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Submissions from 2021

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A Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma., Sidra Adil, Rehan Zafar Paracha, Salma Tariq, Maryum Nisar, Sadaf Ijaz, Amnah Siddiqa, Zamir Hussain, and Afreenish Amir

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A functional variant on 20q13.33 related to glioma risk alters enhancer activity and modulates expression of multiple genes., Mourad Wagdy Ali, C Pawan K Patro, Jacqueline Jufen Zhu, Christopher H Dampier, Sarah J Plummer, Cem Kuscu, Mazhar Adli, Ching C Lau, Rose K Lai, and Graham Casey

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The Accreditation Council for Genetic Counseling's response to COVID-19 impact on genetic counseling programs., Dawn C Allain, Susan Randall Armel, Erin P Carmany, Heather Creswick, Sarah B McBrien, E Kate Reed, and Janet L Williams

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Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data., Matthew C Altman, Darawan Rinchai, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Mohamed Alfaki, Scott R Presnell, Prasong Khaenam, Aaron Ayllón-Benítez, Fleur Mougin, Patricia Thébault, Laurent Chiche, Noemie Jourde-Chiche, J Theodore Phillips, Goran Klintmalm, Anne O'Garra, Matthew Berry, Chloe Bloom, Robert J Wilkinson, Christine M Graham, Marc Lipman, Ganjana Lertmemongkolchai, Davide Bedognetti, Rodolphe Thiebaut, Farrah Kheradmand, Asuncion Mejias, Octavio Ramilo, Karolina Palucka, Virginia Pascual, Jacques Banchereau, and Damien Chaussabel

The influence of uncertainty and uncertainty tolerance on attitudes and self-efficacy about genomic tumor testing., Eric C Anderson, Alexandra Hinton, Christine W Lary, Tania Strout, Andrey Antov, Emily A Edelman, Petra Helbig, Kate Reed, Jens Rueter, and Paul K J Han

Splicing alterations in healthy aging and disease., Brittany Lynn Angarola and Olga Anczuków

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Population and subspecies diversity at mouse centromere satellites., Uma P Arora, Caleigh Charlebois, Raman Akinyanju Lawal, and Beth L Dumont

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A Platform for Experimental Precision Medicine: The Extended BXD Mouse Family., David G Ashbrook, Danny Arends, Pjotr Prins, Megan K Mulligan, Suheeta Roy, Evan G Williams, Cathleen Lutz, Alicia Valenzuela, Casey J Bohl, Jesse F Ingels, Melinda S McCarty, Arthur G Centeno, Reinmar Hager, Johan Auwerx, Lu Lu, and Robert W Williams

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Regen med therapeutic opportunities for fighting COVID-19., Anthony Atala, Alicia Henn, Martha Lundberg, Taby Ahsan, Jordan Greenberg, Jeff Krukin, Steven Lynum, Cathleen Lutz, Kyle Cetrulo, Mohammad Albanna, Taciana Pereira, Shannon Eaker, and Joshua Hunsberger

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Differential RNA methylation using multivariate statistical methods., Deepak Nag Ayyala, Jianan Lin, and Zhengqing Ouyang

Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of collaborative cross mouse strains and their inbred founders., Jared R Bagley, Elissa J Chesler, Vivek M. Philip, Center for Systems Genetics of Addiction, and James D Jentsch

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SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis., Adam L Bailey, Oleksandr Dmytrenko, Lina Greenberg, Andrea L Bredemeyer, Pan Ma, Jing Liu, Vinay Penna, Emma S Winkler, Sanja Sviben, Erin Brooks, Ajith P Nair, Kent A Heck, Aniket S Rali, Leo Simpson, Mehrdad Saririan, Dan Hobohm, W Tom Stump, James A Fitzpatrick, Xuping Xie, Xianwen Zhang, Pei-Yong Shi, J Travis Hinson, Weng-Tein Gi, Constanze Schmidt, Florian Leuschner, Chieh-Yu Lin, Michael S Diamond, Michael J Greenberg, and Kory J Lavine

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The mouse Gene Expression Database (GXD): 2021 update., Richard M. Baldarelli, Constance M. Smith, Jacqueline H. Finger, Terry F. Hayamizu, Ingeborg J. McCright, Jingxia Xu, David R. Shaw, Jonathan S Beal, Olin Blodgett, Jeff Campbell, Lori E. Corbani, Pete J. Frost, Sharon C Giannatto, Dave Miers, James A. Kadin, Joel E Richardson, and Martin Ringwald

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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine., Yasaman Barekatain, Jeffrey J Ackroyd, Victoria C Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H Poral, Theresa Tran, Dimitra K Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S Ballato, Eliot I Behr, Ana C deCarvalho, Roel G W Verhaak, John de Groot, Jason T Huse, John M Asara, Raghu Kalluri, and Florian L Muller

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Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers., Paola Bargagna-Mohan, Gwendolyn Schultz, Bruce Rheaume, Ephraim F Trakhtenberg, Paul Robson, Sonali Pal-Ghosh, Mary Ann Stepp, Katherine S Given, Wendy B Macklin, and Royce Mohan

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A nomenclature for echinoderm genes., Thomas R Beatman, Katherine M Buckley, Gregory A. Cary, Veronica F Hinman, and Charles A Ettensohn

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Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery., Bahar Behsaz, Edna Bode, Alexey Gurevich, Yan-Ni Shi, Florian Grundmann, Deepa Acharya, Andrés Mauricio Caraballo-Rodríguez, Amina Bouslimani, Morgan Panitchpakdi, Annabell Linck, Changhui Guan, Julia Oh, Pieter C Dorrestein, Helge B Bode, Pavel A Pevzner, and Hosein Mohimani

Know Your Model: A brief history of making mutant mouse genetic models., Susan M. Bello, Michelle N Perry, and Cynthia Smith

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Genome-Based Targeted Sequencing as a Reproducible Microbial Community Profiling Assay., Jacquelynn Benjamino, Benjamin Leopold, Daniel S Phillips, and Mark D Adams

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Genome-Based Targeted Sequencing as a Reproducible Microbial Community Profiling Assay., Jacquelynn Benjamino, Benjamin Leopold, Daniel S Phillips, and Mark D Adams

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Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation., Sarah J Benjamin, Kelly L Hawley, Paola Vera-Licona, Carson J La Vake, Jorge L Cervantes, Yijun Ruan, Justin D Radolf, and Juan C Salazar

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A resource of targeted mutant mouse lines for 5,061 genes., Marie-Christine Birling, Atsushi Yoshiki, David J Adams, Shinya Ayabe, Arthur L Beaudet, Joanna Bottomley, Allan Bradley, Steve D M Brown, Antje Bürger, Wendy Bushell, Francesco Chiani, Hsian-Jean Genie Chin, Skevoulla Christou, Gemma F Codner, Francesco J DeMayo, Mary E Dickinson, Brendan Doe, Leah Rae Donahue, Martin D Fray, Alessia Gambadoro, Xiang Gao, Marina Gertsenstein, Alba Gomez-Segura, Leslie Goodwin, Jason D Heaney, Yann Hérault, Martin Hrabe de Angelis, Si-Tse Jiang, Monica J Justice, Petr Kasparek, Ruairidh E King, Ralf Kühn, Ho Lee, Young Jae Lee, Zhiwei Liu, K C Kent Lloyd, Isabel Lorenzo, Ann-Marie Mallon, Colin McKerlie, Terrence F Meehan, Violeta Munoz Fuentes, Stuart Newman, Lauryl M J Nutter, Goo Taeg Oh, Guillaume Pavlovic, Ramiro Ramirez-Solis, Barry Rosen, Edward J Ryder, Luis A Santos, Joel Schick, John R Seavitt, Radislav Sedlacek, Claudia Seisenberger, Je Kyung Seong, William C Skarnes, Tania Sorg, Karen P Steel, Masaru Tamura, Glauco P Tocchini-Valentini, Chi-Kuang Leo Wang, Hannah Wardle-Jones, Marie Wattenhofer-Donzé, Sara Wells, Michael V. Wiles, Brandon J Willis, Joshua A Wood, Wolfgang Wurst, Ying Xu, International Mouse Phenotyping Consortium IMPC, Lydia Teboul, and Stephen A. Murray

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Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology., Judith A. Blake, Richard M. Baldarelli, James A. Kadin, Joel E Richardson, Cynthia Smith, Carol J Bult, and Mouse Genome Database Group

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Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse., Ruby Boateng, Nathaniel Boechat, Philipp P Henrich, and Ewelina Bolcun-Filas

Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology., Nassim Bouteldja, Barbara M Klinkhammer, Roman D Bülow, Patrick Droste, Simon W Otten, Saskia Freifrau von Stillfried, Julia Moellmann, Susan Sheehan, Ron Korstanje, Sylvia Menzel, Peter Bankhead, Matthias Mietsch, Charis Drummer, Michael Lehrke, Rafael Kramann, Jürgen Floege, Peter Boor, and Dorit Merhof

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System-Level Analysis of Alzheimer's Disease Prioritizes Candidate Genes for Neurodegeneration., Jeffrey L Brabec, Montana Kay Lara, Anna L. Tyler, and J Matthew Mahoney

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Aberrant type 1 immunity drives susceptibility to mucosal fungal infections., Timothy J Break, Vasileios Oikonomou, Nicolas Dutzan, Jigar V Desai, Marc Swidergall, Tilo Freiwald, Daniel Chauss, Oliver J Harrison, Julie Alejo, Drake W Williams, Stefania Pittaluga, Chyi-Chia R Lee, Nicolas Bouladoux, Muthulekha Swamydas, Kevin W Hoffman, Teresa Greenwell-Wild, Vincent M Bruno, Lindsey B Rosen, Wint Lwin, Andy Renteria, Sergio M Pontejo, John P Shannon, Ian A Myles, Peter Olbrich, Elise M N Ferré, Monica Schmitt, Daniel Martin, Daniel L Barber, Norma V Solis, Luigi D Notarangelo, David V. Serreze, Mitsuru Matsumoto, Heather D Hickman, Philip M Murphy, Mark S Anderson, Jean K Lim, Steven M Holland, Scott G Filler, Behdad Afzali, Yasmine Belkaid, Niki M Moutsopoulos, and Michail S Lionakis

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Rasa3 regulates stage-specific cell cycle progression in murine erythropoiesis., Elena C Brindley, Julien Papoin, Lauren Kennedy, Ray F. Robledo, Steven L. Ciciotte, Theodosia A Kalfa, Luanne L. Peters, and Lionel Blanc

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Host genetic control of gut microbiome composition., Jason A. Bubier, Elissa J Chesler, and George M. Weinstock

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SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence., Rita A Busuttil, Joshy George, Colin M House, Stephen Lade, Catherine Mitchell, Natasha S Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, and Alex Boussioutas

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Accelerating functional gene discovery in osteoarthritis., Natalie C Butterfield, Katherine F Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S Mannan, Anne-Tounsia Adoum, Victoria D Leitch, John G Logan, Julian A Waung, Elena Ghirardello, Lorraine Southam, Scott E Youlten, J Mark Wilkinson, Elizabeth A McAninch, Valerie E Vancollie, Fiona Kussy, Jacqueline K White, Christopher J Lelliott, David J Adams, Richard Jacques, Antonio C Bianco, Alan Boyde, Eleftheria Zeggini, Peter I Croucher, Graham R Williams, and J H Duncan Bassett

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Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE., Simone Caielli, Jacob Cardenas, Adriana Almeida de Jesus, Jeanine Baisch, Lynnette Walters, Jean Philippe Blanck, Preetha Balasubramanian, Cristy Stagnar, Marina Ohouo, Seunghee Hong, Lorien Nassi, Katie Stewart, Julie Fuller, Jinghua Gu, Jacques Banchereau, Tracey Wright, Raphaela Goldbach-Mansky, and Virginia Pascual

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Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid., Zhigang Cai, Xiaoyu Lu, Chi Zhang, Sai Nelanuthala, Fabiola Aguilera, Abigail Hadley, Baskar Ramdas, Fang Fang, Kenneth Nephew, Jonathan J Kotzin, Adam Williams, Jorge Henao-Mejia, Laura Haneline, and Reuben Kapur

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The Impact of Experiential Learning in Host-Pathogen Research on Medical Students' Interests and Attitudes towards Microbiology and Immunology., Jorge Cervantes and Bo-Young Hong

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A Practical Guide to Metabolomics Software Development., Hui-Yin Chang, Sean M Colby, Xiuxia Du, Javier D Gomez, Maximilian J Helf, Katerina Kechris, Christine R Kirkpatrick, Shuzhao Li, Gary J Patti, Ryan S Renslow, Shankar Subramaniam, Mukesh Verma, Jianguo Xia, and Jamey D Young

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Flow cytometric identification of T fh 13 cells in mouse and human, Jennifer S Chen, Jessica D S Grassmann, Uthaman Gowthaman, Sam J Olyha, Tregony Simoneau, M Cecilia Berin, Stephanie C Eisenbarth, and Adam Williams

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A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin., Phaneendra Chennampally, Ambreen Sayed-Zahid, Prabakaran Soundararajan, Jocelyn Sharp, Gregory A. Cox, Scott D Collins, and Rosemary L Smith

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epihet for intra-tumoral epigenetic heterogeneity analysis and visualization., Xiaowen Chen, Haitham Ashoor, Ryan Musich, Jiahui Wang, Mingsheng Zhang, Chao Zhang, Mingyang Lu, and Sheng Li

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iCSDB: an integrated database of CRISPR screens., Ahyoung Choi, Insu Jang, Heewon Han, Min-Seo Kim, Jinhyuk Choi, Jieun Lee, Sung-Yup Cho, Yukyung Jun, Charles Lee, Jaesang Kim, Byungwook Lee, and Sanghyuk Lee

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Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing., Colin M Cleary, Brenda M Milla, Fu-Shan Kuo, Shaun James, William F Flynn, Paul Robson, and Daniel K Mulkey

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The Gene Ontology resource: enriching a GOld mine., Gene Ontology Consortium, Judith A. Blake, Mary E. Dolan, Harold J. Drabkin, and David P. Hill

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The genetic basis of inter-individual variation in recovery from traumatic brain injury., Daniel Cortes and Martin Pera

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Diagnostics and correction of batch effects in large-scale proteomic studies: a tutorial., Jelena Čuklina, Chloe H Lee, Evan G Williams, Tatjana Sajic, Ben C Collins, María Rodríguez Martínez, Varun S Sharma, Fabian Wendt, Sandra Goetze, Gregory R Keele, Bernd Wollscheid, Ruedi Aebersold, and Patrick G A Pedrioli

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E2F6 initiates stable epigenetic silencing of germline genes during embryonic development., Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anaïs F Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N Robinson, Christian Hagemeier, and Michael Weber

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Interpretable prioritization of splice variants in diagnostic next-generation sequencing., Daniel Danis, Julius O B Jacobsen, Leigh Carmody, Michael Gargano, Julie A McMurry, Ayushi Hegde, Melissa A Haendel, Giorgio Valentini, Damian Smedley, and Peter N Robinson

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Identification of the Adult Hematopoietic Liver as the Primary Reservoir for the Recruitment of Pro-regenerative Macrophages Required for Salamander Limb Regeneration., Ryan J Debuque, Andrew J Hart, Gabriela H Johnson, Nadia Rosenthal, and James W Godwin

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Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia., Anne P de Groot, Yoriko Saito, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Kaori Sato, Hiroshi Kajita, Takashi Watanabe, Masatoshi Takagi, Daisuke Tomizawa, Katsuyoshi Koh, Mariko Eguchi, Eiichi Ishii, Osamu Ohara, Leonard D. Shultz, Shuki Mizutani, and Fumihiko Ishikawa

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Genetic background determines renal response to chronic lithium treatment in female mice., Theun de Groot, Rosalinda A. Doty, Lars Damen, Ruben Baumgarten, Steffi Bressers, Joline Kraak, Peter M T Deen, and Ron Korstanje

Studying Tumor Angiogenesis and Cancer Invasion in a Three-Dimensional Vascularized Breast Cancer Micro-Environment., Madhuri Dey, Bugra Ayan, Marina Yurieva, Derya Unutmaz, and Ibrahim T Ozbolat

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SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus., Mikail Dogan, Lina Kozhaya, Lindsey Placek, Courtney Gunter, Mesut Yigit, Rachel Hardy, Matthew Plassmeyer, Paige Coatney, Kimberleigh Lillard, Zaheer Bukhari, Michael Kleinberg, Chelsea Hayes, Moshe Arditi, Ellen Klapper, Noah Merin, Bruce Tsan-Tang Liang, Raavi Gupta, Oral Alpan, and Derya Unutmaz

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INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants., Chenyang Dong, Shane P Simonett, Sunyoung Shin, Donnie S Stapleton, Kathryn L Schueler, Gary Churchill, Leina Lu, Xiaoxiao Liu, Fulai Jin, Yan Li, Alan D Attie, Mark P Keller, and Sündüz Keleş

Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed, G L Drusano, Robert A Bonomo, Steven M Marshall, Laura J Rojas, Mark D Adams, Maria F Mojica, Barry N Kreiswirth, Liang Chen, Nino Mtchedlidze, Meredith Bacci, Michael Vicchiarelli, Jürgen B Bulitta, and Arnold Louie

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Haplotype-resolved diverse human genomes and integrated analysis of structural variation., Peter Ebert, Peter A Audano, Qihui Zhu, Bernardo Rodriguez-Martin, David Porubsky, Marc Jan Bonder, Arvis Sulovari, Jana Ebler, Weichen Zhou, Rebecca Serra Mari, Feyza Yilmaz, Xuefang Zhao, PingHsun Hsieh, Joyce Lee, Sushant Kumar, Jiadong Lin, Tobias Rausch, Yu Chen, Jingwen Ren, Martin Santamarina, Wolfram Höps, Hufsah Ashraf, Nelson T Chuang, Xiaofei Yang, Katherine M Munson, Alexandra P Lewis, Susan Fairley, Luke J Tallon, Wayne E Clarke, Anna O Basile, Marta Byrska-Bishop, André Corvelo, Uday S Evani, Tsung-Yu Lu, Mark J P Chaisson, Junjie Chen, Chong Li, Harrison Brand, Aaron M Wenger, Maryam Ghareghani, William T Harvey, Benjamin Raeder, Patrick Hasenfeld, Allison A Regier, Haley J Abel, Ira M Hall, Paul Flicek, Oliver Stegle, Mark B Gerstein, Jose M C Tubio, Zepeng Mu, Yang I Li, Xinghua Shi, Alex R Hastie, Kai Ye, Zechen Chong, Ashley D Sanders, Michael C Zody, Michael E Talkowski, Ryan E Mills, Scott E Devine, Charles Lee, Jan O Korbel, Tobias Marschall, and Evan E Eichler

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Maximizing the potential of aggressive mouse tumor models in preclinical drug testing., M Tarek Elghetany, Jia-Min Ho, Lois Hew Shi-Qi, Sekar Karthik, Jack M F Su, Qi Lin, YuChen Du, Jianhe Shen, Wing-Yuk Chow, Ching C Lau, Adekunle Adesina, Angela Major, Anat Erdreich-Epstein, Kam-Man Hui, Xiao-Nan Li, and Wan-Yee Teo

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Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin., Helen B Everts, Kathleen A Silva, Adriana N Schmidt, Susan Opalenik, F Jason Duncan, Lloyd E King, John P Sundberg, and David E Ong

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Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis., Marion Failler, Ariadna Giro-Perafita, Mikito Owa, Shalini Srivastava, Chi Yun, David J Kahler, Derya Unutmaz, Francisco J Esteva, Irma Sánchez, and Brian D Dynlacht

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A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears., Amanda Fazzalari, Giacomo Basadonna, Alper Kucukural, Kahraman Tanriverdi, Milka Koupenova, Natalie Pozzi, Jahnavi Kakuturu, Ann-Kristin U Friedrich, Ron Korstanje, Nicholas Fowler, Jerrold L Belant, Dean E Beyer, Marjory B Brooks, Eric W Dickson, Meghan Blackwood, Chris Mueller, J Alexander Palesty, Jane E Freedman, and Mitchell A Cahan

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Draft Genome Sequences of 27 Northern Maine Clinical Isolates., Larry Feinstein, Kendra Batchelder, Lydia Tilley, and Grace Stafford

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Differences in cancer patients' and clinicians' preferences for disclosure of uncertain genomic tumor testing results., Anny T Fenton, Eric C Anderson, Elizabeth Scharnetzki, Kate Reed, Emily A Edelman, Andrey Antov, Jens Rueter, Paul K J Han, and MCGI Working Group

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A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram., Sherise D Ferguson, Tiffany R Hodges, Nazanin K Majd, Kristin Alfaro-Munoz, Wajd N Al-Holou, Dima Suki, John F de Groot, Gregory N Fuller, Lee Xue, Miao Li, Carmen Jacobs, Ganesh Rao, Rivka R Colen, Joanne Xiu, Roel G W Verhaak, David Spetzler, Mustafa Khasraw, Raymond Sawaya, James P Long, and Amy B Heimberger

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Ex uno, plures-From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology., Elvira Forte, Michael A McLellan, Daniel A Skelly, and Nadia Rosenthal

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Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart., Elvira Forte, Mona Panahi, Nicoleta Baxan, Fu Siong Ng, Joseph J Boyle, Jane Branca, Olivia Bedard, Muneer G. Hasham, Lindsay Benson, Sian E Harding, Nadia Rosenthal, and Susanne Sattler

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Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart., Elvira Forte, Bryant Perkins, Amalia Sintou, Harkaran S Kalkat, Angelos Papanikolaou, Catherine Jenkins, Mashael Alsubaie, Rasheda A Chowdhury, Theodore M Duffy, Daniel A Skelly, Jane Branca, Mohamed Bellahcene, Michael D Schneider, Sian E Harding, Milena B Furtado, Fu Siong Ng, Muneer G. Hasham, Nadia Rosenthal, and Susanne Sattler

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Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples., Chunxiao Fu, Michal Marczyk, Michael Samuels, Alexander J Trevarton, Jiaxin Qu, Rosanna Lau, Lili Du, Todd Pappas, Bruno V Sinn, Rebekah E Gould, Lajos Pusztai, Christos Hatzis, and W Fraser Symmans

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Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities., Carl M Gay, C Allison Stewart, Elizabeth M Park, Lixia Diao, Sarah M Groves, Simon Heeke, Barzin Y Nabet, Junya Fujimoto, Luisa M Solis, Wei Lu, Yuanxin Xi, Robert J Cardnell, Qi Wang, Giulia Fabbri, Kasey R Cargill, Natalie I Vokes, Kavya Ramkumar, Bingnan Zhang, Carminia M Della Corte, Paul Robson, Stephen G Swisher, Jack A Roth, Bonnie S Glisson, David S Shames, Ignacio I Wistuba, Jing Wang, Vito Quaranta, John Minna, John V Heymach, and Lauren Averett Byers

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Action detection using a neural network elucidates the genetics of mouse grooming behavior., Brian Q Geuther, Asaf Peer, Hao He, Gautam Sabnis, Vivek M. Philip, and Vivek Kumar

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Genetic mapping of renal glutathione suggests a novel regulatory locus on the murine X chromosome and overlap with hepatic glutathione regulation., Rebecca L Gould, Steven W Craig, Susan McClatchy, Gary A Churchill, and Robert Pazdro

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Quantitative trait mapping in Diversity Outbred mice identifies novel genomic regions associated with the hepatic glutathione redox system., Rebecca L Gould, Steven W Craig, Susan McClatchy, Gary A Churchill, and Robert Pazdro

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Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network., Mathys Grapotte, Manu Saraswat, Chloé Bessière, Christophe Menichelli, Jordan A Ramilowski, Jessica Severin, Yoshihide Hayashizaki, Masayoshi Itoh, Michihira Tagami, Mitsuyoshi Murata, Miki Kojima-Ishiyama, Shohei Noma, Shuhei Noguchi, Takeya Kasukawa, Akira Hasegawa, Harukazu Suzuki, Hiromi Nishiyori-Sueki, Martin C Frith, FANTOM Consortium, Clément Chatelain, Piero Carninci, Michiel J L de Hoon, Wyeth W Wasserman, Laurent Bréhélin, Charles-Henri Lecellier, Judith A. Blake, and Carol J Bult

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Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution., Dustin Griesemer, James R Xue, Steven K Reilly, Jacob C Ulirsch, Kalki Kukreja, Joe R Davis, Masahiro Kanai, David K Yang, John C Butts, Mehmet H Guney, Jeremy Luban, Stephen B Montgomery, Hilary K Finucane, Carl D Novina, Ryan Tewhey, and Pardis C Sabeti

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy., Matthias Gromeier, Michael C Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, Hai Yan, Yiping He, Annick Desjardins, James E Herndon, Frederick S Varn, Roel G W Verhaak, Junfei Zhao, Dani P Bolognesi, Allan H Friedman, Henry S Friedman, Frances McSherry, Andrea M Muscat, Eric S Lipp, Smita K Nair, Mustafa Khasraw, Katherine B Peters, Dina Randazzo, John H Sampson, Roger E McLendon, Darell D Bigner, and David M Ashley

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Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet., Diana E Gutierrez Lopez, Laura M Lashinger, George M. Weinstock, and Molly S Bray

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The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment., Melissa A Haendel, Christopher G Chute, Tellen D Bennett, David A Eichmann, Justin Guinney, Warren A Kibbe, Philip R O Payne, Emily R Pfaff, Peter N Robinson, Joel H Saltz, Heidi Spratt, Christine Suver, John Wilbanks, Adam B Wilcox, Andrew E Williams, Chunlei Wu, Clair Blacketer, Robert L Bradford, James J Cimino, Marshall Clark, Evan W Colmenares, Patricia A Francis, Davera Gabriel, Alexis Graves, Raju Hemadri, Stephanie S Hong, George Hripscak, Dazhi Jiao, Jeffrey G Klann, Kristin Kostka, Adam M Lee, Harold P Lehmann, Lora Lingrey, Robert T Miller, Michele Morris, Shawn N Murphy, Karthik Natarajan, Matvey B Palchuk, Usman Sheikh, Harold Solbrig, Shyam Visweswaran, Anita Walden, Kellie M Walters, Griffin M Weber, Xiaohan Tanner Zhang, Richard L Zhu, Benjamin Amor, Andrew T Girvin, Amin Manna, Nabeel Qureshi, Michael G Kurilla, Sam G Michael, Lili M Portilla, Joni L Rutter, Christopher P Austin, and Ken R Gersing

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Letter to the Editor: Response to Biesecker et al., Ada Hamosh, Joanna S Amberger, Carol A Bocchini, Joann Bodurtha, Carol J Bult, Christopher G Chute, Garry R Cutting, Harry C Dietz, Helen V Firth, Richard A Gibbs, Wayne W Grody, Melissa A Haendel, James R Lupski, Jennifer E Posey, Peter N Robinson, Lynn M Schriml, Alan F Scott, Nara L Sobreira, David Valle, Nan Wu, and Sonja A Rasmussen

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An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis., Christian C D Harman, Will Bailis, Jun Zhao, Louisa Hill, Rihao Qu, Ruaidhrí P Jackson, Justin A Shyer, Holly R Steach, Yuval Kluger, Loyal A Goff, John L Rinn, Adam Williams, Jorge Henao-Mejia, and Richard A Flavell

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17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex., David E Harrison, Randy Strong, Peter C. Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Marisa Lopez-Cruzan, Francesca Macchiarini, James F Nelson, Alessandro Bitto, Amy L Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M Stearns, Molly A. Bogue, and Richard A Miller

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Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia, M Hashimoto, Y Saito, R Nakagawa, I Ogahara, S Takagi, S Takata, H Amitani, M Endo, H Yuki, J A. Ramilowski, Leonard D. Shultz, and Et Al

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A case for revisiting Nodal signaling in human pluripotent stem cells., Kevin Hayes, Yun-Kyo Kim, and Martin F Pera

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3D genomics across the tree of life reveals condensin II as a determinant of architecture type., Claire Hoencamp, Olga Dudchenko, Ahmed M O Elbatsh, Sumitabha Brahmachari, Jonne A Raaijmakers, Tom van Schaik, Ángela Sedeño Cacciatore, Vinícius G Contessoto, Roy G H P van Heesbeen, Bram van den Broek, Aditya N Mhaskar, Hans Teunissen, Brian Glenn St Hilaire, David Weisz, Arina D Omer, Melanie Pham, Zane Colaric, Zhenzhen Yang, Suhas S P Rao, Namita Mitra, Christopher Lui, Weijie Yao, Ruqayya Khan, Leonid L Moroz, Andrea Kohn, Judy St Leger, Alexandria Mena, Karen Holcroft, Maria Cristina Gambetta, Fabian Lim, Emma Farley, Nils Stein, Alexander Haddad, Daniel Chauss, Ayse Sena Mutlu, Meng C Wang, Neil D Young, Evin Hildebrandt, Hans H Cheng, Christopher J Knight, Theresa L U Burnham, Kevin A Hovel, Andrew J Beel, Pierre-Jean Mattei, Roger D Kornberg, Wesley C Warren, Gregory Cary, José Luis Gómez-Skarmeta, Veronica Hinman, Kerstin Lindblad-Toh, Federica Di Palma, Kazuhiro Maeshima, Asha S Multani, Sen Pathak, Liesl Nel-Themaat, Richard R Behringer, Parwinder Kaur, René H Medema, Bas van Steensel, Elzo de Wit, José N Onuchic, Michele Di Pierro, Erez Lieberman Aiden, and Benjamin D Rowland

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Cisplatin increases immune activity of monocytes and cytotoxic T-cells in a murine model of epithelial ovarian cancer., Daniel Hopkins, Hector Sanchez, Brent Berwin, and Ivy Wilkinson-Ryan

Do gene expression findings from mouse models of cocaine use recapitulate human cocaine use disorder in reward circuitry?, Spencer B Huggett, Jason A. Bubier, Elissa J Chesler, and Rohan H C Palmer

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Multiple PDZ domain protein maintains patterning of the apical cytoskeleton in sensory hair cells., Amandine Jarysta and Basile Tarchini

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CRISPR screens identify a novel combination treatment targeting BCL-X L and WNT signaling for KRAS/BRAF-mutated colorectal cancers, Hae Rim Jung, Yumi Oh, Deukchae Na, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Jiwon Kim, Sang Eun Lee, Eui Man Jeong, Joon Yong An, Chang Ohk Sung, Won-Suk Lee, Charles Lee, and Sung-Yup Cho

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muCNV: Genotyping Structural Variants for Population-level Sequencing., Goo Jun, Fritz Sedlazeck, Qihui Zhu, Adam English, Ginger Metcalf, Hyun Min Kang, Human Genome Structural Variation Consortium, Charles Lee, Richard Gibbs, and Eric Boerwinkle

3D Bioprinting for fabrication of tissue models of COVID-19 infection., Anisha Kabir, Pallab Datta, Julia Oh, Adam Williams, Veli Ozbolat, Derya Unutmaz, and Ibrahim T Ozbolat

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Development of a Novel Orthotopic Gastric Cancer Mouse Model., Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, and Charles Lee

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Classification of Molecular Subtypes of High-Grade Serous Ovarian Cancer by MALDI-Imaging., Wanja Kassuhn, Oliver Klein, Silvia Darb-Esfahani, Hedwig Lammert, Sylwia Handzik, Eliane T Taube, Wolfgang D Schmitt, Carlotta Keunecke, David Horst, Felix Dreher, Joshy George, David D Bowtell, Oliver Dorigo, Michael Hummel, Jalid Sehouli, Nils Blüthgen, Hagen Kulbe, and Elena I Braicu

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Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model., Gregory R Keele, Jeremy W Prokop, Hong He, Katie Holl, John Littrell, Aaron W Deal, Yunjung Kim, Patrick B Kyle, Esinam Attipoe, Ashley C Johnson, Katie L Uhl, Olivia L Sirpilla, Seyedehameneh Jahanbakhsh, Melanie Robinson, Shawn Levy, William Valdar, Michael R Garrett, and Leah C Solberg Woods

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Heritability of fat distributions in male mice from the founder strains of the Diversity Outbred mouse population., Brendan T Keenan, Jeanette C Webster, Andrew S Wiemken, Nir Lavi-Romer, Teresa Nguyen, Karen L. Svenson, Raymond J Galante, Gary A Churchill, Stephen Pickup, Allan I Pack, and Richard J Schwab

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Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation., Shubham Khetan, Susan Kales, Romy Kursawe, Alexandria Jillette, Jacob C Ulirsch, Steven K Reilly, Duygu Ucar, Ryan Tewhey, and Michael L. Stitzel

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Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome., Gihyeon Kim, Misun Kim, Minji Kim, Changho Park, Youngmin Yoon, Doo-Hyeon Lim, Hyeonju Yeo, Seunghyun Kang, Yeong-Geun Lee, Nam-In Beak, Jongsung Lee, Sujeong Kim, Jee Young Kwon, Won Woo Choi, Charles Lee, Kyoung Wan Yoon, Hansoo Park, and Dong-Geol Lee

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High-throughput measurement of fibroblast rhythms reveals genetic heritability of circadian phenotypes in diversity outbred mice and their founder strains., Sam-Moon Kim, Chelsea A Vadnie, Vivek M. Philip, Leona H. Gagnon, Kodavali V Chowdari, Elissa J Chesler, Colleen A McClung, and Ryan W Logan

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Genomic profile of metastatic breast cancer patient-derived xenografts established using percutaneous biopsy., Seongyeong Kim, Dongjin Shin, Ahrum Min, Minjung Kim, Deukchae Na, Han-Byeol Lee, Han Suk Ryu, Yaewon Yang, Go-Un Woo, Kyung-Hun Lee, Dae-Won Lee, Tae-Yong Kim, Charles Lee, Seock-Ah Im, and Jong-Il Kim

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Perspective of mesenchymal transformation in glioblastoma., Yona Kim, Frederick S Varn, Sung-Hye Park, Byung Woo Yoon, Hye Ran Park, Charles Lee, Roel G W Verhaak, and Sun Ha Paek

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EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia., Katie S Kindt, Anil Akturk, Amandine Jarysta, Matthew Day, Alisha Beirl, Michaela Flonard, and Basile Tarchini

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Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus., Kathryn M Kingsmore, Prathyusha Bachali, Michelle D Catalina, Andrea R Daamen, Sarah E Heuer, Robert D Robl, Amrie C Grammer, and Peter E Lipsky

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Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer., Emre Kocakavuk, Kevin J Anderson, Frederick S Varn, Kevin C Johnson, Samirkumar B Amin, Erik P Sulman, Martijn P Lolkema, Floris P Barthel, and Roel G W Verhaak

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The Human Phenotype Ontology in 2021., Sebastian Köhler, Michael Gargano, Nicolas Matentzoglu, Leigh Carmody, David Lewis-Smith, Nicole A Vasilevsky, Daniel Danis, Ganna Balagura, Gareth Baynam, Amy M Brower, Tiffany J Callahan, Christopher G Chute, Johanna L Est, Peter D Galer, Shiva Ganesan, Matthias Griese, Matthias Haimel, Julia Pazmandi, Marc Hanauer, Nomi L Harris, Michael J Hartnett, Maximilian Hastreiter, Fabian Hauck, Yongqun He, Tim Jeske, Hugh Kearney, Gerhard Kindle, Christoph Klein, Katrin Knoflach, Roland Krause, David Lagorce, Julie A McMurry, Jillian A Miller, Monica C Munoz-Torres, Rebecca L Peters, Christina K Rapp, Ana M Rath, Shahmir A Rind, Avi Z Rosenberg, Michael M Segal, Markus G Seidel, Damian Smedley, Tomer Talmy, Yarlalu Thomas, Samuel A Wiafe, Julie Xian, Zafer Yüksel, Ingo Helbig, Christopher J Mungall, Melissa A Haendel, and Peter N Robinson

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Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA., Lingling Kong, David O Valdivia, Christian M Simon, Cera W Hassinan, Nicolas Delestrée, Daniel M Ramos, Jae Hong Park, Celeste M Pilato, Xixi Xu, Melissa Crowder, Chloe C Grzyb, Zachary A King, Marco Petrillo, Kathryn J Swoboda, Crystal Davis, Cathleen Lutz, Alexander H Stephan, Xin Zhao, Marla Weetall, Nikolai A Naryshkin, Thomas O Crawford, George Z Mentis, and Charlotte J Sumner

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Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2., Feria A Ladha, Ketan Thakar, Anthony M Pettinato, Nicholas Legere, Shahnaz Ghahremani, Rachel Cohn, Robert Romano, Emily Meredith, Yu-Sheng Chen, and J Travis Hinson