Content Posted in 2020
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes., Heike Kollmus, Helmut Fuchs, Christoph Lengger, Hamed Haselimashhadi, Molly A. Bogue, Manuela A Östereicher, Marion Horsch, Thure Adler, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Johannes Beckers, Julia Calzada-Wack, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Tanja Klein-Rodewald, Holger Maier, Philipp Mayer-Kuckuk, Gregor Miller, Kristin Moreth, Frauke Neff, Birgit Rathkolb, Ildikó Rácz, Jan Rozman, Nadine Spielmann, Irina Treise, Dirk Busch, Jochen Graw, Thomas Klopstock, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Jeremy Mason, Arturo Torres, Mouse Phenome Database Team, Rudi Balling, Terry Mehaan, Valerie Gailus-Durner, Klaus Schughart, and Martin Hrabě de Angelis
Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation., Eraj Shafiq Khokhar, Sneha Borikar, Elizabeth Eudy, Timothy M Stearns, Kira Young, and Jennifer J. Trowbridge
A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice., Jason A. Bubier, Vivek M. Philip, Christopher Quince, James Campbell, Yanjiao Zhou, Tatiana Vishnivetskaya, Suman Duvvuru, Rachel Hageman Blair, Juliet Ndukum, Kevin D Donohue, Carmen M Foster, David J Mellert, George M. Weinstock, Cymbeline T Culiat, Bruce F O'Hara, Anthony V Palumbo, Mircea Podar, and Elissa J Chesler
Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine., Zeeshan Ahmed, Khalid Mohamed, Saman Zeeshan, and XinQi Dong
A Universal, Genomewide GuideFinder for CRISPR/Cas9 Targeting in Microbial Genomes., Michelle Spoto, Changhui Guan, Elizabeth Fleming, and Julia Oh
Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses., L J Blumberg, J E Humphries, S D Jones, L B Pearce, R Holgate, A Hearn, J Cheung, A Mahmood, B Del Tito, J S Graydon, L E Stolz, A Bitonti, S Purohit, D de Graaf, K Kacena, J T Andersen, Gregory J. Christianson, Derry C. Roopenian, J J Hubbard, A K Gandhi, K Lasseter, M Pyzik, and R S Blumberg
Cancer Stem Cells: Notes for Authors., Connie J Eaves and Martin Pera
Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development., Chew Yee Ngan, Chee-Hong Wong, Harianto Tjong, Wenbo Wang, Rachel L Goldfeder, Cindy Choi, Hao He, Liang Gong, Junyan Lin, Barbara Urban, Julianna Chow, Meihong Li, Joanne Lim, Vivek M. Philip, Stephen A. Murray, Haoyi Wang, and Chia-Lin Wei
Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice., Charles B Wright, Hironori Uehara, Younghee Kim, Tetsuhiro Yasuma, Reo Yasuma, Shuichiro Hirahara, Ryan D Makin, Ivana Apicella, Felipe Pereira, Yosuke Nagasaka, Siddharth Narendran, Shinichi Fukuda, Romulo Albuquerque, Benjamin J Fowler, Ana Bastos-Carvalho, Philippe Georgel, Izuho Hatada, Bo Chang, Nagaraj Kerur, Balamurali K Ambati, Jayakrishna Ambati, and Bradley D Gelfand
circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan., Shahnaz Haque, Ryan M Ames, Karen Moore, Luke C Pilling, Luanne L. Peters, Stefania Bandinelli, Luigi Ferrucci, and Lorna W Harries
Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype-like Cluster., Yanfei Chen, Masako Nakanishi, Eddy J Bautista, Veneta Qendro, Erica Sodergren, Daniel W Rosenberg, and George M. Weinstock
Comparative Molecular Life History of Spontaneous Canine and Human Gliomas., Samirkumar B Amin, Kevin J Anderson, C Elizabeth Boudreau, Emmanuel Martinez-Ledesma, Emre Kocakavuk, Kevin C Johnson, Floris P Barthel, Frederick S Varn, Cynthia Kassab, Xiaoyang Ling, Hoon Kim, Mary Barter, Ching C Lau, Chew Yee Ngan, Margaret Chapman, Jennifer W Koehler, James P Long, Andrew D Miller, C Ryan Miller, Brian F Porter, Daniel R Rissi, Christina Mazcko, Amy K LeBlanc, Peter J Dickinson, Rebecca A Packer, Amanda R Taylor, John H Rossmeisl, Kevin D Woolard, Amy B Heimberger, Jonathan M Levine, and Roel G W Verhaak
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells., Yoshiki Higashijima, Yusuke Matsui, Teppei Shimamura, Ryo Nakaki, Nao Nagai, Shuichi Tsutsumi, Yohei Abe, Verena M Link, Mizuko Osaka, Masayuki Yoshida, Ryo Watanabe, Toshihiro Tanaka, Akashi Taguchi, Mai Miura, Xiaoan Ruan, Guoliang Li, Tsuyoshi Inoue, Masaomi Nangaku, Hiroshi Kimura, Tetsushi Furukawa, Hiroyuki Aburatani, Youichiro Wada, Yijun Ruan, Christopher K Glass, and Yasuharu Kanki
CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4., Andrew M. Garrett, Peter J Bosch, David M Steffen, Leah C Fuller, Charles G Marcucci, Alexis A Koch, Preeti Bais, Joshua A Weiner, and Robert W. Burgess
Decoy exosomes provide protection against bacterial toxins., Matthew D Keller, Krystal L Ching, Feng-Xia Liang, Avantika Dhabaria, Kayan Tam, Beatrix M Ueberheide, Derya Unutmaz, Victor J Torres, and Ken Cadwell
Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites., Elie Hammam, Guruprasad Ananda, Ameya Sinha, Christine Scheidig-Benatar, Mylene Bohec, Peter R Preiser, Peter C Dedon, Artur Scherf, and Shruthi S Vembar
Disruption in murine Eml1 perturbs retinal lamination during early development., Gayle B. Collin, J Won, Mark P. Krebs, W J Hicks, Jeremy R. Charette, Juergen K. Naggert, and Patsy M. Nishina
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer., Kadir C Akdemir, Victoria T Le, Sahaana Chandran, Yilong Li, Roel G W Verhaak, Rameen Beroukhim, Peter J Campbell, Lynda Chin, Jesse R Dixon, P Andrew Futreal, PCAWG Structural Variation Working Groug, and PCAWG Consortium
Distinct mechanisms of dissemination of NDM-1 metallo- β-lactamase in, Mark D Adams, Fernando Pasteran, German M Traglia, Jasmine Martinez, Fanny Huang, Christine Liu, Jennifer S Fernandez, Carolina Lopez, Lisandro J Gonzalez, Ezequiel Albornoz, Alejandra Corso, Alejandro J Vila, Robert A Bonomo, and Maria Soledad Ramirez
Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy., Jeremy M Sullivan, William W Motley, Janel O Johnson, William H Aisenberg, Katherine L Marshall, Katy Es Barwick, Lingling Kong, Jennifer S Huh, Pamela C Saavedra-Rivera, Meriel M McEntagart, Marie-Helene Marion, Lucy A Hicklin, Hamid Modarres, Emma L Baple, Mohamed H Farah, Aamir Zuberi, Cathleen Lutz, Rachelle Gaudet, Bryan J Traynor, Andrew H Crosby, and Charlotte J Sumner
Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice., Elvira Forte, Daniel A Skelly, Mandy Chen, Sandra Daigle, Kaesi A Morelli, Olivia Hon, Vivek M. Philip, Mauro W Costa, Nadia Rosenthal, and Milena B Furtado
EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma., Shaofang Wu, Feng Gao, Siyuan Zheng, Chen Zhang, Emmanuel Martinez-Ledesma, Ravesanker Ezhilarasan, Jie Ding, Xiaolong Li, Ningping Feng, Asha Multani, Erik P Sulman, Roel G W Verhaak, John F de Groot, Tim P Heffernan, W K Alfred Yung, and Dimpy Koul
From GWAS Association to Function: Candidate Gene Screening Within Insulin Resistance-Associated Genomic Loci Using a Preadipocyte Differentiation Model., Feria A Ladha, Michael L. Stitzel, and J Travis Hinson
GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone., Joonho Suh, Na-Kyung Kim, Seung-Hoon Lee, Je-Hyun Eom, Youngkyun Lee, Joo-Cheol Park, Kyung Mi Woo, Jeong-Hwa Baek, Jung-Eun Kim, Hyun-Mo Ryoo, Se-Jin Lee, and Yun-Sil Lee
Gene therapies for axonal neuropathies: Available strategies, successes to date, and what to target next., Kathryn H Morelli, Courtney L Hatton, Scott Q Harper, and Robert W. Burgess
Genetic Interactions Affect Lung Function in Patients with Systemic Sclerosis., Anna L. Tyler, J Matthew Mahoney, and Gregory W. Carter
Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer's disease., Ravi S Pandey, Leah C. Graham, Asli Uyar, Christoph Preuss, Gareth R Howell, and Gregory W. Carter
Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma., Rachael A Vaubel, Shulan Tian, Dioval Remonde, Mark A Schroeder, Ann C Mladek, Gaspar J Kitange, Alissa Caron, Thomas M Kollmeyer, Rebecca Grove, Sen Peng, Brett L Carlson, Daniel J Ma, Gobinda Sarkar, Lisa Evers, Paul A Decker, Huihuang Yan, Harshil D Dhruv, Michael E Berens, Qianghu Wang, Bianca M Marin, Eric W Klee, Andrea Califano, Daniel H LaChance, Jeanette E Eckel-Passow, Roel G W Verhaak, Erik P Sulman, Terry C Burns, Fredrick B Meyer, Brian P O'Neill, Nhan L Tran, Caterina Giannini, Robert B Jenkins, Ian F Parney, and Jann N Sarkaria
Genomic Medicine Year in Review: 2019., Teri A Manolio, Carol J Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Gail P Jarvik, Howard L McLeod, George A Mensah, Mary V Relling, Dan M Roden, Robb Rowley, Cecelia Tamburro, Marc S Williams, and Eric D Green
Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data., Haitham Ashoor, Xiaowen Chen, Wojciech Rosikiewicz, Jiahui Wang, Albert Cheng, Ping Wang, Yijun Ruan, and Sheng Li
GXD's RNA-Seq and Microarray Experiment Search: using curated metadata to reliably find mouse expression studies of interest., Constance M. Smith, James W Godwin, Richard M. Baldarelli, Jonathan S Beal, Olin Blodgett, Sharon C Giannatto, Joel E Richardson, and Martin Ringwald
HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots., Catrina Spruce, Sibongakonke Dlamini, Guruprasad Ananda, Naomi Bronkema, Hui Tian, Kenneth Paigen, Gregory W. Carter, and Christopher L. Baker
High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains., Brendan T Keenan, Raymond J Galante, Jie Lian, Petr Simecek, Daniel M. Gatti, Lin Zhang, Diane C Lim, Karen L. Svenson, Gary Churchill, and Allan I Pack
Host-Specific Evolutionary and Transmission Dynamics Shape the Functional Diversification of Staphylococcus epidermidis in Human Skin., Wei Zhou, Michelle Spoto, Rachel Hardy, Changhui Guan, Elizabeth Fleming, Peter J Larson, Joseph S Brown, and Julia Oh
Human and mouse essentiality screens as a resource for disease gene discovery., Pilar Cacheiro, Violeta Muñoz-Fuentes, Stephen A. Murray, Mary E Dickinson, Maja Bucan, Lauryl M J Nutter, Kevin A Peterson, Hamed Haselimashhadi, Ann M Flenniken, Hugh Morgan, Henrik Westerberg, Tomasz Konopka, Chih-Wei Hsu, Audrey Christiansen, Denise G Lanza, Arthur L Beaudet, Jason D Heaney, Helmut Fuchs, Valerie Gailus-Durner, Tania Sorg, Jan Prochazka, Vendula Novosadova, Christopher J Lelliott, Hannah Wardle-Jones, Sara Wells, Lydia Teboul, Heather Cater, Michelle Stewart, Tertius Hough, Wolfgang Wurst, Radislav Sedlacek, David J Adams, John R Seavitt, Glauco Tocchini-Valentini, Fabio Mammano, Robert E Braun, Colin McKerlie, Yann Herault, Martin Hrabě de Angelis, Ann-Marie Mallon, K C Kent Lloyd, Steve D M Brown, Helen Parkinson, Terrence F Meehan, Damian Smedley, Genomics England Research Consortium, and International Mouse Phenotyping Consortium
Implications of increased S100β and Tau5 proteins in dystrophic nerves of two mdx mouse models for Duchenne muscular dystrophy., Vidya S Krishnan, Annemieke Aartsma-Rus, Maurice Overzier, Cathleen Lutz, Laurent P. Bogdanik, and Miranda D Grounds
Improving Characterization of Understudied Human Microbiomes Using Targeted Phylogenetics., Bruce A Rosa, Kathie Mihindukulasuriya, Kymberlie Hallsworth-Pepin, Aye Wollam, John Martin, Caroline Snowden, William Michael Dunne, George M. Weinstock, C A Burnham, and Makedonka Mitreva
LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding., Huacheng Luo, Qin Yu, Yang Liu, Ming Tang, Mingwei Liang, Dingpeng Zhang, Tsan Sam Xiao, Lizi Wu, Ming Tan, Yijun Ruan, Jörg Bungert, and Jianrong Lu
LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia., Justin H Layer, Michael Christy, Lindsey Placek, Derya Unutmaz, Yan Guo, and Utpal P Davé
Long non-coding RNAs in immune regulation and their potential as therapeutic targets., Dinesh Babu Uthaya Kumar and Adam Williams
Loss of ADAMTS19 causes progressive non-syndromic heart valve disease., Florian Wünnemann, Asaf Ta-Shma, Christoph Preuss, Severine Leclerc, Patrick Piet van Vliet, Andrea Oneglia, Maryse Thibeault, Emily Nordquist, Joy Lincoln, Franka Scharfenberg, Christoph Becker-Pauly, Philipp Hofmann, Kirstin Hoff, Enrique Audain, Hans-Heiner Kramer, Wojciech Makalowski, Amiram Nir, Sebastian S Gerety, Matthew Hurles, Johanna Comes, Anne Fournier, Hanna Osinska, Jeffrey Robins, Michel Pucéat, Orly Elpeleg, Marc-Phillip Hitz, and Gregor Andelfinger
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation., Zeda Zhang, Chuanli Zhou, Xiaoling Li, Spencer D Barnes, Su Deng, Elizabeth Hoover, Chi-Chao Chen, Young Sun Lee, Yanxiao Zhang, Choushi Wang, Lauren A Metang, Chao Wu, Carla Rodriguez Tirado, Nickolas A Johnson, John Wongvipat, Kristina Navrazhina, Zhen Cao, Danielle Choi, Chun-Hao Huang, Eliot Linton, Xiaoping Chen, Yupu Liang, Christopher E Mason, Elisa de Stanchina, Wassim Abida, Amaia Lujambio, Sheng Li, Scott W Lowe, Joshua T Mendell, Venkat S Malladi, Charles L Sawyers, and Ping Mu
Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure., Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G Tolman, Syed Hameed, Yusef Seymens, Eric Dang, Anil K Mandal, Sirisha Senthil, Rohit C Khanna, Meha Kabra, Inderjeet Kaur, Simon W M John, Subhabrata Chakrabarti, and K Saidas Nair
Low SATB1 Expression Promotes IL-5 and IL-9 Expression in Sézary Syndrome., Alberto Herrera, Simon Fredholm, Anthony Cheng, Eleni P Mimitou, Angelina Seffens, Michal Bar-Natan, Amy Sun, Jo-Ann Latkowski, Andreas Willerslew-Olsen, Terkild B Buus, Maria Gluud, Thorbjørn Krejsgaard, Sara Torres-Rusillo, Charlotte Menné Bonefeld, Anders Woetmann, Carsten Geisler, Larisa J Geskin, Zhengqing Ouyang, Peter Smibert, Niels Ødum, and Sergei B Koralov
Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B., Ana Rita Batista, Oliver D King, Christopher P Reardon, Crystal Davis, Shankaracharya, Vivek M. Philip, Heather Gray-Edwards, Neil Aronin, Cathleen Lutz, John Landers, and Miguel Sena-Esteves
Methods for comparative ChIA-PET and Hi-C data analysis., Dan Capurso, Zhonghui Tang, and Yijun Ruan
miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells., Clarice X Lim, Bernett Lee, Olivia Geiger, Christina Passegger, Michaela Beitzinger, Johann Romberger, Anika Stracke, Christoph Högenauer, Anton Stift, Heribert Stoiber, Michael Poidinger, Armin Zebisch, Gunter Meister, Adam Williams, Richard A Flavell, Jorge Henao-Mejia, and Herbert Strobl
Molecular and clonal evolution in recurrent metastatic gliosarcoma., Kevin J Anderson, Aaron C Tan, Jonathon Parkinson, Michael Back, Marina Kastelan, Allison Newey, Janice Brewer, Helen Wheeler, Amanda L Hudson, Samirkumar B Amin, Kevin C Johnson, Floris P Barthel, Roel G W Verhaak, and Mustafa Khasraw
Molecular Biology and Evolution of Cancer: From Discovery to Action., Jason A Somarelli, Heather Gardner, Vincent L Cannataro, Ella F Gunady, Amy M Boddy, Norman A Johnson, Jeffrey Nicholas Fisk, Stephen G Gaffney, Jeffrey Chuang, Sheng Li, Francesca D Ciccarelli, Anna R Panchenko, Kate Megquier, Sudhir Kumar, Alex Dornburg, James DeGregori, and Jeffrey P Townsend
Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study., Kaspar Draaisma, Aikaterini Chatzipli, Martin Taphoorn, Melissa Kerkhof, Astrid Weyerbrock, Marc Sanson, Ann Hoeben, Slávka Lukacova, Giuseppe Lombardi, Sieger Leenstra, Monique Hanse, Ruth Fleischeuer, Colin Watts, Joseph McAbee, Nicos Angelopoulos, Thierry Gorlia, Vassilis Golfinopoulos, Johan M Kros, Roel G W Verhaak, Vincent Bours, Martin J van den Bent, Ultan McDermott, Pierre A Robe, and Pim J French
Molecular profiling of CNS tumors for the treatment and management of disease., Qian Nie, Meng-Chang Hsiao, Harshpreet Chandok, Shannon Rowe, Matthew Prego, Bridgette Meyers, Gregory Omerza, Andrew N Hesse, Jasmina Uvalic, Melissa Soucy, Daniel Bergeron, Michael Peracchio, Shelbi Burns, Kevin Kelly, Jens Rueter, and Honey V Reddi
Molecular profiling of gynecologic cancers for treatment and management of disease - demonstrating clinical significance using the AMP/ASCO/CAP guidelines for interpretation and reporting of somatic variants., Qian Nie, Gregory Omerza, Harshpreet Chandok, Matthew Prego, Meng-Chang Hsiao, Bridgette Meyers, Andrew N Hesse, Jasmina Uvalic, Melissa Soucy, Daniel Bergeron, Michael Peracchio, Shelbi Burns, Kevin Kelly, Shannon Rowe, Jens Rueter, and Honey V Reddi
Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data., Molly A. Bogue, Vivek M. Philip, David O Walton, Stephen C. Grubb, Matthew H Dunn, Georgi Kolishovski, Jake Emerson, Gaurab Mukherjee, Timothy M Stearns, Hao He, Vinita Sinha, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, and Elissa J Chesler
MSIsensor-pro: Fast, Accurate, and Matched-normal-sample-free Detection of Microsatellite Instability., Peng Jia, Xiaofei Yang, Li Guo, Bowen Liu, Jiadong Lin, Hao Liang, Jianyong Sun, Chengsheng Zhang, and Kai Ye
Mutation Yield of a Custom 212-Gene Next-Generation Sequencing Panel for Solid Tumors: Clinical Experience of the First 260 Cases Tested Using the JAX ActionSeq™ Assay., Pavalan Selvam, Meng-Chang Hsiao, Gregory Omerza, Daniel Bergeron, Shannon Rowe, Jasmina Uvalic, Melissa Soucy, Michael Peracchio, Shelbi Burns, Bridgette Meyers, Matthew Prego, Qian Nie, Guruprasad Ananda, Harshpreet Chandok, Kevin Kelly, Andrew N Hesse, and Honey V Reddi
New statistical method identifies cytokines that distinguish stool microbiomes., Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George M. Weinstock, and William D Shannon
Nitrosative stress and lipid homeostasis as a mechanism for zileuton hepatotoxicity and resistance in genetically sensitive mice., Dahea You, Lascelles E Lyn-Cook, Daniel M. Gatti, Natalie Bell, Philip R Mayeux, Laura P James, William B Mattes, Gary J Larson, and Alison H Harrill
Nomenclature: Naming Your Gene-Modified Mouse., Alicia Valenzuela
Overlapping spectrums: The clinicogenetic commonalities between Charcot-Marie-Tooth and other neurodegenerative diseases., Paige B Martin, Amy N Hicks, Sarah E Holbrook, and Gregory A. Cox
PATHBIO: an international training program for precision mouse phenotyping., Jesus Ruberte, Paul N Schofield, Cord Brakebusch, Peter Vogel, Yann Herault, Guillem Gracia, Colin McKerlie, Martin Hrabĕ de Angelis, Michael Hagn, and John P Sundberg
Precise Spatiotemporal Control of Nodal Na, Yael Eshed-Eisenbach, Jerome Devaux, Anna Vainshtein, Ofra Golani, Se-Jin Lee, Konstantin Feinberg, Natasha Sukhanov, Daniel S Greenspan, Keiichiro Susuki, Matthew N Rasband, and Elior Peles
Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis., Udita Datta, Sarah E Schoenrock, Jason A. Bubier, Molly A. Bogue, James D Jentsch, Ryan W Logan, Lisa M Tarantino, and Elissa J Chesler
pyBedGraph: a Python package for fast operations on 1-dimensional genomic signal tracks., Henry B Zhang, Minji Kim, Jeffrey Chuang, and Yijun Ruan
Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice., Sambra D Redick, Linda Leehy, Ann R Rittenhouse, David M Blodgett, Alan G Derr, Alper Kucukural, Manuel G Garber, Leonard D. Shultz, Dale L Greiner, Jennifer P Wang, David M Harlan, Rita Bortell, and Agata Jurczyk
Sestrins induce natural killer function in senescent-like CD8, Branca I Pereira, Roel P H De Maeyer, Luciana P Covre, Djamel Nehar-Belaid, Alessio Lanna, Sophie Ward, Radu Marches, Emma S Chambers, Daniel C O Gomes, Natalie E Riddell, Mala K Maini, Vitor H Teixeira, Samuel M Janes, Derek W Gilroy, Anis Larbi, Neil A Mabbott, Duygu Ucar, George A Kuchel, Sian M Henson, Jessica Strid, Jun H Lee, Jacques Banchereau, and Arne N Akbar
Sexual-dimorphism in human immune system aging., Eladio J Márquez, Cheng-Han Chung, Radu Marches, Robert J Rossi, Djamel Nehar-Belaid, Alper Eroglu, David J Mellert, George A Kuchel, Jacques Banchereau, and Duygu Ucar
Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes., Leigh Carmody, Hannah Blau, Daniel Danis, Xingman A Zhang, Jean-Philippe Gourdine, Nicole Vasilevsky, Peter Krawitz, Miles D Thompson, and Peter N Robinson
Soft windowing application to improve analysis of high-throughput phenotyping data., Hamed Haselimashhadi, Jeremy C Mason, Violeta Munoz-Fuentes, Federico López-Gómez, Kolawole Babalola, Elif F Acar, Vivek Kumar, Jacqui White, Ann M Flenniken, Ruairidh King, Ewan Straiton, John Richard Seavitt, Angelina Gaspero, Arturo Garza, Audrey E Christianson, Chih-Wei Hsu, Corey L Reynolds, Denise G Lanza, Isabel Lorenzo, Jennie R Green, Juan J Gallegos, Ritu Bohat, Rodney C Samaco, Surabi Veeraragavan, Jong Kyoung Kim, Gregor Miller, Helmult Fuchs, Lillian Garrett, Lore Becker, Yeon Kyung Kang, David Clary, Soo Young Cho, Masaru Tamura, Nobuhiko Tanaka, Kyung Dong Soo, Alexandr Bezginov, Ghina Bou About, Marie-France Champy, Laurent Vasseur, Sophie Leblanc, Hamid Meziane, Mohammed Selloum, Patrick T Reilly, Nadine Spielmann, Holger Maier, Valerie Gailus-Durner, Tania Sorg, Masuya Hiroshi, Obata Yuichi, Jason D Heaney, Mary E Dickinson, Wurst Wolfgang, Glauco P Tocchini-Valentini, Kevin C Kent Lloyd, Colin McKerlie, Je Kyung Seong, Herault Yann, Martin Hrabé de Angelis, Steve D M Brown, Damian Smedley, Paul Flicek, Ann-Marie Mallon, Helen Parkinson, and Terrence F Meehan
SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia., Joanna R Sinnakannu, Kian Leong Lee, Shanshan Cheng, Jia Li, Mengge Yu, Siew Peng Tan, Clara Chong Hui Ong, Huihua Li, Hein Than, Olga Anczuków, Adrian R Krainer, Xavier Roca, Steven G Rozen, Jabed Iqbal, Henry Yang, Charles Chuah, and Sin Tiong Ong
Stimulus Complexity and Mouse Strain Drive Escalation of Operant Sensation Seeking Within and Across Sessions in C57BL/6J and DBA/2J Mice., Price E. Dickson and Guy Mittleman
Structure-based discovery of a small-molecule inhibitor of methicillin-resistant, Jie Liu, Lina Kozhaya, Victor J Torres, Derya Unutmaz, and Min Lu
Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis., Yvonne A Evrard, Anuj Srivastava, Jelena Randjelovic, Nci PDXNet Consortium, James H Doroshow, Dennis A Dean, Jeffrey S Morris, and Jeffrey Chuang
Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable., Chunhua Dai, John T Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle Dean, Nripesh Prasad, Shawn E Levy, Dale L Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C Powers
Techniques for the generation of humanized mouse models for immuno-oncology., Chun I. Yu, Florentina Marches, Te-Chia Wu, Jan Martinek, and Karolina Palucka
TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice., Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Laura Bongiovanni, Alain de Bruin, Dennis Beringer, Sanne van Dooremalen, Leonard D. Shultz, Fumihiko Ishikawa, Zsolt Sebestyen, Trudy Straetemans, and Jürgen Kuball
The acquisition of positional information across the radial axis of the cochlea., Vidhya Munnamalai and Donna M Fekete
The Deep Genome Project., K C Kent Lloyd, David J Adams, Gareth Baynam, Arthur L Beaudet, Fatima Bosch, Kym M Boycott, Robert E Braun, Mark Caulfield, Ronald Cohn, Mary E Dickinson, Michael S Dobbie, Ann M Flenniken, Paul Flicek, Sanjeev Galande, Xiang Gao, Anne Grobler, Jason D Heaney, Yann Herault, Martin Hrabě de Angelis, James R Lupski, Stanislas Lyonnet, Ann-Marie Mallon, Fabio Mammano, Calum A MacRae, Roderick McInnes, Colin McKerlie, Terrence F Meehan, Stephen A Murray, Lauryl M J Nutter, Yuichi Obata, Helen Parkinson, Michael S Pepper, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Damian Smedley, Glauco Tocchini-Valentini, David Valle, Chi-Kuang Leo Wang, Sara Wells, Jacqueline K White, Wolfgang Wurst, Ying Xu, and Steve D M Brown
The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice., Valeria Gerbino, Esther Kaunga, Junqiang Ye, Daniele Canzio, Sean O'Keeffe, Noam D Rudnick, Paolo Guarnieri, Cathleen Lutz, and Tom Maniatis
The Monarch Initiative in 2019: an integrative data and analytic platform connecting phenotypes to genotypes across species., Kent A Shefchek, Nomi L Harris, Michael Gargano, Nicolas Matentzoglu, Deepak Unni, Matthew Brush, Daniel Keith, Tom Conlin, Nicole Vasilevsky, Xingmin Aaron Zhang, James P Balhoff, Larry Babb, Susan M. Bello, Hannah Blau, Yvonne Bradford, Seth Carbon, Leigh Carmody, Lauren E Chan, Valentina Cipriani, Alayne Cuzick, Maria D Rocca, Nathan Dunn, Shahim Essaid, Petra Fey, Chris Grove, Jean-Phillipe Gourdine, Ada Hamosh, Midori Harris, Ingo Helbig, Maureen Hoatlin, Marcin Joachimiak, Simon Jupp, Kenneth B Lett, Suzanna E Lewis, Craig McNamara, Zoë M Pendlington, Clare Pilgrim, Tim Putman, Vida Ravanmehr, Justin Reese, Erin Riggs, Sofia Robb, Paola Roncaglia, James Seager, Erik Segerdell, Morgan Similuk, Andrea L Storm, Courtney Thaxon, Anne Thessen, Julius O B Jacobsen, Julie A McMurry, Tudor Groza, Sebastian Köhler, Damian Smedley, Peter N Robinson, Christopher J Mungall, Melissa A Haendel, Monica C Munoz-Torres, and David Osumi-Sutherland
The XY Body: An Attractive Chromatin Domain., Mary Ann Handel
Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells., Insoo Hyun, Megan Munsie, Martin F Pera, Nicolas C Rivron, and Janet Rossant
Transplanting cells from old but not young donors causes physical dysfunction in older recipients., Binsheng Wang, Zukai Liu, Vicky P Chen, Lichao Wang, Christina L Inman, Yueying Zhou, Chun Guo, Tamar Tchkonia, David W Rowe, George A Kuchel, Paul Robson, James L Kirkland, and Ming Xu
Treating Cancer as an Invasive Species., Javad Noorbakhsh, Zi-Ming Zhao, James C Russell, and Jeffrey H Chuang
V-SVA: an R Shiny application for detecting and annotating hidden sources of variation in single cell RNA-seq data., Nathan Lawlor, Eladio J Marquez, Donghyung Lee, and Duygu Ucar