Content Posted in 2021
100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report., Damian Smedley, Katherine R Smith, Antonio Martin, Ellen A Thomas, Ellen M McDonagh, Valentina Cipriani, Jamie M Ellingford, Gavin Arno, Arianna Tucci, Jana Vandrovcova, Georgia Chan, Hywel J Williams, Thiloka Ratnaike, Wei Wei, Kathleen Stirrups, Kristina Ibanez, Loukas Moutsianas, Matthias Wielscher, Anna Need, Michael R Barnes, Letizia Vestito, James Buchanan, Sarah Wordsworth, Sofie Ashford, Karola Rehmström, Emily Li, Gavin Fuller, Philip Twiss, Olivera Spasic-Boskovic, Sally Halsall, R Andres Floto, Kenneth Poole, Annette Wagner, Sarju G Mehta, Mark Gurnell, Nigel Burrows, Roger James, Christopher Penkett, Eleanor Dewhurst, Stefan Gräf, Rutendo Mapeta, Mary Kasanicki, Andrea Haworth, Helen Savage, Melanie Babcock, Martin G Reese, Mark Bale, Emma Baple, Christopher Boustred, Helen Brittain, Anna de Burca, Marta Bleda, Andrew Devereau, Dina Halai, Eik Haraldsdottir, Zerin Hyder, Dalia Kasperaviciute, Christine Patch, Dimitris Polychronopoulos, Angela Matchan, Razvan Sultana, Mina Ryten, Ana L T Tavares, Carolyn Tregidgo, Clare Turnbull, Matthew Welland, Suzanne Wood, Catherine Snow, Eleanor Williams, Sarah Leigh, Rebecca E Foulger, Louise C Daugherty, Olivia Niblock, Ivone U S Leong, Caroline F Wright, Jim Davies, Charles Crichton, James Welch, Kerrie Woods, Lara Abulhoul, Paul Aurora, Detlef Bockenhauer, Alexander Broomfield, Maureen A Cleary, Tanya Lam, Mehul Dattani, Emma Footitt, Vijeya Ganesan, Stephanie Grunewald, Sandrine Compeyrot-Lacassagne, Francesco Muntoni, Clarissa Pilkington, Rosaline Quinlivan, Nikhil Thapar, Colin Wallis, Lucy R Wedderburn, Austen Worth, Teofila Bueser, Cecilia Compton, Charu Deshpande, Hiva Fassihi, Eshika Haque, Louise Izatt, Dragana Josifova, Shehla Mohammed, Leema Robert, Sarah Rose, Deborah Ruddy, Robert Sarkany, Genevieve Say, Adam C Shaw, Agata Wolejko, Bishoy Habib, Gavin Burns, Sarah Hunter, Russell J Grocock, Sean J Humphray, Peter N Robinson, Melissa Haendel, Michael A Simpson, Siddharth Banka, Jill Clayton-Smith, Sofia Douzgou, Georgina Hall, Huw B Thomas, Raymond T O'Keefe, Michel Michaelides, Anthony T Moore, Sam Malka, Nikolas Pontikos, Andrew C Browning, Volker Straub, Gráinne S Gorman, Rita Horvath, Richard Quinton, Andrew M Schaefer, Patrick Yu-Wai-Man, Doug M Turnbull, Robert McFarland, Robert W Taylor, Emer O'Connor, Janice Yip, Katrina Newland, Huw R Morris, James Polke, Nicholas W Wood, Carolyn Campbell, Carme Camps, Kate Gibson, Nils Koelling, Tracy Lester, Andrea H Németh, Claire Palles, Smita Patel, Noemi B A Roy, Arjune Sen, John Taylor, Pilar Cacheiro, Julius O Jacobsen, Eleanor G Seaby, Val Davison, Lyn Chitty, Angela Douglas, Kikkeri Naresh, Dom McMullan, Sian Ellard, I Karen Temple, Andrew D Mumford, Gill Wilson, Phil Beales, Maria Bitner-Glindzicz, Graeme Black, John R Bradley, Paul Brennan, John Burn, Patrick F Chinnery, Perry Elliott, Frances Flinter, Henry Houlden, Melita Irving, William Newman, Shamima Rahman, John A Sayer, Jenny C Taylor, Andrew R Webster, Andrew O M Wilkie, Willem H Ouwehand, F Lucy Raymond, John Chisholm, Sue Hill, David Bentley, Richard H Scott, Tom Fowler, Augusto Rendon, and Mark Caulfield
17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex., David E Harrison, Randy Strong, Peter C. Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Marisa Lopez-Cruzan, Francesca Macchiarini, James F Nelson, Alessandro Bitto, Amy L Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M Stearns, Molly A. Bogue, and Richard A Miller
3D Bioprinting for fabrication of tissue models of COVID-19 infection., Anisha Kabir, Pallab Datta, Julia Oh, Adam Williams, Veli Ozbolat, Derya Unutmaz, and Ibrahim T Ozbolat
3D-cardiomics: A spatial transcriptional atlas of the mammalian heart., Monika Mohenska, Nathalia M Tan, Alex Tokolyi, Milena B Furtado, Mauro W Costa, Andrew J Perry, Jessica Hatwell-Humble, Karel van Duijvenboden, Hieu T Nim, Yuan M M Ji, Natalie Charitakis, Denis Bienroth, Francesca Bolk, Celine Vivien, Anja S Knaupp, David R Powell, David A Elliott, Enzo R Porrello, Susan K Nilsson, Gonzalo Del Monte-Nieto, Nadia A Rosenthal, Fernando J Rossello, Jose M Polo, and Mirana Ramialison
3D genomics across the tree of life reveals condensin II as a determinant of architecture type., Claire Hoencamp, Olga Dudchenko, Ahmed M O Elbatsh, Sumitabha Brahmachari, Jonne A Raaijmakers, Tom van Schaik, Ángela Sedeño Cacciatore, Vinícius G Contessoto, Roy G H P van Heesbeen, Bram van den Broek, Aditya N Mhaskar, Hans Teunissen, Brian Glenn St Hilaire, David Weisz, Arina D Omer, Melanie Pham, Zane Colaric, Zhenzhen Yang, Suhas S P Rao, Namita Mitra, Christopher Lui, Weijie Yao, Ruqayya Khan, Leonid L Moroz, Andrea Kohn, Judy St Leger, Alexandria Mena, Karen Holcroft, Maria Cristina Gambetta, Fabian Lim, Emma Farley, Nils Stein, Alexander Haddad, Daniel Chauss, Ayse Sena Mutlu, Meng C Wang, Neil D Young, Evin Hildebrandt, Hans H Cheng, Christopher J Knight, Theresa L U Burnham, Kevin A Hovel, Andrew J Beel, Pierre-Jean Mattei, Roger D Kornberg, Wesley C Warren, Gregory Cary, José Luis Gómez-Skarmeta, Veronica Hinman, Kerstin Lindblad-Toh, Federica Di Palma, Kazuhiro Maeshima, Asha S Multani, Sen Pathak, Liesl Nel-Themaat, Richard R Behringer, Parwinder Kaur, René H Medema, Bas van Steensel, Elzo de Wit, José N Onuchic, Michele Di Pierro, Erez Lieberman Aiden, and Benjamin D Rowland
AAV9-mediated FIG4 delivery prolongs life span in Charcot-Marie-Tooth disease type 4J mouse model., Maximiliano Presa, Rachel M Bailey, Crystal Davis, Tara Murphy, Jenn Cook, Randy Walls, Hannah Wilpan, Laurent P. Bogdanik, Guy M Lenk, Robert W. Burgess, Steven J Gray, and Cathleen Lutz
ABCC4/MRP4 contributes to the aggressiveness of Myc-associated epithelial ovarian cancer., Moonsun Jung, Jixuan Gao, Leanna Cheung, Angelika Bongers, Klaartje Somers, Molly Clifton, Emma E Ramsay, Amanda J Russell, Emanuele Valli, Andrew J Gifford, Joshy George, Catherine J Kennedy, Matthew J Wakefield, Monique Topp, Gwo-Yaw Ho, Clare L Scott, David D Bowtell, Anna deFazio, Murray D Norris, Michelle Haber, and Michelle J Henderson
Aberrant type 1 immunity drives susceptibility to mucosal fungal infections., Timothy J Break, Vasileios Oikonomou, Nicolas Dutzan, Jigar V Desai, Marc Swidergall, Tilo Freiwald, Daniel Chauss, Oliver J Harrison, Julie Alejo, Drake W Williams, Stefania Pittaluga, Chyi-Chia R Lee, Nicolas Bouladoux, Muthulekha Swamydas, Kevin W Hoffman, Teresa Greenwell-Wild, Vincent M Bruno, Lindsey B Rosen, Wint Lwin, Andy Renteria, Sergio M Pontejo, John P Shannon, Ian A Myles, Peter Olbrich, Elise M N Ferré, Monica Schmitt, Daniel Martin, Daniel L Barber, Norma V Solis, Luigi D Notarangelo, David V. Serreze, Mitsuru Matsumoto, Heather D Hickman, Philip M Murphy, Mark S Anderson, Jean K Lim, Steven M Holland, Scott G Filler, Behdad Afzali, Yasmine Belkaid, Niki M Moutsopoulos, and Michail S Lionakis
A case for revisiting Nodal signaling in human pluripotent stem cells., Kevin Hayes, Yun-Kyo Kim, and Martin F Pera
Accelerating functional gene discovery in osteoarthritis., Natalie C Butterfield, Katherine F Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S Mannan, Anne-Tounsia Adoum, Victoria D Leitch, John G Logan, Julian A Waung, Elena Ghirardello, Lorraine Southam, Scott E Youlten, J Mark Wilkinson, Elizabeth A McAninch, Valerie E Vancollie, Fiona Kussy, Jacqueline K White, Christopher J Lelliott, David J Adams, Richard Jacques, Antonio C Bianco, Alan Boyde, Eleftheria Zeggini, Peter I Croucher, Graham R Williams, and J H Duncan Bassett
A Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma., Sidra Adil, Rehan Zafar Paracha, Salma Tariq, Maryum Nisar, Sadaf Ijaz, Amnah Siddiqa, Zamir Hussain, and Afreenish Amir
A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions., Miguel Rodríguez de Los Santos, Marion Rivalan, Friederike S David, Alexander Stumpf, Julika Pitsch, Despina Tsortouktzidis, Laura Moreno Velasquez, Anne Voigt, Karl Schilling, Daniele Mattei, Melissa Long, Guido Vogt, Alexej Knaus, Björn Fischer-Zirnsak, Lars Wittler, Bernd Timmermann, Peter N Robinson, Denise Horn, Stefan Mundlos, Uwe Kornak, Albert J Becker, Dietmar Schmitz, York Winter, and Peter M Krawitz
Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2., Feria A Ladha, Ketan Thakar, Anthony M Pettinato, Nicholas Legere, Shahnaz Ghahremani, Rachel Cohn, Robert Romano, Emily Meredith, Yu-Sheng Chen, and J Travis Hinson
Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy., Hsin-Chieh Wu, Domitille Rérolle, Caroline Berthier, Rita Hleihel, Takashi Sakamoto, Samuel Quentin, Shirine Benhenda, Claudia Morganti, Chengchen Wu, Lidio Conte, Sylvie Rimsky, Marie Sebert, Emmanuelle Clappier, Sylvie Souquere, Stéphanie Gachet, Jean Soulier, Sylvère Durand, Jennifer J. Trowbridge, Paule Bénit, Pierre Rustin, Hiba El Hajj, Emmanuel Raffoux, Lionel Ades, Raphael Itzykson, Hervé Dombret, Pierre Fenaux, Olivier Espeli, Guido Kroemer, Lorenzo Brunetti, Tak W Mak, Valérie Lallemand-Breitenbach, Ali Bazarbachi, Brunangelo Falini, Keisuke Ito, Maria Paola Martelli, and Hugues de Thé
Action detection using a neural network elucidates the genetics of mouse grooming behavior., Brian Q Geuther, Asaf Peer, Hao He, Gautam Sabnis, Vivek M. Philip, and Vivek Kumar
A functional variant on 20q13.33 related to glioma risk alters enhancer activity and modulates expression of multiple genes., Mourad Wagdy Ali, C Pawan K Patro, Jacqueline Jufen Zhu, Christopher H Dampier, Sarah J Plummer, Cem Kuscu, Mazhar Adli, Ching C Lau, Rose K Lai, and Graham Casey
Age and Genetic Background Modify Hybrid Male Sterility in House Mice., Samuel J Widmayer, Mary Ann Handel, and David L Aylor
Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus., Kathryn M Kingsmore, Prathyusha Bachali, Michelle D Catalina, Andrea R Daamen, Sarah E Heuer, Robert D Robl, Amrie C Grammer, and Peter E Lipsky
A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin., Phaneendra Chennampally, Ambreen Sayed-Zahid, Prabakaran Soundararajan, Jocelyn Sharp, Gregory A. Cox, Scott D Collins, and Rosemary L Smith
A missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis., Yeming Yang, Xiao Li, Jieping Wang, Junkai Tan, Bernie Fitzmaurice, Patsy M. Nishina, Kuanxiang Sun, Wanli Tian, Wenjing Liu, Xuyang Liu, Bo Chang, and Xianjun Zhu
A modular master regulator landscape controls cancer transcriptional identity., Evan O Paull, Alvaro Aytes, Sunny J Jones, Prem S Subramaniam, Federico M Giorgi, Eugene F Douglass, Somnath Tagore, Brennan Chu, Alessandro Vasciaveo, Siyuan Zheng, Roel G W Verhaak, Cory Abate-Shen, Mariano J Alvarez, and Andrea Califano
AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data., Asa Thibodeau, Alper Eroglu, Christopher S McGinnis, Nathan Lawlor, Djamel Nehar-Belaid, Romy Kursawe, Radu Marches, Daniel N Conrad, George A Kuchel, Zev J Gartner, Jacques Banchereau, Michael L. Stitzel, A Ercument Cicek, and Duygu Ucar
An Algorithm to Quantitatively Predict Feature-Based Equivalence Between Mouse Inbred Strain Genomes, Rex Asabor
An Asp to Strike Out Cancer? Therapeutic Possibilities Arising from Aspartate's Emerging Roles in Cell Proliferation and Survival., Iiro Taneli Helenius, Hanumantha Rao Madala, and Jing-Ruey Joanna Yeh
A new graph-based clustering method with application to single-cell RNA-seq data from human pancreatic islets., Hao Wu, Disheng Mao, Yuping Zhang, Zhiyi Chi, Michael L. Stitzel, and Zhengqing Ouyang
A New Twist: The Combination of Sulbactam/Avibactam Enhances Sulbactam Activity against Carbapenem-Resistant, Fernando Pasteran, Jose Cedano, Michelle Baez, Ezequiel Albornoz, Melina Rapoport, Jose Osteria, Sabrina Montaña, Casin Le, Grace Ra, Robert A Bonomo, Marcelo E Tolmasky, Mark D Adams, Alejandra Corso, and Maria Soledad Ramirez
An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity., Michael Closser, Yuchun Guo, Ping Wang, Tulsi Patel, Sumin Jang, Jennifer Hammelman, Joriene C De Nooij, Rachel Kopunova, Esteban O Mazzoni, Yijun Ruan, David K Gifford, and Hynek Wichterle
An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis., Christian C D Harman, Will Bailis, Jun Zhao, Louisa Hill, Rihao Qu, Ruaidhrí P Jackson, Justin A Shyer, Holly R Steach, Yuval Kluger, Loyal A Goff, John L Rinn, Adam Williams, Jorge Henao-Mejia, and Richard A Flavell
A nomenclature for echinoderm genes., Thomas R Beatman, Katherine M Buckley, Gregory A. Cary, Veronica F Hinman, and Charles A Ettensohn
An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation., Andrew M Lerner, Austin J Hepperla, Gregory R Keele, Hashem A Meriesh, Hayretin Yumerefendi, David Restrepo, Seth Zimmerman, James E Bear, Brian Kuhlman, Ian J Davis, and Brian D Strahl
A novel treatment strategy for lapatinib resistance in a subset of HER2-amplified gastric cancer., Gang Ning, Qihui Zhu, Wonyoung Kang, Hamin Lee, Leigh Maher, Yun-Suhk Suh, Michael Michaud, Mayerlin Silva, Jee Young Kwon, Chengsheng Zhang, and Charles Lee
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma., Joseph R Podojil, Alexander P Glaser, Dylan Baker, Elise T Courtois, Damiano Fantini, Yanni Yu, Valerie Eaton, Santhosh Sivajothi, Mingyi Chiang, Arighno Das, Kimberly A McLaughlin, Paul Robson, Stephen D Miller, and Joshua J Meeks
A Platform for Experimental Precision Medicine: The Extended BXD Mouse Family., David G Ashbrook, Danny Arends, Pjotr Prins, Megan K Mulligan, Suheeta Roy, Evan G Williams, Cathleen Lutz, Alicia Valenzuela, Casey J Bohl, Jesse F Ingels, Melinda S McCarty, Arthur G Centeno, Reinmar Hager, Johan Auwerx, Lu Lu, and Robert W Williams
A Practical Guide to Metabolomics Software Development., Hui-Yin Chang, Sean M Colby, Xiuxia Du, Javier D Gomez, Maximilian J Helf, Katerina Kechris, Christine R Kirkpatrick, Shuzhao Li, Gary J Patti, Ryan S Renslow, Shankar Subramaniam, Mukesh Verma, Jianguo Xia, and Jamey D Young
A protocol for rapid and parallel isolation of myocytes and non-myocytes from multiple mouse hearts., Gabriella E Farrugia, Michael A McLellan, Kate L Weeks, Aya Matsumoto, Charles D Cohen, Crisdion Krstevski, Taylah L Gaynor, Adam C Parslow, Julie R McMullen, and Alexander R Pinto
A resource of targeted mutant mouse lines for 5,061 genes., Marie-Christine Birling, Atsushi Yoshiki, David J Adams, Shinya Ayabe, Arthur L Beaudet, Joanna Bottomley, Allan Bradley, Steve D M Brown, Antje Bürger, Wendy Bushell, Francesco Chiani, Hsian-Jean Genie Chin, Skevoulla Christou, Gemma F Codner, Francesco J DeMayo, Mary E Dickinson, Brendan Doe, Leah Rae Donahue, Martin D Fray, Alessia Gambadoro, Xiang Gao, Marina Gertsenstein, Alba Gomez-Segura, Leslie Goodwin, Jason D Heaney, Yann Hérault, Martin Hrabe de Angelis, Si-Tse Jiang, Monica J Justice, Petr Kasparek, Ruairidh E King, Ralf Kühn, Ho Lee, Young Jae Lee, Zhiwei Liu, K C Kent Lloyd, Isabel Lorenzo, Ann-Marie Mallon, Colin McKerlie, Terrence F Meehan, Violeta Munoz Fuentes, Stuart Newman, Lauryl M J Nutter, Goo Taeg Oh, Guillaume Pavlovic, Ramiro Ramirez-Solis, Barry Rosen, Edward J Ryder, Luis A Santos, Joel Schick, John R Seavitt, Radislav Sedlacek, Claudia Seisenberger, Je Kyung Seong, William C Skarnes, Tania Sorg, Karen P Steel, Masaru Tamura, Glauco P Tocchini-Valentini, Chi-Kuang Leo Wang, Hannah Wardle-Jones, Marie Wattenhofer-Donzé, Sara Wells, Michael V. Wiles, Brandon J Willis, Joshua A Wood, Wolfgang Wurst, Ying Xu, International Mouse Phenotyping Consortium IMPC, Lydia Teboul, and Stephen A. Murray
A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs., Basile Tarchini
Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (, Josyf C Mychaleckyj, Erkka Valo, Takaharu Ichimura, Tarunveer S Ahluwalia, Christian Dina, Rachel G Miller, Ivan G Shabalin, Beata Gyorgy, JingJing Cao, Suna Onengut-Gumuscu, Eiichiro Satake, Adam M Smiles, Jani K Haukka, David-Alexandre Tregouet, Tina Costacou, Kristina O'Neil, Andrew D Paterson, Carol Forsblom, Hillary A Keenan, Marcus G Pezzolesi, Marlon Pragnell, Andrzej Galecki, Stephen S Rich, Niina Sandholm, Ronald Klein, Barbara E Klein, Katalin Susztak, Trevor J Orchard, Ron Korstanje, George L King, Samy Hadjadj, Peter Rossing, Joseph V Bonventre, Per-Henrik Groop, James H Warram, and Andrzej S Krolewski
A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage., Xueqing Zou, Gene Ching Chiek Koh, Arjun Scott Nanda, Andrea Degasperi, Katie Urgo, Theodoros I Roumeliotis, Chukwuma A Agu, Cherif Badja, Sophie Momen, Jamie Young, Tauanne Dias Amarante, Lucy Side, Glen Brice, Vanesa Perez-Alonso, Daniel Rueda, Celine Gomez, Wendy Bushell, Rebecca Harris, Jyoti S Choudhary, Josef Jiricny, William C Skarnes, and Serena Nik-Zainal
A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin., Abigail E Starcher, Kristen Peissig, James B Stanton, Gary A Churchill, Dunpeng Cai, Joshua T Maxwell, Arthur Grider, Kim Love, Shi-You Chen, Amanda E Coleman, Emma Strauss, and Robert Pazdro
A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures., Arushi Varshney, Yasuhiro Kyono, Venkateswaran Ramamoorthi Elangovan, Collin Wang, Michael R Erdos, Narisu Narisu, Ricardo D'Oliveira Albanus, Peter Orchard, Michael L. Stitzel, Francis S Collins, Jacob O Kitzman, and Stephen C J Parker
A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram., Sherise D Ferguson, Tiffany R Hodges, Nazanin K Majd, Kristin Alfaro-Munoz, Wajd N Al-Holou, Dima Suki, John F de Groot, Gregory N Fuller, Lee Xue, Miao Li, Carmen Jacobs, Ganesh Rao, Rivka R Colen, Joanne Xiu, Roel G W Verhaak, David Spetzler, Mustafa Khasraw, Raymond Sawaya, James P Long, and Amy B Heimberger
Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice., Se-Hoon Lee, Sung-Yup Cho, Youngmin Yoon, Changho Park, Jinyoung Sohn, Jin-Ju Jeong, Bu-Nam Jeon, Mongjoo Jang, Choa An, Suro Lee, Yun Yeon Kim, Gihyeon Kim, Sujeong Kim, Yunjae Kim, Gwang Bin Lee, Eun Ju Lee, Sang Gyun Kim, Hong Sook Kim, Yeongmin Kim, Hyun Kim, Hyun-Suk Yang, Sarang Kim, Seonggon Kim, Hayung Chung, Myeong Hee Moon, Myung Hee Nam, Jee Young Kwon, Sungho Won, Joon-Suk Park, George M. Weinstock, Charles Lee, Kyoung Wan Yoon, and Hansoo Park
Bioinformatics Core Survey Highlights the Challenges Facing Data Analysis Facilities., Julie A Dragon, Chris Gates, Shannan Ho Sui, John N Hutchinson, Radha Krishna Murthy Karuturi, Alper Kucukural, Shawn Polson, Alberto Riva, Matthew Lee Settles, Jyothi Thimmapuram, and Stuart S Levine
Biomedical and societal impacts of in vitro embryo models of mammalian development., Naomi Moris, Cantas Alev, Martin Pera, and Alfonso Martinez Arias
Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation, Masaru Miyano, Rosalyn W Sayaman, Sundus F Shalabi, Parijat Senapati, Jennifer C Lopez, Brittany Lynn Angarola, Stefan Hinz, Arrianna Zirbes, Olga Anczuków, Lisa D Yee, Mina S Sedrak, Martha R Stampfer, Victoria L Seewaldt, and Mark A LaBarge
CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear., Cong Tian, Kenneth R. Johnson, Jaclynn M Lett, Robert Voss, Alec N Salt, Jared J Hartsock, Peter S Steyger, and Kevin K Ohlemiller
Capsule carbohydrate structure determines virulence in Acinetobacter baumannii., Yuli Talyansky, Travis B Nielsen, Jun Yan, Ulrike Carlino-Macdonald, Gisela Di Venanzio, Somnath Chakravorty, Amber Ulhaq, Mario F Feldman, Thomas A Russo, Evgeny Vinogradov, Brian Luna, Meredith S Wright, Mark D Adams, and Brad Spellberg
Cell Cycle Profile of Spermatogonial Stem Cells, Diego Trujillo
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1., Yalan Zhang, Luis Varela, Klara Szigeti-Buck, Adam Williams, Milan Stoiljkovic, Matija Šestan-Peša, Jorge Henao-Mejia, Pasquale D'Acunzo, Efrat Levy, Richard A Flavell, Tamas L Horvath, and Leonard K Kaczmarek
Challenges to making an egg., Richard M Schultz and John J. Eppig
Characterisation of ST25 NDM-1-producing Acinetobacter spp. strains leading the increase in NDM-1 emergence in Argentina., Deja Rodgers, Fernando Pasteran, Manuel Calderon, Sara Jaber, German M Traglia, Ezequiel Albornoz, Alejandra Corso, Alejandro J Vila, Robert A Bonomo, Mark D Adams, and María Soledad Ramírez
Characterizing Long COVID: Deep Phenotype of a Complex Condition., Rachel R Deer, Madeline A Rock, Nicole Vasilevsky, Leigh Carmody, Halie Rando, Alfred J Anzalone, Marc D Basson, Tellen D Bennett, Timothy Bergquist, Eilis A Boudreau, Carolyn T Bramante, James Brian Byrd, Tiffany J Callahan, Lauren E Chan, Haitao Chu, Christopher G Chute, Ben D Coleman, Hannah E Davis, Joel Gagnier, Casey S Greene, William B Hillegass, Ramakanth Kavuluru, Wesley D Kimble, Farrukh M Koraishy, Sebastian Köhler, Chen Liang, Feifan Liu, Hongfang Liu, Vithal Madhira, Charisse R Madlock-Brown, Nicolas Matentzoglu, Diego R Mazzotti, Julie A McMurry, Douglas S McNair, Richard A Moffitt, Teshamae S Monteith, Ann M Parker, Mallory A Perry, Emily Pfaff, Justin T Reese, Joel Saltz, Robert A Schuff, Anthony E Solomonides, Julian Solway, Heidi Spratt, Gary S Stein, Anupam A Sule, Umit Topaloglu, George D Vavougios, Liwei Wang, Melissa A Haendel, and Peter N Robinson
Characterizing Motor Phenotypes of the Spontaneous Mutant NM5084, Jacqueline Garcia
Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet., Diana E Gutierrez Lopez, Laura M Lashinger, George M. Weinstock, and Molly S Bray
Cisplatin increases immune activity of monocytes and cytotoxic T-cells in a murine model of epithelial ovarian cancer., Daniel Hopkins, Hector Sanchez, Brent Berwin, and Ivy Wilkinson-Ryan
Classification of Molecular Subtypes of High-Grade Serous Ovarian Cancer by MALDI-Imaging., Wanja Kassuhn, Oliver Klein, Silvia Darb-Esfahani, Hedwig Lammert, Sylwia Handzik, Eliane T Taube, Wolfgang D Schmitt, Carlotta Keunecke, David Horst, Felix Dreher, Joshy George, David D Bowtell, Oliver Dorigo, Michael Hummel, Jalid Sehouli, Nils Blüthgen, Hagen Kulbe, and Elena I Braicu
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies., Joseph A McQuail, Amy R Dunn, Yaakov Stern, Carol A Barnes, Gerd Kempermann, Peter R Rapp, Catherine C Kaczorowski, and Thomas C Foster
Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia, M Hashimoto, Y Saito, R Nakagawa, I Ogahara, S Takagi, S Takata, H Amitani, M Endo, H Yuki, J A. Ramilowski, Leonard D. Shultz, and Et Al
Community oncologists' perceptions and utilization of large-panel genomic tumor testing., Eric C Anderson, Alexandra C Hinton, Christine W Lary, Anny T H R Fenton, Andrey Antov, Emily A Edelman, Petra Helbig, Kate Reed, Susan Miesfeldt, Christian A Thomas, Michael J Hall, J Scott Roberts, Jens Rueter, Paul K J Han, and MCGI Working Group
Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment., Hua Sun, Song Cao, R Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C Wendl, Sherri R Davies, Matthew H Bailey, Tina M Primeau, Jeremy Hoog, Jacqueline L Mudd, Dennis A Dean, Rajesh Patidar, Li Chen, Matthew A Wyczalkowski, Reyka G Jayasinghe, Fernanda Martins Rodrigues, Nadezhda V Terekhanova, Yize Li, Kian-Huat Lim, Andrea Wang-Gillam, Brian A Van Tine, Cynthia X Ma, Rebecca Aft, Katherine C Fuh, Julie K Schwarz, Jose P Zevallos, Sidharth V Puram, John F Dipersio, NCI PDXNet Consortium, Brandi Davis-Dusenbery, Matthew J Ellis, Michael T Lewis, Michael A Davies, Meenhard Herlyn, Bingliang Fang, Jack A Roth, Alana L Welm, Bryan E Welm, Funda Meric-Bernstam, Feng Chen, Ryan C Fields, Shunqiang Li, Ramaswamy Govindan, James H Doroshow, Jeffrey A Moscow, Yvonne A Evrard, Jeffrey Chuang, Benjamin J Raphael, Li Ding, Carol J Bult, and Peter N Robinson
Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study., Adrian L Oblak, Peter B Lin, Kevin P Kotredes, Ravi S Pandey, Dylan Garceau, Harriet M. Jackson, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary A Cope, Gabriela J Little, Sean-Paul G Williams, Carl Ash, Adam Bleckert, Tim Ragan, Benjamin A Logsdon, Lara M Mangravite, Stacey J Sukoff Rizzo, Paul R Territo, Gregory W. Carter, Gareth R Howell, Michael Sasner, and Bruce T Lamb
Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors, Tamara J Phillips, Tyler A. Roy, Sara J Aldrich, Harue Baba, Jason Erk, John R K Mootz, Cheryl Reed, and Elissa J Chesler
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts., Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Rajesh Patidar, Li Chen, Sandra Scherer, Matthew H Bailey, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Yuanxin Xi, Jing Wang, Jayamanna Wickramasinghe, Andrew V Kossenkov, Vito W Rebecca, Hua Sun, R Jay Mashl, Sherri R Davies, Ryan Jeon, Christian Frech, Jelena Randjelovic, Jacqueline Rosains, Francesco Galimi, Andrea Bertotti, Adam Lafferty, Alice C O'Farrell, Elodie Modave, Diether Lambrechts, Petra Ter Brugge, Violeta Serra, Elisabetta Marangoni, Rania El Botty, Hyunsoo Kim, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A Dean, Brandi Davis-Dusenbery, Yvonne A Evrard, James H Doroshow, Alana L Welm, Bryan E Welm, Michael T Lewis, Bingliang Fang, Jack A Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael A Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Claudio Isella, Jeffrey A Moscow, Livio Trusolino, Annette T Byrne, Jos Jonkers, Carol J Bult, Enzo Medico, Jeffrey Chuang, PDXNET Consortium, and EurOPDX Consortium
Conservation of Human GWAS Variants in the Mouse Genome, Connor Kean
Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing., Anna Thrun, Aitor Garzia, Yu Kigoshi-Tansho, Pratik R Patil, Charles S Umbaugh, Teresa Dallinger, Jia Liu, Sylvia Kreger, Annarita Patrizi, Gregory A. Cox, Thomas Tuschl, and Claudio A P Joazeiro
Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers., Paola Bargagna-Mohan, Gwendolyn Schultz, Bruce Rheaume, Ephraim F Trakhtenberg, Paul Robson, Sonali Pal-Ghosh, Mary Ann Stepp, Katherine S Given, Wendy B Macklin, and Royce Mohan
CRISPR screens identify a novel combination treatment targeting BCL-X L and WNT signaling for KRAS/BRAF-mutated colorectal cancers, Hae Rim Jung, Yumi Oh, Deukchae Na, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Jiwon Kim, Sang Eun Lee, Eui Man Jeong, Joon Yong An, Chang Ohk Sung, Won-Suk Lee, Charles Lee, and Sung-Yup Cho
Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart., Elvira Forte, Bryant Perkins, Amalia Sintou, Harkaran S Kalkat, Angelos Papanikolaou, Catherine Jenkins, Mashael Alsubaie, Rasheda A Chowdhury, Theodore M Duffy, Daniel A Skelly, Jane Branca, Mohamed Bellahcene, Michael D Schneider, Sian E Harding, Milena B Furtado, Fu Siong Ng, Muneer G. Hasham, Nadia Rosenthal, and Susanne Sattler
Cultivation of common bacterial species and strains from human skin, oral, and gut microbiota., Elizabeth Fleming, Victor Pabst, Zoe Scholar, Ruoyun Xiong, Anita Y Voigt, Wei Zhou, Amelia Hoyt, Rachel Hardy, Anna Peterson, Ryan Beach, Yvette Ondouah-Nzutchi, Jinhong Dong, Lucinda Bateman, Suzanne D Vernon, and Julia Oh
CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice., Deniz Koyuncu, Muhammad Khalid Khan Niazi, Thomas Tavolara, Claudia Abeijon, Melanie L Ginese, Yanghui Liao, Carolyn Mark, Aubrey Specht, Adam C Gower, Blanca I Restrepo, Daniel M Gatti, Igor Kramnik, Metin Gurcan, Bülent Yener, and Gillian Beamer
Deciphering Quantitative Phenotypes in Complex Diseases using Gene Co-Expression Modules, Nikhil Milind
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging., Kira Young, Elizabeth Eudy, Rebecca Bell, Matthew A Loberg, Timothy M Stearns, Devyani Sharma, Lars Velten, Simon Haas, Marie-Dominique Filippi, and Jennifer J. Trowbridge
Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model., Nicole K Polinski, Terina N Martinez, Alexander Gorodinsky, Ralph Gareus, Michael Sasner, Mark Herberth, Robert Switzer, Syed O Ahmad, Mali Cosden, Monika Kandebo, Robert E Drolet, Peter D Buckett, Weisong Shan, Yi Chen, Lee J Pellegrino, Gregory D Ellsworth, Leo B Dungan, Warren D Hirst, Sean W Clark, and Kuldip D Dave
Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology., Markus Terrey, Scott I Adamson, Jeffrey H Chuang, and Susan L Ackerman
Definition of erythroid cell-positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection., Darawan Rinchai, Matthew C Altman, Oceane Konza, Signe Hässler, Federica Martina, Mohammed Toufiq, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Karolina Palucka, Asuncion Mejias, Octavio Ramilo, Davide Bedognetti, Encarnita Mariotti-Ferrandiz, David Klatzmann, and Damien Chaussabel
Determining the Molecular Mechanisms of Type 1 Diabetes Resistance in Nfkbid Transgenic Non-Obese Diabetic Mice, Anna Quinlan
Developing and validating model systems for immuno-oncology., Claire E McCarthy, Nastaran Zahir, Mariam Eljanne, Elad Sharon, Emile E Voest, and Karolina Palucka
Developing a Pipeline for Integrating Large Datasets to select candidate Late Onset Alzhei1ner's Disease (LOAD) genes, Sarah Shapley
Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data., Matthew C Altman, Darawan Rinchai, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Mohamed Alfaki, Scott R Presnell, Prasong Khaenam, Aaron Ayllón-Benítez, Fleur Mougin, Patricia Thébault, Laurent Chiche, Noemie Jourde-Chiche, J Theodore Phillips, Goran Klintmalm, Anne O'Garra, Matthew Berry, Chloe Bloom, Robert J Wilkinson, Christine M Graham, Marc Lipman, Ganjana Lertmemongkolchai, Davide Bedognetti, Rodolphe Thiebaut, Farrah Kheradmand, Asuncion Mejias, Octavio Ramilo, Karolina Palucka, Virginia Pascual, Jacques Banchereau, and Damien Chaussabel
Development of a Novel Orthotopic Gastric Cancer Mouse Model., Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, and Charles Lee
Development of Parasympathetic Innervation in Aqueous Humor Drainage Structures, Madhumithaq Gautham
Diagnostics and correction of batch effects in large-scale proteomic studies: a tutorial., Jelena Čuklina, Chloe H Lee, Evan G Williams, Tatjana Sajic, Ben C Collins, María Rodríguez Martínez, Varun S Sharma, Fabian Wendt, Sandra Goetze, Gregory R Keele, Bernd Wollscheid, Ruedi Aebersold, and Patrick G A Pedrioli
Dietary Vitamin A Impacts Refractory Telogen., Liye Suo, Christine VanBuren, Eylul Damla Hovland, Natalia Y Kedishvili, John P Sundberg, and Helen B Everts
Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant., Ray F. Robledo, Steven L. Ciciotte, Joel H Graber, Yue Zhao, Amy J Lambert, Babette Gwynn, Nathaniel J Maki, Elena C Brindley, Emily Hartman, Lionel Blanc, and Luanne L. Peters
Differential effects of two catalytic mutations on full-length PRDM9 and its isolated PR/SET domain reveal a case of pseudomodularity., Natalie Powers, Timothy Billings, Kenneth Paigen, and Petko M. Petkov
Differential RNA methylation using multivariate statistical methods., Deepak Nag Ayyala, Jianan Lin, and Zhengqing Ouyang
Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR-FlowFISH., Steven K Reilly, Sager J Gosai, Alan Gutierrez, Ava Mackay-Smith, Jacob C Ulirsch, Masahiro Kanai, Kousuke Mouri, Daniel Berenzy, Susan Kales, Gina M Butler, Adrianne Gladden-Young, Redwan M Bhuiyan, Michael L. Stitzel, Hilary K Finucane, Pardis C Sabeti, and Ryan Tewhey
Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution., Qiancheng You, Anthony Cheng, Xi Gu, Bryan T Harada, Miao Yu, Tong Wu, Bing Ren, Zhengqing Ouyang, and Chuan He
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network., Mathys Grapotte, Manu Saraswat, Chloé Bessière, Christophe Menichelli, Jordan A Ramilowski, Jessica Severin, Yoshihide Hayashizaki, Masayoshi Itoh, Michihira Tagami, Mitsuyoshi Murata, Miki Kojima-Ishiyama, Shohei Noma, Shuhei Noguchi, Takeya Kasukawa, Akira Hasegawa, Harukazu Suzuki, Hiromi Nishiyori-Sueki, Martin C Frith, FANTOM Consortium, Clément Chatelain, Piero Carninci, Michiel J L de Hoon, Wyeth W Wasserman, Laurent Bréhélin, Charles-Henri Lecellier, Judith A. Blake, and Carol J Bult
Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin., Jeffrey M. Harder, Chelsea Guymer, John P M Wood, Evangelia Daskalaki, Glyn Chidlow, Chi Zhang, Revathi Balasubramanian, Brynn H Cardozo, Nicole E Foxworth, Kelly E Deering, Tionna B Ouellette, Christa Montgomery, Craig E Wheelock, Robert J Casson, Pete A Williams, and Simon W M John
Diverse dystonin gene mutations cause distinct patterns of, Nozomu Yoshioka, Yudai Kabata, Momona Kuriyama, Norihisa Bizen, Li Zhou, Dang M Tran, Masato Yano, Atsushi Yoshiki, Tatsuo Ushiki, Thomas J. Sproule, Riichiro Abe, and Hirohide Takebayashi
DNA methylation-calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation., Yang Liu, Wojciech Rosikiewicz, Ziwei Pan, Nathaniel L. Jillette, Ping Wang, Aziz Taghbalout, Jonathan Foox, Christopher Mason, Martin Carroll, Albert Cheng, and Sheng Li
Do gene expression findings from mouse models of cocaine use recapitulate human cocaine use disorder in reward circuitry?, Spencer B Huggett, Jason A. Bubier, Elissa J Chesler, and Rohan H C Palmer
Draft Genome Sequences of 27 Northern Maine Clinical Isolates., Larry Feinstein, Kendra Batchelder, Lydia Tilley, and Grace Stafford
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status., Peishan Li, Mingyang Lu, Jiayuan Shi, Li Hua, Zheng Gong, Qing Li, Leonard D. Shultz, and Guangwen Ren
E2F6 initiates stable epigenetic silencing of germline genes during embryonic development., Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anaïs F Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N Robinson, Christian Hagemeier, and Michael Weber
Effects of kinship correction on inflation of genetic interaction statistics in commonly used mouse populations., Anna L. Tyler, Baha El Kassaby, Georgi Kolishovski, Jake Emerson, Ann E Wells, J Matthew Mahoney, and Gregory W. Carter
Embryonic and Neonatal Mouse Cochleae Are Susceptible to Zika Virus Infection., Vidhya Munnamalai, Nabilah H Sammudin, Caryl A Young, Ankita Thawani, Richard J Kuhn, and Donna M Fekete
Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed, G L Drusano, Robert A Bonomo, Steven M Marshall, Laura J Rojas, Mark D Adams, Maria F Mojica, Barry N Kreiswirth, Liang Chen, Nino Mtchedlidze, Meredith Bacci, Michael Vicchiarelli, Jürgen B Bulitta, and Arnold Louie
Employees' Views and Ethical, Legal, and Social Implications Assessment of Voluntary Workplace Genomic Testing, Kunal Sanghavi, W Gregory Feero, Debra JH Mathews, Anya ER Prince, Lori Lyn Price, Edison Liu, Kyle Brothers, J Scott Roberts, and Charles Lee
Empowering Medicine, the 2018 Annual Report of The Jackson Laboratory, The Jackson Laboratory
EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia., Katie S Kindt, Anil Akturk, Amandine Jarysta, Matthew Day, Alisha Beirl, Michaela Flonard, and Basile Tarchini
Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis., Diana Monsivais, Takashi Nagashima, Renata Prunskaite-Hyyryläinen, Kaori Nozawa, Keisuke Shimada, Suni Tang, Clark Hamor, Julio E Agno, Fengju Chen, Ramya P Masand, Steven L Young, Chad J Creighton, Francesco J DeMayo, Masahito Ikawa, Se-Jin Lee, and Martin M Matzuk
Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo., Laura M Vecchio, Patricia Sullivan, Amy R Dunn, Marie Kristel Bermejo, Rong Fu, Shababa T Masoud, Emil Gregersen, Nikhil M Urs, Reza Nazari, Poul Henning Jensen, Amy Ramsey, David S Goldstein, Gary W Miller, and Ali Salahpour
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma., Mayinuer Maitituoheti, Emily Z Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K Singh, Ayush T Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B Amin, Sneha Sharma, Maura Williams, Neha S Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B Axelrad, Nazanin E Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q Chang, Davis R Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, and Kunal Rai
Enhancing Lymph Node Structure in Humanized Mice, Ana Castaner
Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models., Satoshi Muraoka, Mark P Jedrychowski, Naotoshi Iwahara, Mohammad Abdullah, Kristen D. Onos, Kelly J Keezer, Jianqiao Hu, Seiko Ikezu, Gareth R Howell, Steven P Gygi, and Tsuneya Ikezu
epihet for intra-tumoral epigenetic heterogeneity analysis and visualization., Xiaowen Chen, Haitham Ashoor, Ryan Musich, Jiahui Wang, Mingsheng Zhang, Chao Zhang, Mingyang Lu, and Sheng Li
Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE., Simone Caielli, Jacob Cardenas, Adriana Almeida de Jesus, Jeanine Baisch, Lynnette Walters, Jean Philippe Blanck, Preetha Balasubramanian, Cristy Stagnar, Marina Ohouo, Seunghee Hong, Lorien Nassi, Katie Stewart, Julie Fuller, Jinghua Gu, Jacques Banchereau, Tracey Wright, Raphaela Goldbach-Mansky, and Virginia Pascual
Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin., Helen B Everts, Kathleen A Silva, Adriana N Schmidt, Susan Opalenik, F Jason Duncan, Lloyd E King, John P Sundberg, and David E Ong
Exogenous expression of Scgblcl in understanding its role in cardiac function, Kevin Guerrero
Expectations and blind spots for structural variation detection from long-read assemblies and short-read genome sequencing technologies., Xuefang Zhao, Ryan L Collins, Wan-Ping Lee, Alexandra M Weber, Yukyung Jun, Qihui Zhu, Ben Weisburd, Yongqing Huang, Peter A Audano, Harold Wang, Mark Walker, Chelsea Lowther, Jack Fu, Mark B Gerstein, Scott E Devine, Tobias Marschall, Jan O Korbel, Evan E Eichler, Mark J P Chaisson, Charles Lee, Ryan E Mills, Harrison Brand, and Michael E Talkowski
Ex uno, plures-From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology., Elvira Forte, Michael A McLellan, Daniel A Skelly, and Nadia Rosenthal
Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes., David C Katz, J David Aponte, Wei Liu, Rebecca M Green, Jessica M Mayeux, K Michael Pollard, Daniel Pomp, Steven C. Munger, Stephen A Murray, Charles C Roseman, Christopher J Percival, James Cheverud, Ralph S Marcucio, and Benedikt Hallgrímsson
FANCM regulates repair pathway choice at stalled replication forks., Arvind Panday, Nicholas A Willis, Rajula Elango, Francesca Menghi, Erin E Duffey, Edison Liu, and Ralph Scully
Fasting blood glucose as a predictor of mortality: Lost in translation., Dushani L Palliyaguru, Eric J Shiroma, John K Nam, Eleonora Duregon, Camila Vieira Ligo Teixeira, Nathan L Price, Michel Bernier, Simonetta Camandola, Kelli L Vaughan, Ricki J Colman, Andrew Deighan, Ron Korstanje, Luanne L. Peters, Stephanie L Dickinson, Keisuke Ejima, Eleanor M Simonsick, Lenore J Launer, Chee W Chia, Josephine Egan, David B Allison, Gary A Churchill, Rozalyn M Anderson, Luigi Ferrucci, Julie A Mattison, and Rafael de Cabo
Fibroblasts: Origins, definitions, and functions in health and disease., Maksim V Plikus, Xiaojie Wang, Sarthak Sinha, Elvira Forte, Sean M Thompson, Erica L Herzog, Ryan R Driskell, Nadia Rosenthal, Jeff Biernaskie, and Valerie Horsley
Flow cytometric identification of T fh 13 cells in mouse and human, Jennifer S Chen, Jessica D S Grassmann, Uthaman Gowthaman, Sam J Olyha, Tregony Simoneau, M Cecilia Berin, Stephanie C Eisenbarth, and Adam Williams
Framework to Assess Optimal Sequencing Depth Involving Long Noncoding RNAs, Bajram Metjahic
Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation., Shubham Khetan, Susan Kales, Romy Kursawe, Alexandria Jillette, Jacob C Ulirsch, Steven K Reilly, Duygu Ucar, Ryan Tewhey, and Michael L. Stitzel
Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A., Se-Jin Lee, Adam Lehar, Yewei Liu, Chi Hai Ly, Quynh-Mai Pham, Michael Michaud, Renata Rydzik, Daniel W Youngstrom, Michael M Shen, Vesa Kaartinen, Emily L Germain-Lee, and Thomas A Rando
GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells., Thomas S Lisse, Manju Sharma, Neda Vishlaghi, Sri Ramulu N Pullagura, and Robert E Braun
Gender-Based Deep Learning Firefly Optimization Method for Test Data Generation., Wenning Zhang, Chongyang Jiao, Qinglei Zhou, Yang Liu, and Ting Xu
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family., Suheeta Roy, Maroun Bou Sleiman, Pooja Jha, Jesse F Ingels, Casey J Chapman, Melinda S McCarty, Jesse D Ziebarth, Michael Hook, Anna Sun, Wenyuan Zhao, Jinsong Huang, Sarah M Neuner, Lynda A Wilmott, Thomas M Shapaker, Arthur G Centeno, David G Ashbrook, Megan K Mulligan, Catherine Kaczorowski, Liza Makowski, Yan Cui, Robert W Read, Richard A Miller, Khyobeni Mozhui, Evan G Williams, Saunak Sen, Lu Lu, Johan Auwerx, and Robert W Williams
Genetic analysis of Pycr1 and Pycr2 in mice., Morgane G Stum, Abby Tadenev, Kevin L. Seburn, Kathy E Miers, Pak P Poon, Christopher R McMaster, Carolyn Robinson, Coleen C. Kane, Kathleen A Silva, Paul F Cliften, John P Sundberg, Laura G Reinholdt, Simon W M John, and Robert W. Burgess
Genetic background determines renal response to chronic lithium treatment in female mice., Theun de Groot, Rosalinda A. Doty, Lars Damen, Ruben Baumgarten, Steffi Bressers, Joline Kraak, Peter M T Deen, and Ron Korstanje
Genetic background modifies vulnerability to glaucoma-related phenotypes in, Nicholas G Tolman, Revathi Balasubramanian, Danilo G Macalinao, Alison L Kearney, Katharine H MacNicoll, Christa L Montgomery, Wilhelmine N de Vries, Ian J Jackson, Sally H Cross, Krishnakumar Kizhatil, K Saidas Nair, and Simon W M John
Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates., Anna Trofka, Bau-Lin Huang, Jianjian Zhu, William F Heinz, Valentin Magidson, Yuki Shibata, Yun-Bo Shi, Basile Tarchini, H Scott Stadler, Mirindi Kabangu, Nour W Al Haj Baddar, S Randal Voss, and Susan Mackem
Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains., Sean M Mooney-Leber, Dana Zeid, Prescilla Garcia-Trevizo, Laurel R Seemiller, Molly A. Bogue, Stephen C. Grubb, Gary Peltz, and Thomas J Gould
Genetic mapping of renal glutathione suggests a novel regulatory locus on the murine X chromosome and overlap with hepatic glutathione regulation., Rebecca L Gould, Steven W Craig, Susan McClatchy, Gary A Churchill, and Robert Pazdro
Genome-Based Targeted Sequencing as a Reproducible Microbial Community Profiling Assay., Jacquelynn Benjamino, Benjamin Leopold, Daniel S Phillips, and Mark D Adams
Genome-scale CRISPR screening identifies cell cycle and protein ubiquitination processes as druggable targets for erlotinib-resistant lung cancer., Jieun Lee, Ahyoung Choi, Sung-Yup Cho, Yukyung Jun, Deukchae Na, Ahra Lee, Giyong Jang, Jee Young Kwon, Jaesang Kim, Sanghyuk Lee, and Charles Lee
Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution., Dustin Griesemer, James R Xue, Steven K Reilly, Jacob C Ulirsch, Kalki Kukreja, Joe R Davis, Masahiro Kanai, David K Yang, John C Butts, Mehmet H Guney, Jeremy Luban, Stephen B Montgomery, Hilary K Finucane, Carl D Novina, Ryan Tewhey, and Pardis C Sabeti
Genomic profile of metastatic breast cancer patient-derived xenografts established using percutaneous biopsy., Seongyeong Kim, Dongjin Shin, Ahrum Min, Minjung Kim, Deukchae Na, Han-Byeol Lee, Han Suk Ryu, Yaewon Yang, Go-Un Woo, Kyung-Hun Lee, Dae-Won Lee, Tae-Yong Kim, Charles Lee, Seock-Ah Im, and Jong-Il Kim
GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans., K Saidas Nair, Chitrangda Srivastava, Robert V Brown, Swanand Koli, Hélène Choquet, Hong Soon Kang, Yien-Ming Kuo, Sara A Grimm, Caleb Sutherland, Alexandra Badea, G Allan Johnson, Yin Zhao, Jie Yin, Kyoko Okamoto, Graham Clark, Terete Borrás, Gulab Zode, Krishnakumar Kizhatil, Subhabrata Chakrabarti, Simon W M John, Eric Jorgenson, and Anton M Jetten
Glycine Supplementation in a Mouse Model of Charcot Marie Tooth Type 2D, Kamari Weaver
Hair follicle dystrophy in a litter of domestic cats resembling lanceolate hair mutant mice., Ana Rostaher, Sonya Bettenay, Lisa Specht, Kathleen A Silva, Lesley S Bechtold, Jiang Chen, Monir Majzoub, Ralf S Mueller, and John P Sundberg
Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis., Jennifer M SanMiguel, Kira Young, and Jennifer J. Trowbridge
Haplotype-resolved diverse human genomes and integrated analysis of structural variation., Peter Ebert, Peter A Audano, Qihui Zhu, Bernardo Rodriguez-Martin, David Porubsky, Marc Jan Bonder, Arvis Sulovari, Jana Ebler, Weichen Zhou, Rebecca Serra Mari, Feyza Yilmaz, Xuefang Zhao, PingHsun Hsieh, Joyce Lee, Sushant Kumar, Jiadong Lin, Tobias Rausch, Yu Chen, Jingwen Ren, Martin Santamarina, Wolfram Höps, Hufsah Ashraf, Nelson T Chuang, Xiaofei Yang, Katherine M Munson, Alexandra P Lewis, Susan Fairley, Luke J Tallon, Wayne E Clarke, Anna O Basile, Marta Byrska-Bishop, André Corvelo, Uday S Evani, Tsung-Yu Lu, Mark J P Chaisson, Junjie Chen, Chong Li, Harrison Brand, Aaron M Wenger, Maryam Ghareghani, William T Harvey, Benjamin Raeder, Patrick Hasenfeld, Allison A Regier, Haley J Abel, Ira M Hall, Paul Flicek, Oliver Stegle, Mark B Gerstein, Jose M C Tubio, Zepeng Mu, Yang I Li, Xinghua Shi, Alex R Hastie, Kai Ye, Zechen Chong, Ashley D Sanders, Michael C Zody, Michael E Talkowski, Ryan E Mills, Scott E Devine, Charles Lee, Jan O Korbel, Tobias Marschall, and Evan E Eichler
Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of collaborative cross mouse strains and their inbred founders., Jared R Bagley, Elissa J Chesler, Vivek M. Philip, Center for Systems Genetics of Addiction, and James D Jentsch
Heritability of fat distributions in male mice from the founder strains of the Diversity Outbred mouse population., Brendan T Keenan, Jeanette C Webster, Andrew S Wiemken, Nir Lavi-Romer, Teresa Nguyen, Karen L. Svenson, Raymond J Galante, Gary A Churchill, Stephen Pickup, Allan I Pack, and Richard J Schwab
Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel., Lauren S Bailey, Jared R Bagley, Rainy Dodd, Ashley A Olson, Mikayla Bolduc, Vivek M. Philip, Laura G Reinholdt, Stacey J Sukoff Rizzo, Lisa Tarantino, Leona H. Gagnon, Elissa J Chesler, and James David Jentsch
High-throughput measurement of fibroblast rhythms reveals genetic heritability of circadian phenotypes in diversity outbred mice and their founder strains., Sam-Moon Kim, Chelsea A Vadnie, Vivek M. Philip, Leona H. Gagnon, Kodavali V Chowdari, Elissa J Chesler, Colleen A McClung, and Ryan W Logan
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine., Yasaman Barekatain, Jeffrey J Ackroyd, Victoria C Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H Poral, Theresa Tran, Dimitra K Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S Ballato, Eliot I Behr, Ana C deCarvalho, Roel G W Verhaak, John de Groot, Jason T Huse, John M Asara, Raghu Kalluri, and Florian L Muller
Host genetic control of gut microbiome composition., Jason A. Bubier, Elissa J Chesler, and George M. Weinstock
Hotspots of Human Mutation., Alex V Nesta, Denisse Tafur, and Christine R Beck
HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions., Elspeth A Bruford, Cristina R Antonescu, Andrew J Carroll, Arul Chinnaiyan, Ian A Cree, Nicholas C P Cross, Raymond Dalgleish, Robert Peter Gale, Christine J Harrison, Rosalind J Hastings, Jean-Loup Huret, Bertil Johansson, Michelle Le Beau, Cristina Mecucci, Fredrik Mertens, Roel G W Verhaak, and Felix Mitelman
Human KIT+ myeloid cells facilitate visceral metastasis by melanoma., Chun I. Yu, Jan Martinek, Te-Chia Wu, Kyung In Kim, Joshy George, Elaheh Ahmadzadeh, Richard S. Maser, Florentina Marches, Patrick Metang, Pierre Authie, Vanessa K P Oliveira, Victor G Wang, Jeffrey Chuang, Paul Robson, Jacques Banchereau, and Karolina Palucka
Human macrophage polarization in the response to, Alberto Marin, Kristopher Van Huss, John Corbett, Sangjin Kim, Jonathon Mohl, Bo-Young Hong, and Jorge Cervantes
Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant., Zhefu Que, Maria I Olivero-Acosta, Jingliang Zhang, Muriel Eaton, Anke M Tukker, Xiaoling Chen, Jiaxiang Wu, Junkai Xie, Tiange Xiao, Kyle Wettschurack, Layan Yunis, J Marshall Shafer, James A Schaber, Jean-Christophe Rochet, Aaron B Bowman, Chongli Yuan, Zhuo Huang, Chang-Deng Hu, Darci J Trader, William C Skarnes, and Yang Yang
Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid., Zhigang Cai, Xiaoyu Lu, Chi Zhang, Sai Nelanuthala, Fabiola Aguilera, Abigail Hadley, Baskar Ramdas, Fang Fang, Kenneth Nephew, Jonathan J Kotzin, Adam Williams, Jorge Henao-Mejia, Laura Haneline, and Reuben Kapur
iCSDB: an integrated database of CRISPR screens., Ahyoung Choi, Insu Jang, Heewon Han, Min-Seo Kim, Jinhyuk Choi, Jieun Lee, Sung-Yup Cho, Yukyung Jun, Charles Lee, Jaesang Kim, Byungwook Lee, and Sanghyuk Lee
Identification of Candidate miRNAs as Therapeutic Targets and Biomarkers for Lung Cancer through Differential Expression Analysis, Antonio Mendoza
Identification of cell-surface glycans that mediate motility-dependent binding and internalization of Pseudomonas aeruginosa by phagocytes., Hector Sanchez, Daniel Hopkins, Sally Demirdjian, Cecilia Gutierrez, George A O'Toole, Sriram Neelamegham, and Brent Berwin
Identification of the Adult Hematopoietic Liver as the Primary Reservoir for the Recruitment of Pro-regenerative Macrophages Required for Salamander Limb Regeneration., Ryan J Debuque, Andrew J Hart, Gabriela H Johnson, Nadia Rosenthal, and James W Godwin
Identifying genetic interactions related to diabetes using phenotype, Gabriella E. Tenoria
Identifying the Cause of Decreased Urine pH of Mice on A Caloric Restriction., James Mejia
Immuno-transcriptomic profiling of extracranial pediatric solid malignancies., Andrew S Brohl, Sivasish Sindiri, Jun S Wei, David Milewski, Hsien-Chao Chou, Young K Song, Xinyu Wen, Jeetendra Kumar, Hue V Reardon, Uma S Mudunuri, Jack R Collins, Sushma Nagaraj, Vineela Gangalapudi, Manoj Tyagi, Yuelin J Zhu, Katherine E Masih, Marielle E Yohe, Jack F Shern, Yue Qi, Udayan Guha, Daniel Catchpoole, Rimas J Orentas, Igor B Kuznetsov, Nicolas J Llosa, John A Ligon, Brian K Turpin, Daniel G Leino, Shintaro Iwata, Irene L Andrulis, Jay S Wunder, Silvia R C Toledo, Paul S Meltzer, Ching C Lau, Beverly A Teicher, Heather Magnan, Marc Ladanyi, and Javed Khan
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA., Lingling Kong, David O Valdivia, Christian M Simon, Cera W Hassinan, Nicolas Delestrée, Daniel M Ramos, Jae Hong Park, Celeste M Pilato, Xixi Xu, Melissa Crowder, Chloe C Grzyb, Zachary A King, Marco Petrillo, Kathryn J Swoboda, Crystal Davis, Cathleen Lutz, Alexander H Stephan, Xin Zhao, Marla Weetall, Nikolai A Naryshkin, Thomas O Crawford, George Z Mentis, and Charlotte J Sumner
Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models., Lisa M. Burzenski, Benjamin E. Low, Vivek Kohar, Leonard D. Shultz, Michael V. Wiles, and Vishnu Hosur
Induction of Stress-Induced Renal Cellular Senescence In Vitro: Impact of Mouse Strain Genetic Diversity., Chieh Ming Liao, Vera Christine Wulfmeyer, Maxine Swallow, Christine Susanne Falk, Hermann Haller, Ron Korstanje, Anette Melk, and Roland Schmitt
INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants., Chenyang Dong, Shane P Simonett, Sunyoung Shin, Donnie S Stapleton, Kathryn L Schueler, Gary Churchill, Leina Lu, Xiaoxiao Liu, Fulai Jin, Yan Li, Alan D Attie, Mark P Keller, and Sündüz Keleş
Inflammasome as an Inflammatory Response to Ocular Hypertension, Annabelle Feist
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS., Jennifer J. Trowbridge and Daniel T Starczynowski
In situ Chromatin Interaction Analysis Using Paired-End Tag Sequencing., Ping Wang, Yuliang Feng, Kun Zhu, Haoxi Chai, Ya-Ting Chang, Xiaofei Yang, Xiyuan Liu, Chen Shen, Eva Gega, Byoungkoo Lee, Minji Kim, Xiaoan Ruan, and Yijun Ruan
Integrated analysis of the molecular pathogenesis of FDXR-associated disease., Jesse D Slone, Li Yang, Yanyan Peng, Luis F Queme, Belinda S. Harris, Stacey J Sukoff Rizzo, Torrian Green, Jennifer L Ryan, Michael P Jankowski, Laura G Reinholdt, and Taosheng Huang
Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery., Bahar Behsaz, Edna Bode, Alexey Gurevich, Yan-Ni Shi, Florian Grundmann, Deepa Acharya, Andrés Mauricio Caraballo-Rodríguez, Amina Bouslimani, Morgan Panitchpakdi, Annabell Linck, Changhui Guan, Julia Oh, Pieter C Dorrestein, Helge B Bode, Pavel A Pevzner, and Hosein Mohimani
Integration of evidence across human and model organism studies: A meeting report., Rohan H C Palmer, Emma C Johnson, Hyejung Won, Renato Polimanti, Manav Kapoor, Apurva Chitre, Molly A. Bogue, Chelsie E Benca-Bachman, Clarissa C Parker, Anurag Verma, Timothy Reynolds, Jason Ernst, Michael Bray, Soo Bin Kwon, Dongbing Lai, Bryan C Quach, Nathan C Gaddis, Laura Saba, Hao Chen, Michael Hawrylycz, Shan Zhang, Yuan Zhou, Spencer Mahaffey, Christian Fischer, Sandra Sanchez-Roige, Anita Bandrowski, Qing Lu, Li Shen, Vivek M. Philip, Joel Gelernter, Laura J Bierut, Dana B Hancock, Howard J Edenberg, Eric O Johnson, Eric J Nestler, Peter B Barr, Pjotr Prins, Desmond J Smith, Schahram Akbarian, Thorgeir Thorgeirsson, David O Walton, Erich Baker, Daniel Jacobson, Abraham A Palmer, Michael Miles, Elissa J Chesler, Jake Emerson, Arpana Agrawal, Maryann Martone, and Robert W Williams
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway., Yen-Chen Lin, Meenakshi Sundaram Kumar, Nandini Ramesh, Eric N Anderson, Aivi T Nguyen, Boram Kim, Simon Cheung, Justin A McDonough, William C Skarnes, Rodrigo Lopez-Gonzalez, John E Landers, Nicolas L Fawzi, Ian R A Mackenzie, Edward B Lee, Jeffrey A Nickerson, David Grunwald, Udai B Pandey, and Daryl A Bosco
Interpretable prioritization of splice variants in diagnostic next-generation sequencing., Daniel Danis, Julius O B Jacobsen, Leigh Carmody, Michael Gargano, Julie A McMurry, Ayushi Hegde, Melissa A Haendel, Giorgio Valentini, Damian Smedley, and Peter N Robinson
Inter-Strain Epigenomic Profiling Reveals a Candidate IAP Master Copy in C3H Mice., Rita Rebollo, Mariana Galvão-Ferrarini, Liane Gagnier, Ying Zhang, Ardian Ferraj, Christine R Beck, Matthew C Lorincz, and Dixie L Mager
Introduction to mammalian genome special issue: the microbiome in human health and disease., Guillaume Pavlovic, Je Kyung Seong, and George M. Weinstock
Investigating the effects of APOE-£4 on angiogenesis and blood brain barrier integrity in early stages of cerebrovascular development, Larisa Kavetsky
Investigation of the Influence of Nudtl 9 and Dpp 7 Genes on Alzheimer's Disease Progression, Brianna Gurdon
JAK2 regulates paclitaxel resistance in triple negative breast cancers., Jongmin Han, Jihui Yun, Mingji Quan, Wonyoung Kang, Ji-Gwang Jung, Woohang Heo, Songbin Li, Kyu Jin Lee, Hye-Youn Son, Ju Hee Kim, Jaeyong Choi, Dong-Young Noh, Deukchae Na, Han Suk Ryu, Charles Lee, Jong-Il Kim, and Hyeong-Gon Moon
John Fuller Oral History, John Fuller
KG-COVID-19: A Framework to Produce Customized Knowledge Graphs for COVID-19 Response., Justin T Reese, Deepak Unni, Tiffany J Callahan, Luca Cappelletti, Vida Ravanmehr, Seth Carbon, Kent A Shefchek, Benjamin M Good, James P Balhoff, Tommaso Fontana, Hannah Blau, Nicolas Matentzoglu, Nomi L Harris, Monica C Munoz-Torres, Melissa A Haendel, Peter N Robinson, Marcin P Joachimiak, and Christopher J Mungall
Know Your Model: A brief history of making mutant mouse genetic models., Susan M. Bello, Michelle N Perry, and Cynthia Smith
Know Your Model: A knockout does not always make a null., Susan M. Bello, Michelle N Perry, and Cynthia Smith
Know Your Model: Microbiota & phenotypes., Michelle N Perry, Susan M. Bello, and Cynthia Smith
Know Your Model: Recombinase-expressing mice., Michelle N Perry, Susan M. Bello, and Cynthia Smith
Know Your Model: The role of sex in phenotype penetrance and severity., Susan M. Bello, Michelle N Perry, and Cynthia Smith
Know Your Model: When parental origin matters., Susan M. Bello, Michelle N Perry, and Cynthia Smith
Know Your Model: Why mouse inbred strain contribution matters., Michelle N Perry, Susan M. Bello, and Cynthia Smith
Large scale enzyme based xenobiotic identification for exposomics., Ken H Liu, Choon M Lee, Grant Singer, Preeti Bais, Francisco Castellanos, Michael H Woodworth, Thomas R Ziegler, Colleen S Kraft, Gary W Miller, Shuzhao Li, Young-Mi Go, Edward T Morgan, and Dean P Jones
Letter to the Editor: Response to Biesecker et al., Ada Hamosh, Joanna S Amberger, Carol A Bocchini, Joann Bodurtha, Carol J Bult, Christopher G Chute, Garry R Cutting, Harry C Dietz, Helen V Firth, Richard A Gibbs, Wayne W Grody, Melissa A Haendel, James R Lupski, Jennifer E Posey, Peter N Robinson, Lynn M Schriml, Alan F Scott, Nara L Sobreira, David Valle, Nan Wu, and Sonja A Rasmussen
Local versus systemic control of bone and skeletal muscle mass by components of the transforming growth factor-β signaling pathway., Yewei Liu, Adam Lehar, Renata Rydzik, Harshpreet Chandok, Yun-Sil Lee, Daniel W Youngstrom, Joshy George, Martin M Matzuk, Emily L Germain-Lee, and Se-Jin Lee
Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With, Xin Zhou, Jethro Johnson, Daniel Spakowicz, Wenyu Zhou, Yanjiao Zhou, Erica Sodergren, Michael Snyder, and George M. Weinstock
Long noncoding RNA SMUL suppresses SMURF2 production-mediated muscle atrophy via nonsense-mediated mRNA decay., Bolin Cai, Zhenhui Li, Manting Ma, Jing Zhang, Shaofen Kong, Bahareldin Ali Abdalla, Haiping Xu, Endashaw Jebessa, Xiquan Zhang, Raman Akinyanju Lawal, and Qinghua Nie
Lymphocyte Proliferation in response to Cardiomyosin ex vivo, Elias Tzor-Pacheco
Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation., Sarah J Benjamin, Kelly L Hawley, Paola Vera-Licona, Carson J La Vake, Jorge L Cervantes, Yijun Ruan, Justin D Radolf, and Juan C Salazar
Maximizing the potential of aggressive mouse tumor models in preclinical drug testing., M Tarek Elghetany, Jia-Min Ho, Lois Hew Shi-Qi, Sekar Karthik, Jack M F Su, Qi Lin, YuChen Du, Jianhe Shen, Wing-Yuk Chow, Ching C Lau, Adekunle Adesina, Angela Major, Anat Erdreich-Epstein, Kam-Man Hui, Xiao-Nan Li, and Wan-Yee Teo
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights., Zhiqiang Pang, Jasmine Chong, Guangyan Zhou, David Anderson de Lima Morais, Le Chang, Michel Barrette, Carol Gauthier, Pierre-Étienne Jacques, Shuzhao Li, and Jianguo Xia
Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis., Leslie A Sepaniac, Whitney Martin, Louise A. Dionne, Timothy M Stearns, Laura G Reinholdt, and Jason Stumpff
Modeling seizures in the Human Phenotype Ontology according to contemporary ILAE concepts makes big phenotypic data tractable., David Lewis-Smith, Peter D Galer, Ganna Balagura, Hugh Kearney, Shiva Ganesan, Mahgenn Cosico, Margaret O'Brien, Priya Vaidiswaran, Roland Krause, Colin A Ellis, Rhys H Thomas, Peter N Robinson, and Ingo Helbig
Modeling the Genetic Regulatory Network of Epithelial- Mesenchymal Transition, Dan Ramirez
Modifiable Lifestyle Factors in Alzheimer Disease: An Opportunity to Transform the Therapeutic Landscape Through Transdisciplinary Collaboration., Timothy J Hohman and Catherine Kaczorowski
Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis., Hui Tian and Petko M. Petkov
Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics., Emily Swanzey, Callan O'Connor, and Laura G Reinholdt
Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology., Judith A. Blake, Richard M. Baldarelli, James A. Kadin, Joel E Richardson, Cynthia Smith, Carol J Bult, and Mouse Genome Database Group
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density., Anna L Swan, Christine Schütt, Jan Rozman, Maria Del Mar Muñiz Moreno, Stefan Brandmaier, Michelle Simon, Stefanie Leuchtenberger, Mark Griffiths, Robert Brommage, Piia Keskivali-Bond, Harald Grallert, Thomas Werner, Raffaele Teperino, Lore Becker, Gregor Miller, Ala Moshiri, John R Seavitt, Derek D Cissell, Terrence F Meehan, Elif F Acar, Christopher J Lelliott, Ann M Flenniken, Marie-France Champy, Tania Sorg, Abdel Ayadi, Robert E Braun, Heather Cater, Mary E Dickinson, Paul Flicek, Juan Gallegos, Elena J Ghirardello, Jason D Heaney, Sylvie Jacquot, Connor Lally, John G Logan, Lydia Teboul, Jeremy Mason, Nadine Spielmann, Colin McKerlie, Stephen A. Murray, Lauryl M J Nutter, Kristian F Odfalk, Helen Parkinson, Jan Prochazka, Corey L Reynolds, Mohammed Selloum, Frantisek Spoutil, Karen L. Svenson, Taylor S Vales, Sara E Wells, Jacqueline K White, Radislav Sedlacek, Wolfgang Wurst, Kent K C Lloyd, Peter I Croucher, Helmut Fuchs, Graham R Williams, Duncan Bassett, Valerie Gailus-Durner, Yann Herault, Ann-Marie Mallon, Steve D M Brown, Philipp Mayer-Kuckuk, Martin Hrabe de Angelis, and IMPC Consortium
muCNV: Genotyping Structural Variants for Population-level Sequencing., Goo Jun, Fritz Sedlazeck, Qihui Zhu, Adam English, Ginger Metcalf, Hyun Min Kang, Human Genome Structural Variation Consortium, Charles Lee, Richard Gibbs, and Eric Boerwinkle
Multi-omic and multi-species meta-analyses of nicotine consumption., Rohan H C Palmer, Chelsie E Benca-Bachman, Spencer B Huggett, Jason A. Bubier, John E McGeary, Nikhil Ramgiri, Jenani Srijeyanthan, Jingjing Yang, Peter M Visscher, Jian Yang, Valerie S Knopik, and Elissa J Chesler
Multiple PDZ domain protein maintains patterning of the apical cytoskeleton in sensory hair cells., Amandine Jarysta and Basile Tarchini
Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B., Gauthier Schang, Luisina Ongaro, Hailey Schultz, Ying Wang, Xiang Zhou, Emilie Brûlé, Ulrich Boehm, Se-Jin Lee, and Daniel J Bernard
Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease., Hongtian Stanley Yang, Kristen D. Onos, Kwangbom Choi, Kelly J Keezer, Daniel A Skelly, Gregory W. Carter, and Gareth R Howell
Neurokinin B-Expressing Neurons of the Central Extended Amygdala Mediate Inhibitory Synaptic Input onto Melanin-Concentrating Hormone Neuron Subpopulations., Akie Fujita, Lily Zhong, Monica S Antony, Elizabeth Chamiec-Case, Laura E Mickelsen, Scott E Kanoski, William F Flynn, and Alexander C Jackson
Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction., James R Tribble, Amin Otmani, Shanshan Sun, Sevannah A Ellis, Gloria Cimaglia, Rupali Vohra, Melissa Jöe, Emma Lardner, Abinaya P Venkataraman, Alberto Domínguez-Vicent, Eirini Kokkali, Seungsoo Rho, Gauti Jóhannesson, Robert W. Burgess, Peter G Fuerst, Rune Brautaset, Miriam Kolko, James E Morgan, Jonathan G Crowston, Marcela Votruba, and Pete A Williams
Novel CTNND2-TERT fusion in a spindle cell liposarcoma., Michael Occidental, Guomiao Shen, Xiaojun Feng, Kelsey Zhu, Kevin Kelly, Qian Nie, Honey V Reddi, Eleftheria Lakiotaki, Nora Athina Viniou, Penelope Korkolopoulou, Konstantinos Linos, and George Jour
Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments., Maulasri Bhatta, Gautam N Shenoy, Jenni L Loyall, Brian D Gray, Meghana Bapardekar, Alexis Conway, Hans Minderman, Raymond J Kelleher, Beatriz M Carreno, Gerald Linette, Leonard D. Shultz, Kunle Odunsi, Sathy V Balu-Iyer, Koon Yan Pak, and Richard B Bankert
Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription., Yanfen Zhu, Amit D Gujar, Chee-Hong Wong, Harianto Tjong, Chew Yee Ngan, Liang Gong, Yi-An Chen, Hoon Kim, Jihe Liu, Meihong Li, Adam Mil-Homens, Rahul Maurya, Chris Kuhlberg, Fanyue Sun, Eunhee Yi, Ana C deCarvalho, Yijun Ruan, Roel G W Verhaak, and Chia-Lin Wei
Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes., Stephen R Wellard, Yujiao Zhang, Chris Shults, Xueqi Zhao, Matthew Mckay, Stephen A. Murray, and Philip W Jordan
Patients' Expectations of Benefits From Large-Panel Genomic Tumor Testing in Rural Community Oncology Practices., Eric C Anderson, John DiPalazzo, Emily A Edelman, Petra Helbig, Kate Reed, Susan Miesfeldt, Christian Thomas, F Lee Lucas, Anny T H R Fenton, Andrey Antov, Michael J Hall, J Scott Roberts, Jens Rueter, and Paul K J Han
Patterns and mechanisms of sex ratio distortion in the Collaborative Cross mouse mapping population., Brett A Haines, Francesca Barradale, and Beth L Dumont
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities., Carl M Gay, C Allison Stewart, Elizabeth M Park, Lixia Diao, Sarah M Groves, Simon Heeke, Barzin Y Nabet, Junya Fujimoto, Luisa M Solis, Wei Lu, Yuanxin Xi, Robert J Cardnell, Qi Wang, Giulia Fabbri, Kasey R Cargill, Natalie I Vokes, Kavya Ramkumar, Bingnan Zhang, Carminia M Della Corte, Paul Robson, Stephen G Swisher, Jack A Roth, Bonnie S Glisson, David S Shames, Ignacio I Wistuba, Jing Wang, Vito Quaranta, John Minna, John V Heymach, and Lauren Averett Byers
PD-1 Blockade Aggravates Epstein-Barr Virus + Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4 + T Cell Dysregulations., Valery Volk, Sebastian J Theobald, Simon Danisch, Sahamoddin Khailaie, Maja Kalbarczyk, Andreas Schneider, Julia Bialek-Waldmann, Nicole Krönke, Yun Deng, Britta Eiz-Vesper, Anna Christina Dragon, Constantin von Kaisenberg, Stefan Lienenklaus, Andre Bleich, James Keck, Michael Meyer-Hermann, Frank Klawonn, Wolfgang Hammerschmidt, Henri-Jacques Delecluse, Christian Münz, Friedrich Feuerhake, and Renata Stripecke
Perspective of mesenchymal transformation in glioblastoma., Yona Kim, Frederick S Varn, Sung-Hye Park, Byung Woo Yoon, Hye Ran Park, Charles Lee, Roel G W Verhaak, and Sun Ha Paek
Pervasive and CpG-dependent promoter-like characteristics of transcribed enhancers., Robin Steinhaus, Tonatiuh Gonzalez, Dominik Seelow, and Peter N Robinson
Petri Net modelling approach for analysing the behaviour of Wnt/[inline-formula removed] -catenin and Wnt/Ca 2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy., Nazia Azim, Jamil Ahmad, Nadeem Iqbal, Amnah Siddiqa, Abdul Majid, Javaria Ashraf, and Fazal Jalil
Pharmacological and Behavioral Characterization of the Reward Pathway in Diverse Mice, Avery Lopez
PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522., Emily Maguire, Georgina E Menzies, Thomas Phillips, Michael Sasner, Harriet M Williams, Magdalena A Czubala, Neil Evans, Emma L Cope, Rebecca Sims, Gareth R Howell, Emyr Lloyd-Evans, Julie Williams, Nicholas D Allen, and Philip R Taylor
PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease., Alex G Nackenoff, Timothy J Hohman, Sarah M Neuner, Carolyn S Akers, Nicole C Weitzel, Alena Shostak, Shawn M Ferguson, Bret Mobley, David A Bennett, Julie A Schneider, Angela L Jefferson, Catherine C Kaczorowski, and Matthew S Schrag
Population and subspecies diversity at mouse centromere satellites., Uma P Arora, Caleigh Charlebois, Raman Akinyanju Lawal, and Beth L Dumont
PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock., Christina M Kelliher, Randy Lambreghts, Qijun Xiang, Christopher L. Baker, Jennifer J Loros, and Jay C Dunlap
Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform., Gautam N Shenoy, Christopher J Greene, Maulasri Bhatta, Miren L Baroja, Jenni L Loyall, Sathy V Balu-Iyer, Raymond J Kelleher, Beatriz M Carreno, Gerald P Linette, Leonard D. Shultz, and Richard B Bankert
Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts., Deukchae Na, Jeesoo Chae, Sung-Yup Cho, Wonyoung Kang, Ahra Lee, Seoyeon Min, Jinjoo Kang, Min Jung Kim, Jaeyong Choi, Woochan Lee, Dongjin Shin, Ahrum Min, Yu-Jin Kim, Kyung-Hun Lee, Tae-Yong Kim, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, Woo-Ho Kim, Hansoo Park, Seock-Ah Im, Han-Kwang Yang, Charles Lee, and Jong-Il Kim
Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs., Tsung-Yu Lu, Human Genome Structural Variation Consortium, Mark J P Chaisson, Charles Lee, and Qihui Zhu
Prognostic gene expression signature for high-grade serous ovarian cancer., J Millstein, T Budden, E L Goode, M S Anglesio, A Talhouk, M P Intermaggio, H S Leong, S Chen, W Elatre, B Gilks, T Nazeran, M Volchek, R C Bentley, C Wang, D S Chiu, S Kommoss, S C Y Leung, J Senz, A Lum, V Chow, H Sudderuddin, R Mackenzie, Joshy George, AOCS Group, S Fereday, J Hendley, N Traficante, H Steed, J M Koziak, M Köbel, I A McNeish, T Goranova, D Ennis, G Macintyre, D Silva De Silva, T Ramón Y Cajal, J García-Donas, S Hernando Polo, G C Rodriguez, K L Cushing-Haugen, H R Harris, C S Greene, R A Zelaya, S Behrens, R T Fortner, P Sinn, E Herpel, J Lester, J Lubiński, O Oszurek, A Tołoczko, C Cybulski, J Menkiszak, C L Pearce, M C Pike, C Tseng, J Alsop, V Rhenius, H Song, M Jimenez-Linan, A M Piskorz, A Gentry-Maharaj, C Karpinskyj, M Widschwendter, N Singh, C J Kennedy, R Sharma, P R Harnett, B Gao, S E Johnatty, R Sayer, J Boros, S J Winham, G L Keeney, S H Kaufmann, M C Larson, H Luk, B Y Hernandez, P J Thompson, L R Wilkens, M E Carney, B Trabert, J Lissowska, L Brinton, M E Sherman, C Bodelon, S Hinsley, L A Lewsley, R Glasspool, S N Banerjee, E A Stronach, P Haluska, I Ray-Coquard, S Mahner, B Winterhoff, D Slamon, D A Levine, L E Kelemen, J Benitez, J Chang-Claude, J Gronwald, A H Wu, U Menon, M T Goodman, J M Schildkraut, N Wentzensen, R Brown, A Berchuck, G Chenevix-Trench, A deFazio, S A Gayther, M J García, M J Henderson, M A Rossing, A Beeghly-Fadiel, P A Fasching, S Orsulic, B Y Karlan, G E Konecny, D G Huntsman, D D Bowtell, J D Brenton, J A Doherty, P D P Pharoah, and S J Ramus
Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney., Yuka Takemon, Joel M Chick, Isabela Gerdes Gyuricza, Daniel A Skelly, Olivier Devuyst, Steven P Gygi, Gary Churchill, and Ron Korstanje
Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models., Brianna Gurdon and Catherine Kaczorowski
Quantitative trait mapping in Diversity Outbred mice identifies novel genomic regions associated with the hepatic glutathione redox system., Rebecca L Gould, Steven W Craig, Susan McClatchy, Gary A Churchill, and Robert Pazdro
Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer., Emre Kocakavuk, Kevin J Anderson, Frederick S Varn, Kevin C Johnson, Samirkumar B Amin, Erik P Sulman, Martijn P Lolkema, Floris P Barthel, and Roel G W Verhaak
Rapamycin rejuvenates oral health in aging mice., Jonathan Y An, Kristopher A Kerns, Andrew R Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, and Matt Kaeberlein
Rapid Modeling of Developmental Disorders Using CRISPR/ Cas9, Ali Ladha
Rasa3 regulates stage-specific cell cycle progression in murine erythropoiesis., Elena C Brindley, Julien Papoin, Lauren Kennedy, Ray F. Robledo, Steven L. Ciciotte, Theodosia A Kalfa, Luanne L. Peters, and Lionel Blanc
Reactome and the Gene Ontology: Digital convergence of data resources., Benjamin M Good, Kimberly Van Auken, David P. Hill, Huaiyu Mi, Seth Carbon, James P Balhoff, Laurent-Philippe Albou, Paul D Thomas, Christopher J Mungall, Judith A. Blake, and Peter D'Eustachio
Regen med therapeutic opportunities for fighting COVID-19., Anthony Atala, Alicia Henn, Martha Lundberg, Taby Ahsan, Jordan Greenberg, Jeff Krukin, Steven Lynum, Cathleen Lutz, Kyle Cetrulo, Mohammad Albanna, Taciana Pereira, Shannon Eaker, and Joshua Hunsberger
Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape., Jose D Aponte, David C Katz, Daniela M Roth, Marta Vidal-García, Wei Liu, Fernando Andrade, Charles C Roseman, Stephen A Murray, James Cheverud, Daniel Graf, Ralph S Marcucio, and Benedikt Hallgrímsson
Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy., Christopher J Terranova, Ming Tang, Mayinuer Maitituoheti, Ayush T Raman, Archit K Ghosh, Jonathan Schulz, Samirkumar B Amin, Elias Orouji, Katarzyna Tomczak, Sharmistha Sarkar, Junna Oba, Caitlin Creasy, Chang-Jiun Wu, Samia Khan, Rossana Lazcano, Khalida Wani, Anand Singh, Praveen Barrodia, Dongyu Zhao, Kaifu Chen, Lauren E Haydu, Wei-Lien Wang, Alexander J Lazar, Scott E Woodman, Chantale Bernatchez, and Kunal Rai
RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition., Malwina Prater, Russell S Hamilton, Hong Wa Yung, Andrew M Sharkey, Paul Robson, N Erlyani Abd Hamid, Eric Jauniaux, D Stephen Charnock-Jones, Graham J Burton, and Tereza Cindrova-Davies
Role of MicroRNA in Inflammatory Bowel Disease: Clinical Evidence and the Development of Preclinical Animal Models., Kanika Suri, Jason A. Bubier, Michael V. Wiles, Leonard D. Shultz, Mansoor M Amiji, and Vishnu Hosur
RUNX1-mediated alphaherpesvirus-host trans-species chromatin interaction promotes viral transcription., Ke Xiao, Dan Xiong, Gong Chen, Jinsong Yu, Yue Li, Kening Chen, Lu Zhang, Yangyang Xu, Qian Xu, Xi Huang, Anran Gao, Kai Cao, Keji Yan, Jinxia Dai, Xueying Hu, Yijun Ruan, Zhenfang Fu, Guoliang Li, and Gang Cao
Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment., Anthony M Pettinato, Dasom Yoo, Jennifer VanOudenhove, Yu-Sheng Chen, Rachel Cohn, Feria A Ladha, Xiulan Yang, Ketan Thakar, Robert Romano, Nicolas Legere, Emily Meredith, Paul Robson, Michael Regnier, Justin L Cotney, Charles E Murry, and J Travis Hinson
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis., Adam L Bailey, Oleksandr Dmytrenko, Lina Greenberg, Andrea L Bredemeyer, Pan Ma, Jing Liu, Vinay Penna, Emma S Winkler, Sanja Sviben, Erin Brooks, Ajith P Nair, Kent A Heck, Aniket S Rali, Leo Simpson, Mehrdad Saririan, Dan Hobohm, W Tom Stump, James A Fitzpatrick, Xuping Xie, Xianwen Zhang, Pei-Yong Shi, J Travis Hinson, Weng-Tein Gi, Constanze Schmidt, Florian Leuschner, Chieh-Yu Lin, Michael S Diamond, Michael J Greenberg, and Kory J Lavine
SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus., Mikail Dogan, Lina Kozhaya, Lindsey Placek, Courtney Gunter, Mesut Yigit, Rachel Hardy, Matthew Plassmeyer, Paige Coatney, Kimberleigh Lillard, Zaheer Bukhari, Michael Kleinberg, Chelsea Hayes, Moshe Arditi, Ellen Klapper, Noah Merin, Bruce Tsan-Tang Liang, Raavi Gupta, Oral Alpan, and Derya Unutmaz
Selection shapes the landscape of functional variation in wild house mice., Raman Akinyanju Lawal, Uma P Arora, and Beth L Dumont
Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model., Gregory R Keele, Jeremy W Prokop, Hong He, Katie Holl, John Littrell, Aaron W Deal, Yunjung Kim, Patrick B Kyle, Esinam Attipoe, Ashley C Johnson, Katie L Uhl, Olivia L Sirpilla, Seyedehameneh Jahanbakhsh, Melanie Robinson, Shawn Levy, William Valdar, Michael R Garrett, and Leah C Solberg Woods
Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study., Shiwani Mahajan, Rajesh Srinivasan, Carrie A Redlich, Sara K Huston, Kelly M Anastasio, Lisa Cashman, Dorothy S Massey, Andrew Dugan, Dan Witters, Jenny Marlar, Shu-Xia Li, Zhenqiu Lin, Domonique Hodge, Manas Chattopadhyay, Mark D Adams, Charles Lee, Lokinendi V Rao, Chris Stewart, Karthik Kuppusamy, Albert I Ko, and Harlan M Krumholz
Severe deficiency of the voltage-gated sodium channel Na V 1.2 elevates neuronal excitability in adult mice., Jingliang Zhang, Xiaoling Chen, Muriel Eaton, Jiaxiang Wu, Zhixiong Ma, Shirong Lai, Anthony Park, Talha S Ahmad, Zhefu Que, Ji Hea Lee, Tiange Xiao, Yuansong Li, Yujia Wang, Maria I Olivero-Acosta, James A Schaber, Krishna Jayant, Chongli Yuan, Zhuo Huang, Nadia A Lanman, William C Skarnes, and Yang Yang
Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitry., William Paden, Kelly Barko, Rachel Puralewski, Kelly M Cahill, Zhiguang Huo, Micah A Shelton, George C Tseng, Ryan W Logan, and Marianne L Seney
Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder., Robert Hitzemann, Susan E Bergeson, Ari E Berman, Jason A. Bubier, Elissa J Chesler, Deborah A Finn, Matthew Hein, Paula Hoffman, Andrew Holmes, Brent R Kisby, Denesa Lockwood, Kerrie H Lodowski, Michelle McManus, Julie A Owen, Angela R Ozburn, Praneetha Panthagani, Igor Ponomarev, Laura Saba, Boris Tabakoff, Aashlesha Walchale, Robert W Williams, and Tamara J Phillips
Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor., Marie Saitou, Skyler Resendez, Apoorva J Pradhan, Fuguo Wu, Natasha C Lie, Nancy J Hall, Qihui Zhu, Laura G Reinholdt, Yoko Satta, Leo Speidel, Shigeki Nakagome, Neil A Hanchard, Gary Churchill, Charles Lee, G Ekin Atilla-Gokcumen, Xiuqian Mu, and Omer Gokcumen
SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence., Rita A Busuttil, Joshy George, Colin M House, Stephen Lade, Catherine Mitchell, Natasha S Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, and Alex Boussioutas
Shared and distinctive features of the gut microbiome of C57BL/6 mice from different vendors and production sites, and in response to a new vivarium., Lauren L Long, Karen L. Svenson, Anthony J Mourino, Michael Michaud, James R Fahey, Linda L Waterman, Kathy L Vandegrift, and Mark D Adams
Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer., C Allison Stewart, Carl M Gay, Yuanxin Xi, Santhosh Sivajothi, V Sivakamasundari, Junya Fujimoto, Mohan Bolisetty, Patrice M Hartsfield, Veerakumar Balasubramaniyan, Milind D Chalishazar, Cesar Moran, Neda Kalhor, John Stewart, Hai Tran, Stephen G Swisher, Jack A Roth, Jianjun Zhang, John de Groot, Bonnie Glisson, Trudy G Oliver, John V Heymach, Ignacio Wistuba, Paul Robson, Jing Wang, and Lauren Averett Byers
Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28., Nathan Lawlor, Djamel Nehar-Belaid, Jessica D S Grassmann, Marlon Stoeckius, Peter Smibert, Michael L. Stitzel, Virginia Pascual, Jacques Banchereau, Adam Williams, and Duygu Ucar
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes., Neal G Ravindra, Mia Madel Alfajaro, Victor Gasque, Nicholas C Huston, Han Wan, Klara Szigeti-Buck, Yuki Yasumoto, Allison M Greaney, Victoria Habet, Ryan D Chow, Jennifer S Chen, Jin Wei, Renata B Filler, Bao Wang, Guilin Wang, Laura E Niklason, Ruth R Montgomery, Stephanie C Eisenbarth, Sidi Chen, Adam Williams, Akiko Iwasaki, Tamas L Horvath, Ellen F Foxman, Richard W Pierce, Anna Marie Pyle, David van Dijk, and Craig B Wilen
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response., Kevin C Johnson, Kevin J Anderson, Elise T Courtois, Amit D Gujar, Floris P Barthel, Frederick S Varn, Diane Luo, Martine Seignon, Eunhee Yi, Hoon Kim, Marcos R H Estecio, Dacheng Zhao, Ming Tang, Nicholas E Navin, Rahul Maurya, Chew Yee Ngan, Niels Verburg, Philip C de Witt Hamer, Ketan Bulsara, Michael Samuels, Sunit Das, Paul Robson, and Roel G W Verhaak
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction., Lukas S Tombor, David John, Simone F Glaser, Guillermo Luxán, Elvira Forte, Milena B Furtado, Nadia Rosenthal, Nina Baumgarten, Marcel H Schulz, Janina Wittig, Eva-Maria Rogg, Yosif Manavski, Ariane Fischer, Marion Muhly-Reinholz, Kathrin Klee, Mario Looso, Carmen Selignow, Till Acker, Sofia-Iris Bibli, Ingrid Fleming, Ralph Patrick, Richard P Harvey, Wesley T Abplanalp, and Stefanie Dimmeler
SMN protein is required throughout life to prevent spinal muscular atrophy disease progression., Xin Zhao, Zhihua Feng, Nicole Risher, Anna Mollin, Josephine Sheedy, Karen K Y Ling, Jana Narasimhan, Amal Dakka, John D Baird, Hasane Ratni, Cathleen Lutz, Karen S Chen, Nikolai A Naryshkin, Chien-Ping Ko, Ellen Welch, Friedrich Metzger, and Marla Weetall
Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing., Colin M Cleary, Brenda M Milla, Fu-Shan Kuo, Shaun James, William F Flynn, Paul Robson, and Daniel K Mulkey
Sox2 controls neural stem cell self-renewal through a Fos-centered gene regulatory network., Miriam Pagin, Mattias Pernebrink, Simone Giubbolini, Cristiana Barone, Gaia Sambruni, Yanfen Zhu, Matteo Chiara, Sergio Ottolenghi, Giulio Pavesi, Chia-Lin Wei, Claudio Cantù, and Silvia K Nicolis
Spatial and temporal expression of PORCN is highly dynamic in the developing mouse cochlea., Brianna L Oliver, Caryl A Young, and Vidhya Munnamalai
Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity., Jonas Malkmus, Laurène Ramos Martins, Shalu Jhanwar, Bonnie Kircher, Victorio Palacio, Rushikesh Sheth, Francisca Leal, Amandine Duchesne, Javier Lopez-Rios, Kevin A Peterson, Robert Reinhardt, Koh Onimaru, Martin J Cohn, Aimée Zuniga, and Rolf Zeller
Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome., Gihyeon Kim, Misun Kim, Minji Kim, Changho Park, Youngmin Yoon, Doo-Hyeon Lim, Hyeonju Yeo, Seunghyun Kang, Yeong-Geun Lee, Nam-In Beak, Jongsung Lee, Sujeong Kim, Jee Young Kwon, Won Woo Choi, Charles Lee, Kyoung Wan Yoon, Hansoo Park, and Dong-Geol Lee
Spinal motor neuron loss occurs through a p53-and-p21-independent mechanism in the Smn, Emily J Reedich, Martin Kalski, Nicholas Armijo, Gregory A. Cox, and Christine J DiDonato
Spinal motor neuron loss occurs through a p53-and-p21-independent mechanism in the Smn, Emily J Reedich, Martin Kalski, Nicholas Armijo, Gregory A. Cox, and Christine J DiDonato
Splicing alterations in healthy aging and disease., Brittany Lynn Angarola and Olga Anczuków
SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma., Hongda Liu, Zheng Gong, Kangshuai Li, Qun Zhang, Zekuan Xu, and Yunfei Xu
Strain-Specific Peptide (SSP) Interference Reference Sample: A Genetically Encoded Quality Control for Isobaric Tagging Strategies., Tian Zhang, Gregory R Keele, Gary A Churchill, Steven P Gygi, and Joao A Paulo
Stromal regulation of neutrophils during lung metastasis of breast cancer, Sarah Marsden
Structural Variant in Mitochondrial-Associated Gene (MRPL3) Induces Adult-Onset Neurodegeneration with Memory Impairment in the Mouse., Lindsay S Cahill, Jessie M Cameron, Julie Winterburn, Patrick Macos, Johnathan Hoggarth, Misko Dzamba, Michael Brudno, Lauryl M J Nutter, Thomas J. Sproule, Robert W. Burgess, R Mark Henkelman, and John G Sled
Studying Tumor Angiogenesis and Cancer Invasion in a Three-Dimensional Vascularized Breast Cancer Micro-Environment., Madhuri Dey, Bugra Ayan, Marina Yurieva, Derya Unutmaz, and Ibrahim T Ozbolat
System-Level Analysis of Alzheimer's Disease Prioritizes Candidate Genes for Neurodegeneration., Jeffrey L Brabec, Montana Kay Lara, Anna L. Tyler, and J Matthew Mahoney
Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH., Daniel M Ramos, William C Skarnes, Andrew B Singleton, Mark R Cookson, and Michael E Ward
Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples., Chunxiao Fu, Michal Marczyk, Michael Samuels, Alexander J Trevarton, Jiaxin Qu, Rosanna Lau, Lili Du, Todd Pappas, Bruno V Sinn, Rebekah E Gould, Lajos Pusztai, Christos Hatzis, and W Fraser Symmans
Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia., Anne P de Groot, Yoriko Saito, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Kaori Sato, Hiroshi Kajita, Takashi Watanabe, Masatoshi Takagi, Daisuke Tomizawa, Katsuyoshi Koh, Mariko Eguchi, Eiichi Ishii, Osamu Ohara, Leonard D. Shultz, Shuki Mizutani, and Fumihiko Ishikawa
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules., Kamini Singh, Jianan Lin, Nicolas Lecomte, Prathibha Mohan, Askan Gokce, Viraj R Sanghvi, Man Jiang, Olivera Grbovic-Huezo, Antonija Burčul, Stefan G Stark, Paul B Romesser, Qing Chang, Jerry P Melchor, Rachel K Beyer, Mark Duggan, Yoshiyuki Fukase, Guangli Yang, Ouathek Ouerfelli, Agnes Viale, Elisa de Stanchina, Andrew W Stamford, Peter T Meinke, Gunnar Rätsch, Steven D Leach, Zhengqing Ouyang, and Hans-Guido Wendel
Targeting metabolism to reverse T-cell exhaustion in chronic viral infections., John D Sears, Kevin J Waldron, Jian Wei, and Chih-Hao (Lucas) Chang
Targeting T cell metabolism for immunotherapy., Jie Gao, Yanbo Liu, Jian Wei, Linlan Jiang, Jianwen Mao, Chih-Hao Chang, and Duojiao Wu
Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., Se-Jin Lee
Ten simple rules for providing effective bioinformatics research support., Judit Kumuthini, Michael Chimenti, Sven Nahnsen, Alexander Peltzer, Rebone Meraba, Ross McFadyen, Gordon Wells, Deanne Taylor, Mark Maienschein-Cline, Jian-Liang Li, Jyothi Thimmapuram, Radha Murthy-Karuturi, and Lyndon Zass
Term Matrix: a novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns., Valerie Wood, Seth Carbon, Midori A Harris, Antonia Lock, Stacia R Engel, David P. Hill, Kimberly Van Auken, Helen Attrill, Marc Feuermann, Pascale Gaudet, Ruth C Lovering, Sylvain Poux, Kim M Rutherford, and Christopher J Mungall
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes., Jinxiu Rui, Songyan Deng, Ana Luisa Perdigoto, Gerald Ponath, Romy Kursawe, Nathan Lawlor, Tomokazu Sumida, Maya Levine-Ritterman, Michael L. Stitzel, David Pitt, Jun Lu, and Kevan C Herold
The Accreditation Council for Genetic Counseling's response to COVID-19 impact on genetic counseling programs., Dawn C Allain, Susan Randall Armel, Erin P Carmany, Heather Creswick, Sarah B McBrien, E Kate Reed, and Janet L Williams
The case for open science: rare diseases., Yaffa R Rubinstein, Peter N Robinson, William A Gahl, Paul Avillach, Gareth Baynam, Helene Cederroth, Rebecca M Goodwin, Stephen C Groft, Mats G Hansson, Nomi L Harris, Vojtech Huser, Deborah Mascalzoni, Julie A McMurry, Matthew Might, Christoffer Nellaker, Barend Mons, Dina N Paltoo, Jonathan Pevsner, Manuel Posada, Alison P Rockett-Frase, Marco Roos, Tamar B Rubinstein, Domenica Taruscio, Esther van Enckevort, and Melissa A Haendel
The Clp1 R140H mutation alters tRNA metabolism and mRNA 3' processing in mouse models of pontocerebellar hypoplasia, Caitlin E Monaghan, Scott I Adamson, Mridu Kapur, Jeffrey H Chuang, and Susan L Ackerman
The Combined Analysis of Pleiotropy and Epistasis (CAPE)., Anna L. Tyler, Jake Emerson, Baha El Kassaby, Ann E Wells, Vivek M. Philip, and Gregory W. Carter
The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice., Brendan T Keenan, Raymond J Galante, Jie Lian, Lin Zhang, Xiaofeng Guo, Olivia J Veatch, Elissa J Chesler, W Timothy O'Brien, Karen L. Svenson, Gary Churchill, and Allan I Pack
The Effects of a High-Fat Diet on State-Dependent Activation of the Bed Nucleus of the Stria Terminalis, Katherinne Rabanal
The Effects of AlCF Knock Out on Stressed Mouse Kidneys, Bailey Hixon
The exploration of pluripotency space: Charting cell state transitions in peri-implantation development., Martin Pera and Janet Rossant
The First Annual Report (1937) of The Jackson Laboratory, The Jackson Laboratory
The Gene Ontology resource: enriching a GOld mine., Gene Ontology Consortium, Judith A. Blake, Mary E. Dolan, Harold J. Drabkin, and David P. Hill
The genetic basis of inter-individual variation in recovery from traumatic brain injury., Daniel Cortes and Martin Pera
The Gut Microbiome and Substance Use Disorder., Jordan T Russell, Yanjiao Zhou, George M. Weinstock, and Jason A. Bubier
The Human Phenotype Ontology in 2021., Sebastian Köhler, Michael Gargano, Nicolas Matentzoglu, Leigh Carmody, David Lewis-Smith, Nicole A Vasilevsky, Daniel Danis, Ganna Balagura, Gareth Baynam, Amy M Brower, Tiffany J Callahan, Christopher G Chute, Johanna L Est, Peter D Galer, Shiva Ganesan, Matthias Griese, Matthias Haimel, Julia Pazmandi, Marc Hanauer, Nomi L Harris, Michael J Hartnett, Maximilian Hastreiter, Fabian Hauck, Yongqun He, Tim Jeske, Hugh Kearney, Gerhard Kindle, Christoph Klein, Katrin Knoflach, Roland Krause, David Lagorce, Julie A McMurry, Jillian A Miller, Monica C Munoz-Torres, Rebecca L Peters, Christina K Rapp, Ana M Rath, Shahmir A Rind, Avi Z Rosenberg, Michael M Segal, Markus G Seidel, Damian Smedley, Tomer Talmy, Yarlalu Thomas, Samuel A Wiafe, Julie Xian, Zafer Yüksel, Ingo Helbig, Christopher J Mungall, Melissa A Haendel, and Peter N Robinson
The Impact of Experiential Learning in Host-Pathogen Research on Medical Students' Interests and Attitudes towards Microbiology and Immunology., Jorge Cervantes and Bo-Young Hong
The influence of uncertainty and uncertainty tolerance on attitudes and self-efficacy about genomic tumor testing., Eric C Anderson, Alexandra Hinton, Christine W Lary, Tania Strout, Andrey Antov, Emily A Edelman, Petra Helbig, Kate Reed, Jens Rueter, and Paul K J Han
The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy., Emily L Spaulding, Timothy J Hines, Preeti Bais, Abigail LD Tadenev, Robert Schneider, Dakota Jewett, B Pattavina, S L Pratt, K H Morelli, M G Stum, David P. Hill, C Gobet, M Pipis, M M Reilly, M J Jennings, R Horvath, Y Bai, M E Shy, B Alvarez-Castelao, E M Schuman, Laurent P. Bogdanik, E Storkebaum, and Robert W. Burgess
The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse., Brian J Paul, Kristina Palmer, Lindsey Rhea, Melissa Carlson, Jocelyn Sharp, C Herbert Pratt, Stephen A Murray, and Martine Dunnwald
The mouse Gene Expression Database (GXD): 2021 update., Richard M. Baldarelli, Constance M. Smith, Jacqueline H. Finger, Terry F. Hayamizu, Ingeborg J. McCright, Jingxia Xu, David R. Shaw, Jonathan S Beal, Olin Blodgett, Jeff Campbell, Lori E. Corbani, Pete J. Frost, Sharon C Giannatto, Dave Miers, James A. Kadin, Joel E Richardson, and Martin Ringwald
The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment., Melissa A Haendel, Christopher G Chute, Tellen D Bennett, David A Eichmann, Justin Guinney, Warren A Kibbe, Philip R O Payne, Emily R Pfaff, Peter N Robinson, Joel H Saltz, Heidi Spratt, Christine Suver, John Wilbanks, Adam B Wilcox, Andrew E Williams, Chunlei Wu, Clair Blacketer, Robert L Bradford, James J Cimino, Marshall Clark, Evan W Colmenares, Patricia A Francis, Davera Gabriel, Alexis Graves, Raju Hemadri, Stephanie S Hong, George Hripscak, Dazhi Jiao, Jeffrey G Klann, Kristin Kostka, Adam M Lee, Harold P Lehmann, Lora Lingrey, Robert T Miller, Michele Morris, Shawn N Murphy, Karthik Natarajan, Matvey B Palchuk, Usman Sheikh, Harold Solbrig, Shyam Visweswaran, Anita Walden, Kellie M Walters, Griffin M Weber, Xiaohan Tanner Zhang, Richard L Zhu, Benjamin Amor, Andrew T Girvin, Amin Manna, Nabeel Qureshi, Michael G Kurilla, Sam G Michael, Lili M Portilla, Joni L Rutter, Christopher P Austin, and Ken R Gersing
The NIH Somatic Cell Genome Editing program., Krishanu Saha, Erik J Sontheimer, P J Brooks, Melinda R Dwinell, Charles A Gersbach, David R Liu, Stephen A. Murray, Shengdar Q Tsai, Ross C Wilson, Daniel G Anderson, Aravind Asokan, Jillian F Banfield, Krystof S Bankiewicz, Gang Bao, Jeff W M Bulte, Nenad Bursac, Jarryd M Campbell, Daniel F Carlson, Elliot L Chaikof, Zheng-Yi Chen, R Holland Cheng, Karl J Clark, David T Curiel, James E Dahlman, Benjamin E Deverman, Mary E Dickinson, Jennifer A Doudna, Stephen C Ekker, Marina E Emborg, Guoping Feng, Benjamin S Freedman, David M Gamm, Guangping Gao, Ionita C Ghiran, Peter M Glazer, Shaoqin Gong, Jason D Heaney, Jon D Hennebold, John T Hinson, Anastasia Khvorova, Samira Kiani, William R Lagor, Kit S Lam, Kam W Leong, Jon E Levine, Jennifer A Lewis, Cathleen Lutz, Danith H Ly, Samantha Maragh, Paul B McCray, Todd C McDevitt, Oleg Mirochnitchenko, Ryuji Morizane, Niren Murthy, Randall S Prather, John A Ronald, Subhojit Roy, Sushmita Roy, Venkata Sabbisetti, W Mark Saltzman, Philip J Santangelo, David J Segal, Mary Shimoyama, Melissa C Skala, Alice F Tarantal, John C Tilton, George A Truskey, Moriel Vandsburger, Jonathan K Watts, Kevin D Wells, Scot A Wolfe, Qiaobing Xu, Wen Xue, Guohua Yi, and Jiangbing Zhou
The Role of STK35 in Germ Cell Development and Fertility, Bailey Shevenell
The Role of TIMP3 Mutation on the Development of Age-Related Macular Degeneration, Nicole Wilkinson
The Salivary Mycobiome Contains 2 Ecologically Distinct Mycotypes., Bo-Young Hong, A Hoare, A Cardenas, A K Dupuy, L Choquette, A L Salner, P K Schauer, U Hegde, D E Peterson, A Dongari-Bagtzoglou, L D Strausbaugh, and P I Diaz
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing., Sara Parsa, Ana Ortega-Molina, Hsia-Yuan Ying, Man Jiang, Matt Teater, Jiahui Wang, Chunying Zhao, Ed Reznik, Joyce P Pasion, David Kuo, Prathibha Mohan, Shenqiu Wang, Jeannie M Camarillo, Paul M Thomas, Neeraj Jain, Javier Garcia-Bermudez, Byoung-Kyu Cho, Wayne Tam, Neil L Kelleher, Nicholas Socci, Ahmet Dogan, Elisa De Stanchina, Giovanni Ciriello, Michael R Green, Sheng Li, Kivanc Birsoy, Ari M Melnick, and Hans-Guido Wendel
Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice., Ivy L Debreceni, Michael S Chimenti, David V. Serreze, Aron M Geurts, Yi-Guang Chen, and Scott M Lieberman
Transcription factors, their targets, and their role in breast cancer, Jessica Creelman
Transfer learning-trained convolutional neural networks identify novel MRI biomarkers of Alzheimer's disease progression., Yi Li, Annat Haber, Christoph Preuss, Cai John, Asli Uyar, Hongtian Stanley Yang, Benjamin A Logsdon, Vivek M. Philip, Radha Krishna Murthy Karuturi, Gregory W. Carter, and Alzheimer's Disease Neuroimaging Initative
Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank., Michael P Vitek, Joseph A Araujo, Michael Fossel, Barry D Greenberg, Gareth R Howell, Stacey J Sukoff Rizzo, Nicholas T Seyfried, Andrea J Tenner, Paul R Territo, Manfred Windisch, Lisa J Bain, April Ross, Maria C Carrillo, Bruce T Lamb, and Rebecca M Edelmayer
Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity., Zhengzheng S Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E Vancollie, Ximena Ibarra-Soria, Helen V Firth, Debra Rimmington, I Sadaf Farooqi, Christopher J Lelliott, Steven C. Munger, Stephen O'Rahilly, Anne C Ferguson-Smith, Anthony P Coll, and Darren W Logan
tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase., Amila Zuko, Moushami Mallik, Robin Thompson, Emily L Spaulding, Anne R Wienand, Marije Been, Abigail L D Tadenev, Nick van Bakel, Céline Sijlmans, Leonardo A Santos, Julia Bussmann, Marica Catinozzi, Sarada Das, Divita Kulshrestha, Robert W. Burgess, Zoya Ignatova, and Erik Storkebaum
TRPV4 Antagonism Prevents Mechanically Induced Myotonia., Chris Dupont, Kevin Novak, Kirsten Denman, Jessica H Myers, Jeremy M Sullivan, Phillip V Walker, Nicklaus L Brown, David R Ladle, Laurent P. Bogdanik, Cathleen Lutz, Andrew A Voss, Charlotte J Sumner, and Mark M Rich
Tryptophan catabolism reflects disease activity in human tuberculosis., Jeffrey M Collins, Amnah Siddiqa, Dean P Jones, Ken Liu, Russell R Kempker, Azhar Nizam, N Sarita Shah, Nazir Ismail, Samuel G Ouma, Nestani Tukvadze, Shuzhao Li, Cheryl L Day, Jyothi Rengarajan, James Cm Brust, Neel R Gandhi, Joel D Ernst, Henry M Blumberg, and Thomas R Ziegler
Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart., Elvira Forte, Mona Panahi, Nicoleta Baxan, Fu Siong Ng, Joseph J Boyle, Jane Branca, Olivia Bedard, Muneer G. Hasham, Lindsay Benson, Sian E Harding, Nadia Rosenthal, and Susanne Sattler
Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H., Kevin P Kotredes, Adrian Oblak, Ravi S Pandey, Peter Bor-Chian Lin, Dylan Garceau, Harriet M. Jackson, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarycek, Melisa Belanger, Zackary Cope, Kate E Foley, Benjamin A Logsdon, Lara M Mangravite, Stacey J Sukoff Rizzo, Paul R Territo, Gregory W. Carter, Michael Sasner, Bruce T Lamb, and Gareth R Howell
Uncovering Modifier Genes of X-Linked Alport Syndrome Using a Novel Multiparent Mouse Model., Yuka Takemon, Valerie Wright, Bernard Davenport, Daniel M. Gatti, Susan Sheehan, Kelsey Letson, Holly S Savage, Rachel Lennon, and Ron Korstanje
Understanding the Role of Fibroblasts post-Myocardial Infarction, Maureen Ekwebelem
Using Genetic and Species Diversity to Tackle Kidney Disease., Michael R Garrett and Ron Korstanje
Utilizing image and caption information for biomedical document classification., Pengyuan Li, Xiangying Jiang, Gongbo Zhang, Juan Trelles Trabucco, Daniela Raciti, Cynthia Smith, Martin Ringwald, G Elisabeta Marai, Cecilia Arighi, and Hagit Shatkay
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy., Matthias Gromeier, Michael C Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, Hai Yan, Yiping He, Annick Desjardins, James E Herndon, Frederick S Varn, Roel G W Verhaak, Junfei Zhao, Dani P Bolognesi, Allan H Friedman, Henry S Friedman, Frances McSherry, Andrea M Muscat, Eric S Lipp, Smita K Nair, Mustafa Khasraw, Katherine B Peters, Dina Randazzo, John H Sampson, Roger E McLendon, Darell D Bigner, and David M Ashley
Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis., Marion Failler, Ariadna Giro-Perafita, Mikito Owa, Shalini Srivastava, Chi Yun, David J Kahler, Derya Unutmaz, Francisco J Esteva, Irma Sánchez, and Brian D Dynlacht
Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse., Ruby Boateng, Nathaniel Boechat, Philipp P Henrich, and Ewelina Bolcun-Filas