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Submissions from 2018

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Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells., Mohammad Alsady, Theun de Groot, Marleen L A Kortenoeven, Claudia Carmone, Kim Neijman, Melissa Bekkenkamp-Grovenstein, Udo Engelke, Ron Wevers, Ruben Baumgarten, Ron Korstanje, and Peter M T Deen

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NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network., David J Anderson, David I Kaplan, Katrina M Bell, Katerina Koutsis, John M Haynes, Richard J Mills, Dean G Phelan, Elizabeth L Qian, Ana Rita Leitoguinho, Deevina Arasaratnam, Tanya Labonne, Elizabeth S Ng, Richard P Davis, Simona Casini, Robert Passier, James E Hudson, Enzo R Porrello, Mauro W Costa, Arash Rafii, Clare L Curl, Lea M Delbridge, Richard P Harvey, Alicia Oshlack, Michael M Cheung, Christine L Mummery, Stephen Petrou, Andrew G Elefanty, Edouard G Stanley, and David A Elliott

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Capturing Totipotent Stem Cells., Christopher L. Baker and Martin F Pera

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Immunotherapy: Cancer vaccines on the move., Jacques Banchereau and Karolina Palucka

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Reconstructing the molecular life history of gliomas., Floris P Barthel, Pieter Wesseling, and Roel G W Verhaak

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FusorSV: an algorithm for optimally combining data from multiple structural variation detection methods., Timothy Becker, Wan-Ping Lee, Joseph Leone, Qihui Zhu, Chengsheng Zhang, Silvia Liu, Jack Sargent, Kritika Shanker, Adam Mil-Homens, Eliza Cerveira, Mallory Ryan, Jane Cha, Fabio C P Navarro, Timur Galeev, Mark Gerstein, Ryan E Mills, Dong-Guk Shin, Charles Lee, and Ankit Malhotra

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Disease Ontology: improving and unifying disease annotations across species., Susan M. Bello, Mary Shimoyama, Elvira Mitraka, Stanley J F Laulederkind, Cynthia Smith, Janan T. Eppig, and Lynn M Schriml

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Mouse Phenome Database: an integrative database and analysis suite for curated empirical phenotype data from laboratory mice., Molly A. Bogue, Stephen C. Grubb, David O Walton, Vivek M. Philip, Georgi Kolishovski, Timothy M Stearns, Matthew H Dunn, Daniel A Skelly, Beena Kadakkuzha, Gregg TeHennepe, Govindarajan Kunde-Ramamoorthy, and Elissa J Chesler

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α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes., Marcela Brissova, Rachana Haliyur, Diane Saunders, Shristi Shrestha, Chunhua Dai, David M Blodgett, Rita Bottino, Martha Campbell-Thompson, Radhika Aramandla, Gregory Poffenberger, Jill Lindner, Fong Cheng Pan, Matthias G von Herrath, Dale L Greiner, Leonard D. Shultz, May Sanyoura, Louis H Philipson, Mark Atkinson, David M Harlan, Shawn E Levy, Nripesh Prasad, Roland Stein, and Alvin C Powers

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Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment., Elena Britti, Fabien Delaspre, Anat Feldman, Melissa Osborne, Hagar Greif, Jordi Tamarit, and Joaquim Ros

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In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions., S R Burstein, F Valsecchi, H Kawamata, M Bourens, R Zeng, Aamir Zuberi, T A Milner, S M Cloonan, Cathleen Lutz, A Barrientos, and G Manfredi

The "adipose tissue expandability" hypothesis: a potential mechanism for insulin resistance in obese youth., Sonia Caprio, Bridget Pierpont, and Romy Kursawe

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Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma., Young Kwang Chae, Jonathan F Anker, Preeti Bais, Sandeep Namburi, Francis J Giles, and Jeffrey H Chuang

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JEPEGMIX2: improved gene-level joint analysis of eQTLs in cosmopolitan cohorts., Chris Chatzinakos, Donghyung Lee, Bradley T Webb, Vladimir I Vladimirov, Kenneth S Kendler, and Silviu-Alin Bacanu

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Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4, Seung-Chul Choi, Zhiwei Xu, Wei Li, Hong Yang, Derry C. Roopenian, Herbert C Morse, and Laurence Morel

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Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions., Anant Chopra, Matthew L Kutys, Kehan Zhang, William J Polacheck, Calvin C Sheng, Rebeccah J Luu, Jeroen Eyckmans, J Travis Hinson, Jonathan G Seidman, Christine E Seidman, and Christopher S Chen

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Alterations in the Rho pathway contribute to Epstein-Barr virus-induced lymphomagenesis in immunosuppressed environments., Sung-Yup Cho, Chang Ohk Sung, Jeesoo Chae, Jieun Lee, Deukchae Na, Wonyoung Kang, Jinjoo Kang, Seoyeon Min, Ahra Lee, Eunhye Kwak, Jooyoung Kim, Boram Choi, Hyunsoo Kim, Jeffrey H Chuang, Hyo-Kyung Pak, Chan-Sik Park, Sanghui Park, Young Hyeh Ko, Dakeun Lee, Jin Roh, Min-Sun Cho, Seongyeol Park, Young Seok Ju, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, James Keck, Jacques Banchereau, Edison T Liu, Woo-Ho Kim, Hansoo Park, Han-Kwang Yang, Jong-Il Kim, and Charles Lee

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Sensing the cilium, digital capture of ciliary data for comparative genomics investigations., Karen R. Christie and Judith A. Blake

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Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling., Enrique J Cobos, Chelsea A Nickerson, Fuying Gao, Vijayendran Chandran, Inmaculada Bravo-Caparrós, Rafael González-Cano, Priscilla Riva, Nick A Andrews, Alban Latremoliere, Corey R Seehus, Gloria Perazzoli, Francisco R Nieto, Nicole Joller, Michio W Painter, Chi Him Eddie Ma, Takao Omura, Elissa J Chesler, Daniel H Geschwind, Giovanni Coppola, Manu Rangachari, Clifford J Woolf, and Michael Costigan

Enterotypes in the landscape of gut microbial community composition., Paul I Costea, Falk Hildebrand, Arumugam Manimozhiyan, Fredrik Bäckhed, Martin J Blaser, Frederic D Bushman, Willem M de Vos, S Dusko Ehrlich, Claire M Fraser, Masahira Hattori, Curtis Huttenhower, Ian B Jeffery, Dan Knights, James D Lewis, Ruth E Ley, Howard Ochman, Paul W O'Toole, Christopher Quince, David A Relman, Fergus Shanahan, Shinichi Sunagawa, Jun Wang, George M. Weinstock, Gary D Wu, Georg Zeller, Liping Zhao, Jeroen Raes, Rob Knight, and Peer Bork

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Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling., Hannah A DeBerg, Mussaret B Zaidi, Matthew C Altman, Prasong Khaenam, Vivian H Gersuk, Freddy D Campos, Iza Perez-Martinez, Mario Meza-Segura, Damien Chaussabel, Jacques Banchereau, Teresa Estrada-Garcia, and Peter S Linsley

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Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma., Ana C deCarvalho, Hoon Kim, Laila M Poisson, Mary E Winn, Claudius Mueller, David Cherba, Julie Koeman, Sahil Seth, Alexei Protopopov, Michelle Felicella, Siyuan Zheng, Asha Multani, Yongying Jiang, Jianhua Zhang, Do-Hyun Nam, Emanuel F Petricoin, Lynda Chin, Tom Mikkelsen, and Roel G W Verhaak

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Exploring autophagy with Gene Ontology., Paul Denny, Marc Feuermann, David P. Hill, Ruth C Lovering, Helene Plun-Favreau, and Paola Roncaglia

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The innate immune response to ischemic injury: a multiscale modeling perspective., Elena Dimitrova, Leslie A Caromile, Reinhard Laubenbacher, and Linda H Shapiro

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The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells., Jianwen Dong, Soon Young Park, Nghi Nguyen, Ravesanker Ezhilarasan, Emmanuel Martinez-Ledesma, Shaofang Wu, Verlene Henry, Yuji Piao, Ningyi Tiao, David Brunell, Clifford Stephan, Roel G W Verhaak, Erik Sulman, Veerakumar Balasubramaniyan, and John F de Groot

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SARNAclust: Semi-automatic detection of RNA protein binding motifs from immunoprecipitation data., Ivan Dotu, Scott I Adamson, Benjamin Coleman, Cyril Fournier, Emma Ricart-Altimiras, Eduardo Eyras, and Jeffrey H Chuang

Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice., Philip A Durost, Ken-Edwin Aryee, Fatima Manzoor, Roland M Tisch, Christian Mueller, Agata Jurczyk, Leonard D. Shultz, and Michael A Brehm

Reproduction: Oocytes Call, Granulosa Cells Connect., John J. Eppig

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Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions., Nicolas Floc'h, Matthew J Martin, Jonathan W Riess, Jonathan P Orme, Anna D Staniszewska, Ludovic Ménard, Maria Emanuela Cuomo, Daniel J O'Neill, Richard A Ward, M Raymond V Finlay, Darren McKerrecher, Mingshan Cheng, Daniel P Vang, Rebekah A Burich, James G. Keck, David R Gandara, Philip C Mack, and Darren A E Cross

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Gearing up to handle the mosaic nature of life in the quest for orthologs., Kristoffer Forslund, Cecile Pereira, Salvador Capella-Gutierrez, Alan Sousa da Silva, Adrian Altenhoff, Jaime Huerta-Cepas, Matthieu Muffato, Mateus Patricio, Klaas Vandepoele, Ingo Ebersberger, Judith A. Blake, Jesualdo Tomás Fernández Breis, The Quest for Orthologs Consortium, Brigitte Boeckmann, Toni Gabaldón, Erik Sonnhammer, Christophe Dessimoz, and Suzanna Lewis

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Profiling of epidermal lipids in a mouse model of dermatitis: Identification of potential biomarkers., Jackeline Franco, Christina Ferreira, Tiago J Paschoal Sobreira, John P Sundberg, and Harm HogenEsch

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Identifying noncoding risk variants using disease-relevant gene regulatory networks., Long Gao, Yasin Uzun, Peng Gao, Bing He, Xiaoke Ma, Jiahui Wang, Shizhong Han, and Kai Tan

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Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer., Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valérie Garès, Elizabeth L Christie, Maartje C A Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, Thomas Mikeska, Giada V Zapparoli, Kaushalya Amarasinghe, Sean M Grimmond, John V Pearson, Nicola Waddell, Jillian Hung, Colin J R Stewart, Raghwa Sharma, Prue E Allan, Peter F Rambau, Orla McNally, Linda Mileshkin, Anne Hamilton, Sumitra Ananda, Marisa Grossi, Paul A Cohen, Yee C Leung, Robert M Rome, Philip Beale, Penny Blomfield, Michael Friedlander, Alison Brand, Alexander Dobrovic, Martin Köbel, Paul Harnett, Brad H Nelson, David D L Bowtell, and Anna deFazio

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Method of derivation and differentiation of mouse embryonic stem cells generating synchronous neuronal networks., Elena V Gazina, Emma Morrisroe, Gunarathna D C Mendis, Anna E Michalska, Joseph Chen, Christian M Nefzger, Benjamin N Rollo, Christopher A Reid, Martin Pera, and Steven Petrou

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Culture-independent analysis of liver abscess using nanopore sequencing., Liang Gong, Yao-Ting Huang, Chee-Hong Wong, Wen-Cheng Chao, Zong-Yen Wu, Chia-Lin Wei, and Po-Yu Liu

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A human endothelial cell-based recycling assay for screening of FcRn targeted molecules., Algirdas Grevys, Jeannette Nilsen, Kine M K Sand, Muluneh B Daba, Inger Øynebråten, Malin Bern, Martin B McAdam, Stian Foss, Tilman Schlothauer, Terje E Michaelsen, Gregory J. Christianson, Derry C. Roopenian, Richard S Blumberg, Inger Sandlie, and Jan Terje Andersen

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Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease., Andrew N Hesse, William Fabricius, Christian A Thomas, Ramesh Gaindh, Robert Christman, Pavalan Selvam, Matthew Prego, Gregory Lewis, Jasmina Uvalic, Daniel Bergeron, Shelbi Burns, Bridgette Sisson, Kevin Kelly, Jens Rueter, and Honey V Reddi

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Meta-analysis of the lung microbiota in pulmonary tuberculosis., Bo-Young Hong, Joseph N Paulson, O Colin Stine, George M. Weinstock, and Jorge L Cervantes

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ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin., Vishnu Hosur, Michelle L Farley, Lisa M. Burzenski, Leonard D. Shultz, and Michael V. Wiles

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Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources., Liang-Chin Huang, Karen E Ross, Timothy R Baffi, Harold J. Drabkin, Krzysztof J Kochut, Zheng Ruan, Peter D'Eustachio, Daniel McSkimming, Cecilia Arighi, Chuming Chen, Darren A Natale, Cynthia Smith, Pascale Gaudet, Alexandra C Newton, Cathy Wu, and Natarajan Kannan

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Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice., Jianjun Hu, Fengyun Sun, and Mary Ann Handel

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TumorFusions: an integrative resource for cancer-associated transcript fusions., Xin Hu, Qianghu Wang, Ming Tang, Floris P Barthel, Samirkumar B Amin, Kosuke Yoshihara, Frederick M Lang, Emmanuel Martinez-Ledesma, Soo Hyun Lee, Siyuan Zheng, and Roel G W Verhaak

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Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice., Kenneth R. Johnson, Leona H. Gagnon, Cong Tian, Chantal M. Longo-Guess, Benjamin E. Low, Michael V. Wiles, and Amy E Kiernan

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Reproducibility and replicability of rodent phenotyping in preclinical studies., Neri Kafkafi, Joseph Agassi, Elissa J Chesler, John C Crabbe, Wim E Crusio, David Eilam, Robert Gerlai, Ilan Golani, Alex Gomez-Marin, Ruth Heller, Fuad Iraqi, Iman Jaljuli, Natasha A Karp, Hugh Morgan, George Nicholson, Donald W Pfaff, S Helene Richter, Philip B Stark, Oliver Stiedl, Victoria Stodden, Lisa M Tarantino, Valter Tucci, William Valdar, Robert W Williams, Hanno Würbel, and Yoav Benjamini

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Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats., Gregory R Keele, Jeremy W Prokop, Hong He, Katie Holl, John Littrell, Aaron Deal, Sanja Francic, Leilei Cui, Daniel M. Gatti, Karl W Broman, Michael Tschannen, Shirng-Wern Tsaih, Maie Zagloul, Yunjung Kim, Brittany Baur, Joseph Fox, Melanie Robinson, Shawn Levy, Michael J Flister, Richard Mott, William Valdar, and Leah C Solberg Woods

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Genetic Drivers of Pancreatic Islet Function., Mark P Keller, Daniel M. Gatti, Kathryn L Schueler, Mary E Rabaglia, Donnie S Stapleton, Petr Simecek, Matthew J Vincent, Sadie Allen, Aimee Teo Broman, Rhonda Bacher, Christina Kendziorski, Karl W Broman, Brian S Yandell, Gary A Churchill, and Alan D Attie

Evaluation of exome filtering techniques for the analysis of clinically relevant genes., Kristin D Kernohan, Taila Hartley, Najmeh Alirezaie, Care4Rare Canada Consortium, Peter N Robinson, David A Dyment, and Kym M Boycott

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Characterization of glycosylphosphatidylinositol biosynthesis defects by clinical features, flow cytometry, and automated image analysis., Alexej Knaus, Jean Tori Pantel, Manuela Pendziwiat, Nurulhuda Hajjir, Max Zhao, Tzung-Chien Hsieh, Max Schubach, Yaron Gurovich, Nicole Fleischer, Marten Jäger, Sebastian Köhler, Hiltrud Muhle, Christian Korff, Rikke S Møller, Allan Bayat, Patrick Calvas, Nicolas Chassaing, Hannah Warren, Steven Skinner, Raymond Louie, Christina Evers, Marc Bohn, Hans-Jürgen Christen, Myrthe van den Born, Ewa Obersztyn, Agnieszka Charzewska, Milda Endziniene, Fanny Kortüm, Natasha Brown, Peter N Robinson, Helenius J Schelhaas, Yvonne Weber, Ingo Helbig, Stefan Mundlos, Denise Horn, and Peter M Krawitz

The Impact of Adherens and Tight Junctions on Physiological Function and Pathological Changes in the Retina., Yang Kong, Juergen K. Naggert, and Patsy M. Nishina

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ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells., Jocelyn F Krey, Rachel A Dumont, Philip A Wilmarth, Larry L David, Kenneth R. Johnson, and Peter G Barr-Gillespie

Serial immunological parameters in a phase II trial of exemestane and low-dose oral cyclophosphamide in advanced hormone receptor-positive breast cancer., Maryann Kwa, Xiaochun Li, Yelena Novik, Ruth Oratz, Komal Jhaveri, Jennifer Wu, Ping Gu, Marleen Meyers, Franco Muggia, James Speyer, Alyssa Iwano, Maryam Bonakdar, Lina Kozhaya, Ece Tavukcuoglu, Bahar Budan, Roy Raad, Judith D Goldberg, Derya Unutmaz, and Sylvia Adams

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A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression., Ina Kycia, Brooke N Wolford, Jeroen R Huyghe, Christian Fuchsberger, Swarooparani Vadlamudi, Romy Kursawe, Ryan P Welch, Ricardo d'Oliveira Albanus, Asli Uyar, Shubham Khetan, Nathan Lawlor, Mohan Bolisetty, Anubhuti Mathur, Johanna Kuusisto, Markku Laakso, Duygu Ucar, Karen L Mohlke, Michael Boehnke, Francis S Collins, Stephen C J Parker, and Michael L. Stitzel

Cell Labeling with Magneto-Endosymbionts and the Dissection of the Subcellular Location, Fate, and Host Cell Interactions., Kayla R Lee, Abdul Wakeel, Papia Chakraborty, Chandler S Foote, Lauren Kajiura, Joyce C Barrozo, Andrea C Chan, Alexey V Bazarov, Ryan Spitler, Peter M Kutny, James M. Denegre, Robert A. Taft, Joachim Seemann, Bradley W Rice, Christopher H Contag, Brian K Rutt, and Caleb B Bell

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Digestion-ligation-only Hi-C is an efficient and cost-effective method for chromosome conformation capture., Da Lin, Ping Hong, Siheng Zhang, Weize Xu, Muhammad Jamal, Keji Yan, Yingying Lei, Liang Li, Yijun Ruan, Zhen F Fu, Guoliang Li, and Gang Cao

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Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model., Qilai Long, Tzu-Yin Lin, Yee Huang, Xiaocen Li, Ai-Hong Ma, Hongyong Zhang, Randy Carney, Susan Airhart, Kit S Lam, Ralph W deVere White, Chong-Xian Pan, and Yuanpei Li

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Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology., Ruth C Lovering, Paola Roncaglia, Douglas G Howe, Stanley J F Laulederkind, Varsha K Khodiyar, Tanya Z Berardini, Susan Tweedie, Rebecca E Foulger, David Osumi-Sutherland, Nancy H Campbell, Rachael P Huntley, Philippa J Talmud, Judith A. Blake, Ross Breckenridge, Paul R Riley, Pier D Lambiase, Perry M Elliott, Lucie Clapp, Andrew Tinker, and David P. Hill

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Triple Vectors Expand AAV Transfer Capacity in the Retina., Andrea Maddalena, Patrizia Tornabene, Paola Tiberi, Renato Minopoli, Anna Manfredi, Margherita Mutarelli, Settimio Rossi, Francesca Simonelli, Juergen K. Naggert, Davide Cacchiarelli, and Alberto Auricchio

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Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours., Xiaotu Ma, Yu Liu, Yanling Liu, Ludmil B Alexandrov, Michael N Edmonson, Charles Gawad, Xin Zhou, Yongjin Li, Michael C Rusch, John Easton, Robert Huether, Veronica Gonzalez-Pena, Mark R Wilkinson, Leandro C Hermida, Sean Davis, Edgar Sioson, Stanley Pounds, Xueyuan Cao, Rhonda E Ries, Zhaoming Wang, Xiang Chen, Li Dong, Sharon J Diskin, Malcolm A Smith, Jaime M Guidry Auvil, Paul S Meltzer, Ching C Lau, Elizabeth J Perlman, John M Maris, Soheil Meshinchi, Stephen P Hunger, Daniela S Gerhard, and Jinghui Zhang

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Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through, Tapan Kumar Mistri, Wibowo Arindrarto, Wei Ping Ng, Choayang Wang, Leng Hiong Lim, Lili Sun, Ian Chambers, Thorsten Wohland, and Paul Robson

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Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy., Zhongying Mo, Xiaobei Zhao, Huaqing Liu, Qinghua Hu, Xu-Qiao Chen, Jessica Pham, Na Wei, Ze Liu, Jiadong Zhou, Robert W. Burgess, Samuel L Pfaff, C Thomas Caskey, Chengbiao Wu, Ge Bai, and Xiang-Lei Yang

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The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans., Mansa A Munshi, Justin M Gardin, Ashutosh Singh, Chiara Luberto, Robert Rieger, Tejas Bouklas, Bettina C Fries, and Maurizio Del Poeta

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The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection., Andrea M Muscat, Nicholas C Wong, Katharine J Drummond, Elizabeth M Algar, Mustafa Khasraw, Roel G W Verhaak, Kathryn Field, Mark A Rosenthal, and David M Ashley

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A commensal strain of Staphylococcus epidermidis protects against skin neoplasia., Teruaki Nakatsuji, Tiffany H Chen, Anna M Butcher, Lynnie L Trzoss, Sang-Jip Nam, Karina T Shirakawa, Wei Zhou, Julia Oh, Michael Otto, William Fenical, and Richard L Gallo

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Animal models for evaluation of albumin-based therapeutics, Jeannette Nilsen, Inger Sandlie, Derry C. Roopenian, and Jan Terje Andersen

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Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo"., Lauryl M J Nutter, Jason D Heaney, K C Kent Lloyd, Stephen A. Murray, John R Seavitt, William C Skarnes, Lydia Teboul, Steve D M Brown, and Mark Moore

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Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies., Lori L O'Brien, Qiuyu Guo, Emad Bahrami-Samani, Joo-Seop Park, Sean M Hasso, Young-Jin Lee, Alan Fang, Albert D Kim, Jinjin Guo, Trudy M Hong, Kevin A Peterson, Scott Lozanoff, Ramya Raviram, Bing Ren, Ben Fogelgren, Andrew D Smith, Anton Valouev, and Andrew P McMahon

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Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function., Laura Padrón-Barthe, María Villalba-Orero, Jesús M Gómez-Salinero, Rebeca Acín-Pérez, Sara Cogliati, Marina López-Olañeta, Paula Ortiz-Sánchez, Elena Bonzón-Kulichenko, Jesús Vázquez, Pablo García-Pavía, Nadia Rosenthal, José Antonio Enríquez, and Enrique Lara-Pezzi

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PRDM9 and Its Role in Genetic Recombination., Kenneth Paigen and Petko M. Petkov

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Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error., Seyyedhassan Paylakhi, Cassandre Labelle-Dumais, Nicholas G Tolman, Michael A Sellarole, Yusef Seymens, Joseph Saunders, Hesham Lakosha, Wilhelmine N de Vries, Andrew C Orr, Piotr Topilko, Simon W M John, and K Saidas Nair

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Developmental constraint through negative pleiotropy in the zygomatic arch., Christopher J Percival, Rebecca Green, Charles C Roseman, Daniel M. Gatti, Judy Morgan, Stephen A. Murray, Leah Rae Donahue, Jessica M Mayeux, K Michael Pollard, Kunjie Hua, Daniel Pomp, Ralph Marcucio, and Benedikt Hallgrímsson

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Integrative Personal Omics Profiles during Periods of Weight Gain and Loss., Brian D Piening, Wenyu Zhou, Kévin Contrepois, Hannes Röst, Gucci Jijuan Gu Urban, Tejaswini Mishra, Blake M Hanson, Eddy J Bautista, Shana Leopold, Christine Y Yeh, Daniel Spakowicz, Imon Banerjee, Cynthia Chen, Kimberly Kukurba, Dalia Perelman, Colleen Craig, Elizabeth Colbert, Denis Salins, Shannon Rego, Sunjae Lee, Cheng Zhang, Jessica Wheeler, M Reza Sailani, Liang Liang, Charles Abbott, Mark Gerstein, Adil Mardinoglu, Ulf Smith, Daniel L Rubin, Sharon Pitteri, Erica Sodergren Weinstock, Tracey L McLaughlin, George M. Weinstock, and Michael P Snyder

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Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation., Shashikant Pujar, Nuala A O'Leary, Catherine M Farrell, Jane E Loveland, Jonathan M Mudge, Craig Wallin, Carlos G Girón, Mark Diekhans, If Barnes, Ruth Bennett, Andrew E Berry, Eric Cox, Claire Davidson, Tamara Goldfarb, Jose M Gonzalez, Toby Hunt, John Jackson, Vinita Joardar, Mike P Kay, Vamsi K Kodali, Fergal J Martin, Monica McAndrews, Kelly M McGarvey, Michael Murphy, Bhanu Rajput, Sanjida H Rangwala, Lillian D Riddick, Ruth L Seal, Marie-Marthe Suner, David Webb, Sophia Zhu, Bronwen L Aken, Elspeth A Bruford, Carol J Bult, Adam Frankish, Terence Murphy, and Kim D Pruitt

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Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During Murine Embryogenesis Does Not Involve miRNA Biogenesis., Sri Ramulu N Pullagura, F William Buaas, Nichelle Gray, Lindsey C Krening, Anuj Srivastava, and Robert E Braun

Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development., Jeremy Racine, Isabel Stewart, Jeremy Ratiu, Gregory J. Christianson, Emily Lowell, Kelsay Helm, Jennifer Allocco, Richard S. Maser, Yi-Guang Chen, Cathleen Lutz, Derry C. Roopenian, Jennifer Schloss, Teresa P DiLorenzo, and David V. Serreze

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Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr, Peter C. Reifsnyder, Sergey Ryzhov, Kevin Flurkey, Rea P Anunciado-Koza, Ian Mills, David E Harrison, and Robert A Koza

An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates the "Perfect Storm"., Laura J Rojas, George M. Weinstock, Elsa De La Cadena, Lorena Diaz, Rafael Rios, Blake M Hanson, Joseph S Brown, Purva Vats, Daniel S Phillips, Hoan Nguyen, Kristine M Hujer, Adriana Correa, Mark D Adams, Federico Perez, Erica Sodergren Weinstock, Apurva Narechania, Paul J Planet, Maria V Villegas, Robert A Bonomo, and Cesar A Arias

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Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia., Bruce A Rosa, Taniawati Supali, Lincoln Gankpala, Yenny Djuardi, Erliyani Sartono, Yanjiao Zhou, Kerstin Fischer, John Martin, Rahul Tyagi, Fatorma K Bolay, Peter U Fischer, Maria Yazdanbakhsh, and Makedonka Mitreva

Screening Gene Knockout Mice for Variation in Bone Mass: Analysis by μCT and Histomorphometry., David W Rowe, Douglas J Adams, Seung-Hyun Hong, Caibin Zhang, Dong-Guk Shin, C Renata Rydzik, Li Chen, Zhihua Wu, Gaven Garland, Dana A Godfrey, John P Sundberg, and Cheryl Ackert-Bicknell

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Identification of genetic elements in metabolism by high-throughput mouse phenotyping., Jan Rozman, Birgit Rathkolb, Manuela A Oestereicher, Christine Schütt, Aakash Chavan Ravindranath, Stefanie Leuchtenberger, Sapna Sharma, Martin Kistler, Monja Willershäuser, Robert Brommage, Terrence F Meehan, Jeremy Mason, Hamed Haselimashhadi, Tertius Hough, Ann-Marie Mallon, Sara Wells, Luis Santos, Christopher J Lelliott, Jacqueline K White, Tania Sorg, Marie-France Champy, Lynette R Bower, Corey L Reynolds, Ann M Flenniken, Stephen A. Murray, Lauryl M J Nutter, Karen L. Svenson, David West, Glauco P Tocchini-Valentini, Arthur L Beaudet, Fatima Bosch, Robert E Braun, Michael S Dobbie, Xiang Gao, Yann Herault, Ala Moshiri, Bret A Moore, K C Kent Lloyd, Colin McKerlie, Hiroshi Masuya, Nobuhiko Tanaka, Paul Flicek, Helen E Parkinson, Radislav Sedlacek, Je Kyung Seong, Chi-Kuang Leo Wang, Mark Moore, Steve D Brown, Matthias H Tschöp, Wolfgang Wurst, Martin Klingenspor, Eckhard Wolf, Johannes Beckers, Fausto Machicao, Andreas Peter, Harald Staiger, Hans-Ulrich Häring, Harald Grallert, Monica Campillos, Holger Maier, Helmut Fuchs, Valerie Gailus-Durner, Thomas Werner, and Martin Hrabe de Angelis

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Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes., Ivan Rusyn, Steven R Kleeberger, Kimberly A McAllister, John E French, and Karen L. Svenson

A prospective microbiome-wide association study of food sensitization and food allergy in early childhood., Jessica H Savage, Kathleen A Lee-Sarwar, Joanne Sordillo, Supinda Bunyavanich, Yanjiao Zhou, George O'Connor, Megan Sandel, Leonard B Bacharier, Robert Zeiger, Erica Sodergren Weinstock, George M. Weinstock, Diane R Gold, Scott T Weiss, and Augusto A Litonjua

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Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli., Lisa M Schechter, David P Creely, Cherilyn D Garner, Dee Shortridge, Hoan Nguyen, Lei Chen, Blake M Hanson, Erica Sodergren Weinstock, George M. Weinstock, W Michael Dunne, Alex van Belkum, and Shana R Leopold

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HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression., Jennifer Schloss, Riyasat Ali, Jeremy Racine, Harry D Chapman, David V. Serreze, and Teresa P DiLorenzo

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Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis., Manju Sharma and Robert E Braun

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Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size., John R Shorter, Wei Huang, Ju Youn Beak, Kunjie Hua, Daniel M. Gatti, Fernando Pardo-Manuel de Villena, Daniel Pomp, and Brian C Jensen

Role of TGF-β in Self-Peptide Regulation of Autoimmunity., Bhagirath Singh, Michael D Krawetz, Rachel M De Lima, Rinee Mukherjee, Pratibha Chaturvedi, Edwin Lee-Chan, Edward H. Leiter, and Kelly L Summers

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Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases., Rajan Singh, Shehla Pervin, Se-Jin Lee, Alan Kuo, Victor Grijalva, John David, Laurent Vergnes, and Srinivasa T Reddy

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Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart., Daniel A Skelly, Galen T Squiers, Michael A McLellan, Mohan T Bolisetty, Paul Robson, Nadia A Rosenthal, and Alexander R Pinto

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Mouse Genome Database (MGD)-2018: knowledgebase for the laboratory mouse., Cynthia Smith, Judith A. Blake, James A. Kadin, Joel E Richardson, Carol J Bult, and Mouse Genome Database Group

Nervous system., Jessica M. Snyder, Catherine E. Hagan, Brad Bolon, and C Dirk Keene

Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver., Jessica R Spengler, Greg Saturday, Kerry J Lavender, Cynthia Martellaro, James G. Keck, Stuart T Nichol, Christina F Spiropoulou, Heinz Feldmann, and Joseph Prescott

Skin and adnexa., John P Sundberg, Carmen J. Booth, Lillian B. Nanney, Philip Fleckman, and Lloyd E. King Jr

Training mouse pathologists: 16th annual workshop on the pathology of mouse models of human disease., John P Sundberg, Kelli Boyd, Harm Hogenesch, Alexander Yu Nikitin, Piper M Treuting, and Jerrold M Ward

Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias., John P Sundberg, Maria K Hordinsky, Wilma Bergfeld, Yolanda M Lenzy, Amy J McMichael, Angela M Christiano, Tracy McGregor, Kurt S Stenn, Raja K Sivamani, C Herbert Pratt, and Lloyd E King

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Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model., Chad A Tagge, Andrew M Fisher, Olga V Minaeva, Amanda Gaudreau-Balderrama, Juliet A Moncaster, Xiao-Lei Zhang, Mark W Wojnarowicz, Noel Casey, Haiyan Lu, Olga N Kokiko-Cochran, Sudad Saman, Maria Ericsson, Kristen D. Onos, Ronel Veksler, Vladimir V Senatorov, Asami Kondo, Xiao Z Zhou, Omid Miry, Linnea R Vose, Katisha R Gopaul, Chirag Upreti, Christopher J Nowinski, Robert C Cantu, Victor E Alvarez, Audrey M Hildebrandt, Erich S Franz, Janusz Konrad, James A Hamilton, Ning Hua, Yorghos Tripodis, Andrew T Anderson, Gareth R Howell, Daniela Kaufer, Garth F Hall, Kun P Lu, Richard M Ransohoff, Robin O Cleveland, Neil W Kowall, Thor D Stein, Bruce T Lamb, Bertrand R Huber, William C Moss, Alon Friedman, Patric K Stanton, Ann C McKee, and Lee E Goldstein

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Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions., Ryo Tamura, Kosuke Yoshihara, Tetsuya Saito, Ryosuke Ishimura, Juan Emmanuel Martínez-Ledesma, Hu Xin, Tatsuya Ishiguro, Yutaro Mori, Kaoru Yamawaki, Kazuaki Suda, Seiya Sato, Hiroaki Itamochi, Teiichi Motoyama, Yoichi Aoki, Shujiro Okuda, Cristine R Casingal, Hirofumi Nakaoka, Ituro Inoue, Roel G W Verhaak, Masaaki Komatsu, and Takayuki Enomoto

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3D Axon Growth by Exogenous Electrical Stimulus and Soluble Factors., Min D Tang-Schomer

Proteomics and metabolomics for analysis of the dynamics of microbiota., Alex Van Belkum, David Broadwell, Douglas Lovern, Lauren M Petersen, George M. Weinstock, and W Michael Dunne

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Plain-language medical vocabulary for precision diagnosis., Nicole A Vasilevsky, Erin D Foster, Mark E Engelstad, Leigh Carmody, Matt Might, Chip Chambers, Hugh J S Dawkins, Janine Lewis, Maria G Della Rocca, Michelle Snyder, Cornelius F Boerkoel, Ana Rath, Sharon F Terry, Alastair Kent, Beverly Searle, Gareth Baynam, Erik Jones, Pam Gavin, Michael Bamshad, Jessica Chong, Tudor Groza, David Adams, Adam C Resnick, Allison P Heath, Chris Mungall, Ingrid A Holm, Kayli Rageth, Catherine A Brownstein, Kent Shefchek, Julie A McMurry, Peter N Robinson, Sebastian Köhler, and Melissa A Haendel

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Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects., Simona Volpi, Carol J Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Howard J Jacob, Melpomeni Kasapi, Howard L McLeod, Dan M Roden, Marc S Williams, Eric D Green, Laura Lyman Rodriguez, Samuel Aronson, Larisa H Cavallari, Joshua C Denny, Lynn G Dressler, Julie A Johnson, Teri E Klein, J Steven Leeder, Micheline Piquette-Miller, Minoli Perera, Laura J Rasmussen-Torvik, Heidi L Rehm, Marylyn D Ritchie, Todd C Skaar, Nikhil Wagle, Richard Weinshilboum, Kristin W Weitzel, Robert Wildin, John Wilson, Teri A Manolio, and Mary V Relling