Content Posted in 2020
100 Years of evolving gene-disease complexities and scientific debutants., Saman Zeeshan, Ruoyun Xiong, Bruce T Liang, and Zeeshan Ahmed
3D bioprinting for reconstituting the cancer microenvironment., Pallab Datta, Madhuri Dey, Zaman Ataie, Derya Unutmaz, and Ibrahim T Ozbolat
3D-GNOME 2.0: a three-dimensional genome modeling engine for predicting structural variation-driven alterations of chromatin spatial structure in the human genome., Michal Wlasnowolski, Michal Sadowski, Tymon Czarnota, Karolina Jodkowska, Przemyslaw Szalaj, Zhonghui Tang, Yijun Ruan, and Dariusz Plewczynski
AbGRI4, a novel antibiotic resistance island in multiply antibiotic-resistant Acinetobacter baumannii clinical isolates., Agnes P Chan, Yongwook Choi, Thomas H Clarke, Lauren M Brinkac, Richard C White, Michael R Jacobs, Robert A Bonomo, Mark D Adams, and Derrick E Fouts
Abrogated AID Function Prolongs Survival and Diminishes Renal Pathology in the BXSB Mouse Model of Systemic Lupus Erythematosus., Jing Zhu, Alayna N Hay, Ashley A Potter, Madison W Richwine, Thomas J. Sproule, Tanya LeRoith, John J Wilson, Muneer G. Hasham, Derry C. Roopenian, and Caroline M Leeth
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities., Ravi S Narayan, Piet Molenaar, Jian Teng, Fleur M G Cornelissen, Irene Roelofs, Renee Menezes, Rogier Dik, Tonny Lagerweij, Yoran Broersma, Naomi Petersen, Jhon Alexander Marin Soto, Eelke Brands, Philip van Kuiken, Maria C Lecca, Kristiaan J Lenos, Sjors G J G In 't Veld, Wessel van Wieringen, Frederick F Lang, Erik Sulman, Roel G W Verhaak, Brigitta G Baumert, Lucas J A Stalpers, Louis Vermeulen, Colin Watts, David Bailey, Ben J Slotman, Rogier Versteeg, David Noske, Peter Sminia, Bakhos A Tannous, Tom Wurdinger, Jan Koster, and Bart A Westerman
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes., Heike Kollmus, Helmut Fuchs, Christoph Lengger, Hamed Haselimashhadi, Molly A. Bogue, Manuela A Östereicher, Marion Horsch, Thure Adler, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Johannes Beckers, Julia Calzada-Wack, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Tanja Klein-Rodewald, Holger Maier, Philipp Mayer-Kuckuk, Gregor Miller, Kristin Moreth, Frauke Neff, Birgit Rathkolb, Ildikó Rácz, Jan Rozman, Nadine Spielmann, Irina Treise, Dirk Busch, Jochen Graw, Thomas Klopstock, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Jeremy Mason, Arturo Torres, Mouse Phenome Database Team, Rudi Balling, Terry Mehaan, Valerie Gailus-Durner, Klaus Schughart, and Martin Hrabě de Angelis
A Computational analysis of cardiac aging using mRNA and protein expression data., Daniel Alfonsetti
ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vaccines and Therapeutics., Judith A Hewitt, Cathleen Lutz, William C Florence, M Louise M Pitt, Srinivas Rao, Jay Rappaport, and Nancy L Haigwood
ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility., Elizabeth Snyder, Lauren Chukrallah, Kelly Seltzer, Leslie Goodwin, and Robert E Braun
Addressing the batch effect issue for LC/MS metabolomics data in data preprocessing., Qin Liu, Douglas Walker, Karan Uppal, Zihe Liu, Chunyu Ma, ViLinh Tran, Shuzhao Li, Dean P Jones, and Tianwei Yu
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T, Rabab Nasrallah, Charlotte J Imianowski, Lara Bossini-Castillo, Francis M Grant, Mikail Dogan, Lindsey Placek, Lina Kozhaya, Paula Kuo, Firas Sadiyah, Sarah K Whiteside, Maxwell R Mumbach, Dafni Glinos, Panagiota Vardaka, Carly E Whyte, Teresa Lozano, Toshitsugu Fujita, Hodaka Fujii, Adrian Liston, Simon Andrews, Adeline Cozzani, Jie Yang, Suman Mitra, Enrico Lugli, Howard Y Chang, Derya Unutmaz, Gosia Trynka, and Rahul Roychoudhuri
A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency, Dana M Talsness, Katie G Owings, Emily Coelho, Gaelle Mercenne, John M Pleinis, Raghavendran Partha, Kevin A Hope, Aamir Zuberi, Nathan L Clark, Cathleen Lutz, Aylin R Rodan, and Clement Y Chow
Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation., Eraj Shafiq Khokhar, Sneha Borikar, Elizabeth Eudy, Timothy M Stearns, Kira Young, and Jennifer J. Trowbridge
A guide to writing systematic reviews of rare disease treatments to generate FAIR-compliant datasets: building a Treatabolome., Antonio Atalaia, Rachel Thompson, Alberto Corvo, Leigh Carmody, Davide Piscia, Leslie Matalonga, Alfons Macaya, Angela Lochmuller, Bertrand Fontaine, Birte Zurek, Carles Hernandez-Ferrer, Carola Rheinard, David Gómez-Andrés, Jean-François Desaphy, Katherine Schon, Katja Lohmann, Matthew J Jennings, Matthis Synofzik, Olaf Riess, Rabah Ben Yaou, Teresinha Evangelista, Thiloka Ratnaike, Virginie Bros-Facer, Gulcin Gumus, Rita Horvath, Patrick Chinnery, Steven Laurie, Holm Graessner, Peter N Robinson, Hanns Lochmuller, Sergi Beltran, and Gisèle Bonne
A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer., Alex H Wagner, Brian Walsh, Georgia Mayfield, David Tamborero, Dmitriy Sonkin, Kilannin Krysiak, Jordi Deu-Pons, Ryan P Duren, Jianjiong Gao, Julie McMurry, Sara E. Patterson, Catherine Del Vecchio Fitz, Beth A Pitel, Ozman U Sezerman, Kyle Ellrott, Jeremy L Warner, Damian T Rieke, Tero Aittokallio, Ethan Cerami, Deborah I Ritter, Lynn M Schriml, Robert R Freimuth, Melissa Haendel, Gordana Raca, Subha Madhavan, Michael Baudis, Jacques S Beckmann, Rodrigo Dienstmann, Debyani Chakravarty, Xuan Shirley Li, Susan Mockus, Olivier Elemento, Nikolaus Schultz, Nuria Lopez-Bigas, Mark Lawler, Jeremy Goecks, Malachi Griffith, Obi L Griffith, and Adam A Margolin
A large-scale genome-lipid association map guides lipid identification., Vanessa Linke, Katherine A Overmyer, Ian J Miller, Dain R Brademan, Paul D Hutchins, Edna A Trujillo, Thiru R Reddy, Jason D Russell, Emily M Cushing, Kathryn L Schueler, Donald S Stapleton, Mary E Rabaglia, Mark P Keller, Daniel M Gatti, Gregory R Keele, Duy Pham, Karl W Broman, Gary A Churchill, Alan D Attie, and Joshua J Coon
Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy., Peiheng Gan, Michaela Patterson, Hirofumi Watanabe, Kristy Wang, Reilly A Edmonds, Laura G Reinholdt, and Henry M Sucov
A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice., Jason A. Bubier, Vivek M. Philip, Christopher Quince, James Campbell, Yanjiao Zhou, Tatiana Vishnivetskaya, Suman Duvvuru, Rachel Hageman Blair, Juliet Ndukum, Kevin D Donohue, Carmen M Foster, David J Mellert, George M. Weinstock, Cymbeline T Culiat, Bruce F O'Hara, Anthony V Palumbo, Mircea Podar, and Elissa J Chesler
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers., Sung-Yup Cho, Yumi Oh, Eui Man Jeong, Sanghui Park, Dakeun Lee, Xiaorui Wang, Qiqi Zeng, Hongyu Qin, Fang Hu, Hui Gong, Xi Liu, Guanjun Zhang, Deukchae Na, Jieun Lee, Jeesoo Chae, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, Jong-Il Kim, Hansoo Park, Chengsheng Zhang, Han-Kwang Yang, and Charles Lee
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics., Malin Bern, Jeannette Nilsen, Mattia Ferrarese, Kine M K Sand, Torleif T Gjølberg, Heidrun E Lode, Robert J Davidson, Rodney M Camire, Espen S Bækkevold, Stian Foss, Algirdas Grevys, Bjørn Dalhus, John J Wilson, Lene S Høydahl, Gregory J. Christianson, Derry C. Roopenian, Tilman Schlothauer, Terje E Michaelsen, Morten C Moe, Silvia Lombardi, Mirko Pinotti, Inger Sandlie, Alessio Branchini, and Jan Terje Andersen
An expanded mouse testis transcriptome and mass spectrometry defines novel proteins., Jaya Gamble, Joel Chick, Kelly Seltzer, Joel H Graber, Steven Gygi, Robert E Braun, and Elizabeth M Snyder
An Improved Phenotype-Driven Tool for Rare Mendelian Variant Prioritization: Benchmarking Exomiser on Real Patient Whole-Exome Data., Valentina Cipriani, Nikolas Pontikos, Gavin Arno, Panagiotis I Sergouniotis, Eva Lenassi, Penpitcha Thawong, Daniel Danis, Michel Michaelides, Andrew R Webster, Anthony T Moore, Peter N Robinson, Julius O B Jacobsen, and Damian Smedley
An intact C-terminal end of albumin is required for its long half-life in humans., Jeannette Nilsen, Esben Trabjerg, Algirdas Grevys, Claudia Azevedo, Stephen O Brennan, Maria Stensland, John J Wilson, Kine Marita Knudsen Sand, Malin Bern, Bjørn Dalhus, Derry C. Roopenian, Inger Sandlie, Kasper Dyrberg Rand, and Jan Terje Andersen
A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei., Jaishree Tripathi, Charis-Patricia Segeritz, Gareth Griffiths, Wendy Bushell, Ludovic Vallier, William C Skarnes, Maria M Mota, and Oliver Billker
A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei., Jaishree Tripathi, Charis-Patricia Segeritz, Gareth Griffiths, Wendy Bushell, Ludovic Vallier, William C Skarnes, Maria M Mota, and Oliver Billker
A novel mouse model expressing human forms for complement receptors CR1 and CR2., Harriet M. Jackson, Kate E Foley, Rita O'Rourke, Timothy M Stearns, Dina Fathalla, B Paul Morgan, and Gareth R Howell
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease., Christoph Preuss, Ravi S Pandey, Erin Piazza, Alexander D Fine, Asli Uyar, Thanneer Perumal, Dylan Garceau, Kevin P Kotredes, Harriet M. Williams, Lara M Mangravite, Bruce T Lamb, Adrian L Oblak, Gareth R Howell, Michael Sasner, Benjamin A Logsdon, MODEL-AD Consortium, and Gregory W. Carter
Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells., Marion Bouvet, Olivier Claude, Maguelonne Roux, Daniel A Skelly, Nihar Masurkar, Nathalie Mougenot, Sophie Nadaud, Catherine Blanc, Clément Delacroix, Solenne Chardonnet, Cédric Pionneau, Claire Perret, Elisa Yaniz-Galende, Nadia Rosenthal, David-Alexandre Trégouët, Giovanna Marazzi, Jean-Sébastien Silvestre, David Sassoon, and Jean-Sébastien Hulot
Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients., Daniel Spakowicz, Shaoke Lou, Brian Barron, Jose L Gomez, Tianxiao Li, Qing Liu, Nicole Grant, Xiting Yan, Rebecca Hoyd, George M. Weinstock, Geoffrey L Chupp, and Mark Gerstein
A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome., Chunting Ye, Hongyuan Yang, Mingshan Cheng, Leonard D. Shultz, Dale L Greiner, Michael A Brehm, and James G. Keck
Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine., Zeeshan Ahmed, Khalid Mohamed, Saman Zeeshan, and XinQi Dong
Association of CNVs with methylation variation., Xinghua Shi, Saranya Radhakrishnan, Jia Wen, Jin Yun Chen, Junjie Chen, Brianna Ashlyn Lam, Ryan E Mills, Barbara E Stranger, Charles Lee, and Sunita R Setlur
Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age., Cory M Willis, Alexandra M Nicaise, Ernesto R Bongarzone, Maria Givogri, Cory R Reiter, Olivia Heintz, Evan R Jellison, Pearl A Sutter, Gregg TeHennepe, Guruprasad Ananda, Anthony T Vella, and Stephen J Crocker
A supervised learning framework for chromatin loop detection in genome-wide contact maps., Tarik J Salameh, Xiaotao Wang, Fan Song, Bo Zhang, Sage M Wright, Chachrit Khunsriraksakul, Yijun Ruan, and Feng Yue
A Thalamic Orphan Receptor Drives Variability in Short-Term Memory., Kuangfu Hsiao, Chelsea Noble, Wendy Pitman, Nakul Yadav, Suraj Kumar, Gregory R Keele, Andrea Terceros, Matt Kanke, Tara Conniff, Christopher Cheleuitte-Nieves, Ravi Tolwani, Praveen Sethupathy, and Priyamvada Rajasethupathy
A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears., Amanda Fazzalari, Giacomo Basadonna, Alper Kucukural, Kahraman Tanriverdi, Milka Koupenova, Natalie Pozzi, Jahnavi Kakuturu, Ann-Kristin U Friedrich, Ron Korstanje, Nicholas Fowler, Jerrold L Belant, Dean E Beyer, Marjory B Brooks, Eric W Dickson, Meghan Blackwood, Chris Mueller, J Alexander Palesty, Jane E Freedman, and Mitchell A Cahan
A Universal, Genomewide GuideFinder for CRISPR/Cas9 Targeting in Microbial Genomes., Michelle Spoto, Changhui Guan, Elizabeth Fleming, and Julia Oh
Automated generation of gene summaries at the Alliance of Genome Resources., Ranjana Kishore, Valerio Arnaboldi, Ceri E Van Slyke, Juancarlos Chan, Robert S Nash, Jose M Urbano, Mary E. Dolan, Stacia R Engel, Mary Shimoyama, Paul W Sternberg, and The Alliance Of Genome Resources
Bayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics., Kwangbom Choi, Yang Chen, Daniel A Skelly, and Gary A Churchill
Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses., L J Blumberg, J E Humphries, S D Jones, L B Pearce, R Holgate, A Hearn, J Cheung, A Mahmood, B Del Tito, J S Graydon, L E Stolz, A Bitonti, S Purohit, D de Graaf, K Kacena, J T Andersen, Gregory J. Christianson, Derry C. Roopenian, J J Hubbard, A K Gandhi, K Lasseter, M Pyzik, and R S Blumberg
C11orf95-RELA reprograms 3D epigenome in supratentorial ependymoma., Jacqueline Jufen Zhu, Nathaniel L. Jillette, Xiao-Nan Li, Albert Cheng, and Ching C Lau
Canagliflozin extends life span in genetically heterogeneous male but not female mice., Richard A Miller, David E Harrison, David B Allison, Molly A. Bogue, Lucas Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej Galecki, W Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin A Javors, Warren C Ladiges, Francesca Macchiarini, James Nelson, Peter C. Reifsnyder, Nadia Rosenthal, Marianna Sadagurski, Adam B Salmon, Daniel L Smith, Jessica M Snyder, David B Lombard, and Randy Strong
Cancer Stem Cells: Notes for Authors., Connie J Eaves and Martin Pera
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation., Melanie R Shapiro, Wen-I Yeh, Joshua R Longfield, John Gallagher, Caridad M Infante, Sarah Wellford, Amanda L Posgai, Mark A Atkinson, Martha Campbell-Thompson, Scott M Lieberman, David V. Serreze, Aron M Geurts, Yi-Guang Chen, and Todd M Brusko
CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice., Cheng Ye, Benjamin E. Low, Michael V. Wiles, Todd M Brusko, David V. Serreze, and John P Driver
Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus., Laura E Mickelsen, William F Flynn, Kristen Springer, Lydia Wilson, Eric J Beltrami, Mohan Bolisetty, Paul Robson, and Alexander C Jackson
Challenges in Developing a Human Model System for Skin Microbiome Research., Peter J Larson, Derrick Chong, Elizabeth Fleming, and Julia Oh
Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine., Sarah A Schoenrock, Padam Kumar, Alexander Gómez-A, Price E. Dickson, Sam-Moon Kim, Lauren Bailey, Sofia Neira, Kyle D Riker, Joseph Farrington, Christiann H Gaines, Saad Khan, Troy D Wilcox, Tyler A. Roy, Michael R Leonardo, Ashley A Olson, Leona H. Gagnon, Vivek M. Philip, William Valdar, Fernando Pardo-Manuel de Villena, James D Jentsch, Ryan W Logan, Colleen A McClung, Donita L Robinson, Elissa J Chesler, and Lisa M Tarantino
ChIA-PIPE: A fully automated pipeline for comprehensive ChIA-PET data analysis and visualization., Byoungkoo Lee, Jiahui Wang, Liuyang Cai, Minji Kim, Sandeep Namburi, Harianto Tjong, Yuliang Feng, Ping Wang, Zhonghui Tang, Ahmed Abbas, Chia-Lin Wei, Yijun Ruan, and Sheng Li
Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development., Chew Yee Ngan, Chee-Hong Wong, Harianto Tjong, Wenbo Wang, Rachel L Goldfeder, Cindy Choi, Hao He, Liang Gong, Junyan Lin, Barbara Urban, Julianna Chow, Meihong Li, Joanne Lim, Vivek M. Philip, Stephen A. Murray, Haoyi Wang, and Chia-Lin Wei
Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia., Ping Wang, Zhonghui Tang, Byoungkoo Lee, Jacqueline Jufen Zhu, Liuyang Cai, Przemyslaw Szalaj, Simon Zhongyuan Tian, Meizhen Zheng, Dariusz Plewczynski, Xiaoan Ruan, Edison T Liu, Chia-Lin Wei, and Yijun Ruan
Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice., Charles B Wright, Hironori Uehara, Younghee Kim, Tetsuhiro Yasuma, Reo Yasuma, Shuichiro Hirahara, Ryan D Makin, Ivana Apicella, Felipe Pereira, Yosuke Nagasaka, Siddharth Narendran, Shinichi Fukuda, Romulo Albuquerque, Benjamin J Fowler, Ana Bastos-Carvalho, Philippe Georgel, Izuho Hatada, Bo Chang, Nagaraj Kerur, Balamurali K Ambati, Jayakrishna Ambati, and Bradley D Gelfand
circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan., Shahnaz Haque, Ryan M Ames, Karen Moore, Luke C Pilling, Luanne L. Peters, Stefania Bandinelli, Luigi Ferrucci, and Lorna W Harries
Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype-like Cluster., Yanfei Chen, Masako Nakanishi, Eddy J Bautista, Veneta Qendro, Erica Sodergren, Daniel W Rosenberg, and George M. Weinstock
Comparative Molecular Life History of Spontaneous Canine and Human Gliomas., Samirkumar B Amin, Kevin J Anderson, C Elizabeth Boudreau, Emmanuel Martinez-Ledesma, Emre Kocakavuk, Kevin C Johnson, Floris P Barthel, Frederick S Varn, Cynthia Kassab, Xiaoyang Ling, Hoon Kim, Mary Barter, Ching C Lau, Chew Yee Ngan, Margaret Chapman, Jennifer W Koehler, James P Long, Andrew D Miller, C Ryan Miller, Brian F Porter, Daniel R Rissi, Christina Mazcko, Amy K LeBlanc, Peter J Dickinson, Rebecca A Packer, Amanda R Taylor, John H Rossmeisl, Kevin D Woolard, Amy B Heimberger, Jonathan M Levine, and Roel G W Verhaak
Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice., Jeffrey M. Harder, Pete A. Williams, Catherine E. Braine, Hongyuan Yang, Jocelyn M Thomas, Nicole E Foxworth, Simon W M John, and Gareth R Howell
Comprehensive overview of COVID-19 clinical trials., Kiran Ejaz, Tanveer Kauser, and Amnah Siddiqa
Content and Performance of the MiniMUGA Genotyping Array, a New Tool To Improve Rigor and Reproducibility in Mouse Research., John Sebastian Sigmon, Matthew W Blanchard, Ralph S Baric, Timothy A Bell, Jennifer Brennan, Gudrun A Brockmann, A Wesley Burks, J Mauro Calabrese, Kathleen M Caron, Richard E Cheney, Dominic Ciavatta, Frank Conlon, David B Darr, James Faber, Craig Franklin, Timothy R Gershon, Lisa Gralinski, Bin Gu, Christiann H Gaines, Robert S Hagan, Ernest G Heimsath, Mark T Heise, Pablo Hock, Folami Ideraabdullah, J Charles Jennette, Tal Kafri, Anwica Kashfeen, Mike Kulis, Vivek Kumar, Colton Linnertz, Alessandra Livraghi-Butrico, K C Kent Lloyd, Cathleen Lutz, Rachel M Lynch, Terry Magnuson, Glenn K Matsushima, Rachel McMullan, Darla R Miller, Karen L Mohlke, Sheryl S Moy, Caroline Murphy, Maya Najarian, Lori O'Brien, Abraham A Palmer, Benjamin D Philpot, Scott H Randell, Laura G Reinholdt, Yuyu Ren, Steve Rockwood, Allison R Rogala, Avani Saraswatula, Christopher M Sassetti, Jonathan C Schisler, Sarah A Schoenrock, Ginger D Shaw, John R Shorter, Clare M Smith, Celine L St Pierre, Lisa M Tarantino, David W Threadgill, William Valdar, Barbara J Vilen, Keegan Wardwell, Jason K Whitmire, Lucy Williams, Mark J Zylka, Martin T Ferris, Leonard McMillan, and Fernando Pardo-Manuel de Villena
Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using d-Alanine Auxotrophy., David Dodds, Jeffrey L Bose, Ming-De Deng, Gilles R Dubé, Trudy H Grossman, Alaina Kaiser, Kashmira Kulkarni, Roger Leger, Sara Mootien-Boyd, Azim Munivar, Julia Oh, Matthew Pestrak, Komal Rajpura, Alexander P Tikhonov, Traci Turecek, and Travis Whitfill
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells., Yoshiki Higashijima, Yusuke Matsui, Teppei Shimamura, Ryo Nakaki, Nao Nagai, Shuichi Tsutsumi, Yohei Abe, Verena M Link, Mizuko Osaka, Masayuki Yoshida, Ryo Watanabe, Toshihiro Tanaka, Akashi Taguchi, Mai Miura, Xiaoan Ruan, Guoliang Li, Tsuyoshi Inoue, Masaomi Nangaku, Hiroshi Kimura, Tetsushi Furukawa, Hiroyuki Aburatani, Youichiro Wada, Yijun Ruan, Christopher K Glass, and Yasuharu Kanki
COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice., Cathleen Lutz, Leigh Maher, Charles Lee, and Wonyoung Kang
CRISPR artificial splicing factors., Menghan Du, Nathaniel L. Jillette, Jacqueline Jufen Zhu, Sheng Li, and Albert Wu Cheng
CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4., Andrew M. Garrett, Peter J Bosch, David M Steffen, Leah C Fuller, Charles G Marcucci, Alexis A Koch, Preeti Bais, Joshua A Weiner, and Robert W. Burgess
Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia., Andrew R Ouellette, Sarah M Neuner, Logan Dumitrescu, Laura C. Anderson, Daniel M. Gatti, Emily R Mahoney, Jason A. Bubier, Gary Churchill, Luanne L. Peters, Matthew J Huentelman, Jeremy H Herskowitz, Hyun-Sik Yang, Alexandra N Smith, Christiane Reitz, Brian W Kunkle, Charles C White, Philip L De Jager, Julie A Schneider, David A Bennett, Nicholas T Seyfried, Alzheimer's Disease Genetics Consortium, Elissa J Chesler, Niran Hadad, Timothy J Hohman, and Catherine Kaczorowski
CsrA Supports both Environmental Persistence and Host-Associated Growth of Acinetobacter baumannii., John M Farrow, Greg Wells, Samantha Palethorpe, Mark D Adams, and Everett C Pesci
CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence., Yue Zhao, Ziwei Pan, Sandeep Namburi, Andrew Pattison, Atara Posner, Shiva Balachander, Carolyn Paisie, Honey V Reddi, Jens Rueter, Anthony J Gill, Stephen Fox, Kanwal P S Raghav, William F Flynn, Richard W Tothill, Sheng Li, Radha Krishna Murthy Karuturi, and Joshy George
Dapagliflozin Does Not Directly Affect Human α or β Cells., Chunhua Dai, John T Walker, Alena Shostak, Yasir Bouchi, Greg Poffenberger, Nathaniel J Hart, David A Jacobson, M Wade Calcutt, Rita Bottino, Dale L Greiner, Leonard D. Shultz, Owen P McGuinness, E Danielle Dean, and Alvin C Powers
Deciphering functional redundancy in the human microbiome., Liang Tian, Xu-Wen Wang, Ang-Kun Wu, Yuhang Fan, Jonathan Friedman, Amber Dahlin, Matthew K Waldor, George M. Weinstock, Scott T Weiss, and Yang-Yu Liu
Decoding the mechanisms underlying cell-fate decision-making during stem cell differentiation by random circuit perturbation., Bin Huang, Mingyang Lu, Madeline Galbraith, Herbert Levine, Jose N Onuchic, and Dongya Jia
Decoy exosomes provide protection against bacterial toxins., Matthew D Keller, Krystal L Ching, Feng-Xia Liang, Avantika Dhabaria, Kayan Tam, Beatrix M Ueberheide, Derya Unutmaz, Victor J Torres, and Ken Cadwell
Decreased pancreatic acinar cell number in type 1 diabetes., Jordan J Wright, Diane C Saunders, Chunhua Dai, Greg Poffenberger, Brynn Cairns, David V. Serreze, David M Harlan, Rita Bottino, Marcela Brissova, and Alvin C Powers
Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma., Noah E Berlow, Catherine S Grasso, Michael J Quist, Mingshan Cheng, Regina Gandour-Edwards, Brian S Hernandez, Joel E Michalek, Christopher Ryan, Paul Spellman, Ranadip Pal, Lynn S Million, Mark Renneker, and Charles Keller
Deep learning-based cross-classifications reveal conserved spatial behaviors within tumor histological images., Javad Noorbakhsh, Saman Farahmand, Ali Foroughi Pour, Sandeep Namburi, Dennis Caruana, David Rimm, Mohammad Soltanieh-Ha, Kourosh Zarringhalam, and Jeffrey Chuang
Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology., Nassim Bouteldja, Barbara M Klinkhammer, Roman D Bülow, Patrick Droste, Simon W Otten, Saskia Freifrau von Stillfried, Julia Moellmann, Susan Sheehan, Ron Korstanje, Sylvia Menzel, Peter Bankhead, Matthias Mietsch, Charis Drummer, Michael Lehrke, Rafael Kramann, Jürgen Floege, Peter Boor, and Dorit Merhof
Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity., Leah C. Graham, Heidi Kocalis, Ileana Soto, and Gareth R Howell
Depletion of CLK2 sensitizes glioma stem-like cells to PI3K/mTOR and FGFR inhibitors., Soon Young Park, Sandeep Mittal, Jianwen Dong, Kangjin Jeong, Emmanuel Martinez-Ledesma, Yuji Piao, Sabbir Khan, Verlene Henry, Roel G W Verhaak, Nazanin Majd, Veerakumar Balasubramaniyan, and John F de Groot
Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands., M Heath Farris, Pamela A Texter, Agustin A Mora, Michael V. Wiles, Ellen F Mac Garrigle, Sybil A Klaus, and Kristine Rosfjord
Development and validation of a novel 29-plex Y-STR typing system for forensic application., Min Li, Wei Zhou, Yilun Zhang, Lei Huang, Xinjie Wang, Jun Wu, Meng Meng, Hongran Wang, Chengtao Li, and Yingnan Bian
Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)., Aline Talhouk, Joshy George, Chen Wang, Timothy Budden, Tuan Zea Tan, Derek S Chiu, Stefan Kommoss, Huei San Leong, Stephanie Chen, Maria P Intermaggio, Blake Gilks, Tayyebeh M Nazeran, Mila Volchek, Wafaa Elatre, Rex C Bentley, Janine Senz, Amy Lum, Veronica Chow, Hanwei Sudderuddin, Robertson Mackenzie, Samuel C Y Leong, Geyi Liu, Dustin Johnson, Billy Chen, Aocs Group, Jennifer Alsop, Susana N Banerjee, Sabine Behrens, Clara Bodelon, Alison H Brand, Louise Brinton, Michael E Carney, Yoke-Eng Chiew, Kara L Cushing-Haugen, Cezary Cybulski, Darren Ennis, Sian Fereday, Renée T Fortner, Jesús García-Donas, Aleksandra Gentry-Maharaj, Rosalind Glasspool, Teodora Goranova, Casey S Greene, Paul Haluska, Holly R Harris, Joy Hendley, Brenda Y Hernandez, Esther Herpel, Mercedes Jimenez-Linan, Chloe Karpinskyj, Scott H Kaufmann, Gary L Keeney, Catherine J Kennedy, Martin Köbel, Jennifer M Koziak, Melissa C Larson, Jenny Lester, Liz-Anne Lewsley, Jolanta Lissowska, Jan Lubiński, Hugh Luk, Geoff Macintyre, Sven Mahner, Iain A McNeish, Janusz Menkiszak, Nikilyn Nevins, Ana Osorio, Oleg Oszurek, José Palacios, Samantha Hinsley, Celeste L Pearce, Malcolm C Pike, Anna M Piskorz, Isabelle Ray-Coquard, Valerie Rhenius, Cristina Rodriguez-Antona, Raghwa Sharma, Mark E Sherman, Dilrini De Silva, Naveena Singh, Peter Sinn, Dennis Slamon, Honglin Song, Helen Steed, Euan A Stronach, Pamela J Thompson, Aleksandra Tołoczko, Britton Trabert, Nadia Traficante, Chiu-Chen Tseng, Martin Widschwendter, Lynne R Wilkens, Stacey J Winham, Boris Winterhoff, Alicia Beeghly-Fadiel, Javier Benitez, Andrew Berchuck, James D Brenton, Robert Brown, Jenny Chang-Claude, Georgia Chenevix-Trench, Anna deFazio, Peter A Fasching, María J García, Simon A Gayther, Marc T Goodman, Jacek Gronwald, Michelle J Henderson, Beth Y Karlan, Linda E Kelemen, Usha Menon, Sandra Orsulic, Paul D P Pharoah, Nicolas Wentzensen, Anna H Wu, Joellen M Schildkraut, Mary Anne Rossing, Gottfried E Konecny, David G Huntsman, Ruby Yun-Ju Huang, Ellen L Goode, Susan J Ramus, Jennifer A Doherty, David D Bowtell, and Michael S Anglesio
Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human, Anthony M Pettinato, Feria A Ladha, David J Mellert, Nicholas Legere, Rachel Cohn, Robert Romano, Ketan Thakar, Yu-Sheng Chen, and J Travis Hinson
Differences in cancer patients' and clinicians' preferences for disclosure of uncertain genomic tumor testing results., Anny T Fenton, Eric C Anderson, Elizabeth Scharnetzki, Kate Reed, Emily A Edelman, Andrey Antov, Jens Rueter, Paul K J Han, and MCGI Working Group
Differences in Gut Microbiome in Hospitalized Immunocompetent vs. Immunocompromised Children, Including Those With Sickle Cell Disease., Sindhu Mohandas, Vijaya L Soma, Thi Dong Binh Tran, Erica Sodergren, Tresa Ambooken, David L Goldman, George M. Weinstock, and Betsy C Herold
Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy., Liwei Jiang, Yi-Jun Wang, Jing Zhao, Mayuko Uehara, Qingming Hou, Vivek Kasinath, Takaharu Ichimura, Naima Banouni, Li Dai, Xiaofei Li, Dale L Greiner, Leonard D. Shultz, Xiaolong Zhang, Zhen-Yu Jim Sun, Ian Curtin, Nicholas E Vangos, Zoe C Yeoh, Ezekiel A Geffken, Hyuk-Soo Seo, Ze-Xian Liu, Gregory J Heffron, Khalid Shah, Sirano Dhe-Paganon, and Reza Abdi
Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites., Elie Hammam, Guruprasad Ananda, Ameya Sinha, Christine Scheidig-Benatar, Mylene Bohec, Peter R Preiser, Peter C Dedon, Artur Scherf, and Shruthi S Vembar
Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis, Jason A. Bubier, Vivek M. Philip, Price E. Dickson, Guy Mittleman, and Elissa J Chesler
Disruption in murine Eml1 perturbs retinal lamination during early development., Gayle B. Collin, J Won, Mark P. Krebs, W J Hicks, Jeremy R. Charette, Juergen K. Naggert, and Patsy M. Nishina
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer., Kadir C Akdemir, Victoria T Le, Sahaana Chandran, Yilong Li, Roel G W Verhaak, Rameen Beroukhim, Peter J Campbell, Lynda Chin, Jesse R Dixon, P Andrew Futreal, PCAWG Structural Variation Working Groug, and PCAWG Consortium
Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in, Mark D Adams, Fernando Pasteran, German M Traglia, Jasmine Martinez, Fanny Huang, Christine Liu, Jennifer S Fernandez, Carolina Lopez, Lisandro J Gonzalez, Ezequiel Albornoz, Alejandra Corso, Alejandro J Vila, Robert A Bonomo, and Maria Soledad Ramirez
Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy., Jeremy M Sullivan, William W Motley, Janel O Johnson, William H Aisenberg, Katherine L Marshall, Katy Es Barwick, Lingling Kong, Jennifer S Huh, Pamela C Saavedra-Rivera, Meriel M McEntagart, Marie-Helene Marion, Lucy A Hicklin, Hamid Modarres, Emma L Baple, Mohamed H Farah, Aamir Zuberi, Cathleen Lutz, Rachelle Gaudet, Bryan J Traynor, Andrew H Crosby, and Charlotte J Sumner
Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice., Elvira Forte, Daniel A Skelly, Mandy Chen, Sandra Daigle, Kaesi A Morelli, Olivia Hon, Vivek M. Philip, Mauro W Costa, Nadia Rosenthal, and Milena B Furtado
Effort-related decision making in humanized COMT mice: Effects of Val, Jen-Hau Yang, Rose E Presby, Suzanne Cayer, Renee A Rotolo, Peter A Perrino, R Holly Fitch, Merce Correa, Elissa J Chesler, and John D Salamone
EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma., Shaofang Wu, Feng Gao, Siyuan Zheng, Chen Zhang, Emmanuel Martinez-Ledesma, Ravesanker Ezhilarasan, Jie Ding, Xiaolong Li, Ningping Feng, Asha Multani, Erik P Sulman, Roel G W Verhaak, John F de Groot, Tim P Heffernan, W K Alfred Yung, and Dimpy Koul
Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation., Olivia J Marola, Stephanie B Syc-Mazurek, Gareth R Howell, and Richard T Libby
Evidence for a Novel Endometrioid Carcinogenic Sequence in the Fallopian Tube With Unique Beta-Catenin Expression., Jan Brouwer, Kyle C Strickland, Gang Ning, Cindy B Schmelkin, David L Kolin, Jonathan Hecht, Marisa R Nucci, Marian J Mourits, Wa Xian, and Christopher P Crum
Evolution: Is Recombination Rate Variation Adaptive?, Beth L Dumont
EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8., Hui Tian, Timothy Billings, and Petko M. Petkov
Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility., Mridu Kapur, Archan Ganguly, Gabor Nagy, Scott I Adamson, Jeffrey Chuang, Wayne N Frankel, and Susan L Ackerman
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers., Hoon Kim, Nam-Phuong Nguyen, Kristen Turner, Sihan Wu, Amit D Gujar, Jens Luebeck, Jihe Liu, Viraj Deshpande, Utkrisht Rajkumar, Sandeep Namburi, Samirkumar B Amin, Eunhee Yi, Francesca Menghi, Johannes H Schulte, Anton G Henssen, Howard Y Chang, Christine R Beck, Paul S Mischel, Vineet Bafna, and Roel G W Verhaak
FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity., Jonathan J Hubbard, Michal Pyzik, Timo Rath, Lisa K Kozicky, Kine M K Sand, Amit K Gandhi, Algirdas Grevys, Stian Foss, Susan C Menzies, Jonathan N Glickman, Edda Fiebiger, Derry C. Roopenian, Inger Sandlie, Jan Terje Andersen, Laura M Sly, Kristi Baker, and Richard S Blumberg
From GWAS Association to Function: Candidate Gene Screening Within Insulin Resistance-Associated Genomic Loci Using a Preadipocyte Differentiation Model., Feria A Ladha, Michael L. Stitzel, and J Travis Hinson
Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human, Benjamin E. Low, Gregory J. Christianson, Emily Lowell, Wenning Qin, and Michael V. Wiles
GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone., Joonho Suh, Na-Kyung Kim, Seung-Hoon Lee, Je-Hyun Eom, Youngkyun Lee, Joo-Cheol Park, Kyung Mi Woo, Jeong-Hwa Baek, Jung-Eun Kim, Hyun-Mo Ryoo, Se-Jin Lee, and Yun-Sil Lee
GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells., thomas lisse, Manju Sharma, Neda Vishlaghi, Sri Ramulu N Pullagura, and Robert E Braun
Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation., Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace Stafford, Vivek Kohar, Leonard D. Shultz, and Michael V. Wiles
Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data., Jovan Tanevski, Thin Nguyen, Buu Truong, Nikos Karaiskos, Mehmet Eren Ahsen, Xinyu Zhang, Chang Shu, Ke Xu, Xiaoyu Liang, Ying Hu, Hoang Vv Pham, Li Xiaomei, Thuc D Le, Adi L Tarca, Gaurav Bhatti, Roberto Romero, Nestoras Karathanasis, Phillipe Loher, Yang Chen, Zhengqing Ouyang, Disheng Mao, Yuping Zhang, Maryam Zand, Jianhua Ruan, Christoph Hafemeister, Peng Qiu, Duc Tran, Tin Nguyen, Attila Gabor, Thomas Yu, Justin Guinney, Enrico Glaab, Roland Krause, Peter Banda, DREAM SCTC Consortium, Gustavo Stolovitzky, Nikolaus Rajewsky, Julio Saez-Rodriguez, and Pablo Meyer
Gene therapies for axonal neuropathies: Available strategies, successes to date, and what to target next., Kathryn H Morelli, Courtney L Hatton, Scott Q Harper, and Robert W. Burgess
Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice., David A Hillis, Liran Yadgary, George M. Weinstock, Fernando Pardo-Manuel de Villena, Daniel Pomp, Alexandra S Fowler, Shizhong Xu, Frank Chan, and Theodore Garland
Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice., Rong Yuan, C J M Musters, Yun Zhu, Tracy R Evans, Yujie Sun, Elissa J Chesler, Luanne L. Peters, David E Harrison, and Andrzej Bartke
Genetic Identification and Drug-Resistance Characterization of, Jorge Cervantes, Noemí Yokobori, and Bo-Young Hong
Genetic Interactions Affect Lung Function in Patients with Systemic Sclerosis., Anna L. Tyler, J Matthew Mahoney, and Gregory W. Carter
Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer's disease., Ravi S Pandey, Leah C. Graham, Asli Uyar, Christoph Preuss, Gareth R Howell, and Gregory W. Carter
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D., Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B Prasad, Olof Asplund, Amanda Bennett, Michael Boehnke, Andrew A Brown, Michael R Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K Iyengar, Paul Johnson, Ulrika Krus, Patrick E MacDonald, Anubha Mahajan, Jocelyn E Manning Fox, Narisu Narisu, Vibe Nylander, Peter Orchard, Nikolay Oskolkov, Nikolaos I Panousis, Anthony Payne, Michael L. Stitzel, Swarooparani Vadlamudi, Ryan Welch, Francis S Collins, Karen L Mohlke, Anna L Gloyn, Laura J Scott, Emmanouil T Dermitzakis, Leif Groop, Stephen C J Parker, and Mark I McCarthy
Genetic variants and functional pathways associated with resilience to Alzheimer's disease., Logan Dumitrescu, Emily R Mahoney, Shubhabrata Mukherjee, Michael L Lee, William S Bush, Corinne D Engelman, Qiongshi Lu, David W Fardo, Emily H Trittschuh, Jesse Mez, Catherine Kaczorowski, Hector Hernandez Saucedo, Keith F Widaman, Rachel Buckley, Michael Properzi, Elizabeth Mormino, Hyun-Sik Yang, Tessa Harrison, Trey Hedden, Kwangsik Nho, Shea J Andrews, Doug Tommet, Niran Hadad, R Elizabeth Sanders, Douglas M Ruderfer, Katherine A Gifford, Annah M Moore, Francis Cambronero, Xiaoyuan Zhong, Neha S Raghavan, Badri Vardarajan, Margaret A Pericak-Vance, Lindsay A Farrer, Li-San Wang, Carlos Cruchaga, Gerard Schellenberg, Nancy J Cox, Jonathan L Haines, C Dirk Keene, Andrew J Saykin, Eric B Larson, Reisa A Sperling, Richard Mayeux, David A Bennett, Julie A Schneider, Paul K Crane, Angela L Jefferson, and Timothy J Hohman
Genetic variation regulates opioid-induced respiratory depression in mice., Jason A. Bubier, Hao He, Vivek M. Philip, Tyler A. Roy, Christian Monroy Hernandez, Rebecca Bernat, Kevin D Donohue, Bruce F O'Hara, and Elissa J Chesler
Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue., Owen M Wilkins, Kevin C Johnson, E Andres Houseman, Jessica E King, Carmen J Marsit, and Brock C Christensen
Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma., Rachael A Vaubel, Shulan Tian, Dioval Remonde, Mark A Schroeder, Ann C Mladek, Gaspar J Kitange, Alissa Caron, Thomas M Kollmeyer, Rebecca Grove, Sen Peng, Brett L Carlson, Daniel J Ma, Gobinda Sarkar, Lisa Evers, Paul A Decker, Huihuang Yan, Harshil D Dhruv, Michael E Berens, Qianghu Wang, Bianca M Marin, Eric W Klee, Andrea Califano, Daniel H LaChance, Jeanette E Eckel-Passow, Roel G W Verhaak, Erik P Sulman, Terry C Burns, Fredrick B Meyer, Brian P O'Neill, Nhan L Tran, Caterina Giannini, Robert B Jenkins, Ian F Parney, and Jann N Sarkaria
Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and γ-ray-induced tumors., E F Edmondson, Daniel M Gatti, F A Ray, E L Garcia, C M Fallgren, D A Kamstock, and M M Weil
Genomic Medicine Year in Review: 2019., Teri A Manolio, Carol J Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Gail P Jarvik, Howard L McLeod, George A Mensah, Mary V Relling, Dan M Roden, Robb Rowley, Cecelia Tamburro, Marc S Williams, and Eric D Green
Genomic Medicine Year in Review: 2020., Teri A Manolio, Carol J Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Madison Goldrich, Gail P Jarvik, George A Mensah, Mary V Relling, Dan M Roden, Robb Rowley, Cecelia Tamburro, Marc S Williams, and Eric D Green
Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks., Kelsey H Elliott, Xiaoting Chen, Joseph Salomone, Praneet Chaturvedi, Preston A Schultz, Sai K Balchand, Jeffrey D Servetas, Aimée Zuniga, Rolf Zeller, Brian Gebelein, Matthew T Weirauch, Kevin A Peterson, and Samantha A Brugmann
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions., Patrick Y Wen, Michael Weller, Eudocia Quant Lee, Brian M Alexander, Jill S Barnholtz-Sloan, Floris P Barthel, Tracy T Batchelor, Ranjit S Bindra, Susan M Chang, E Antonio Chiocca, Timothy F Cloughesy, John F DeGroot, Evanthia Galanis, Mark R Gilbert, Monika E Hegi, Craig Horbinski, Raymond Y Huang, Andrew B Lassman, Emilie Le Rhun, Michael Lim, Minesh P Mehta, Ingo K Mellinghoff, Giuseppe Minniti, David Nathanson, Michael Platten, Matthias Preusser, Patrick Roth, Marc Sanson, David Schiff, Susan C Short, Martin J B Taphoorn, Joerg-Christian Tonn, Jonathan Tsang, Roel G W Verhaak, Andreas von Deimling, Wolfgang Wick, Gelareh Zadeh, David A Reardon, Kenneth D Aldape, and Martin J van den Bent
GlyGen: Computational and Informatics Resources for Glycoscience., William S York, Raja Mazumder, Rene Ranzinger, Nathan Edwards, Robel Kahsay, Kiyoko F Aoki-Kinoshita, Matthew P Campbell, Richard D Cummings, Ten Feizi, Maria Martin, Darren A Natale, Nicolle H Packer, Robert J Woods, Gaurav Agarwal, Sena Arpinar, Sanath Bhat, Judith A. Blake, Leyla Jael Garcia Castro, Brian Fochtman, Jeffrey Gildersleeve, Radoslav Goldman, Xavier Holmes, Vinamra Jain, Sujeet Kulkarni, Rupali Mahadik, Akul Mehta, Reza Mousavi, Sandeep Nakarakommula, Rahi Navelkar, Nagarajan Pattabiraman, Michael J Pierce, Karen Ross, Preethi Vasudev, Jeet Vora, Tatiana Williamson, and Wenjin Zhang
Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data., Haitham Ashoor, Xiaowen Chen, Wojciech Rosikiewicz, Jiahui Wang, Albert Cheng, Ping Wang, Yijun Ruan, and Sheng Li
GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis., Markus Terrey, Scott I Adamson, Alana L Gibson, Tianda Deng, Ryuta Ishimura, Jeffrey Chuang, and Susan L Ackerman
GXD's RNA-Seq and Microarray Experiment Search: using curated metadata to reliably find mouse expression studies of interest., Constance M. Smith, James W Godwin, Richard M. Baldarelli, Jonathan S Beal, Olin Blodgett, Sharon C Giannatto, Joel E Richardson, and Martin Ringwald
HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis., Guy Karlebach, Peter Hansen, Diogo FT Veiga, Robin Steinhaus, Daniel Danis, Sheng Li, Olga Anczuków, and Peter N Robinson
Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α., Shivani N Mann, Niran Hadad, Molly Nelson Holte, Alicia R Rothman, Roshini Sathiaseelan, Samim Ali Mondal, Martin-Paul Agbaga, Archana Unnikrishnan, Malayannan Subramaniam, John Hawse, Derek M Huffman, Willard M Freeman, and Michael B Stout
HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots., Catrina Spruce, Sibongakonke Dlamini, Guruprasad Ananda, Naomi Bronkema, Hui Tian, Kenneth Paigen, Gregory W. Carter, and Christopher L. Baker
Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients., Jihyun Lee, Suzanne D Vernon, Patricia Jeys, Weam Ali, Andrea Campos, Derya Unutmaz, Brayden Yellman, and Lucinda Bateman
Heritable genetic background alters survival and phenotype of Mll-AF9-induced leukemias., Kira Young, Matthew A Loberg, Elizabeth Eudy, Logan S Schwartz, Kristina D Mujica, and Jennifer J. Trowbridge
High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy., Michael A McLellan, Daniel A Skelly, Malathi S I Dona, Galen T Squiers, Gabriella E Farrugia, Taylah L Gaynor, Charles D Cohen, Raghav Pandey, Henry Diep, Antony Vinh, Nadia Rosenthal, and Alexander R Pinto
High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains., Brendan T Keenan, Raymond J Galante, Jie Lian, Petr Simecek, Daniel M. Gatti, Lin Zhang, Diane C Lim, Karen L. Svenson, Gary Churchill, and Allan I Pack
Host-Specific Evolutionary and Transmission Dynamics Shape the Functional Diversification of Staphylococcus epidermidis in Human Skin., Wei Zhou, Michelle Spoto, Rachel Hardy, Changhui Guan, Elizabeth Fleming, Peter J Larson, Joseph S Brown, and Julia Oh
Human and mouse essentiality screens as a resource for disease gene discovery., Pilar Cacheiro, Violeta Muñoz-Fuentes, Stephen A. Murray, Mary E Dickinson, Maja Bucan, Lauryl M J Nutter, Kevin A Peterson, Hamed Haselimashhadi, Ann M Flenniken, Hugh Morgan, Henrik Westerberg, Tomasz Konopka, Chih-Wei Hsu, Audrey Christiansen, Denise G Lanza, Arthur L Beaudet, Jason D Heaney, Helmut Fuchs, Valerie Gailus-Durner, Tania Sorg, Jan Prochazka, Vendula Novosadova, Christopher J Lelliott, Hannah Wardle-Jones, Sara Wells, Lydia Teboul, Heather Cater, Michelle Stewart, Tertius Hough, Wolfgang Wurst, Radislav Sedlacek, David J Adams, John R Seavitt, Glauco Tocchini-Valentini, Fabio Mammano, Robert E Braun, Colin McKerlie, Yann Herault, Martin Hrabě de Angelis, Ann-Marie Mallon, K C Kent Lloyd, Steve D M Brown, Helen Parkinson, Terrence F Meehan, Damian Smedley, Genomics England Research Consortium, and International Mouse Phenotyping Consortium
Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel., Amy R Dunn, Niran Hadad, Sarah M Neuner, Ji-Gang Zhang, Vivek M. Philip, Logan Dumitrescu, Timothy J Hohman, Jeremy H Herskowitz, Kristen M S O'Connell, and Catherine Kaczorowski
Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice., Sarah E Heuer, Sarah M Neuner, Niran Hadad, Kristen M S O'Connell, Robert W Williams, Vivek M. Philip, Chris Gaiteri, and Catherine Kaczorowski
Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors., Lin Qi, Mari Kogiso, Yuchen Du, Huiyuan Zhang, Frank K Braun, Yulun Huang, Wan-Yee Teo, Holly Lindsay, Sibo Zhao, Patricia Baxter, Xiumei Zhao, Litian Yu, Zhigang Liu, Xingding Zhang, Jack Mf Su, Adekunle Adesina, Jianhua Yang, Murali Chintagumpala, Laszlo Perlaky, Chris Tsz-Kwong Man, Ching C Lau, and Xiao-Nan Li
Implications of increased S100β and Tau5 proteins in dystrophic nerves of two mdx mouse models for Duchenne muscular dystrophy., Vidya S Krishnan, Annemieke Aartsma-Rus, Maurice Overzier, Cathleen Lutz, Laurent P. Bogdanik, and Miranda D Grounds
Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils., Vishnu Hosur, Daniel A Skelly, Christopher Francis, Benjamin E. Low, Vivek Kohar, Lisa M. Burzenski, Mansoor M Amiji, Leonard D. Shultz, and Michael V. Wiles
Improving Characterization of Understudied Human Microbiomes Using Targeted Phylogenetics., Bruce A Rosa, Kathie Mihindukulasuriya, Kymberlie Hallsworth-Pepin, Aye Wollam, John Martin, Caroline Snowden, William Michael Dunne, George M. Weinstock, C A Burnham, and Makedonka Mitreva
Improving preclinical to clinical translation in Alzheimer's disease research., Stacey J Sukoff Rizzo, Andi Masters, Kristen D. Onos, Sara Quinney, Michael Sasner, Adrian Oblak, Bruce T Lamb, Paul R Territo, and MODEL-AD Consortium
Innovations, challenges, and minimal information for standardization of humanized mice., Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl-Dimiter Bissig, Brian Soper, Terrence Meeham, Li-Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb-Parsy, Johannes Sam, Amar Deep Sharma, Andreas Trumpp, Livio Trusolino, Carol J Bult, and Leonard D. Shultz
Integrating image caption information into biomedical document classification in support of biocuration., Xiangying Jiang, Pengyuan Li, James A. Kadin, Judith A. Blake, Martin Ringwald, and Hagit Shatkay
Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats., Eric C Exner, Aron M Geurts, Brian R Hoffmann, Marc Casati, Timothy Stodola, Nikita R Dsouza, Michael Zimmermann, Julian H Lombard, and Andrew S Greene
Interpretable Clinical Genomics with a Likelihood Ratio Paradigm., Peter N Robinson, Vida Ravanmehr, Julius O B Jacobsen, Daniel Danis, Xingmin Aaron Zhang, Leigh Carmody, Michael Gargano, Courtney L Thaxton, UNC Biocuration Core, Guy Karlebach, Justin Reese, Manuel Holtgrewe, Sebastian Köhler, Julie A McMurry, Melissa A Haendel, and Damian Smedley
Interpretation of psychiatric genome-wide association studies with multispecies heterogeneous functional genomic data integration., Timothy Reynolds, Emma C Johnson, Spencer B Huggett, Jason A. Bubier, Rohan H C Palmer, Arpana Agrawal, Erich J Baker, and Elissa J Chesler
Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral disease., Mary E. Dolan, David P. Hill, Gaurab Mukherjee, Monica McAndrews, Elissa J Chesler, and Judith A. Blake
Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice., John P Sundberg, C Herbert Pratt, Leslie P. Goodwin, Kathleen A Silva, Victoria E. Kennedy, Christopher S Potter, Anisa Dunham, Beth A. Sundberg, and Harm HogenEsch
LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding., Huacheng Luo, Qin Yu, Yang Liu, Ming Tang, Mingwei Liang, Dingpeng Zhang, Tsan Sam Xiao, Lizi Wu, Ming Tan, Yijun Ruan, Jörg Bungert, and Jianrong Lu
LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia., Justin H Layer, Michael Christy, Lindsey Placek, Derya Unutmaz, Yan Guo, and Utpal P Davé
Lipidomic Profiling of the Epidermis in a Mouse Model of Dermatitis Reveals Sexual Dimorphism and Changes in Lipid Composition before the Onset of Clinical Disease., Jackeline Franco, Bartek Rajwa, Christina R Ferreira, John P Sundberg, and Harm HogenEsch
Long non-coding RNAs in immune regulation and their potential as therapeutic targets., Dinesh Babu Uthaya Kumar and Adam Williams
Loss of ADAMTS19 causes progressive non-syndromic heart valve disease., Florian Wünnemann, Asaf Ta-Shma, Christoph Preuss, Severine Leclerc, Patrick Piet van Vliet, Andrea Oneglia, Maryse Thibeault, Emily Nordquist, Joy Lincoln, Franka Scharfenberg, Christoph Becker-Pauly, Philipp Hofmann, Kirstin Hoff, Enrique Audain, Hans-Heiner Kramer, Wojciech Makalowski, Amiram Nir, Sebastian S Gerety, Matthew Hurles, Johanna Comes, Anne Fournier, Hanna Osinska, Jeffrey Robins, Michel Pucéat, Orly Elpeleg, Marc-Phillip Hitz, and Gregor Andelfinger
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation., Zeda Zhang, Chuanli Zhou, Xiaoling Li, Spencer D Barnes, Su Deng, Elizabeth Hoover, Chi-Chao Chen, Young Sun Lee, Yanxiao Zhang, Choushi Wang, Lauren A Metang, Chao Wu, Carla Rodriguez Tirado, Nickolas A Johnson, John Wongvipat, Kristina Navrazhina, Zhen Cao, Danielle Choi, Chun-Hao Huang, Eliot Linton, Xiaoping Chen, Yupu Liang, Christopher E Mason, Elisa de Stanchina, Wassim Abida, Amaia Lujambio, Sheng Li, Scott W Lowe, Joshua T Mendell, Venkat S Malladi, Charles L Sawyers, and Ping Mu
Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure., Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G Tolman, Syed Hameed, Yusef Seymens, Eric Dang, Anil K Mandal, Sirisha Senthil, Rohit C Khanna, Meha Kabra, Inderjeet Kaur, Simon W M John, Subhabrata Chakrabarti, and K Saidas Nair
Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice., Jane Branca, Benjamin E. Low, Ruth L. Saxl, Jennifer K Sargent, Rosalinda A. Doty, Michael V. Wiles, Beth L Dumont, and Muneer G. Hasham
Low SATB1 Expression Promotes IL-5 and IL-9 Expression in Sézary Syndrome., Alberto Herrera, Simon Fredholm, Anthony Cheng, Eleni P Mimitou, Angelina Seffens, Michal Bar-Natan, Amy Sun, Jo-Ann Latkowski, Andreas Willerslew-Olsen, Terkild B Buus, Maria Gluud, Thorbjørn Krejsgaard, Sara Torres-Rusillo, Charlotte Menné Bonefeld, Anders Woetmann, Carsten Geisler, Larisa J Geskin, Zhengqing Ouyang, Peter Smibert, Niels Ødum, and Sergei B Koralov
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis., Peishan Li, Mingyang Lu, Jiayuan Shi, Zheng Gong, Li Hua, Qing Li, Bora Lim, Xiang H-F Zhang, Xiaowen Chen, Sheng Li, Leonard D. Shultz, and Guangwen Ren
Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B., Ana Rita Batista, Oliver D King, Christopher P Reardon, Crystal Davis, Shankaracharya, Vivek M. Philip, Heather Gray-Edwards, Neil Aronin, Cathleen Lutz, John Landers, and Miguel Sena-Esteves
Machine learning-based automated phenotyping of inflammatory nocifensive behavior in mice., Janine M Wotton, Emma Peterson, Laura C. Anderson, Stephen A. Murray, Robert E Braun, Elissa J Chesler, Jacqueline K White, and Vivek Kumar
Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology., Robert Ietswaart, Seda Arat, Amanda X Chen, Saman Farahmand, Bumjun Kim, William DuMouchel, Duncan Armstrong, Alexander Fekete, Jeffrey J Sutherland, and Laszlo Urban
Mapping systemic lupus erythematosus heterogeneity at the single-cell level., Djamel Nehar-Belaid, Seunghee Hong, Radu Marches, Guo Chen, Mohan Bolisetty, Jeanine Baisch, Lynnette Walters, Marilynn Punaro, Robert J Rossi, Cheng-Han Chung, Richie P Huynh, Prashant Singh, William F Flynn, Joy-Ann Tabanor-Gayle, Navya Kuchipudi, Asuncion Mejias, Magalie A Collet, Anna Lisa Lucido, Karolina Palucka, Paul Robson, Santhanam Lakshminarayanan, Octavio Ramilo, Tracey Wright, Virginia Pascual, and Jacques Banchereau
Mapping the Effects of Genetic Variation on Chromatin State and Gene Expression Reveals Loci That Control Ground State Pluripotency., Daniel A Skelly, Anne M Czechanski, Candice Byers, Selcan Aydin, Catrina Spruce, Chris Olivier, Kwangbom Choi, Daniel M Gatti, Narayanan Raghupathy, Gregory R Keele, Alexander Stanton, Matthew J Vincent, Stephanie L. Dion, Ian Greenstein, Matthew Pankratz, Devin K Porter, Whitney Martin, Callan O'Connor, Wenning Qin, Alison H Harrill, Ted Choi, Gary Churchill, Steven C. Munger, Christopher L. Baker, and Laura G Reinholdt
Mass Cytometry Defines Virus-Specific CD4 + T Cells in Influenza Vaccination, Priyanka B Subrahmanyam, Tyson H Holmes, Dongxia Lin, Laura F Su, Gerlinde Obermoser, Jacques Banchereau, Virginia Pascual, Adolfo García-Sastre, Randy A Albrecht, Karolina Palucka, Mark M Davis, and Holden T Maecker
Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice., Fang Li, Ruijuan Xu, Chih-Li Lin, Benjamin E. Low, Louise Cai, Sally Li, Ping Ji, Liqun Huang, Michael V. Wiles, Yusuf A Hannun, Lina M Obeid, Ye Chen, and Cungui Mao
Mechanisms of T-Cell Exhaustion in Pancreatic Cancer., Didem Saka, Muazzez Gökalp, Betül Piyade, Nedim Can Cevik, Elif Arik Sever, Derya Unutmaz, Güralp O Ceyhan, Ihsan Ekin Demir, and Hande Asimgil
Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies and Myocardial Immune-Complexes During Heart Failure in Rodents and Humans., Amalia Sintou, Catherine Mansfield, Alma Iacob, Rasheda A Chowdhury, Salomon Narodden, Stephen M Rothery, Robert Podovei, Jose L Sanchez-Alonso, Elisa Ferraro, Pamela Swiatlowska, Sian E Harding, Sanjay Prasad, Nadia Rosenthal, Julia Gorelik, and Susanne Sattler
MEK inhibition reprograms CD8 + T lymphocytes into memory stem cells with potent antitumor effects, Vivek Verma, Nazli Jafarzadeh, Shannon Boi, Subhadip Kundu, Zhinuo Jiang, Yiping Fan, Jose Lopez, Rahul Nandre, Peng Zeng, Fatmah Alolaqi, Shamim Ahmad, Pankaj Gaur, Simon T Barry, Viia E Valge-Archer, Paul D Smith, Jacques Banchereau, Mikayel Mkrtichyan, Benjamin Youngblood, Paulo C Rodriguez, Seema Gupta, and Samir N Khleif
Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models., Ying-Wooi Wan, Rami Al-Ouran, Carl G Mangleburg, Thanneer M Perumal, Tom V Lee, Katherine Allison, Vivek Swarup, Cory C Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M Neuner, Catherine Kaczorowski, Vivek M. Philip, Gareth R Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L Dawson, Ted M Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K Sieberts, Larsson Omberg, Kristen D Dang, James A Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J Ebert, David C Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Gregory W. Carter, David A Collier, Todd E Golde, Allan I Levey, David A Bennett, Karol Estrada, T Matthew Townsend, Bin Zhang, Eric Schadt, Philip L De Jager, Nathan D Price, Nilüfer Ertekin-Taner, Zhandong Liu, Joshua M Shulman, Lara M Mangravite, and Benjamin A Logsdon
MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics., Zhiqiang Pang, Jasmine Chong, Shuzhao Li, and Jianguo Xia
Metagenomic growth rate inferences of strains in situ., Akintunde Emiola, Wei Zhou, and Julia Oh
Methods for comparative ChIA-PET and Hi-C data analysis., Dan Capurso, Zhonghui Tang, and Yijun Ruan
MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas., Barbara Oldrini, Nuria Vaquero-Siguero, Quanhua Mu, Paula Kroon, Ying Zhang, Marcos Galán-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason K Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel G W Verhaak, Raul Rabadan, Tao Jiang, Jiguang Wang, and Massimo Squatrito
miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells., Clarice X Lim, Bernett Lee, Olivia Geiger, Christina Passegger, Michaela Beitzinger, Johann Romberger, Anika Stracke, Christoph Högenauer, Anton Stift, Heribert Stoiber, Michael Poidinger, Armin Zebisch, Gunter Meister, Adam Williams, Richard A Flavell, Jorge Henao-Mejia, and Herbert Strobl
Modelling kidney disease using ontology: insights from the Kidney Precision Medicine Project., Edison Ong, Lucy L Wang, Jennifer Schaub, John F O'Toole, Becky Steck, Avi Z Rosenberg, Frederick Dowd, Jens Hansen, Laura Barisoni, Sanjay Jain, Ian H de Boer, M Todd Valerius, Sushrut S Waikar, Christopher Park, Dana C Crawford, Theodore Alexandrov, Christopher R Anderton, Christian Stoeckert, Chunhua Weng, Alexander D Diehl, Christopher J Mungall, Melissa Haendel, Peter N Robinson, Jonathan Himmelfarb, Ravi Iyengar, Matthias Kretzler, Sean Mooney, Yongqun He, and Kidney Precision Medicine Project
Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD., Adrian L Oblak, Stefania Forner, Paul R Territo, Michael Sasner, Gregory W. Carter, Gareth R Howell, Stacey J Sukoff-Rizzo, Benjamin A Logsdon, Lara M Mangravite, Ali Mortazavi, David Baglietto-Vargas, Kim N Green, Grant R MacGregor, Marcelo A Wood, Andrea J Tenner, Frank M LaFerla, Bruce T Lamb, and The MODEL-AD Consortium
Molecular and clonal evolution in recurrent metastatic gliosarcoma., Kevin J Anderson, Aaron C Tan, Jonathon Parkinson, Michael Back, Marina Kastelan, Allison Newey, Janice Brewer, Helen Wheeler, Amanda L Hudson, Samirkumar B Amin, Kevin C Johnson, Floris P Barthel, Roel G W Verhaak, and Mustafa Khasraw
Molecular Biology and Evolution of Cancer: From Discovery to Action., Jason A Somarelli, Heather Gardner, Vincent L Cannataro, Ella F Gunady, Amy M Boddy, Norman A Johnson, Jeffrey Nicholas Fisk, Stephen G Gaffney, Jeffrey Chuang, Sheng Li, Francesca D Ciccarelli, Anna R Panchenko, Kate Megquier, Sudhir Kumar, Alex Dornburg, James DeGregori, and Jeffrey P Townsend
Molecular estimation of neurodegeneration pseudotime in older brains., Sumit Mukherjee, Laura Heath, Christoph Preuss, Suman Jayadev, Gwenn A Garden, Anna K Greenwood, Solveig K Sieberts, Philip L De Jager, Nilüfer Ertekin-Taner, Gregory W. Carter, Lara M Mangravite, and Benjamin A Logsdon
Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study., Kaspar Draaisma, Aikaterini Chatzipli, Martin Taphoorn, Melissa Kerkhof, Astrid Weyerbrock, Marc Sanson, Ann Hoeben, Slávka Lukacova, Giuseppe Lombardi, Sieger Leenstra, Monique Hanse, Ruth Fleischeuer, Colin Watts, Joseph McAbee, Nicos Angelopoulos, Thierry Gorlia, Vassilis Golfinopoulos, Johan M Kros, Roel G W Verhaak, Vincent Bours, Martin J van den Bent, Ultan McDermott, Pierre A Robe, and Pim J French
Molecular profiling of CNS tumors for the treatment and management of disease., Qian Nie, Meng-Chang Hsiao, Harshpreet Chandok, Shannon Rowe, Matthew Prego, Bridgette Meyers, Gregory Omerza, Andrew N Hesse, Jasmina Uvalic, Melissa Soucy, Daniel Bergeron, Michael Peracchio, Shelbi Burns, Kevin Kelly, Jens Rueter, and Honey V Reddi
Molecular profiling of gynecologic cancers for treatment and management of disease - demonstrating clinical significance using the AMP/ASCO/CAP guidelines for interpretation and reporting of somatic variants., Qian Nie, Gregory Omerza, Harshpreet Chandok, Matthew Prego, Meng-Chang Hsiao, Bridgette Meyers, Andrew N Hesse, Jasmina Uvalic, Melissa Soucy, Daniel Bergeron, Michael Peracchio, Shelbi Burns, Kevin Kelly, Shannon Rowe, Jens Rueter, and Honey V Reddi
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss., Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F Hyde, Lisa Stone, Patsy M. Nishina, Mark P. Krebs, and Juergen K. Naggert
Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data., Molly A. Bogue, Vivek M. Philip, David O Walton, Stephen C. Grubb, Matthew H Dunn, Georgi Kolishovski, Jake Emerson, Gaurab Mukherjee, Timothy M Stearns, Hao He, Vinita Sinha, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, and Elissa J Chesler
MSIsensor-pro: Fast, Accurate, and Matched-normal-sample-free Detection of Microsatellite Instability., Peng Jia, Xiaofei Yang, Li Guo, Bowen Liu, Jiadong Lin, Hao Liang, Jianyong Sun, Chengsheng Zhang, and Kai Ye
Mutation Yield of a Custom 212-Gene Next-Generation Sequencing Panel for Solid Tumors: Clinical Experience of the First 260 Cases Tested Using the JAX ActionSeq™ Assay., Pavalan Selvam, Meng-Chang Hsiao, Gregory Omerza, Daniel Bergeron, Shannon Rowe, Jasmina Uvalic, Melissa Soucy, Michael Peracchio, Shelbi Burns, Bridgette Meyers, Matthew Prego, Qian Nie, Guruprasad Ananda, Harshpreet Chandok, Kevin Kelly, Andrew N Hesse, and Honey V Reddi
Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation., Daniel Ortmann, Stephanie Brown, Anne M Czechanski, Selcan Aydin, Daniele Muraro, Yuanhua Huang, Rute A Tomaz, Anna Osnato, Giovanni Canu, Brandon T Wesley, Daniel A Skelly, Oliver Stegle, Ted Choi, Gary A Churchill, Christopher L. Baker, Peter J Rugg-Gunn, Steven C. Munger, Laura G Reinholdt, and Ludovic Vallier
NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease., Paige B Martin, Yu Kigoshi-Tansho, Roger B Sher, Gianina Ravenscroft, Jennifer E Stauffer, Rajesh Kumar, Ryo Yonashiro, Tina Müller, Christopher Griffith, William Allen, Davut Pehlivan, Tamar Haral, Martin Zenker, Denise Howting, Denny Schanze, Eissa A Faqeih, Naif A M Almontashiri, Reza Maroofian, Henry Houlden, Neda Mazaheri, Hamid Galehdari, Ganka Douglas, Jennifer E Posey, Monique Ryan, James R Lupski, Nigel G Laing, Claudio A P Joazeiro, and Gregory A. Cox
New hints towards a precision medicine strategy for IDH wild-type glioblastoma., K White, K Connor, J Clerkin, B M Murphy, M Salvucci, A C O'Farrell, M Rehm, D O'Brien, J H M Prehn, S P Niclou, M L M Lamfers, M Verreault, A Idbaih, Roel G W Verhaak, A Golebiewska, and A T Byrne
New statistical method identifies cytokines that distinguish stool microbiomes., Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George M. Weinstock, and William D Shannon
Nine quick tips for efficient bioinformatics curriculum development and training., Susan McClatchy, Kristin M Bass, Daniel M. Gatti, Adam Moylan, and Gary Churchill
Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice., Dahea You, Lascelles E Lyn-Cook, Daniel M Gatti, Natalie Bell, Philip R Mayeux, Laura P James, William B Mattes, Gary J Larson, and Alison H Harrill
Nomenclature: Naming Your Gene-Modified Mouse., Alicia Valenzuela
Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice., James R Tribble, Jeffrey M. Harder, Pete A Williams, and Simon W M John
Ontologies, knowledge representation, and machine learning for translational research: recent contributions, Peter N Robinson and Melissa A. Haendel
Overlapping spectrums: The clinicogenetic commonalities between Charcot-Marie-Tooth and other neurodegenerative diseases., Paige B Martin, Amy N Hicks, Sarah E Holbrook, and Gregory A. Cox
parSMURF, a high-performance computing tool for the genome-wide detection of pathogenic variants., Alessandro Petrini, Marco Mesiti, Max Schubach, Marco Frasca, Daniel Danis, Matteo Re, Giuliano Grossi, Luca Cappelletti, Tiziana Castrignanò, Peter N Robinson, and Giorgio Valentini
PATHBIO: an international training program for precision mouse phenotyping., Jesus Ruberte, Paul N Schofield, Cord Brakebusch, Peter Vogel, Yann Herault, Guillem Gracia, Colin McKerlie, Martin Hrabĕ de Angelis, Michael Hagn, and John P Sundberg
Phenotate: crowdsourcing phenotype annotations as exercises in undergraduate classes., Willie H Chang, Pouria Mashouri, Alexander X Lozano, Brittney Johnstone, Mia Husić, Annie Olry, Sylvie Maiella, Tugce B Balci, Sarah L Sawyer, Peter N Robinson, Ana Rath, and Michael Brudno
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis., Nathan Leclair, Mattia Brugiolo, Laura M Urbanski, Shane C Lawson, Ketan Thakar, Marina Yurieva, Joshy George, J Travis Hinson, Albert Cheng, Brenton R Graveley, and Olga Anczuków
Precise Spatiotemporal Control of Nodal Na, Yael Eshed-Eisenbach, Jerome Devaux, Anna Vainshtein, Ofra Golani, Se-Jin Lee, Konstantin Feinberg, Natasha Sukhanov, Daniel S Greenspan, Keiichiro Susuki, Matthew N Rasband, and Elior Peles
Predicting the early risk of ophthalmopathy in Graves' disease patients using TCR repertoire., Yue Wang, Yufeng Liu, Xiaofei Yang, Hui Guo, Jiadong Lin, Jinkui Yang, Mingqian He, Jingya Wang, Xiaomei Liu, Tingting Shi, Liping Wu, Chengsheng Zhang, Kai Ye, and Bingyin Shi
Proceedings of the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT) Oligodendroglioma Workshop., Marta Penas-Prado, Jing Wu, Daniel P Cahill, Daniel J Brat, Joseph F Costello, Paul G Kluetz, J Gregory Cairncross, Martin van den Bent, Roel G W Verhaak, Orwa Aboud, Peter Burger, Susan M Chang, Christine Cordova, Raymond Y Huang, Lindsay S Rowe, Martin J B Taphoorn, Mark R Gilbert, Terri S Armstrong, and NCI-CONNECT Oligodendr0glioma Worhshop
Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis., Udita Datta, Sarah E Schoenrock, Jason A. Bubier, Molly A. Bogue, James D Jentsch, Ryan W Logan, Lisa M Tarantino, and Elissa J Chesler
Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling., Elvira Forte, Sandra Daigle, and Nadia Rosenthal
pyBedGraph: a python package for fast operations on 1D genomic signal tracks., Henry B Zhang, Minji Kim, Jeffrey Chuang, and Yijun Ruan
Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle., Ataur Katebi, Vivek Kohar, and Mingyang Lu
Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects., Randy Strong, Richard A Miller, Molly A. Bogue, Elizabeth Fernandez, Martin A Javors, Sergiy Libert, Paul Anthony Marinez, Michael P Murphy, Nicolas Musi, James F Nelson, Michael Petrascheck, Peter C. Reifsnyder, Arlan Richardson, Adam B Salmon, Francesca Macchiarini, and David E Harrison
Realizing the gains and losses in C9ORF72 ALS/FTD., Cathleen Lutz
Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice., Sambra D Redick, Linda Leehy, Ann R Rittenhouse, David M Blodgett, Alan G Derr, Alper Kucukural, Manuel G Garber, Leonard D. Shultz, Dale L Greiner, Jennifer P Wang, David M Harlan, Rita Bortell, and Agata Jurczyk
Reduced GABAergic Neuron Excitability, Altered Synaptic Connectivity, and Seizures in a KCNT1 Gain-of-Function Mouse Model of Childhood Epilepsy., Amy N Shore, Sophie Colombo, William F Tobin, Sabrina Petri, Erin R Cullen, Soledad Dominguez, Christopher D Bostick, Michael A Beaumont, Damian Williams, Dion Khodagholy, Mu Yang, Cathleen M Lutz, Yueqing Peng, Jennifer N Gelinas, David B Goldstein, Michael J Boland, Wayne N Frankel, and Matthew C Weston
Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation., Antonio Galeone, Joshua M Adams, Shinya Matsuda, Maximiliano F. Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M. Lutz, Markus Affolter, Aamir Zuberi, and Hamed Jafar-Nejad
Regulation of meiotic progression by Sertoli-cell androgen signaling., Hailey Larose, Travis Kent, Qianyi Ma, Adrienne Niederriter Shami, Nadia Harerimana, Jun Z Li, Saher Sue Hammoud, and Mary Ann Handel
Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia., Zhigang Cai, Chi Zhang, Jonathan J Kotzin, Adam Williams, Jorge Henao-Mejia, and Reuben Kapur
Sensitivity of comorbidity network analysis., Jason Cory Brunson, Thomas P Agresta, and Reinhard Laubenbacher
Sestrins induce natural killer function in senescent-like CD8, Branca I Pereira, Roel P H De Maeyer, Luciana P Covre, Djamel Nehar-Belaid, Alessio Lanna, Sophie Ward, Radu Marches, Emma S Chambers, Daniel C O Gomes, Natalie E Riddell, Mala K Maini, Vitor H Teixeira, Samuel M Janes, Derek W Gilroy, Anis Larbi, Neil A Mabbott, Duygu Ucar, George A Kuchel, Sian M Henson, Jessica Strid, Jun H Lee, Jacques Banchereau, and Arne N Akbar
Sexual-dimorphism in human immune system aging., Eladio J Márquez, Cheng-Han Chung, Radu Marches, Robert J Rossi, Djamel Nehar-Belaid, Alper Eroglu, David J Mellert, George A Kuchel, Jacques Banchereau, and Duygu Ucar
Sexual dimorphism in the meiotic requirement for PRDM9: A mammalian evolutionary safeguard., Natalie Powers, Beth L Dumont, Chihiro Emori, Raman Akinyanju Lawal, Catherine Brunton, Kenneth Paigen, Mary Ann Handel, Ewelina Bolcun-Filas, Petko M. Petkov, and Tanmoy Bhattacharyya
Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes., Leigh Carmody, Hannah Blau, Daniel Danis, Xingman A Zhang, Jean-Philippe Gourdine, Nicole Vasilevsky, Peter Krawitz, Miles D Thompson, and Peter N Robinson
Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis B., Zhili Wen, Yuliang Feng, and Xiaohua Yan
Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling, Heather Mary Brown, Stephen A. Murray, Hope Northrup, Kit Sing Au, and Lee A Niswander
Soft windowing application to improve analysis of high-throughput phenotyping data., Hamed Haselimashhadi, Jeremy C Mason, Violeta Munoz-Fuentes, Federico López-Gómez, Kolawole Babalola, Elif F Acar, Vivek Kumar, Jacqui White, Ann M Flenniken, Ruairidh King, Ewan Straiton, John Richard Seavitt, Angelina Gaspero, Arturo Garza, Audrey E Christianson, Chih-Wei Hsu, Corey L Reynolds, Denise G Lanza, Isabel Lorenzo, Jennie R Green, Juan J Gallegos, Ritu Bohat, Rodney C Samaco, Surabi Veeraragavan, Jong Kyoung Kim, Gregor Miller, Helmult Fuchs, Lillian Garrett, Lore Becker, Yeon Kyung Kang, David Clary, Soo Young Cho, Masaru Tamura, Nobuhiko Tanaka, Kyung Dong Soo, Alexandr Bezginov, Ghina Bou About, Marie-France Champy, Laurent Vasseur, Sophie Leblanc, Hamid Meziane, Mohammed Selloum, Patrick T Reilly, Nadine Spielmann, Holger Maier, Valerie Gailus-Durner, Tania Sorg, Masuya Hiroshi, Obata Yuichi, Jason D Heaney, Mary E Dickinson, Wurst Wolfgang, Glauco P Tocchini-Valentini, Kevin C Kent Lloyd, Colin McKerlie, Je Kyung Seong, Herault Yann, Martin Hrabé de Angelis, Steve D M Brown, Damian Smedley, Paul Flicek, Ann-Marie Mallon, Helen Parkinson, and Terrence F Meehan
Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure., Kadir C Akdemir, Victoria T Le, Justin M Kim, Sarah Killcoyne, Devin A King, Ya-Ping Lin, Yanyan Tian, Akira Inoue, Samirkumar B Amin, Frederick S Robinson, Manjunath Nimmakayalu, Rafael E Herrera, Erica J Lynn, Kin Chan, Sahil Seth, Leszek J Klimczak, Moritz Gerstung, Dmitry A Gordenin, John O'Brien, Lei Li, Yonathan Lissanu Deribe, Roel G W Verhaak, Peter J Campbell, Rebecca Fitzgerald, Ashby J Morrison, Jesse R Dixon, and P Andrew Futreal
Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML., Sheng Li, Xiaowen Chen, Jiahui Wang, Cem Meydan, Jacob L Glass, Alan H Shih, Ruud Delwel, Ross L Levine, Christopher E Mason, and Ari M Melnick
SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia., Joanna R Sinnakannu, Kian Leong Lee, Shanshan Cheng, Jia Li, Mengge Yu, Siew Peng Tan, Clara Chong Hui Ong, Huihua Li, Hein Than, Olga Anczuków, Adrian R Krainer, Xavier Roca, Steven G Rozen, Jabed Iqbal, Henry Yang, Charles Chuah, and Sin Tiong Ong
Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling., Sumana R Chintapaludi, Asli Uyar, Harriet M. Jackson, Casey Acklin, Xulong Wang, Michael Sasner, Gregory W. Carter, and Gareth R Howell
STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells., Sascha Kahlfuss, Ulrike Kaufmann, Axel R Concepcion, Lucile Noyer, Dimitrius Raphael, Martin Vaeth, Jun Yang, Priya Pancholi, Mate Maus, James Muller, Lina Kozhaya, Alireza Khodadadi-Jamayran, Zhengxi Sun, Patrick Shaw, Derya Unutmaz, Peter B Stathopulos, Cori Feist, Scott B Cameron, Stuart E Turvey, and Stefan Feske
Stimulus Complexity and Mouse Strain Drive Escalation of Operant Sensation Seeking Within and Across Sessions in C57BL/6J and DBA/2J Mice., Price E. Dickson and Guy Mittleman
Structural variant identification and characterization., Parithi Balachandran and Christine R Beck
Structure-based discovery of a small-molecule inhibitor of methicillin-resistant, Jie Liu, Lina Kozhaya, Victor J Torres, Derya Unutmaz, and Min Lu
Studying the effects of genetic variation on the aminoacyl-tRNA charging pathway using the Diversity Outbred mouse population, Benjamin Allan-Rahill
Supplementation of the ESID registry working definitions for the clinical diagnosis of inborn errors of immunity with encoded human phenotype ontology (HPO) terms., Lukas M Gasteiger, Peter N Robinson, Julia Pazmandi, Kaan Boztug, Mikko R J Seppänen, and Markus G Seidel
Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis., Yvonne A Evrard, Anuj Srivastava, Jelena Randjelovic, James H Doroshow, Dennis A Dean, Jeffrey S Morris, Jeffrey H Chuang, and NCI PDXNet Consortium
Systems biology of ferroptosis: A modeling approach., Anna Konstorum, Lia Tesfay, Bibbin T Paul, Frank M Torti, Reinhard Laubenbacher, and Suzy V Torti
Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable., Chunhua Dai, John T Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle Dean, Nripesh Prasad, Shawn E Levy, Dale L Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C Powers
Targeting antioxidant enzymes enhances the therapeutic efficacy of the BCL-X, Yumi Oh, Hae Rim Jung, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Jiwon Kim, Sang Eun Lee, Chang Ohk Sung, Won-Suk Lee, Charles Lee, Charles Lee, and Sung-Yup Cho
Targeting antioxidant enzymes enhances the therapeutic efficacy of the BCL-X, Yumi Oh, Hae Rim Jung, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Jiwon Kim, Sang Eun Lee, Chang Ohk Sung, Won-Suk Lee, Charles Lee, Eui Man Jeong, and Sung-Yup Cho
Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells., Zhigang Cai, Fabiola Aguilera, Baskar Ramdas, Swapna Vidhur Daulatabad, Rajneesh Srivastava, Jonathan J Kotzin, Martin Carroll, Gerald Wertheim, Adam Williams, Sarath Chandra Janga, Chi Zhang, Jorge Henao-Mejia, and Reuben Kapur
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight., Se-Jin Lee, Adam Lehar, Jessica U Meir, Christina Koch, Andrew Morgan, Lara E Warren, Renata Rydzik, Daniel W Youngstrom, Harshpreet Chandok, Joshy George, Joseph Gogain, Michael Michaud, Thomas A Stoklasek, Yewei Liu, and Emily L Germain-Lee
T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue., Jeremy Racine, Harry Chapman, Rosalinda A. Doty, Brynn Cairns, Timothy J Hines, Abigail L D Tadenev, Laura C. Anderson, Torrian L Green, Meaghan E Dyer, Janine M Wotton, Zoë Bichler, Jacqueline K White, Rachel Ettinger, Robert W. Burgess, and David V. Serreze
Teasing the Immune System to Repair the Heart., Jonathan A Epstein, Nadia Rosenthal, and Arthur M Feldman
Techniques for the generation of humanized mouse models for immuno-oncology., Chun I. Yu, Florentina Marches, Te-Chia Wu, Jan Martinek, and Karolina Palucka
TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice., Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Laura Bongiovanni, Alain de Bruin, Dennis Beringer, Sanne van Dooremalen, Leonard D. Shultz, Fumihiko Ishikawa, Zsolt Sebestyen, Trudy Straetemans, and Jürgen Kuball
TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis., Wojciech Rosikiewicz, Xiaowen Chen, Pilar M Dominguez, Hussein Ghamlouch, Said Aoufouchi, Olivier A Bernard, Ari Melnick, and Sheng Li
The acquisition of positional information across the radial axis of the cochlea., Vidhya Munnamalai and Donna M Fekete
The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137, Bardees M Foda, Ashley E Ciecko, David V. Serreze, William M Ridgway, Aron M Geurts, and Yi-Guang Chen
The Deep Genome Project., K C Kent Lloyd, David J Adams, Gareth Baynam, Arthur L Beaudet, Fatima Bosch, Kym M Boycott, Robert E Braun, Mark Caulfield, Ronald Cohn, Mary E Dickinson, Michael S Dobbie, Ann M Flenniken, Paul Flicek, Sanjeev Galande, Xiang Gao, Anne Grobler, Jason D Heaney, Yann Herault, Martin Hrabě de Angelis, James R Lupski, Stanislas Lyonnet, Ann-Marie Mallon, Fabio Mammano, Calum A MacRae, Roderick McInnes, Colin McKerlie, Terrence F Meehan, Stephen A Murray, Lauryl M J Nutter, Yuichi Obata, Helen Parkinson, Michael S Pepper, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Damian Smedley, Glauco Tocchini-Valentini, David Valle, Chi-Kuang Leo Wang, Sara Wells, Jacqueline K White, Wolfgang Wurst, Ying Xu, and Steve D M Brown
The influence of uncertainty and uncertainty tolerance on attitudes and self-efficacy about genomic tumor testing., Eric C Anderson, Alexandra Hinton, Christine W Lary, Tania Strout, Andrey Antov, Emily A Edelman, Petra Helbig, Kate Reed, Jens Rueter, and Paul K J Han
The involvement of neuroimmune cells in adipose innervation., Magdalena Blaszkiewicz, Elizabeth Wood, Sigi Koizar, Jake Willows, Ryan Anderson, Yu-Hua Tseng, James W Godwin, and Kristy L Townsend
The lethal sex gap: COVID-19., Eladio J Márquez, Jennifer J. Trowbridge, George A Kuchel, Jacques Banchereau, and Duygu Ucar
The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice., Valeria Gerbino, Esther Kaunga, Junqiang Ye, Daniele Canzio, Sean O'Keeffe, Noam D Rudnick, Paolo Guarnieri, Cathleen Lutz, and Tom Maniatis
The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP., Flora Szeri, Stefan Lundkvist, Sylvia Donnelly, Udo F H Engelke, Kyu Rhee, Charlene J Williams, John P Sundberg, Ron A Wevers, Ryan E Tomlinson, Robert S Jansen, and Koen van de Wetering
The Monarch Initiative in 2019: an integrative data and analytic platform connecting phenotypes to genotypes across species., Kent A Shefchek, Nomi L Harris, Michael Gargano, Nicolas Matentzoglu, Deepak Unni, Matthew Brush, Daniel Keith, Tom Conlin, Nicole Vasilevsky, Xingmin Aaron Zhang, James P Balhoff, Larry Babb, Susan M. Bello, Hannah Blau, Yvonne Bradford, Seth Carbon, Leigh Carmody, Lauren E Chan, Valentina Cipriani, Alayne Cuzick, Maria D Rocca, Nathan Dunn, Shahim Essaid, Petra Fey, Chris Grove, Jean-Phillipe Gourdine, Ada Hamosh, Midori Harris, Ingo Helbig, Maureen Hoatlin, Marcin Joachimiak, Simon Jupp, Kenneth B Lett, Suzanna E Lewis, Craig McNamara, Zoë M Pendlington, Clare Pilgrim, Tim Putman, Vida Ravanmehr, Justin Reese, Erin Riggs, Sofia Robb, Paola Roncaglia, James Seager, Erik Segerdell, Morgan Similuk, Andrea L Storm, Courtney Thaxon, Anne Thessen, Julius O B Jacobsen, Julie A McMurry, Tudor Groza, Sebastian Köhler, Damian Smedley, Peter N Robinson, Christopher J Mungall, Melissa A Haendel, Monica C Munoz-Torres, and David Osumi-Sutherland
The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities., Eleanor Herbert, Michelle Stewart, Marie Hutchison, Ann M Flenniken, Dawei Qu, Lauryl M J Nutter, Colin McKerlie, Liane Hobson, Brenda Kick, Bonnie L. Lyons, Jean-Paul Wiegand, Rosalinda A. Doty, Juan Antonio Aguilar-Pimentel, Martin Hrabe de Angelis, Mary Dickinson, John Seavitt, Jacqueline K White, Cheryl L Scudamore, and Sara Wells
The XY body: an attractive chromatin domain., Mary Ann Handel
Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4, Ashley A Viehmann Milam, Juliet M Bartleson, Michael D Buck, Chih-Hao Chang, Alexey Sergushichev, David L Donermeyer, Wing Y Lam, Erika L Pearce, Maxim N Artyomov, and Paul M Allen
Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells., Insoo Hyun, Megan Munsie, Martin F Pera, Nicolas C Rivron, and Janet Rossant
Toward Modeling Context-Specific EMT Regulatory Networks Using Temporal Single Cell RNA-Seq Data., Daniel Ramirez, Vivek Kohar, and Mingyang Lu
Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma., Jason K Sa, Nakho Chang, Hye Won Lee, Hee Jin Cho, Michele Ceccarelli, Luigi Cerulo, Jinlong Yin, Sung Soo Kim, Francesca P Caruso, Mijeong Lee, Donggeon Kim, Young Taek Oh, Yeri Lee, Nam-Gu Her, Byeongkwi Min, Hye-Jin Kim, Da Eun Jeong, Hye-Mi Kim, Hyunho Kim, Seok Chung, Hyun Goo Woo, Jeongwu Lee, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Jinho Kim, Woong-Yang Park, Qianghu Wang, Erik P Sulman, Amy B Heimberger, Michael Lim, Jong Bae Park, Antonio Iavarone, Roel G W Verhaak, and Do-Hyun Nam
Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology., Nikhil Milind, Christoph Preuss, Annat Haber, Guruprasad Ananda, Shubhabrata Mukherjee, Cai John, Sarah Shapley, Benjamin A Logsdon, Paul K Crane, and Gregory W. Carter
Transplanting cells from old but not young donors causes physical dysfunction in older recipients., Binsheng Wang, Zukai Liu, Vicky P Chen, Lichao Wang, Christina L Inman, Yueying Zhou, Chun Guo, Tamar Tchkonia, David W Rowe, George A Kuchel, Paul Robson, James L Kirkland, and Ming Xu
Treating Cancer as an Invasive Species., Javad Noorbakhsh, Zi-Ming Zhao, James C Russell, and Jeffrey H Chuang
Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization., Paweł Trzaskoma, Błażej Ruszczycki, Byoungkoo Lee, Katarzyna K Pels, Katarzyna Krawczyk, Grzegorz Bokota, Andrzej A Szczepankiewicz, Jesse Aaron, Agnieszka Walczak, Małgorzata A Śliwińska, Adriana Magalska, Michal Kadlof, Artur Wolny, Zofia Parteka, Sebastian Arabasz, Magdalena Kiss-Arabasz, Dariusz Plewczyński, Yijun Ruan, and Grzegorz M Wilczyński
Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice., Yoriko Saito, Leonard D. Shultz, and Fumihiko Ishikawa
Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal., Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L. Baker, Tracy C. McGarr, Christine A Wells, and Martin Pera
V-SVA: an R Shiny application for detecting and annotating hidden sources of variation in single-cell RNA-seq data., Nathan Lawlor, Eladio J Marquez, Donghyung Lee, and Duygu Ucar
What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?, Bella Luna Colombini-Ishikiriama, Thiago Jose Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Maria Aparecida Andrade Moreira Machado, Sandra Helena Penha de Oliveira, Vanessa Soares Lara, Andrew S Greene, and Carlos Ferreira Santos