Submissions from 2024
A serum-induced gene signature in hepatocytes is associated with pediatric nonalcoholic fatty liver disease., T Hang Nghiem-Rao, Jethro Johnson, Amy Pan, Samantha N Atkinson, Cynthia Behling, Pippa M Simpson, Mary L Holtz, George M. Weinstock, Jeffrey B Schwimmer, and Nita H Salzman
Using paired-end read orientations to assess technical biases in capture Hi-C., Peter Hansen, Hannah Blau, Jochen Hecht, Guy Karlebach, Alexander Krannich, Robin Steinhaus, Matthias Truss, and Peter N Robinson
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used., David E Harrison, Randy Strong, Peter C. Reifsnyder, Nadia Rosenthal, Ron Korstanje, Elizabeth Fernandez, Kevin Flurkey, Brett C Ginsburg, Meredith D Murrell, Martin A Javors, Marisa Lopez-Cruzan, James F Nelson, Bradley J Willcox, Richard Allsopp, David M Watumull, David G Watumull, Gino Cortopassi, James L Kirkland, Tamar Tchkonia, Young Geun Choi, Matthew J Yousefzadeh, Paul D Robbins, James R Mitchell, Murat Acar, Ethan A Sarnoski, Michael R Bene, Adam Salmon, Navasuja Kumar, and Richard A Miller
Proteins required for stereocilia elongation during mammalian hair cell development ensure precise and steady heights during adult life., Elli I Hartig, Matthew Day, Amandine Jarysta, and Basile Tarchini
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice., Zainul S Hasanali, Alfred L Garfall, Lisa Burzenski, Leonard D. Shultz, Yan Tang, Siddhant Kadu, Neil C Sheppard, Wei Liu, Derek Dopkin, Dan T Vogl, Adam D Cohen, Adam J Waxman, Sandra P Susanibar-Adaniya, Martin Carroll, Edward A Stadtmauer, and David Allman
Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche., Yasmin Henlon, Kavita Panir, Iona McIntyre, Chloe Hogg, Priya Dhami, Antonia O Cuff, Anna Senior, Niky Moolchandani-Adwani, Elise T Courtois, Andrew W Horne, Matthew Rosser, Sascha Ott, and Erin Greaves
Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease., Sarah E Heuer, Erik B Bloss, and Gareth R Howell
Control of hippocampal synaptic plasticity by microglia-dendrite interactions depends on genetic context in mouse models of Alzheimer's disease., Sarah E Heuer, Kelly J Keezer, Amanda A Hewes, Kristen D. Onos, Kourtney Graham, Gareth R Howell, and Erik B Bloss
Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits., Sarah E Heuer, Emily W Nickerson, Gareth R Howell, and Erik B Bloss
Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior., David A Hillis, Liran Yadgary, George M. Weinstock, Fernando Pardo-Manuel de Villena, Daniel Pomp, and Theodore Garland
TTN truncation variants produce sarcomere-integrating proteins of uncertain functional significance., J Travis Hinson and Stuart G Campbell
Clinically relevant mouse models of severe spinal muscular atrophy with respiratory distress type 1., Sarah E Holbrook, Amy N Hicks, Paige B Martin, Timothy J Hines, Harold P Castro, and Gregory A. Cox
Early molecular events of autosomal-dominant Alzheimer's disease in marmosets with PSEN1 mutations., Gregg E Homanics, Jung Eun Park, Lauren Bailey, David J Schaeffer, Lauren Schaeffer, Jie He, Shuoran Li, Tingting Zhang, Annat Haber, Catrina Spruce, Anna Greenwood, Takeshi Murai, Laura Schultz, Lauren Mongeau, Seung-Kwon Ha, Julia Oluoch, Brianne Stein, Sang Ho Choi, Hasi Huhe, Amantha Thathiah, Peter L Strick, Gregory W. Carter, Afonso C Silva, and Stacey J Sukoff Rizzo
Improved DNA Extraction and Amplification Strategy for 16S rRNA Gene Amplicon-Based Microbiome Studies., Bo-Young Hong, Mark Driscoll, Dawn Gratalo, Thomas Jarvie, and George M. Weinstock
Impact and characterization of serial structural variations across humans and great apes., Wolfram Höps, Tobias Rausch, Michael Jendrusch, Jan O Korbel, and Fritz J Sedlazeck
Chapter 18 - Genetic modification of mice using CRISPR-Cas9: Best practices and practical concepts explained, Vishnu Hosur, Benjamin E. Low, and Michael V. Wiles
Instrumented swim test for quantifying motor impairment in rodents., Natasha C Hughes, Dale C Roberts, Basile Tarchini, and Kathleen E Cullen
3D convolutional neural networks predict cellular metabolic pathway use from fluorescence lifetime decay data., Linghao Hu, Daniela De Hoyos, Yuanjiu Lei, A Phillip West, and Alex J Walsh
3-Hydroxyanthranilic Acid Delays Paralysis in, Bradford T Hull, Kayla M Miller, Caroline Corban, Grant Backer, Susan Sheehan, Ron Korstanje, and George L. Sutphin
Advancing stem cell technologies for conservation of wildlife biodiversity., Ashlee M Hutchinson, Ruth Appeltant, Tom Burdon, Qiuye Bao, Rhishikesh Bargaje, Andrea Bodnar, Stuart Chambers, Pierre Comizzoli, Laura Cook, Yoshinori Endo, Bob Harman, Katsuhiko Hayashi, Thomas Hildebrandt, Marisa L Korody, Uma Lakshmipathy, Jeanne F Loring, Clara Munger, Alex H M Ng, Ben Novak, Manabu Onuma, Sara Ord, Monique Paris, Andrew J Pask, Francisco Pelegri, Martin Pera, Ryan Phelan, Benyamin Rosental, Oliver A Ryder, Woranop Sukparangsi, Gareth Sullivan, Nicole Liling Tay, Nikki Traylor-Knowles, Shawn Walker, Antonia Weberling, Deanne J Whitworth, Suzannah A Williams, Jessye Wojtusik, Jun Wu, Qi-Long Ying, Thomas P Zwaka, and Timo N Kohler
Hypertonic Saline Induces Host Protective Immune Responses against, Tran Xuan Ngoc Huy, Trang Thi Nguyen, Said Abdi Salad, Ched Nicole Turbela Aguilar, Alisha Wehdnesday Bernardo Reyes, Lauren Togonon Arayan, WonGi Min, Hu Jang Lee, Huynh Tan Hop, and Suk Kim
Assessing the Performance of Models from the 2022 RSNA Cervical Spine Fracture Detection Competition at a Level I Trauma Center., Zixuan Hu, Markand Patel, Robyn L Ball, Hui Ming Lin, Luciano M Prevedello, Mitra Naseri, Shobhit Mathur, Robert Moreland, Jefferson Wilson, Christopher Witiw, Kristen W Yeom, Qishen Ha, Darragh Hanley, Selim Seferbekov, Hao Chen, Philipp Singer, Christof Henkel, Pascal Pfeiffer, Ian Pan, Harshit Sheoran, Wuqi Li, Adam E Flanders, Felipe C Kitamura, Tyler Richards, Jason Talbott, Ervin Sejdić, and Errol Colak
Microlearning: Evidence-based education that is effective for busy professionals and short attention spans., Therese Ingram, Emily A Edelman, Linda Steinmark, Kalisi Logan, and Kate Reed
Integrative analysis of RNA-sequencing and microarray for the identification of adverse effects of UVB exposure on human skin., Yujin Jang, Hye-Won Na, Dong Yeop Shin, Jun Lee, Jun Pyo Han, Hyun Soo Kim, Su Ji Kim, Eun-Jeong Choi, Charles Lee, Yong Deog Hong, Hyoung-June Kim, and Young Rok Seo
Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis., Amandine Jarysta, Abby Tadenev, Matthew Day, Barry Krawchuk, Benjamin E. Low, Michael V. Wiles, and Basile Tarchini
Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein., Bu-Nam Jeon, Sujeong Kim, Yunjae Kim, Hyunkyung Yu, Changho Park, Gihyeon Kim, Youngeun Ha, Gyeong-Yeon Kim, Hyunuk Kim, Karolina Palucka, Charles Lee, Miyoung Cha, and Hansoo Park
A systematic strategy for identifying causal single nucleotide polymorphisms and their target genes on Juvenile arthritis risk haplotypes., Kaiyu Jiang, Tao Liu, Susan Kales, Ryan Tewhey, Dongkyeong Kim, Yungki Park, and James N Jarvis
An emerging multi-omic understanding of the genetics of opioid addiction., Eric O Johnson, Heidi S Fisher, Kyle A Sullivan, Olivia Corradin, Sandra Sanchez-Roige, Nathan C Gaddis, Yasmine N Sami, Alice Townsend, Erica Teixeira Prates, Mirko Pavicic, Peter Kruse, Elissa J Chesler, Abraham A Palmer, Vanessa Troiani, Jason A. Bubier, Daniel A Jacobson, and Brion S Maher
Activity-dependent transcriptional programs in memory regulate motor recovery after stroke., Mary T Joy and S Thomas Carmichael
Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells., Alma Jukic, Zhengchang Lei, Elizabeth R Cebul, Katherine Pinter, Yommi Tadesse, Amandine Jarysta, Sandeep David, Natalie Mosqueda, Basile Tarchini, and Katie Kindt
Chemokines in the tumor microenvironment: implications for lung cancer and immunotherapy., Haebeen Jung and Silke Paust
Autoregulated splicing of TRA2β programs T cell fate in response to antigen-receptor stimulation, Timofey A Karginov, Antoine Ménoret, Nathan Leclair, Andrew G Harrison, Karthik Chandiran, Jenny E Suarez-Ramirez, Marina Yurieva, Keaton Karlinsey, Penghua Wang, Rachel J O'Neill, Patrick A Murphy, Adam J Adler, Linda S Cauley, Olga Anczuków, Beiyan Zhou, and Anthony T Vella
IsopretGO-analysing and visualizing the functional consequences of differential splicing., Guy Karlebach, Peter Hansen, Kristin Köhler, and Peter N Robinson
Alternative splicing is coupled to gene expression in a subset of variably expressed genes., Guy Karlebach, Robin Steinhaus, Daniel Danis, Maeva Devoucoux, Olga Anczuków, Gloria Sheynkman, Dominik Seelow, and Peter N Robinson
Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML., Ataur Katebi, Xiaowen Chen, Daniel Ramirez, Sheng Li, and Mingyang Lu
Co-transfection of murine NXPE2 and murine glycophorin A confers reactivity with Ter-119., Gregory R Keele, Ariel M Hay, Nadia K Holness, Arijita Jash, Sarah E Ewald, Callan O'Connor, Matthew J Vincent, Monika Dzieciatkowska, Angelo D'Alessandro, Gary Churchill, and James C Zimring
Mapping extrachromosomal DNA amplifications during cancer progression., Hoon Kim, Soyeon Kim, Taylor E Wade, Eunchae Yeo, Anuja Lipsa, Anna Golebiewska, Kevin C Johnson, Sepil An, Junyong Ko, Yoonjoo Nam, Hwa Yeon Lee, Seunghyun Kang, Heesuk Chung, Simone P Niclou, Hyo-Eun Moon, Sun Ha Paek, Vineet Bafna, Jens Luebeck, and Roel G W Verhaak
Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor., Yunjae Kim, Gihyeon Kim, Sujeong Kim, Beomki Cho, Sang-Yeob Kim, Eun-Ju Do, Dong-Jun Bae, Seungil Kim, Mi-Na Kweon, Joon Seon Song, Sang Hyoung Park, Sung Wook Hwang, Mi-Na Kim, Yeongmin Kim, Kyungchan Min, Sung-Han Kim, Mark D Adams, Charles Lee, Hansoo Park, and Sook Ryun Park
Circulating Growth Differentiation Factors 11 and 8, Their Antagonists Follistatin and Follistatin-Like-3, and Risk of Heart Failure in Elders., Jorge R Kizer, Sheena Patel, Peter Ganz, Anne B Newman, Shalender Bhasin, Se-Jin Lee, Peggy M Cawthon, Nathan K LeBrasseur, Sanjiv J Shah, Bruce M Psaty, Russell P Tracy, and Steven R Cummings
Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics., Rebecca L Koch, James B Stanton, Susan McClatchy, Gary Churchill, Steven W Craig, Darian N Williams, Mallory E Johns, Kylah R Chase, Dana L Thiesfeldt, Jessica C Flynt, and Robert Pazdro
Evaluation of Alginate Hydrogel Microstrands for Stromal Cell Encapsulation and Maintenance., Sujith Chander Reddy Kollampally, Xulang Zhang, Nicholas Moskwa, Deirdre A Nelson, Susan T Sharfstein, Melinda Larsen, and Yubing Xie
Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever., Dylan Kotliar, Siddharth Raju, Shervin Tabrizi, Ikponmwosa Odia, Augustine Goba, Mambu Momoh, John Demby Sandi, Parvathy Nair, Eric Phelan, Ridhi Tariyal, Philomena E Eromon, Samar Mehta, Refugio Robles-Sikisaka, Katherine J Siddle, Matt Stremlau, Simbirie Jalloh, Stephen K Gire, Sarah Winnicki, Bridget Chak, Stephen F Schaffner, Matthias Pauthner, Elinor K Karlsson, Sarah R Chapin, Sharon G Kennedy, Luis M Branco, Lansana Kanneh, Joseph J Vitti, Nisha Broodie, Adrianne Gladden-Young, Omowunmi Omoniwa, Pan-Pan Jiang, Nathan Yozwiak, Shannon Heuklom, Lina M Moses, George O Akpede, Danny A Asogun, Kathleen Rubins, Susan Kales, Anise N Happi, Christopher O Iruolagbe, Mercy Dic-Ijiewere, Kelly Iraoyah, Omoregie O Osazuwa, Alexander K Okonkwo, Stefan Kunz, Joseph B McCormick, S Humarr Khan, Anna N Honko, Eric S Lander, Michael B A Oldstone, Lisa Hensley, Onikepe A Folarin, Sylvanus A Okogbenin, Stephan Günther, Hanna M Ollila, Ryan Tewhey, Peter O Okokhere, John S Schieffelin, Kristian G Andersen, Steven K Reilly, Donald S Grant, Robert F Garry, Kayla G Barnes, Christian T Happi, and Pardis C Sabeti
Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology., Kevin P Kotredes, Ravi S Pandey, Scott Persohn, Kierra Elderidge, Charles P Burton, Ethan W Miner, Kathryn A Haynes, Diogo Francisco S Santos, Sean-Paul Williams, Nicholas Heaton, Cynthia M Ingraham, Christopher Lloyd, Dylan Garceau, Rita O'Rourke, Sarah Herrick, Claudia Rangel-Barajas, Surendra Maharjan, Nian Wang, Michael Sasner, Bruce T Lamb, Paul R Territo, Stacey J Sukoff Rizzo, Gregory W. Carter, Gareth R Howell, and Adrian L Oblak
Improvement of variant reclassification in genetic neurodevelopmental conditions., Michelle Kowanda, Rebecca Sheedy Smith, Jamie Lundy, Catherine Kentros, Elisheva Kleinman, Lauren Kasparson Walsh, Gerhard Schratt, Cora M Taylor, and Wendy K Chung
B cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic, Deniz Koyuncu, Thomas Tavolara, Daniel Mario Gatti, Adam C Gower, Melanie L Ginese, Igor Kramnik, Bülent Yener, Usama Sajjad, Muhammad Khalid Khan Niazi, Metin Gurcan, Anas Alsharaydeh, and Gillian Beamer
NLGN4X TCR transgenic T cells to treat gliomas., Christoper Krämer, Michael Kilian, Yu-Chan Chih, Alexandros Kourtesakis, Dirk C Hoffmann, Tamara Boschert, Philipp Koopmann, Khwab Sanghvi, Alice De Roia, Stefanie Jung, Kristine Jähne, Bryan Day, Leonard D. Shultz, Miriam Ratliff, Richard Harbottle, Edward W Green, Rainer Will, Wolfgang Wick, Michael Platten, and Lukas Bunse
Oncogenic composite mutations can be predicted by co-mutations and their chromosomal location., Asli Küçükosmanoglu, Carolien L van der Borden, Lisanne E A de Boer, Roel G W Verhaak, David Noske, Tom Wurdinger, Teodora Radonic, and Bart A Westerman
Imputation of 3D genome structure by genetic-epigenetic interaction modeling in mice., Lauren Kuffler, Daniel A Skelly, Anne M Czechanski, Haley J Fortin, Steven C. Munger, Christopher L. Baker, Laura G Reinholdt, and Gregory W. Carter
Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells., Katarina Kulhankova, Anna X Cheng, Soumba Traore, Maud Auger, Mia Pelletier, Maxime Hervault, Kevin D Wells, Jonathan A Green, Addison Byrne, Benjamin Nelson, Mariana Sponchiado, Chandra Boosani, Caleb S Heffner, Kathy J. Snow, Stephen A. Murray, Raul A Villacreses, Michael V Rector, Nicholas D Gansemer, David A Stoltz, Chantal Allamargot, Frédéric Couture, Colin Hemez, Stéphanie Hallée, Xavier Barbeau, Mario Harvey, Coraline Lauvaux, Bruno Gaillet, Gregory A Newby, David R Liu, Paul B McCray, and David Guay
Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in genetically diverse mice., Sherry L Kurtz, Richard E Baker, Frederick J Boehm, Chelsea C Lehman, Lara R Mittereder, Hamda Khan, Amy P Rossi, Daniel M Gatti, Gillian Beamer, Christopher M Sassetti, and Karen L Elkins
Phenotypic similarity-based approach for variant prioritization for unsolved rare disease: a preliminary methodological report., David Lagorce, Emeline Lebreton, Leslie Matalonga, Oscar Hongnat, Maroua Chahdil, Davide Piscia, Ida Paramonov, Kornelia Ellwanger, Sebastian Köhler, Peter N Robinson, Holm Graessner, Sergi Beltran, Caterina Lucano, Marc Hanauer, and Ana Rath
Network-based analysis predicts interacting genetic modifiers from a meta-mapping study of spike-wave discharge in mice., Montana Kay Lara, Jeffrey L Brabec, Amanda E Hernan, Rod C Scott, Anna L. Tyler, and J Matthew Mahoney
Human Microbiome and Frailty: From Observations of Clinically Relevant Associations to Insights into Biological Mechanisms, Peter J Larson, Wei Zhou, Julie Robison, George A. Kuchel, and Julia Oh
RNA splicing as a biomarker and phenotypic driver of meningioma DNA-methylation groups., Nathan Leclair, Abrar Choudury, William C Chen, Stephen T Magill, Kathleen McCortney, Craig M Horbinski, Zhenhong Chen, Ezequiel Goldschmidt, Charlotte D Eaton, Ketan R Bulsara, Wenya Linda Bi, Akash J Patel, Felix Sahm, David Raleigh, and Olga Anczuków
Genomic sequencing of a pregnancy associated symptomatic meningioma of the diaphragma sellae: a case report., Nathan Leclair, William A Lambert, Qian Wu, Leo Wolansky, Kevin Becker, Lei Li, Lakshmi Leishangthem, and Ketan R Bulsara
The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in hypermitotic meningiomas., Nathan Leclair, Calixto-Hope G Lucas, Kanish Mirchia, Kathleen McCortney, Craig M Horbinski, David R Raleigh, and Olga Anczuków
Folate Deficiency and/or the Genetic Variant Mthfr(677C >T) Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner, Daniel Leclerc, Karen E Christensen, Alaina M Reagan, Vafa Keser, Yan Luan, Olga V Malysheva, Brandi Wasek, Teodoro Bottiglieri, Marie A Caudill, Gareth R Howell, and Rima Rozen
Comprehensive metabolomic analysis identifies key biomarkers and modulators of immunotherapy response in NSCLC patients., Se-Hoon Lee, Sujeong Kim, Jueun Lee, Yunjae Kim, Yanghyun Joo, Jun-Yeong Heo, Heeyeon Lee, Charles Lee, Geum-Sook Hwang, and Hansoo Park
David J. Glass elected to the U.S. National Academy of Sciences., Se-Jin Lee, Bruce Spiegelman, and Kevin Campbell
Emerging CRISPR Therapies for Precision Gene Editing and Modulation in the Cardiovascular Clinic., Nicholas J Legere and J Travis Hinson
An integrative TAD catalog in lymphoblastoid cell lines discloses the functional impact of deletions and insertions in human genomes., Chong Li, Marc Jan Bonder, Sabriya Syed, Matthew Jensen, Human Genome Structural Variation Consortium (HGSVC), HGSVC Functional Analysis Working Group, Mark B Gerstein, Michael C Zody, Mark J P Chaisson, Michael E Talkowski, Tobias Marschall, Jan O Korbel, Evan E Eichler, Charles Lee, and Xinghua Shi
Executing plans to enhance diversity across cancer centers in the United States: opportunities and challenges., Christopher I Li, Sherise Chantell Rogers, Carol J Bult, Carmen E Guerra, Angela Talton, Lovoria B Williams, and Wendy Law
Phenotype Distinctions in Mice Deficient in the Neuron-Specific α3 Subunit of Na,K-ATPase:, Yi Bessie Liu, Elena Arystarkhova, Amanda N Sacino, Margit V Szabari, Cathleen Lutz, Markus Terrey, Natalia S Morsci, Tatjana C Jakobs, Karin Lykke-Hartmann, Allison Brashear, Elenora Napoli, and Kathleen J Sweadner
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation., Jone López-Erauskin, Mariana Bravo-Hernandez, Maximiliano Presa, Michael W Baughn, Ze'ev Melamed, Melinda S Beccari, Ana Rita Agra de Almeida Quadros, Olatz Arnold-Garcia, Aamir Zuberi, Karen Ling, Oleksandr Platoshyn, Elkin Niño-Jara, I Sandra Ndayambaje, Melissa McAlonis-Downes, Larissa Cabrera, Jonathan W Artates, Jennifer L Ryan, Anita Hermann, John Ravits, C Frank Bennett, Paymaan Jafar-Nejad, Frank Rigo, Martin Marsala, Cathleen Lutz, Don W Cleveland, and Clotilde Lagier-Tourenne
Development and Application of Genetic Ancestry Reconstruction Methods to Study Diversity of Patient-Derived Models in the NCI PDXNet Consortium., Paul C Lott, Katherine Chiu, Juanita Elizabeth Quino, April Pangia Vang, Michael W Lloyd, Anuj Srivastava, Jeffrey Chuang, PDXNet Consortium, and Luis G Carvajal-Carmona
Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice., Alison Luciano, Laura Robinson, Gaven Garland, Bonnie Lyons, Ron Korstanje, Andrea Di Francesco, and Gary Churchill
The origin of genetic diversity of indigenous cockfighting chickens of Pakistan by analyzing the mtDNA., Sajid Mahmood, Mian Sayed Khan, Zaib Ullah, Raman Akinyanju Lawal, and Olivier Hanotte
Utility of long-read sequencing for All of Us., M Mahmoud, Y Huang, K Garimella, Peter A Audano, W Wan, N Prasad, R E Handsaker, S Hall, A Pionzio, M C Schatz, M E Talkowski, E E Eichler, S E Levy, and F J Sedlazeck
The complete sequence and comparative analysis of ape sex chromosomes., Kateryna D Makova, Brandon D Pickett, Robert S Harris, Gabrielle A Hartley, Monika Cechova, Karol Pal, Sergey Nurk, DongAhn Yoo, Qiuhui Li, Prajna Hebbar, Barbara C McGrath, Francesca Antonacci, Margaux Aubel, Arjun Biddanda, Matthew Borchers, Erich Bornberg-Bauer, Gerard G Bouffard, Shelise Y Brooks, Lucia Carbone, Laura Carrel, Andrew Carroll, Pi-Chuan Chang, Chen-Shan Chin, Daniel E Cook, Sarah J C Craig, Luciana de Gennaro, Mark Diekhans, Amalia Dutra, Gage H Garcia, Patrick G S Grady, Richard E Green, Diana Haddad, Pille Hallast, William T Harvey, Glenn Hickey, David A Hillis, Savannah J Hoyt, Hyeonsoo Jeong, Kaivan Kamali, Sergei L Kosakovsky Pond, Troy M LaPolice, Charles Lee, Alexandra P Lewis, Yong-Hwee E Loh, Patrick Masterson, Kelly M McGarvey, Rajiv C McCoy, Paul Medvedev, Karen H Miga, Katherine M Munson, Evgenia Pak, Benedict Paten, Brendan J Pinto, Tamara Potapova, Arang Rhie, Joana L Rocha, Fedor Ryabov, Oliver A Ryder, Samuel Sacco, Kishwar Shafin, Valery A Shepelev, Viviane Slon, Steven J Solar, Jessica M Storer, Peter H Sudmant, Sweetalana, Alex Sweeten, Michael G Tassia, Françoise Thibaud-Nissen, Mario Ventura, Melissa A Wilson, Alice C Young, Huiqing Zeng, Xinru Zhang, Zachary A Szpiech, Christian D Huber, Jennifer L Gerton, Soojin V Yi, Michael C Schatz, Ivan A Alexandrov, Sergey Koren, Rachel J O'Neill, Evan E Eichler, and Adam M Phillippy
The primate gut microbiota contributes to interspecific differences in host metabolism., Elizabeth K Mallott, Sahana Kuthyar, Won Lee, Derek Reiman, Hongmei Jiang, Sriram Chitta, E Alexandria Waters, Brian T Layden, Ronen Sumagin, Laura D Manzanares, Guan-Yu Yang, Maria Luisa Savo Sardaro, Stanton Gray, Lawrence E Williams, Yang Dai, James P Curley, Chad R Haney, Emma R Liechty, Christopher W Kuzawa, and Katherine R Amato
The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen., Tathiane M Malta, Thais S Sabedot, Natalia S Morosini, Indrani Datta, Luciano Garofano, Wies Vallentgoed, Frederick S Varn, Kenneth Aldape, Fulvio D'Angelo, Spyridon Bakas, Jill S Barnholtz-Sloan, Hui K Gan, Mohammad Hasanain, Ann-Christin Hau, Kevin C Johnson, Simona Cazacu, Ana C deCarvalho, Mustafa Khasraw, Emre Kocakavuk, Mathilde C M Kouwenhoven, Simona Migliozzi, Simone P Niclou, Johanna M Niers, D Ryan Ormond, Sun Ha Paek, Guido Reifenberger, Peter A Sillevis Smitt, Marion Smits, Lucy F Stead, Martin J van den Bent, Erwin G Van Meir, Annemiek Walenkamp, Tobias Weiss, Michael Weller, Bart A Westerman, Bauke Ylstra, Pieter Wesseling, Anna Lasorella, Pim J French, Laila M Poisson, Roel G W Verhaak, Antonio Iavarone, and Houtan Noushmehr
Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation., Edgar Martínez Duncker Rebolledo, Donovan Chan, Karen E Christensen, Alaina M Reagan, Gareth R Howell, Rima Rozen, and Jacquetta Trasler
A hematology-based clock derived from the Study of Longitudinal Aging in Mice to estimate biological age., Jorge Martinez-Romero, Maria Emilia Fernandez, Michel Bernier, Nathan L Price, William Mueller, Julián Candia, Simonetta Camandola, Osorio Meirelles, Yi-Han Hu, Zhiguang Li, Nigus Asefa, Andrew Deighan, Camila Vieira Ligo Teixeira, Dushani L Palliyaguru, Carlos Serrano, Nicolas Escobar-Velasquez, Stephanie Dickinson, Eric J Shiroma, Luigi Ferrucci, Gary Churchill, David B Allison, Lenore J Launer, Rafael de Cabo, and The Study of Longitudinal Aging in Mice (SLAM) Investigators
The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants., Marie Materna, Ottavia M Delmonte, Marita Bosticardo, Mana Momenilandi, Peyton E Conrey, Bénédicte Charmeteau-De Muylder, Clotilde Bravetti, Rebecca Bellworthy, Axel Cederholm, Frederik Staels, Christian A Ganoza, Samuel Darko, Samir Sayed, Corentin Le Floc'h, Masato Ogishi, Darawan Rinchai, Andrea Guenoun, Alexandre Bolze, Taushif Khan, Adrian Gervais, Renate Krüger, Mirjam Völler, Boaz Palterer, Mahnaz Sadeghi-Shabestari, Anne Langlois de Septenville, Chaim A Schramm, Sanjana Shah, John J Tello-Cajiao, Francesca Pala, Kayla Amini, Jose S Campos, Noemia Santana Lima, Daniel Eriksson, Romain Lévy, Yoann Seeleuthner, Soma Jyonouchi, Manar Ata, Fatima Al Ali, Anna Stittrich, Caroline Deswarte, Anaïs Pereira, Jérôme Mégret, Tom Le Voyer, Paul Bastard, Laureline Berteloot, Michaël Dussiot, Natasha Vladikine, Paula P Cardenas, Emmanuelle Jouanguy, Mashael Alqahtani, Amal Hasan, Thangavel Alphonse Thanaraj, Jérémie Rosain, Fahd Al Qureshah, Vito Sabato, Marie Alexandra Alyanakian, Marianne Leruez-Ville, Flore Rozenberg, Elie Haddad, Jose R Regueiro, Maria L Toribio, Judith R Kelsen, Mansoor Salehi, Shahram Nasiri, Mehdi Torabizadeh, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Nasimeh Vatandoost, Hossein Moravej, Seyed Mohammad Akrami, Mohsen Mazloomrezaei, Aurélie Cobat, Isabelle Meyts, Etsushi Toyofuku, Madoka Nishimura, Kunihiko Moriya, Tomoyuki Mizukami, Kohsuke Imai, Laurent Abel, Bernard Malissen, Fahd Al-Mulla, Fowzan Sami Alkuraya, Nima Parvaneh, Horst von Bernuth, Christian Beetz, Frédéric Davi, Daniel C Douek, Rémi Cheynier, David Langlais, Nils Landegren, Nico Marr, Tomohiro Morio, Mohammad Shahrooei, Rik Schrijvers, Sarah E Henrickson, Hervé Luche, Luigi D Notarangelo, Jean-Laurent Casanova, and Vivien Béziat
Protocol to assess bioenergetics and mitochondrial fuel usage in murine autoreactive immunocytes using the Seahorse Extracellular Flux Analyzer., Colleen L Mayberry, John J Wilson, Britney Sison, and Chih-Hao Chang
Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma., Mason McCrury, Kennith Swafford, Sydnye L Shuttleworth, Syed Hassan Mehdi, Baku Acharya, Debasmita Saha, Kevin Naceanceno, Stephanie D Byrum, Aaron J Storey, Ying-Zhi Xu, Claire Doshier, Vijay Patel, Ginell R Post, Annick De Loose, Analiz Rodriguez, Leonard D. Shultz, Fenghuang Zhan, Donghoon Yoon, Brendan Frett, and Samantha Kendrick
Development of New Diffuse Large B Cell Lymphoma Mouse Models., Syed Hassan Mehdi, Ying-Zhi Xu, Leonard D. Shultz, Eunkyung Kim, Yong Gu Lee, Samantha Kendrick, and Donghoon Yoon
Assessment of Patient-Derived Xenograft Growth and Antitumor Activity: The NCI PDXNet Consensus Recommendations., Funda Meric-Bernstam, Michael W Lloyd, Soner Koc, Yvonne A Evrard, Lisa M McShane, Michael T Lewis, Kurt W Evans, Dali Li, Lawrence Rubinstein, Alana Welm, Dennis A Dean, Anuj Srivastava, Jeffrey W Grover, Min J Ha, Huiqin Chen, Xuelin Huang, Kaushik Varadarajan, Jing Wang, Jack A Roth, Bryan Welm, Ramaswamy Govinden, Li Ding, Salma Kaochar, Nicholas Mitsiades, Luis Carvajal-Carmona, Meenhard Herylyn, Michael A Davies, Geoffrey I Shapiro, Ryan Fields, Jose G Trevino, Joshua C Harrell, NCI PDXNet Consortium, James H Doroshow, Jeffrey Chuang, and Jeffrey A Moscow
Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin., Richard A Miller, David E Harrison, Gino A Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G Geisler, Brett C Ginsburg, Melissa L Han, Catherine C Kaczorowski, Navasuja Kumar, Scott F Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R Mitchell, James F Nelson, Peter C. Reifsnyder, Adam B Salmon, Ron Korstanje, Nadia Rosenthal, and Randy Strong
Common data models to streamline metabolomics processing and annotation, and implementation in a Python pipeline., Joshua M Mitchell, Yuanye Chi, Maheshwor Thapa, Zhiqiang Pang, Jianguo Xia, and Shuzhao Li
Annotation of Metabolites in Stable Isotope Tracing Untargeted Metabolomics via Khipu-web., Joshua M Mitchell, Yuanye Chi, Shujian Zheng, Maheshwor Thapa, Eric Wang, and Shuzhao Li
Tmod2 Is a Regulator of Cocaine Responses through Control of Striatal and Cortical Excitability and Drug-Induced Plasticity, Arojit Mitra, Sean P Deats, Price E. Dickson, Jiuhe Zhu, Justin M Gardin, Brian J Nieman, R Mark Henkelman, Nien-Pei Tsai, Elissa J Chesler, Zhong-Wei Zhang, and Vivek Kumar
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127., Skye Montoya, Jessie Bourcier, Mark Noviski, Hao Lu, Meghan C Thompson, Alexandra Chirino, Jacob Jahn, Anya K Sondhi, Stefan Gajewski, Ying Siow May Tan, Stephanie Yung, Aleksandra Urban, Eric Wang, Cuijuan Han, Xiaoli Mi, Won Jun Kim, Quinlan Sievers, Paul Auger, Hugo Bousquet, Nivetha Brathaban, Brandon Bravo, Melissa Gessner, Cristiana Guiducci, James N Iuliano, Tim Kane, Ratul Mukerji, Panga Jaipal Reddy, Janine Powers, Mateo Sanchez Garcia de Los Rios, Jordan Ye, Carla Barrientos Risso, Daniel Tsai, Gabriel Pardo, Ryan Q Notti, Alejandro Pardo, Maurizio Affer, Vindhya Nawaratne, Tulasigeri M Totiger, Camila Pena-Velasquez, Joanna M Rhodes, Andrew D Zelenetz, Alvaro Alencar, Lindsey E Roeker, Sanjoy Mehta, Ralph Garippa, Adam Linley, Rajesh Kumar Soni, Sigrid S Skånland, Robert J Brown, Anthony R Mato, Gwenn M Hansen, Omar Abdel-Wahab, and Justin Taylor
Speech and language classification in the human phenotype ontology., Angela T Morgan, Ben D Coleman, Adam P Vogel, Alisdair McNeill, and Peter N Robinson
Diverse wild-derived inbred strains provide a new community resource., Michael W Nachman and Beth L Dumont
Human inherited CCR2 deficiency underlies progressive polycystic lung disease., Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasco, Camille Soudée, Corentin Le Floc'h, Mélanie Migaud, Yoann Seeleuthner, Mi-Sun Jang, Eirini Nikolouli, Simin Seyedpour, Hugues Begueret, Jean-François Emile, Pierre Le Guen, Guido Tavazzi, Costanza Natalia Julia Colombo, Federico Capra Marzani, Micol Angelini, Francesca Trespidi, Stefano Ghirardello, Nasrin Alipour, Anne Molitor, Raphael Carapito, Mohsen Mazloomrezaei, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Chantal Brouzes, Pablo Vargas, Alessandro Borghesi, Nico Lachmann, Seiamak Bahram, Bruno Crestani, Susanta Pahari, Larry S Schlesinger, Nico Marr, Dusan Bugonovic, Stéphanie Boisson-Dupuis, Vivien Béziat, Laurent Abel, Raphael Borie, Lisa R Young, Robin Deterding, Mohammad Shahrooei, Nima Rezaei, Nima Parvaneh, Daniel Craven, Philippe Gros, Danielle Malo, Fernando E Sepulveda, Lawrence M Nogee, Nathalie Aladjidi, Bruce C Trapnell, Jean-Laurent Casanova, and Jacinta Bustamante
Analysis of CNS autoimmunity in genetically diverse mice reveals unique phenotypes and mechanisms., Emily A Nelson, Anna L. Tyler, Taylor Lakusta-Wong, Karolyn G Lahue, Katherine C Hankes, Cory Teuscher, Rachel M Lynch, Martin T Ferris, J Matthew Mahoney, and Dimitry N Krementsov
Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro., Travis Nemkov, Alicia Key, Daniel Stephenson, Eric J Earley, Gregory R Keele, Ariel Hay, Pascal Amireault, Madeleine Casimir, Michaël Dussiot, Monika Dzieciatkowska, Julie A Reisz, Xutao Deng, Mars Stone, Steve Kleinman, Steven L Spitalnik, Kirk C Hansen, Philip J Norris, Gary Churchill, Michael P Busch, Nareg Roubinian, Grier P Page, James C Zimring, Arduino Arduini, and Angelo D'Alessandro
Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes., Travis Nemkov, Daniel Stephenson, Eric J Earley, Gregory R Keele, Ariel Hay, Alicia Key, Zachary B Haiman, Christopher Erickson, Monika Dzieciatkowska, Julie A Reisz, Amy Moore, Mars Stone, Xutao Deng, Steven Kleinman, Steven L Spitalnik, Eldad A Hod, Krystalyn E Hudson, Kirk C Hansen, Bernhard O Palsson, Gary Churchill, Nareg Roubinian, Philip J Norris, Michael P Busch, James C Zimring, Grier P Page, and Angelo D'Alessandro
Blackcurrants shape gut microbiota profile and reduce risk of postmenopausal osteoporosis via the gut-bone axis: Evidence from a pilot randomized controlled trial., Briana M Nosal, Staci N Thornton, Manije Darooghegi Mofrad, Junichi R Sakaki, Kyle J Mahoney, Zachary Macdonald, Lauren Daddi, Thi Dong Binh Tran, George M. Weinstock, Yanjiao Zhou, Elaine Choung-Hee Lee, and Ock K Chun
Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber., Luana Nunes Santos, Ângela Maria Sousa Costa, Martin Nikolov, João E Carvalho, Allysson Coelho Sampaio, Frank E Stockdale, Gang Feng Wang, Hozana Andrade Castillo, Mariana Bortoletto Grizante, Stefanie Dudczig, Michelle Vasconcelos, Nadia Rosenthal, Patricia Regina Jusuf, Hieu T Nim, Paulo de Oliveira, Tatiana Guimarães de Freitas Matos, William Nikovits, Izabella Luisa Tambones, Ana Carolina Migliorini Figueira, Michael Schubert, Mirana Ramialison, and José Xavier-Neto
Unraveling the genetics of arsenic toxicity with cellular morphology QTL., Callan O'Connor, Gregory R Keele, Whitney Martin, Tim J Stodola, Daniel M Gatti, Brian Hoffmann, Ron Korstanje, Gary Churchill, and Laura G Reinholdt
Quantitative trait loci mapping provides insights into the genetic regulation of dendritic cell numbers in mouse tissues., Thiago Y Oliveira, Julia Merkenschlager, Thomas Eisenreich, Juliana Bortolatto, Kai-Hui Yao, Daniel M Gatti, Gary Churchill, Michel C Nussenzweig, and Gaëlle Breton
Mapping the metabolic responses to oxaliplatin-based chemotherapy with, Mariola Olkowicz, Khaled Ramadan, Hernando Rosales-Solano, Miao Yu, Aizhou Wang, Marcelo Cypel, and Janusz Pawliszyn
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function., Kazuya Ono, Amandine Jarysta, Natasha C Hughes, Alma Jukic, Hui Ho Vanessa Chang, Michael R Deans, Ruth Anne Eatock, Kathleen E Cullen, Katie S Kindt, and Basile Tarchini
Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction., Kristen D. Onos, Peter B Lin, Ravi S Pandey, Scott A Persohn, Charles P Burton, Ethan W Miner, Kierra Eldridge, Jonathan Nyandu Kanyinda, Kate E Foley, Gregory W. Carter, Gareth R Howell, and Paul R Territo
Randomized feature selection based semi-supervised latent Dirichlet allocation for microbiome analysis., Namitha Pais, Nalini Ravishanker, Sanguthevar Rajasekaran, George M. Weinstock, and Thi Dong Binh Tran
Examining Intercage Transmission of, Michael B Palillo, Noah Mishkin, Mert Aydin, Anthony J Mourino, Rodolfo J Ricart Arbona, and Neil S Lipman
Revisiting Cardiac Biology in the Era of Single Cell and Spatial Omics., Jack A Palmer, Nadia Rosenthal, Sarah A Teichmann, and Monika Litvinukova
Proteomic Profiles of Human Arterioles Isolated From Fresh Adipose Tissue or Following Overnight Storage., Rajan Pandey, Michelle L Roberts, Jingli Wang, Michaela Pereckas, David Jensen, Andrew S Greene, Michael E Widlansky, and Mingyu Liang