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Submissions from 2021

Splicing alterations in healthy aging and disease., Brittany Lynn Angarola and Olga Anczuków

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Population and subspecies diversity at mouse centromere satellites., Uma P Arora, Caleigh Charlebois, Raman Akinyanju Lawal, and Beth L Dumont

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A Platform for Experimental Precision Medicine: The Extended BXD Mouse Family., David G Ashbrook, Danny Arends, Pjotr Prins, Megan K Mulligan, Suheeta Roy, Evan G Williams, Cathleen Lutz, Alicia Valenzuela, Casey J Bohl, Jesse F Ingels, Melinda S McCarty, Arthur G Centeno, Reinmar Hager, Johan Auwerx, Lu Lu, and Robert W Williams

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The mouse Gene Expression Database (GXD): 2021 update., Richard M. Baldarelli, Constance M. Smith, Jacqueline H. Finger, Terry F. Hayamizu, Ingeborg J. McCright, Jingxia Xu, David R. Shaw, Jonathan S Beal, Olin Blodgett, Jeff Campbell, Lori E. Corbani, Pete J. Frost, Sharon C Giannatto, Dave Miers, James A. Kadin, Joel E Richardson, and Martin Ringwald

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Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers., Paola Bargagna-Mohan, Gwendolyn Schultz, Bruce Rheaume, Ephraim F Trakhtenberg, Paul Robson, Sonali Pal-Ghosh, Mary Ann Stepp, Katherine S Given, Wendy B Macklin, and Royce Mohan

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Genome-Based Targeted Sequencing as a Reproducible Microbial Community Profiling Assay., Jacquelynn Benjamino, Benjamin Leopold, Daniel S Phillips, and Mark D Adams

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Genome-Based Targeted Sequencing as a Reproducible Microbial Community Profiling Assay., Jacquelynn Benjamino, Benjamin Leopold, Daniel S Phillips, and Mark D Adams

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A resource of targeted mutant mouse lines for 5,061 genes., Marie-Christine Birling, Atsushi Yoshiki, David J Adams, Shinya Ayabe, Arthur L Beaudet, Joanna Bottomley, Allan Bradley, Steve D M Brown, Antje Bürger, Wendy Bushell, Francesco Chiani, Hsian-Jean Genie Chin, Skevoulla Christou, Gemma F Codner, Francesco J DeMayo, Mary E Dickinson, Brendan Doe, Leah Rae Donahue, Martin D Fray, Alessia Gambadoro, Xiang Gao, Marina Gertsenstein, Alba Gomez-Segura, Leslie Goodwin, Jason D Heaney, Yann Hérault, Martin Hrabe de Angelis, Si-Tse Jiang, Monica J Justice, Petr Kasparek, Ruairidh E King, Ralf Kühn, Ho Lee, Young Jae Lee, Zhiwei Liu, K C Kent Lloyd, Isabel Lorenzo, Ann-Marie Mallon, Colin McKerlie, Terrence F Meehan, Violeta Munoz Fuentes, Stuart Newman, Lauryl M J Nutter, Goo Taeg Oh, Guillaume Pavlovic, Ramiro Ramirez-Solis, Barry Rosen, Edward J Ryder, Luis A Santos, Joel Schick, John R Seavitt, Radislav Sedlacek, Claudia Seisenberger, Je Kyung Seong, William C Skarnes, Tania Sorg, Karen P Steel, Masaru Tamura, Glauco P Tocchini-Valentini, Chi-Kuang Leo Wang, Hannah Wardle-Jones, Marie Wattenhofer-Donzé, Sara Wells, Michael V. Wiles, Brandon J Willis, Joshua A Wood, Wolfgang Wurst, Ying Xu, International Mouse Phenotyping Consortium IMPC, Lydia Teboul, and Stephen A. Murray

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Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology., Judith A. Blake, Richard M. Baldarelli, James A. Kadin, Joel E Richardson, Cynthia Smith, Carol J Bult, and Mouse Genome Database Group

Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology., Nassim Bouteldja, Barbara M Klinkhammer, Roman D Bülow, Patrick Droste, Simon W Otten, Saskia Freifrau von Stillfried, Julia Moellmann, Susan Sheehan, Ron Korstanje, Sylvia Menzel, Peter Bankhead, Matthias Mietsch, Charis Drummer, Michael Lehrke, Rafael Kramann, Jürgen Floege, Peter Boor, and Dorit Merhof

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System-Level Analysis of Alzheimer's Disease Prioritizes Candidate Genes for Neurodegeneration., Jeffrey L Brabec, Montana Kay Lara, Anna L. Tyler, and J Matthew Mahoney

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Aberrant type 1 immunity drives susceptibility to mucosal fungal infections., Timothy J Break, Vasileios Oikonomou, Nicolas Dutzan, Jigar V Desai, Marc Swidergall, Tilo Freiwald, Daniel Chauss, Oliver J Harrison, Julie Alejo, Drake W Williams, Stefania Pittaluga, Chyi-Chia R Lee, Nicolas Bouladoux, Muthulekha Swamydas, Kevin W Hoffman, Teresa Greenwell-Wild, Vincent M Bruno, Lindsey B Rosen, Wint Lwin, Andy Renteria, Sergio M Pontejo, John P Shannon, Ian A Myles, Peter Olbrich, Elise M N Ferré, Monica Schmitt, Daniel Martin, Daniel L Barber, Norma V Solis, Luigi D Notarangelo, David V. Serreze, Mitsuru Matsumoto, Heather D Hickman, Philip M Murphy, Mark S Anderson, Jean K Lim, Steven M Holland, Scott G Filler, Behdad Afzali, Yasmine Belkaid, Niki M Moutsopoulos, and Michail S Lionakis

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Rasa3 regulates stage-specific cell cycle progression in murine erythropoiesis., Elena C Brindley, Julien Papoin, Lauren Kennedy, Ray F. Robledo, Steven L. Ciciotte, Theodosia A Kalfa, Luanne L. Peters, and Lionel Blanc

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Accelerating functional gene discovery in osteoarthritis., Natalie C Butterfield, Katherine F Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S Mannan, Anne-Tounsia Adoum, Victoria D Leitch, John G Logan, Julian A Waung, Elena Ghirardello, Lorraine Southam, Scott E Youlten, J Mark Wilkinson, Elizabeth A McAninch, Valerie E Vancollie, Fiona Kussy, Jacqueline K White, Christopher J Lelliott, David J Adams, Richard Jacques, Antonio C Bianco, Alan Boyde, Eleftheria Zeggini, Peter I Croucher, Graham R Williams, and J H Duncan Bassett

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Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid., Zhigang Cai, Xiaoyu Lu, Chi Zhang, Sai Nelanuthala, Fabiola Aguilera, Abigail Hadley, Baskar Ramdas, Fang Fang, Kenneth Nephew, Jonathan J Kotzin, Adam Williams, Jorge Henao-Mejia, Laura Haneline, and Reuben Kapur

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Flow cytometric identification of T fh 13 cells in mouse and human, Jennifer S Chen, Jessica D S Grassmann, Uthaman Gowthaman, Sam J Olyha, Tregony Simoneau, M Cecilia Berin, Stephanie C Eisenbarth, and Adam Williams

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epihet for intra-tumoral epigenetic heterogeneity analysis and visualization., Xiaowen Chen, Haitham Ashoor, Ryan Musich, Jiahui Wang, Mingsheng Zhang, Chao Zhang, Mingyang Lu, and Sheng Li

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iCSDB: an integrated database of CRISPR screens., Ahyoung Choi, Insu Jang, Heewon Han, Min-Seo Kim, Jinhyuk Choi, Jieun Lee, Sung-Yup Cho, Yukyung Jun, Charles Lee, Jaesang Kim, Byungwook Lee, and Sanghyuk Lee

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The Gene Ontology resource: enriching a GOld mine., Gene Ontology Consortium, Judith A. Blake, Mary E. Dolan, Harold J. Drabkin, and David P. Hill

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The genetic basis of inter-individual variation in recovery from traumatic brain injury., Daniel Cortes and Martin Pera

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Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia., Anne P de Groot, Yoriko Saito, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Kaori Sato, Hiroshi Kajita, Takashi Watanabe, Masatoshi Takagi, Daisuke Tomizawa, Katsuyoshi Koh, Mariko Eguchi, Eiichi Ishii, Osamu Ohara, Leonard D. Shultz, Shuki Mizutani, and Fumihiko Ishikawa

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SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus., Mikail Dogan, Lina Kozhaya, Lindsey Placek, Courtney Gunter, Mesut Yigit, Rachel Hardy, Matthew Plassmeyer, Paige Coatney, Kimberleigh Lillard, Zaheer Bukhari, Michael Kleinberg, Chelsea Hayes, Moshe Arditi, Ellen Klapper, Noah Merin, Bruce Tsan-Tang Liang, Raavi Gupta, Oral Alpan, and Derya Unutmaz

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Haplotype-resolved diverse human genomes and integrated analysis of structural variation., Peter Ebert, Peter A Audano, Qihui Zhu, Bernardo Rodriguez-Martin, David Porubsky, Marc Jan Bonder, Arvis Sulovari, Jana Ebler, Weichen Zhou, Rebecca Serra Mari, Feyza Yilmaz, Xuefang Zhao, PingHsun Hsieh, Joyce Lee, Sushant Kumar, Jiadong Lin, Tobias Rausch, Yu Chen, Jingwen Ren, Martin Santamarina, Wolfram Höps, Hufsah Ashraf, Nelson T Chuang, Xiaofei Yang, Katherine M Munson, Alexandra P Lewis, Susan Fairley, Luke J Tallon, Wayne E Clarke, Anna O Basile, Marta Byrska-Bishop, André Corvelo, Uday S Evani, Tsung-Yu Lu, Mark J P Chaisson, Junjie Chen, Chong Li, Harrison Brand, Aaron M Wenger, Maryam Ghareghani, William T Harvey, Benjamin Raeder, Patrick Hasenfeld, Allison A Regier, Haley J Abel, Ira M Hall, Paul Flicek, Oliver Stegle, Mark B Gerstein, Jose M C Tubio, Zepeng Mu, Yang I Li, Xinghua Shi, Alex R Hastie, Kai Ye, Zechen Chong, Ashley D Sanders, Michael C Zody, Michael E Talkowski, Ryan E Mills, Scott E Devine, Charles Lee, Jan O Korbel, Tobias Marschall, and Evan E Eichler

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A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears., Amanda Fazzalari, Giacomo Basadonna, Alper Kucukural, Kahraman Tanriverdi, Milka Koupenova, Natalie Pozzi, Jahnavi Kakuturu, Ann-Kristin U Friedrich, Ron Korstanje, Nicholas Fowler, Jerrold L Belant, Dean E Beyer, Marjory B Brooks, Eric W Dickson, Meghan Blackwood, Chris Mueller, J Alexander Palesty, Jane E Freedman, and Mitchell A Cahan

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Draft Genome Sequences of 27 Northern Maine Clinical Isolates., Larry Feinstein, Kendra Batchelder, Lydia Tilley, and Grace Stafford

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Differences in cancer patients' and clinicians' preferences for disclosure of uncertain genomic tumor testing results., Anny T Fenton, Eric C Anderson, Elizabeth Scharnetzki, Kate Reed, Emily A Edelman, Andrey Antov, Jens Rueter, Paul K J Han, and MCGI Working Group

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A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram., Sherise D Ferguson, Tiffany R Hodges, Nazanin K Majd, Kristin Alfaro-Munoz, Wajd N Al-Holou, Dima Suki, John F de Groot, Gregory N Fuller, Lee Xue, Miao Li, Carmen Jacobs, Ganesh Rao, Rivka R Colen, Joanne Xiu, Roel G W Verhaak, David Spetzler, Mustafa Khasraw, Raymond Sawaya, James P Long, and Amy B Heimberger

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Ex uno, plures-From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology., Elvira Forte, Michael A McLellan, Daniel A Skelly, and Nadia Rosenthal

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Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart., Elvira Forte, Mona Panahi, Nicoleta Baxan, Fu Siong Ng, Joseph J Boyle, Jane Branca, Olivia Bedard, Muneer G. Hasham, Lindsay Benson, Sian E Harding, Nadia Rosenthal, and Susanne Sattler

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Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart., Elvira Forte, Bryant Perkins, Amalia Sintou, Harkaran S Kalkat, Angelos Papanikolaou, Catherine Jenkins, Mashael Alsubaie, Rasheda A Chowdhury, Theodore M Duffy, Daniel A Skelly, Jane Branca, Mohamed Bellahcene, Michael D Schneider, Sian E Harding, Milena B Furtado, Fu Siong Ng, Muneer G. Hasham, Nadia Rosenthal, and Susanne Sattler

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Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples., Chunxiao Fu, Michal Marczyk, Michael Samuels, Alexander J Trevarton, Jiaxin Qu, Rosanna Lau, Lili Du, Todd Pappas, Bruno V Sinn, Rebekah E Gould, Lajos Pusztai, Christos Hatzis, and W Fraser Symmans

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Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities., Carl M Gay, C Allison Stewart, Elizabeth M Park, Lixia Diao, Sarah M Groves, Simon Heeke, Barzin Y Nabet, Junya Fujimoto, Luisa M Solis, Wei Lu, Yuanxin Xi, Robert J Cardnell, Qi Wang, Giulia Fabbri, Kasey R Cargill, Natalie I Vokes, Kavya Ramkumar, Bingnan Zhang, Carminia M Della Corte, Paul Robson, Stephen G Swisher, Jack A Roth, Bonnie S Glisson, David S Shames, Ignacio I Wistuba, Jing Wang, Vito Quaranta, John Minna, John V Heymach, and Lauren Averett Byers

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Action detection using a neural network elucidates the genetics of mouse grooming behavior., Brian Q Geuther, Asaf Peer, Hao He, Gautam Sabnis, Vivek M. Philip, and Vivek Kumar

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy., Matthias Gromeier, Michael C Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, Hai Yan, Yiping He, Annick Desjardins, James E Herndon, Frederick S Varn, Roel G W Verhaak, Junfei Zhao, Dani P Bolognesi, Allan H Friedman, Henry S Friedman, Frances McSherry, Andrea M Muscat, Eric S Lipp, Smita K Nair, Mustafa Khasraw, Katherine B Peters, Dina Randazzo, John H Sampson, Roger E McLendon, Darell D Bigner, and David M Ashley

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An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis., Christian C D Harman, Will Bailis, Jun Zhao, Louisa Hill, Rihao Qu, Ruaidhrí P Jackson, Justin A Shyer, Holly R Steach, Yuval Kluger, Loyal A Goff, John L Rinn, Adam Williams, Jorge Henao-Mejia, and Richard A Flavell

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17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex., David E Harrison, Randy Strong, Peter C. Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Marisa Lopez-Cruzan, Francesca Macchiarini, James F Nelson, Alessandro Bitto, Amy L Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M Stearns, Molly A. Bogue, and Richard A Miller

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Development of a Novel Orthotopic Gastric Cancer Mouse Model., Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, and Charles Lee

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Classification of Molecular Subtypes of High-Grade Serous Ovarian Cancer by MALDI-Imaging., Wanja Kassuhn, Oliver Klein, Silvia Darb-Esfahani, Hedwig Lammert, Sylwia Handzik, Eliane T Taube, Wolfgang D Schmitt, Carlotta Keunecke, David Horst, Felix Dreher, Joshy George, David D Bowtell, Oliver Dorigo, Michael Hummel, Jalid Sehouli, Nils Blüthgen, Hagen Kulbe, and Elena I Braicu

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Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome., Gihyeon Kim, Misun Kim, Minji Kim, Changho Park, Youngmin Yoon, Doo-Hyeon Lim, Hyeonju Yeo, Seunghyun Kang, Yeong-Geun Lee, Nam-In Beak, Jongsung Lee, Sujeong Kim, Jee Young Kwon, Won Woo Choi, Charles Lee, Kyoung Wan Yoon, Hansoo Park, and Dong-Geol Lee

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High-throughput measurement of fibroblast rhythms reveals genetic heritability of circadian phenotypes in diversity outbred mice and their founder strains., Sam-Moon Kim, Chelsea A Vadnie, Vivek M. Philip, Leona H. Gagnon, Kodavali V Chowdari, Elissa J Chesler, Colleen A McClung, and Ryan W Logan

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Genomic profile of metastatic breast cancer patient-derived xenografts established using percutaneous biopsy., Seongyeong Kim, Dongjin Shin, Ahrum Min, Minjung Kim, Deukchae Na, Han-Byeol Lee, Han Suk Ryu, Yaewon Yang, Go-Un Woo, Kyung-Hun Lee, Dae-Won Lee, Tae-Yong Kim, Charles Lee, Seock-Ah Im, and Jong-Il Kim

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Perspective of mesenchymal transformation in glioblastoma., Yona Kim, Frederick S Varn, Sung-Hye Park, Byung Woo Yoon, Hye Ran Park, Charles Lee, Roel G W Verhaak, and Sun Ha Paek

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The Human Phenotype Ontology in 2021., Sebastian Köhler, Michael Gargano, Nicolas Matentzoglu, Leigh Carmody, David Lewis-Smith, Nicole A Vasilevsky, Daniel Danis, Ganna Balagura, Gareth Baynam, Amy M Brower, Tiffany J Callahan, Christopher G Chute, Johanna L Est, Peter D Galer, Shiva Ganesan, Matthias Griese, Matthias Haimel, Julia Pazmandi, Marc Hanauer, Nomi L Harris, Michael J Hartnett, Maximilian Hastreiter, Fabian Hauck, Yongqun He, Tim Jeske, Hugh Kearney, Gerhard Kindle, Christoph Klein, Katrin Knoflach, Roland Krause, David Lagorce, Julie A McMurry, Jillian A Miller, Monica C Munoz-Torres, Rebecca L Peters, Christina K Rapp, Ana M Rath, Shahmir A Rind, Avi Z Rosenberg, Michael M Segal, Markus G Seidel, Damian Smedley, Tomer Talmy, Yarlalu Thomas, Samuel A Wiafe, Julie Xian, Zafer Yüksel, Ingo Helbig, Christopher J Mungall, Melissa A Haendel, and Peter N Robinson

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Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA., Lingling Kong, David O Valdivia, Christian M Simon, Cera W Hassinan, Nicolas Delestrée, Daniel M Ramos, Jae Hong Park, Celeste M Pilato, Xixi Xu, Melissa Crowder, Chloe C Grzyb, Zachary A King, Marco Petrillo, Kathryn J Swoboda, Crystal Davis, Cathleen Lutz, Alexander H Stephan, Xin Zhao, Marla Weetall, Nikolai A Naryshkin, Thomas O Crawford, George Z Mentis, and Charlotte J Sumner

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Challenges in Developing a Human Model System for Skin Microbiome Research., Peter J Larson, Derrick Chong, Elizabeth Fleming, and Julia Oh

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Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28., Nathan Lawlor, Djamel Nehar-Belaid, Jessica D S Grassmann, Marlon Stoeckius, Peter Smibert, Michael L. Stitzel, Virginia Pascual, Jacques Banchereau, Adam Williams, and Duygu Ucar

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Genome-scale CRISPR screening identifies cell cycle and protein ubiquitination processes as druggable targets for erlotinib-resistant lung cancer., Jieun Lee, Ahyoung Choi, Sung-Yup Cho, Yukyung Jun, Deukchae Na, Ahra Lee, Giyong Jang, Jee Young Kwon, Jaesang Kim, Sanghyuk Lee, and Charles Lee

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Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice., Se-Hoon Lee, Sung-Yup Cho, Youngmin Yoon, Changho Park, Jinyoung Sohn, Jin-Ju Jeong, Bu-Nam Jeon, Mongjoo Jang, Choa An, Suro Lee, Yun Yeon Kim, Gihyeon Kim, Sujeong Kim, Yunjae Kim, Gwang Bin Lee, Eun Ju Lee, Sang Gyun Kim, Hong Sook Kim, Yeongmin Kim, Hyun Kim, Hyun-Suk Yang, Sarang Kim, Seonggon Kim, Hayung Chung, Myeong Hee Moon, Myung Hee Nam, Jee Young Kwon, Sungho Won, Joon-Suk Park, George M. Weinstock, Charles Lee, Kyoung Wan Yoon, and Hansoo Park

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SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma., Hongda Liu, Zheng Gong, Kangshuai Li, Qun Zhang, Zekuan Xu, and Yunfei Xu

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Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study., Shiwani Mahajan, Rajesh Srinivasan, Carrie A Redlich, Sara K Huston, Kelly M Anastasio, Lisa Cashman, Dorothy S Massey, Andrew Dugan, Dan Witters, Jenny Marlar, Shu-Xia Li, Zhenqiu Lin, Domonique Hodge, Manas Chattopadhyay, Mark D Adams, Charles Lee, Lokinendi V Rao, Chris Stewart, Karthik Kuppusamy, Albert I Ko, and Harlan M Krumholz

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Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies., Joseph A McQuail, Amy R Dunn, Yaakov Stern, Carol A Barnes, Gerd Kempermann, Peter R Rapp, Catherine C Kaczorowski, and Thomas C Foster

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Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models., Satoshi Muraoka, Mark P Jedrychowski, Naotoshi Iwahara, Mohammad Abdullah, Kristen D. Onos, Kelly J Keezer, Jianqiao Hu, Seiko Ikezu, Gareth R Howell, Steven P Gygi, and Tsuneya Ikezu

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PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease., Alex G Nackenoff, Timothy J Hohman, Sarah M Neuner, Carolyn S Akers, Nicole C Weitzel, Alena Shostak, Shawn M Ferguson, Bret Mobley, David A Bennett, Julie A Schneider, Angela L Jefferson, Catherine C Kaczorowski, and Matthew S Schrag

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Targeting antioxidant enzymes enhances the therapeutic efficacy of the BCL-X, Yumi Oh, Hae Rim Jung, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Jiwon Kim, Sang Eun Lee, Chang Ohk Sung, Won-Suk Lee, Charles Lee, Eui Man Jeong, and Sung-Yup Cho

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Multi-omic and multi-species meta-analyses of nicotine consumption., Rohan H C Palmer, Chelsie E Benca-Bachman, Spencer B Huggett, Jason A. Bubier, John E McGeary, Nikhil Ramgiri, Jenani Srijeyanthan, Jingjing Yang, Peter M Visscher, Jian Yang, Valerie S Knopik, and Elissa J Chesler

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A modular master regulator landscape controls cancer transcriptional identity., Evan O Paull, Alvaro Aytes, Sunny J Jones, Prem S Subramaniam, Federico M Giorgi, Eugene F Douglass, Somnath Tagore, Brennan Chu, Alessandro Vasciaveo, Siyuan Zheng, Roel G W Verhaak, Cory Abate-Shen, Mariano J Alvarez, and Andrea Califano

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Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH., Daniel M Ramos, William C Skarnes, Andrew B Singleton, Mark R Cookson, and Michael E Ward

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Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes., Neal G Ravindra, Mia Madel Alfajaro, Victor Gasque, Nicholas C Huston, Han Wan, Klara Szigeti-Buck, Yuki Yasumoto, Allison M Greaney, Victoria Habet, Ryan D Chow, Jennifer S Chen, Jin Wei, Renata B Filler, Bao Wang, Guilin Wang, Laura E Niklason, Ruth R Montgomery, Stephanie C Eisenbarth, Sidi Chen, Adam Williams, Akiko Iwasaki, Tamas L Horvath, Ellen F Foxman, Richard W Pierce, Anna Marie Pyle, David van Dijk, and Craig B Wilen

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KG-COVID-19: A Framework to Produce Customized Knowledge Graphs for COVID-19 Response., Justin T Reese, Deepak Unni, Tiffany J Callahan, Luca Cappelletti, Vida Ravanmehr, Seth Carbon, Kent A Shefchek, Benjamin M Good, James P Balhoff, Tommaso Fontana, Hannah Blau, Nicolas Matentzoglu, Nomi L Harris, Monica C Munoz-Torres, Melissa A Haendel, Peter N Robinson, Marcin P Joachimiak, and Christopher J Mungall

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Interpretation of psychiatric genome-wide association studies with multispecies heterogeneous functional genomic data integration., Timothy Reynolds, Emma C Johnson, Spencer B Huggett, Jason A. Bubier, Rohan H C Palmer, Arpana Agrawal, Erich J Baker, and Elissa J Chesler

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A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions., Miguel Rodríguez de Los Santos, Marion Rivalan, Friederike S David, Alexander Stumpf, Julika Pitsch, Despina Tsortouktzidis, Laura Moreno Velasquez, Anne Voigt, Karl Schilling, Daniele Mattei, Melissa Long, Guido Vogt, Alexej Knaus, Björn Fischer-Zirnsak, Lars Wittler, Bernd Timmermann, Peter N Robinson, Denise Horn, Stefan Mundlos, Uwe Kornak, Albert J Becker, Dietmar Schmitz, York Winter, and Peter M Krawitz

Hair follicle dystrophy in a litter of domestic cats resembling lanceolate hair mutant mice., Ana Rostaher, Sonya Bettenay, Lisa Specht, Kathleen A Silva, Lesley S Bechtold, Jiang Chen, Monir Majzoub, Ralf S Mueller, and John P Sundberg

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The NIH Somatic Cell Genome Editing program., Krishanu Saha, Erik J Sontheimer, P J Brooks, Melinda R Dwinell, Charles A Gersbach, David R Liu, Stephen A. Murray, Shengdar Q Tsai, Ross C Wilson, Daniel G Anderson, Aravind Asokan, Jillian F Banfield, Krystof S Bankiewicz, Gang Bao, Jeff W M Bulte, Nenad Bursac, Jarryd M Campbell, Daniel F Carlson, Elliot L Chaikof, Zheng-Yi Chen, R Holland Cheng, Karl J Clark, David T Curiel, James E Dahlman, Benjamin E Deverman, Mary E Dickinson, Jennifer A Doudna, Stephen C Ekker, Marina E Emborg, Guoping Feng, Benjamin S Freedman, David M Gamm, Guangping Gao, Ionita C Ghiran, Peter M Glazer, Shaoqin Gong, Jason D Heaney, Jon D Hennebold, John T Hinson, Anastasia Khvorova, Samira Kiani, William R Lagor, Kit S Lam, Kam W Leong, Jon E Levine, Jennifer A Lewis, Cathleen Lutz, Danith H Ly, Samantha Maragh, Paul B McCray, Todd C McDevitt, Oleg Mirochnitchenko, Ryuji Morizane, Niren Murthy, Randall S Prather, John A Ronald, Subhojit Roy, Sushmita Roy, Venkata Sabbisetti, W Mark Saltzman, Philip J Santangelo, David J Segal, Mary Shimoyama, Melissa C Skala, Alice F Tarantal, John C Tilton, George A Truskey, Moriel Vandsburger, Jonathan K Watts, Kevin D Wells, Scot A Wolfe, Qiaobing Xu, Wen Xue, Guohua Yi, and Jiangbing Zhou

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Identification of cell-surface glycans that mediate motility-dependent binding and internalization of Pseudomonas aeruginosa by phagocytes., Hector Sanchez, Daniel Hopkins, Sally Demirdjian, Cecilia Gutierrez, George A O'Toole, Sriram Neelamegham, and Brent Berwin

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Employees' Views and Ethical, Legal, and Social Implications Assessment of Voluntary Workplace Genomic Testing, Kunal Sanghavi, W Gregory Feero, Debra JH Mathews, Anya ER Prince, Lori Lyn Price, Edison Liu, Kyle Brothers, J Scott Roberts, and Charles Lee

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Challenges to making an egg., Richard M Schultz and John J. Eppig

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Targeting metabolism to reverse T-cell exhaustion in chronic viral infections., John D Sears, Kevin J Waldron, Jian Wei, and Chih-Hao (Lucas) Chang

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Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform., Gautam N Shenoy, Christopher J Greene, Maulasri Bhatta, Miren L Baroja, Jenni L Loyall, Sathy V Balu-Iyer, Raymond J Kelleher, Beatriz M Carreno, Gerald P Linette, Leonard D. Shultz, and Richard B Bankert

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Dietary Vitamin A Impacts Refractory Telogen., Liye Suo, Christine VanBuren, Eylul Damla Hovland, Natalia Y Kedishvili, John P Sundberg, and Helen B Everts

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Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics., Emily Swanzey, Callan O'Connor, and Laura G Reinholdt

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Capsule carbohydrate structure determines virulence in Acinetobacter baumannii., Yuli Talyansky, Travis B Nielsen, Jun Yan, Ulrike Carlino-Macdonald, Gisela Di Venanzio, Somnath Chakravorty, Amber Ulhaq, Mario F Feldman, Thomas A Russo, Evgeny Vinogradov, Brian Luna, Meredith S Wright, Mark D Adams, and Brad Spellberg

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Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology., Markus Terrey, Scott I Adamson, Jeffrey H Chuang, and Susan L Ackerman

EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8., Hui Tian, Timothy Billings, and Petko M. Petkov

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Genetic background modifies vulnerability to glaucoma-related phenotypes in, Nicholas G Tolman, Revathi Balasubramanian, Danilo G Macalinao, Alison L Kearney, Katharine H MacNicoll, Christa L Montgomery, Wilhelmine N de Vries, Ian J Jackson, Sally H Cross, Krishnakumar Kizhatil, K Saidas Nair, and Simon W M John

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Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction., Lukas S Tombor, David John, Simone F Glaser, Guillermo Luxán, Elvira Forte, Milena B Furtado, Nadia Rosenthal, Nina Baumgarten, Marcel H Schulz, Janina Wittig, Eva-Maria Rogg, Yosif Manavski, Ariane Fischer, Marion Muhly-Reinholz, Kathrin Klee, Mario Looso, Carmen Selignow, Till Acker, Sofia-Iris Bibli, Ingrid Fleming, Ralph Patrick, Richard P Harvey, Wesley T Abplanalp, and Stefanie Dimmeler

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Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction., James R Tribble, Amin Otmani, Shanshan Sun, Sevannah A Ellis, Gloria Cimaglia, Rupali Vohra, Melissa Jöe, Emma Lardner, Abinaya P Venkataraman, Alberto Domínguez-Vicent, Eirini Kokkali, Seungsoo Rho, Gauti Jóhannesson, Robert W. Burgess, Peter G Fuerst, Rune Brautaset, Miriam Kolko, James E Morgan, Jonathan G Crowston, Marcela Votruba, and Pete A Williams

The Combined Analysis of Pleiotropy and Epistasis (CAPE)., Anna L. Tyler, Jake Emerson, Baha El Kassaby, Ann E Wells, Vivek M. Philip, and Gregory W. Carter

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MEK inhibition reprograms CD8 + T lymphocytes into memory stem cells with potent antitumor effects, Vivek Verma, Nazli Jafarzadeh, Shannon Boi, Subhadip Kundu, Zhinuo Jiang, Yiping Fan, Jose Lopez, Rahul Nandre, Peng Zeng, Fatmah Alolaqi, Shamim Ahmad, Pankaj Gaur, Simon T Barry, Viia E Valge-Archer, Paul D Smith, Jacques Banchereau, Mikayel Mkrtichyan, Benjamin Youngblood, Paulo C Rodriguez, Seema Gupta, and Samir N Khleif

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Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank., Michael P Vitek, Joseph A Araujo, Michael Fossel, Barry D Greenberg, Gareth R Howell, Stacey J Sukoff Rizzo, Nicholas T Seyfried, Andrea J Tenner, Paul R Territo, Manfred Windisch, Lisa J Bain, April Ross, Maria C Carrillo, Bruce T Lamb, and Rebecca M Edelmayer

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PD-1 Blockade Aggravates Epstein-Barr Virus + Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4 + T Cell Dysregulations., Valery Volk, Sebastian J Theobald, Simon Danisch, Sahamoddin Khailaie, Maja Kalbarczyk, Andreas Schneider, Julia Bialek-Waldmann, Nicole Krönke, Yun Deng, Britta Eiz-Vesper, Anna Christina Dragon, Constantin von Kaisenberg, Stefan Lienenklaus, Andre Bleich, James Keck, Michael Meyer-Hermann, Frank Klawonn, Wolfgang Hammerschmidt, Henri-Jacques Delecluse, Christian Münz, Friedrich Feuerhake, and Renata Stripecke

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Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes., Stephen R Wellard, Yujiao Zhang, Chris Shults, Xueqi Zhao, Matthew Mckay, Stephen A. Murray, and Philip W Jordan

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Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis B., Zhili Wen, Yuliang Feng, and Xiaohua Yan

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Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts., Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Rajesh Patidar, Li Chen, Sandra Scherer, Matthew H Bailey, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Yuanxin Xi, Jing Wang, Jayamanna Wickramasinghe, Andrew V Kossenkov, Vito W Rebecca, Hua Sun, R Jay Mashl, Sherri R Davies, Ryan Jeon, Christian Frech, Jelena Randjelovic, Jacqueline Rosains, Francesco Galimi, Andrea Bertotti, Adam Lafferty, Alice C O'Farrell, Elodie Modave, Diether Lambrechts, Petra Ter Brugge, Violeta Serra, Elisabetta Marangoni, Rania El Botty, Hyunsoo Kim, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A Dean, Brandi Davis-Dusenbery, Yvonne A Evrard, James H Doroshow, Alana L Welm, Bryan E Welm, Michael T Lewis, Bingliang Fang, Jack A Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael A Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Claudio Isella, Jeffrey A Moscow, Livio Trusolino, Annette T Byrne, Jos Jonkers, Carol J Bult, Enzo Medico, Jeffrey Chuang, PDXNET Consortium, and EurOPDX Consortium

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A new graph-based clustering method with application to single-cell RNA-seq data from human pancreatic islets., Hao Wu, Disheng Mao, Yuping Zhang, Zhiyi Chi, Michael L. Stitzel, and Zhengqing Ouyang

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Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease., Hongtian Stanley Yang, Kristen D. Onos, Kwangbom Choi, Kelly J Keezer, Daniel A Skelly, Gregory W. Carter, and Gareth R Howell

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Human KIT+ myeloid cells facilitate visceral metastasis by melanoma., Chun I. Yu, Jan Martinek, Te-Chia Wu, Kyung In Kim, Joshy George, Elaheh Ahmadzadeh, Richard S. Maser, Florentina Marches, Patrick Metang, Pierre Authie, Vanessa K P Oliveira, Victor G Wang, Jeffrey Chuang, Paul Robson, Jacques Banchereau, and Karolina Palucka

Strain-Specific Peptide (SSP) Interference Reference Sample: A Genetically Encoded Quality Control for Isobaric Tagging Strategies., Tian Zhang, Gregory R Keele, Gary A Churchill, Steven P Gygi, and Joao A Paulo

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Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1., Yalan Zhang, Luis Varela, Klara Szigeti-Buck, Adam Williams, Milan Stoiljkovic, Matija Šestan-Peša, Jorge Henao-Mejia, Pasquale D'Acunzo, Efrat Levy, Richard A Flavell, Tamas L Horvath, and Leonard K Kaczmarek