemadamoghadam, Niko Thio, Andrew Pattison, Shiva Balachander, Krista Fisher, Samantha Webb, Colin Wood, Anna DeFazio, Nicholas Wilcken, Bo Gao, Christos S Karapetis, Madhu Singh, Ian M Collins, Gary Richardson, Christopher Steer, Mark Warren, Narayan Karanth, Gavin Wright, Scott Williams, Joshy George, Rodney J Hicks, Alex Boussioutas, Anthony J Gill, Benjamin J Solomon, Huiling Xu, Andrew Fellowes, Stephen B Fox, Penelope Schofield, David Bowtell, Linda Mileshkin, and Richard W Tothill
Semantic representation of neural circuit knowledge in Caenorhabditis elegans., Sharan J Prakash, Kimberly M Van Auken, David P. Hill, and Paul W Sternberg
The Precision Toxicology initiative., PrecisionTox Consortium
Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin., Tara R Price, Donnie S Stapleton, Kathryn L Schueler, Marie K Norris, Brian W Parks, Brian S Yandell, Gary Churchill, William L Holland, Mark P Keller, and Alan D Attie
The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina., Mathilde Pruvost, Julia Patzig, Camila Yattah, Ipek Selcen, Marylens Hernandez, Hye-Jin Park, Sarah Moyon, Shibo Liu, Malia S Morioka, Lindsay S. Shopland, Osama Al-Dalahmah, Jaroslav Bendl, John F Fullard, Panos Roussos, James Goldman, Ye He, Jeffrey L Dupree, and Patrizia Casaccia
STOP-AD portal: Selecting the optimal pharmaceutical for preclinical drug testing in Alzheimer's disease., Sara K Quinney, Kandasamy Murugesh, Adrian Oblak, Kristen D. Onos, Michael Sasner, Anna K Greenwood, Kara H Woo, Stacey J Sukoff Rizzo, and Paul R Territo
Loss of resilience contributes to detrusor underactivity in advanced age., Ramalakshmi Ramasamy, Dylan Baker, Fouad Lemtiri-Chlieh, Dawn A Rosenberg, Eric Woon, Iman M Al-Naggar, Cara C Hardy, Eric S Levine, George A Kuchel, Jenna M Bartley, and Phillip P Smith
Statistical Learning Methods to Identify Nonwear Periods From Accelerometer Data, Sahrej Randhawa, Manoj Sharma, Madalina Fiterau, Jorge A. Banda, Farish Haydel, Kristopher Kapphahn, Donna Matheson, Hyatt Moore IV, Robyn L Ball, Clete Kushida, Scott Delp, Dennis P. Wall, Thomas Robinson, and Manisha Desai
Advancing sepsis clinical research: harnessing transcriptomics for an omics-based strategy - a comprehensive scoping review, Asrar Rashid, Feras Al-Obeidat, Hari Krishnan Kanthimathinathan, Govind Benakatti, Wael Hafez, Raghu Ramiah, Joe Brierley, Benjamin Hanisch, Praveen Khilnani, Christos Kouentis, Berit S. Brusletto, Mohammed Toufiq, Zain Hussain, Harish Vyas, Zainab A. Malik, Maike Schumacher, Rayaz Malik, Shriprasad Deshpande, Nasir Quraishi, Raziya Kadwa, Amrita Sarpal, M. Guftar Shaikh, Javed Sharief, Syed Ahmed Zaki, Rajesh Phatak, Akash Deep, Ahmed Al-Dubai, and Amir Hussain
A dual covariant biomarker approach to Kawasaki disease, using vascular endothelial growth factor A and B gene expression; implications for coronary pathogenesis, Asrar Rashid, Govind Benakatti, Feras Al-Obeidat, Rajesh Phatak, Zainab A. Malik, Javed Sharief, Raziya Kadwa, Wael Hafez, Mohammed Toufiq, Damien Chaussabel, Rayaz Malik, Nasir Quraishi, Syed Ahmed Zaki, Guftar Shaikh, and Amir Hussain