Content Posted in 2024
2003 Annual Report, The Jackson Laboratory
2003 Annual Report, The Jackson Laboratory
2004 Annual Report, The Jackson Laboratory
2005 Annual Report, The Jackson Laboratory
2007 Annual Report, The Jackson Laboratory
2008 Annual Report, The Jackson Laboratory
2009 Annual Report, The Jackson Laboratory
2010 Annual Report, The Jackson Laboratory
2011 Annual Report, The Jackson Laboratory
2012 Annual Report, The Jackson Laboratory
2013 Annual Report, The Jackson Laboratory
2014 Annual Report, The Jackson Laboratory
2015 Annual Report, The Jackson Laboratory
2016 Annual Report, The Jackson Laboratory
2017 Annual Report, The Jackson Laboratory
2018 Annual Report, The Jackson Laboratory
2019 Annual Report, The Jackson Laboratory
3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease., Selene Lomoio, Ravi S Pandey, Nicolas Rouleau, Beatrice Menicacci, WonHee Kim, William L Cantley, Philip G Haydon, David A Bennett, Tracy L Young-Pearse, Gregory W. Carter, David L Kaplan, and Giuseppina Tesco
3D convolutional neural networks predict cellular metabolic pathway use from fluorescence lifetime decay data., Linghao Hu, Daniela De Hoyos, Yuanjiu Lei, A Phillip West, and Alex J Walsh
3-Hydroxyanthranilic Acid Delays Paralysis in, Bradford T Hull, Kayla M Miller, Caroline Corban, Grant Backer, Susan Sheehan, Ron Korstanje, and George L. Sutphin
AAV8 gene therapy reverses cardiac pathology and prevents early mortality in a mouse model of Friedreich's ataxia., Joshua C Chang, Molly R Ryan, Marie C Stark, Su Liu, Pravinkumar Purushothaman, Fria Bolan, Caitlin A Johnson, Mark Champe, Hui Meng, Michael W Lawlor, Sarah Halawani, Lucie V Ngaba, David R Lynch, Crystal Davis, Elena Gonzalo-Gil, Cathleen Lutz, Fabrizia Urbinati, Bala Medicherla, and Carlos Fonck
Aberrant RNA Splicing and Therapeutic Reprogramming in Cancer, Nathan Leclair, Brittany Lynn Angarola, and Olga Anczuków
A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2., Caryl A Young, Emily Burt, and Vidhya Munnamalai
A corpus of GA4GH phenopackets: Case-level phenotyping for genomic diagnostics and discovery., Daniel Danis, Michael J Bamshad, Yasemin Bridges, Andrés Caballero-Oteyza, Pilar Cacheiro, Leigh Carmody, Leonardo Chimirri, Jessica X Chong, Ben D Coleman, Raymond Dalgleish, Peter J Freeman, Adam S L Graefe, Tudor Groza, Peter Hansen, Julius O B Jacobsen, Adam Klocperk, Maaike Kusters, Markus S Ladewig, Anthony J Marcello, Teresa Mattina, Christopher J Mungall, Monica C Munoz-Torres, Justin T Reese, Filip Rehburg, Bárbara C S Reis, Catharina Schuetz, Damian Smedley, Timmy Strauss, Jagadish Chandrabose Sundaramurthi, Sylvia Thun, Kyran Wissink, John F Wagstaff, David Zocche, Melissa A Haendel, and Peter N Robinson
A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo., Camille M Hanes, Kar Men Mah, David M Steffen, Cathy M McLeod, Charles G Marcucci, Leah C Fuller, Robert W. Burgess, Andrew M Garrett, and Joshua A Weiner
Active Molecular Network Discovery Links Lifestyle Variables to Breast Cancer in the Long Island Breast Cancer Study Project., Miao Yu, Qian Li, Georgia Dolios, Peijun Tu, Susan Teitelbaum, Jia Chen, and Lauren Petrick
Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo., Daniel M Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J Park, Victoria L Hewitt, David Zhang, Kevin C Gonzalez, Fiona M Russell, D Grahame Hardie, Julien Prudent, Erik B Bloss, Attila Losonczy, Franck Polleux, and Tommy L Lewis
Activity-dependent transcriptional programs in memory regulate motor recovery after stroke., Mary T Joy and S Thomas Carmichael
A data browsing application for accessing gene and module-level blood transcriptome profiles of healthy pregnant women from high- and low-resource settings., Darawan Rinchai, Tobias Brummaier, Alexandra A Marr, Tanwir Habib, Mohammed Toufiq, Tomoshigue Kino, François Nosten, Souhaila Al Khodor, Annalisa Terranegra, Rose McGready, Basirudeen Syed Ahamed Kabeer, and Damien Chaussabel
Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis., Feng Xiao, Ngoc Uyen Nhi Nguyen, Ping Wang, Shujuan Li, Ching-Cheng Hsu, Suwannee Thet, Wataru Kimura, Xiang Luo, Nicholas T Lam, Ivan Menendez-Montes, Waleed M Elhelaly, Alisson Campos Cardoso, Ana Helena Macedo Pereira, Rohit Singh, Sakthivel Sadayappan, Mohammed Kanchwala, Chao Xing, Feria A Ladha, J Travis Hinson, Roger J Hajjar, Joseph A Hill, and Hesham A Sadek
A dual covariant biomarker approach to Kawasaki disease, using vascular endothelial growth factor A and B gene expression; implications for coronary pathogenesis, Asrar Rashid, Govind Benakatti, Feras Al-Obeidat, Rajesh Phatak, Zainab A. Malik, Javed Sharief, Raziya Kadwa, Wael Hafez, Mohammed Toufiq, Damien Chaussabel, Rayaz Malik, Nasir Quraishi, Syed Ahmed Zaki, Guftar Shaikh, and Amir Hussain
Advancing Animal Models of Human Type 1 Diabetes., David V. Serreze, Jennifer R Dwyer, and Jeremy Racine
Advancing Genomic Cancer Medicine in Rural and Underserved States., Jens Rueter and Edison Liu
Advancing sepsis clinical research: harnessing transcriptomics for an omics-based strategy - a comprehensive scoping review, Asrar Rashid, Feras Al-Obeidat, Hari Krishnan Kanthimathinathan, Govind Benakatti, Wael Hafez, Raghu Ramiah, Joe Brierley, Benjamin Hanisch, Praveen Khilnani, Christos Kouentis, Berit S. Brusletto, Mohammed Toufiq, Zain Hussain, Harish Vyas, Zainab A. Malik, Maike Schumacher, Rayaz Malik, Shriprasad Deshpande, Nasir Quraishi, Raziya Kadwa, Amrita Sarpal, M. Guftar Shaikh, Javed Sharief, Syed Ahmed Zaki, Rajesh Phatak, Akash Deep, Ahmed Al-Dubai, and Amir Hussain
Advancing stem cell technologies for conservation of wildlife biodiversity., Ashlee M Hutchinson, Ruth Appeltant, Tom Burdon, Qiuye Bao, Rhishikesh Bargaje, Andrea Bodnar, Stuart Chambers, Pierre Comizzoli, Laura Cook, Yoshinori Endo, Bob Harman, Katsuhiko Hayashi, Thomas Hildebrandt, Marisa L Korody, Uma Lakshmipathy, Jeanne F Loring, Clara Munger, Alex H M Ng, Ben Novak, Manabu Onuma, Sara Ord, Monique Paris, Andrew J Pask, Francisco Pelegri, Martin Pera, Ryan Phelan, Benyamin Rosental, Oliver A Ryder, Woranop Sukparangsi, Gareth Sullivan, Nicole Liling Tay, Nikki Traylor-Knowles, Shawn Walker, Antonia Weberling, Deanne J Whitworth, Suzannah A Williams, Jessye Wojtusik, Jun Wu, Qi-Long Ying, Thomas P Zwaka, and Timo N Kohler
Age, sex and Alzheimer's disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer's patients., Alicia J Barber, Carmen L Del Genio, Anna Beth Swain, Elizabeth M Pizzi, Sarah C Watson, Vedant N Tapiavala, George J Zanazzi, and Arti B Gaur
Aging and urinary control: Alterations in the brain-bladder axis., Cara C Hardy and Ron Korstanje
A graph theoretical approach to experimental prioritization in genome-scale investigations., Stephen K Grady, Kevin A Peterson, Stephen A. Murray, Erich J Baker, Michael A Langston, and Elissa J Chesler
A hematology-based clock derived from the Study of Longitudinal Aging in Mice to estimate biological age., Jorge Martinez-Romero, Maria Emilia Fernandez, Michel Bernier, Nathan L Price, William Mueller, Julián Candia, Simonetta Camandola, Osorio Meirelles, Yi-Han Hu, Zhiguang Li, Nigus Asefa, Andrew Deighan, Camila Vieira Ligo Teixeira, Dushani L Palliyaguru, Carlos Serrano, Nicolas Escobar-Velasquez, Stephanie Dickinson, Eric J Shiroma, Luigi Ferrucci, Gary Churchill, David B Allison, Lenore J Launer, Rafael de Cabo, and The Study of Longitudinal Aging in Mice (SLAM) Investigators
A host-microbiota interactome reveals extensive transkingdom connectivity., Nicole D Sonnert, Connor E Rosen, Andrew R Ghazi, Eric A Franzosa, Brianna Duncan-Lowey, Jaime A González-Hernández, John D Huck, Yi Yang, Yile Dai, Tyler A Rice, Mytien T Nguyen, Deguang Song, Yiyun Cao, Anjelica L Martin, Agata A Bielecka, Suzanne Fischer, Changhui Guan, Julia Oh, Curtis Huttenhower, Aaron M Ring, and Noah W Palm
Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity., Domenico Tricò, Martina Chiriacò, Jessica Nouws, Alla Vash-Margita, Romy Kursawe, Elena Tarabra, Alfonso Galderisi, Andrea Natali, Cosimo Giannini, Marc Hellerstein, Ele Ferrannini, and Sonia Caprio
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition., Sana Chaudhry, Felipe Beckedorff, Shaista Shabbir Jasdanwala, Tulasigeri M Totiger, Maurizio Affer, Abimbola Eunice Lawal, Skye Montoya, Francesco Tamiro, Olivia Tonini, Alexandra Chirino, Andrew Adams, Anya K Sondhi, Stephen Noudali, Alyssa Mauri Cornista, Miah Nicholls, Jumana Afaghani, Paola Robayo, Daniel Bilbao, Stephen D Nimer, Jose Antonio Rodríguez, Shruti Bhatt, Eric Wang, and Justin Taylor
A machine learning approach for quantifying age-related histological changes in the mouse kidney., Susan Sheehan, Seamus Mawe, Mandy Chen, Jenna Klug, Warren Ladiges, Ron Korstanje, and J Matthew Mahoney
Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells., Katarina Kulhankova, Anna X Cheng, Soumba Traore, Maud Auger, Mia Pelletier, Maxime Hervault, Kevin D Wells, Jonathan A Green, Addison Byrne, Benjamin Nelson, Mariana Sponchiado, Chandra Boosani, Caleb S Heffner, Kathy J. Snow, Stephen A. Murray, Raul A Villacreses, Michael V Rector, Nicholas D Gansemer, David A Stoltz, Chantal Allamargot, Frédéric Couture, Colin Hemez, Stéphanie Hallée, Xavier Barbeau, Mario Harvey, Coraline Lauvaux, Bruno Gaillet, Gregory A Newby, David R Liu, Paul B McCray, and David Guay
An emerging multi-omic understanding of the genetics of opioid addiction., Eric O Johnson, Heidi S Fisher, Kyle A Sullivan, Olivia Corradin, Sandra Sanchez-Roige, Nathan C Gaddis, Yasmine N Sami, Alice Townsend, Erica Teixeira Prates, Mirko Pavicic, Peter Kruse, Elissa J Chesler, Abraham A Palmer, Vanessa Troiani, Jason A. Bubier, Daniel A Jacobson, and Brion S Maher
An evaluation of GPT models for phenotype concept recognition., Tudor Groza, Harry Caufield, Dylan Gration, Gareth Baynam, Melissa A Haendel, Peter N Robinson, Christopher J Mungall, and Justin T Reese
A new era in quantification of animal social behaviors., Jessica D Choi and Vivek Kumar
An interactive web application for exploring systemic lupus erythematosus blood transcriptomic diversity., Eléonore Bettacchioli, Laurent Chiche, Damien Chaussabel, Divi Cornec, Noémie Jourde-Chiche, and Darawan Rinchai
An in vitro neurogenetics platform for precision disease modeling in the mouse., Daniel Cortes, Mélanie Escudero, Austin C Korgan, Arojit Mitra, Alyssa Edwards, Selcan Aydin, Steven C. Munger, Kevin Charland, Zhong-Wei Zhang, Kristen M S O'Connell, Laura G Reinholdt, and Martin Pera
Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats., Shumuye Belay, Gurja Belay, Helen Nigussie, Abulgasim M Ahbara, Abdulfatai Tijjani, Tadelle Dessie, Getinet M Tarekegn, Han Jian-Lin, Siobhan Mor, Helina S Woldekiros, Keith Dobney, Ophelie Lebrasseur, Olivier Hanotte, and Joram M Mwacharo
Anti-cytomegalovirus antibody levels stratify human immune profiles across the lifespan., Makiko Watanabe, Lisa Davidson, Patricia Smith, Peter F Castellucio, Mladen Jergovic, Jennifer L Uhrlaub, Megan J Smithey, Lori E Fantry, Brett Dechambre, Rachel C Wilson, Kenneth C Knox, Jie Ren, Raymond P Stowe, George M. Weinstock, Homer Twigg, and Janko Ž Nikolich
A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis, Brian S White, Xing Yi Woo, Soner Koc, Todd B Sheridan, Steven Neuhauser, Shidan Wang, Yvonne A. Evrard, Li Chen, Ali Foroughi Pour, John D. Landua, R Jay Mashl, Sherri R. Davis, Bingliang Fang, Maria Gabriela Rosa, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill C Rubinstein, Brian J Sanderson, Michael W Lloyd, Sergii Domanskyi, Lacey E. Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, Saul Acevedo, PDXNet Consortium, Brandi N. Davis-Dusenbery, Peter N Robinson, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Luis G. Caravajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J Bult, Dennis A. Dean II, and Jeffrey Chuang
Application of a gene modular approach for clinical phenotype genotype association and sepsis prediction using machinApplication of a gene modular approach for clinical phenotype genotype association and sepsis prediction using machine learning in meningococcal sepsise learning in meningococcal sepsis, Asrar Rashid, Arif Anwary, Feras Al-Obeidat, Joe Brierley, Mohammed Uddin, Hoda Alkhzaimi, Amrita Sarpal, Mohammed Toufiq, Zainab Malik, Raziya Kadwa, Praveen Khilnani, M Guftar Shaikh, Govind Benakatti, Javed Sharief, Syed Ahmed Zaki, Abdulrahman Zeyada, Ahmed Al-Dubai, Wael Hafez, and Amir Hussain
Applications of Organoids in Advancing Drug Discovery and Development., Indiwari Gopallawa, Charu Gupta, Rayan Jawa, Arya Cyril, Vibha Jawa, Narendra Chirmule, and Vikramsingh Gujar
ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification., Samantha M Barnada, Aida Giner de Gracia, Cruz Morenilla-Palao, Maria Teresa López-Cascales, Chiara Scopa, Francis J Waltrich, Harald M M Mikkers, Maria Elena Cicardi, Jonathan Karlin, Davide Trotti, Kevin A Peterson, Samantha A Brugmann, Gijs W E Santen, Steven B McMahon, Eloísa Herrera, and Marco Trizzino
A serum-induced gene signature in hepatocytes is associated with pediatric nonalcoholic fatty liver disease., T Hang Nghiem-Rao, Jethro Johnson, Amy Pan, Samantha N Atkinson, Cynthia Behling, Pippa M Simpson, Mary L Holtz, George M. Weinstock, Jeffrey B Schwimmer, and Nita H Salzman
A signature of five 7-methylguanosine-related genes is a prognostic marker for lung squamous cell carcinoma., Wensheng Liu, Ying Wang, Paola Ulivi, Simona Tavolari, Syed A A Rizvi, Enrico Capobianco, Alfons Navarro, and Yongjun Zhang
A single-cell time-lapse of mouse prenatal development from gastrula to birth., Chengxiang Qiu, Beth K Martin, Ian C Welsh, Riza M Daza, Truc-Mai Le, Xingfan Huang, Eva K Nichols, Megan L Taylor, Olivia Fulton, Diana R O'Day, Anne Roshella Gomes, Saskia Ilcisin, Sanjay Srivatsan, Xinxian Deng, Christine M Disteche, William Stafford Noble, Nobuhiko Hamazaki, Cecilia B Moens, David Kimelman, Junyue Cao, Alexander F Schier, Malte Spielmann, Stephen A. Murray, Cole Trapnell, and Jay Shendure
Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction., Kristen D. Onos, Peter B Lin, Ravi S Pandey, Scott A Persohn, Charles P Burton, Ethan W Miner, Kierra Eldridge, Jonathan Nyandu Kanyinda, Kate E Foley, Gregory W. Carter, Gareth R Howell, and Paul R Territo
Assessment of Patient-Derived Xenograft Growth and Antitumor Activity: The NCI PDXNet Consensus Recommendations., Funda Meric-Bernstam, Michael W Lloyd, Soner Koc, Yvonne A Evrard, Lisa M McShane, Michael T Lewis, Kurt W Evans, Dali Li, Lawrence Rubinstein, Alana Welm, Dennis A Dean, Anuj Srivastava, Jeffrey W Grover, Min J Ha, Huiqin Chen, Xuelin Huang, Kaushik Varadarajan, Jing Wang, Jack A Roth, Bryan Welm, Ramaswamy Govinden, Li Ding, Salma Kaochar, Nicholas Mitsiades, Luis Carvajal-Carmona, Meenhard Herylyn, Michael A Davies, Geoffrey I Shapiro, Ryan Fields, Jose G Trevino, Joshua C Harrell, NCI PDXNet Consortium, James H Doroshow, Jeffrey Chuang, and Jeffrey A Moscow
Association of post-COVID phenotypic manifestations with new-onset psychiatric disease., Ben D Coleman, Elena Casiraghi, Tiffany J Callahan, Hannah Blau, Lauren E Chan, Bryan Laraway, Kevin B Clark, Yochai Re'em, Ken R Gersing, Kenneth J Wilkins, Nomi L Harris, Giorgio Valentini, Melissa A Haendel, Justin T Reese, and Peter N Robinson
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used., David E Harrison, Randy Strong, Peter C. Reifsnyder, Nadia Rosenthal, Ron Korstanje, Elizabeth Fernandez, Kevin Flurkey, Brett C Ginsburg, Meredith D Murrell, Martin A Javors, Marisa Lopez-Cruzan, James F Nelson, Bradley J Willcox, Richard Allsopp, David M Watumull, David G Watumull, Gino Cortopassi, James L Kirkland, Tamar Tchkonia, Young Geun Choi, Matthew J Yousefzadeh, Paul D Robbins, James R Mitchell, Murat Acar, Ethan A Sarnoski, Michael R Bene, Adam Salmon, Navasuja Kumar, and Richard A Miller
A systematic strategy for identifying causal single nucleotide polymorphisms and their target genes on Juvenile arthritis risk haplotypes., Kaiyu Jiang, Tao Liu, Susan Kales, Ryan Tewhey, Dongkyeong Kim, Yungki Park, and James N Jarvis
A team-based approach to cardiogenomic education., Emily A Edelman, Kalisi Logan, Therese Ingram, Kate Reed, Catherine Wicklund, Debra Duquette, and Lisa Dellefave-Castillo
Autoregulated splicing of TRA2β programs T cell fate in response to antigen-receptor stimulation, Timofey A Karginov, Antoine Ménoret, Nathan Leclair, Andrew G Harrison, Karthik Chandiran, Jenny E Suarez-Ramirez, Marina Yurieva, Keaton Karlinsey, Penghua Wang, Rachel J O'Neill, Patrick A Murphy, Adam J Adler, Linda S Cauley, Olga Anczuków, Beiyan Zhou, and Anthony T Vella
B cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic, Deniz Koyuncu, Thomas Tavolara, Daniel Mario Gatti, Adam C Gower, Melanie L Ginese, Igor Kramnik, Bülent Yener, Usama Sajjad, Muhammad Khalid Khan Niazi, Metin Gurcan, Anas Alsharaydeh, and Gillian Beamer
Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations., Elizabeth A Werren, Emily R Peirent, Henna Jantti, Alba Guxholli, Kinshuk Raj Srivastava, Naama Orenstein, Vinodh Narayanan, Wojciech Wiszniewski, Mateusz Dawidziuk, Pawel Gawlinski, Muhammad Umair, Amjad Khan, Shahid Niaz Khan, David Geneviève, Daphné Lehalle, K L I van Gassen, Jacques C Giltay, Renske Oegema, Richard H van Jaarsveld, Rafiullah Rafiullah, Gudrun A Rappold, Rachel Rabin, John G Pappas, Marsha M Wheeler, Michael J Bamshad, Yao-Chang Tsan, Matthew B Johnson, Catherine E Keegan, Anshika Srivastava, and Stephanie L Bielas
Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma., Mason McCrury, Kennith Swafford, Sydnye L Shuttleworth, Syed Hassan Mehdi, Baku Acharya, Debasmita Saha, Kevin Naceanceno, Stephanie D Byrum, Aaron J Storey, Ying-Zhi Xu, Claire Doshier, Vijay Patel, Ginell R Post, Annick De Loose, Analiz Rodriguez, Leonard D. Shultz, Fenghuang Zhan, Donghoon Yoon, Brendan Frett, and Samantha Kendrick
Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes., Travis Nemkov, Daniel Stephenson, Eric J Earley, Gregory R Keele, Ariel Hay, Alicia Key, Zachary B Haiman, Christopher Erickson, Monika Dzieciatkowska, Julie A Reisz, Amy Moore, Mars Stone, Xutao Deng, Steven Kleinman, Steven L Spitalnik, Eldad A Hod, Krystalyn E Hudson, Kirk C Hansen, Bernhard O Palsson, Gary Churchill, Nareg Roubinian, Philip J Norris, Michael P Busch, James C Zimring, Grier P Page, and Angelo D'Alessandro
Blackcurrants shape gut microbiota profile and reduce risk of postmenopausal osteoporosis via the gut-bone axis: Evidence from a pilot randomized controlled trial., Briana M Nosal, Staci N Thornton, Manije Darooghegi Mofrad, Junichi R Sakaki, Kyle J Mahoney, Zachary Macdonald, Lauren Daddi, Thi Dong Binh Tran, George M. Weinstock, Yanjiao Zhou, Elaine Choung-Hee Lee, and Ock K Chun
Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model., Maximiliano Presa, Vi Pham, Somdatta Ray, Pierre-Alexandre Piec, Jennifer L Ryan, Timothy Billings, Harold Coombs, Lars Schlotawa, Troy Lund, Rebecca C Ahrens-Nicklas, and Cathleen Lutz
Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy., Elena R Rhymes, Rebecca L Simkin, Ji Qu, David Villarroel-Campos, Sunaina Surana, Yao Tong, Ryan Shapiro, Robert W. Burgess, Xiang-Lei Yang, Giampietro Schiavo, and James N Sleigh
CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods., The Critical Assessment of Genome Interpretation Consortium
Candidate signatures of positive selection for environmental adaptation in indigenous African cattle: A review., Sumaya Kambal, Abdulfatai Tijjani, Sabah A E Ibrahim, Mohamed-Khair A Ahmed, Joram M Mwacharo, and Olivier Hanotte
CDK4/6 inhibition enhances T-cell immunotherapy on hepatocellular carcinoma cells by rejuvenating immunogenicity., Xiurong Cai, Guo Yin, Shuai Chen, Frank Tacke, Adrien Guillot, and Hanyang Liu
Centromere innovations within a mouse species., Craig W Gambogi, Nootan Pandey, Jennine M Dawicki-McKenna, Uma P Arora, Mikhail A Liskovykh, Jun Ma, Piero Lamelza, Vladimir Larionov, Michael A Lampson, Glennis A Logsdon, Beth L Dumont, and Ben E Black
Chapter 18 - Genetic modification of mice using CRISPR-Cas9: Best practices and practical concepts explained, Vishnu Hosur, Benjamin E. Low, and Michael V. Wiles
Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19., Candice N Baker, Debra Duso, Nagarama Kothapalli, Tricia Hart, Sean Casey, Tres Cookenham, Larry Kummer, Janine Hvizdos, Kathleen Lanzer, Purva Vats, Priya Shanbhag, Isaac Bell, Mike Tighe, Kelsey Travis, Frank Szaba, Jeffrey M. Harder, Olivia Bedard, Natalie Oberding, Jerrold M Ward, Mark D Adams, Cathleen Lutz, Shelton S Bradrick, William W Reiley, and Nadia Rosenthal
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM., Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory Cary, Gregory W. Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, the Emory-Sage-SGC TREAT-AD Center, and Alison D Axtman
Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology., Kevin P Kotredes, Ravi S Pandey, Scott Persohn, Kierra Elderidge, Charles P Burton, Ethan W Miner, Kathryn A Haynes, Diogo Francisco S Santos, Sean-Paul Williams, Nicholas Heaton, Cynthia M Ingraham, Christopher Lloyd, Dylan Garceau, Rita O'Rourke, Sarah Herrick, Claudia Rangel-Barajas, Surendra Maharjan, Nian Wang, Michael Sasner, Bruce T Lamb, Paul R Territo, Stacey J Sukoff Rizzo, Gregory W. Carter, Gareth R Howell, and Adrian L Oblak
Chemokines in the tumor microenvironment: implications for lung cancer and immunotherapy., Haebeen Jung and Silke Paust
Chromosome-Level Genome Assembly for the Angiosperm Silene conica., Peter D Fields, Melody M Weber, Gus Waneka, Amanda K Broz, and Daniel B Sloan
Circulating Growth Differentiation Factors 11 and 8, Their Antagonists Follistatin and Follistatin-Like-3, and Risk of Heart Failure in Elders., Jorge R Kizer, Sheena Patel, Peter Ganz, Anne B Newman, Shalender Bhasin, Se-Jin Lee, Peggy M Cawthon, Nathan K LeBrasseur, Sanjiv J Shah, Bruce M Psaty, Russell P Tracy, and Steven R Cummings
Clinically relevant mouse models of severe spinal muscular atrophy with respiratory distress type 1., Sarah E Holbrook, Amy N Hicks, Paige B Martin, Timothy J Hines, Harold P Castro, and Gregory A. Cox
Closing the gap: using the ECHO model to improve access to hereditary colorectal cancer risk assessment and genetic counseling in the rural setting, Stephanie Sharp, Linda Steinmark, Emily A Edelman, Kate Reed, Kelly Barnes, and Susan Miesfeldt
Co-expression of prepulse inhibition and schizophrenia genes in the mouse and human brain, Lillian Garrett, Dietrich Trümbach, Donghyung Lee, Silvia Mandillo, Rodney Samaco, Ann M. Flenniken, Michelle Stewart, IMPC Consortium, Jacqueline K White, Colin McKerlie, Lauryl M.J. Nutter, Igor Vukobradovic, Surabi Verraragavan, Lisa Yuva, Jason D. Heaney, Mary E. Dickinson, Hamid Meziane, Yann Hérault, Sara Wells, K.C. Kent Lloyd, Lynette Bower, Louise Lanaue, Dave Clary, Annemarie Zimprich, Valerie Gailus-Durner, Helmut Fuchs, Steve D.M. Brown, Elissa J Chesler, Wolfgang Wurst, Martin Hrabě de Angelis, and Sabine M. Hölter
Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma., Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Yvonne A Evrard, Bryan E Welm, David Lum, Mei Yee Koh, Alana L Welm, Jeffrey Chuang, Jeffrey A Moscow, Funda Meric-Bernstam, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Hui Zhang, Li Ding, and Feng Chen
Common data models to streamline metabolomics processing and annotation, and implementation in a Python pipeline., Joshua M Mitchell, Yuanye Chi, Maheshwor Thapa, Zhiqiang Pang, Jianguo Xia, and Shuzhao Li
Complex regulatory networks influence pluripotent cell state transitions in human iPSCs., Timothy D Arthur, Jennifer P Nguyen, Agnieszka D'Antonio-Chronowska, Hiroko Matsui, Nayara S Silva, Isaac N Joshua, iPSCORE Consortium, André D Luchessi, William W Young Greenwald, Matteo D'Antonio, Martin Pera, and Kelly A Frazer
Comprehensive metabolomic analysis identifies key biomarkers and modulators of immunotherapy response in NSCLC patients., Se-Hoon Lee, Sujeong Kim, Jueun Lee, Yunjae Kim, Yanghyun Joo, Jun-Yeong Heo, Heeyeon Lee, Charles Lee, Geum-Sook Hwang, and Hansoo Park
Computational immune synapse analysis reveals T-cell interactions in distinct tumor microenvironments., Victor G Wang, Zichao Liu, Jan Martinek, Ali Foroughi Pour, Jie Zhou, Hannah Boruchov, Kelly Ray, Karolina Palucka, and Jeffrey Chuang
Computer vision segmentation model—deep learning for categorizing microplastic debris, Sarah-Jeanne Royer, Helen Wolter, Astrid E. Delorme, Laurent Lebreton, and Olivier Poirion
Concomitant Ultrarare Mutations in TLR3 and CTPS2 in a Patient with Severe and Recurrent Respiratory Infections in Early Life., Salim Bougarn, Andrea Guennoun, Taushif Khan, Rafah Mackeh, Mehdi Adeli, and Nico Marr
Consensus and controversy in the management of paediatric and adult patients with ovarian immature teratoma: the Malignant Germ Cell International Consortium perspective., Farzana Pashankar, Matthew J Murray, Joanna J Gell, Nicola MacDonald, Jonathan Shamash, Deborah F Billmire, Lindsay Klosterkemper, Thomas Olson, Michelle S Hirsch, Michelle Lockley, Sara Stoneham, and A Lindsay Frazier
Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein., Bu-Nam Jeon, Sujeong Kim, Yunjae Kim, Hyunkyung Yu, Changho Park, Gihyeon Kim, Youngeun Ha, Gyeong-Yeon Kim, Hyunuk Kim, Karolina Palucka, Charles Lee, Miyoung Cha, and Hansoo Park
Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice., Jake W Willows, Zahra Alshahal, Naeemah M Story, Michele J Alves, Pablo Vidal, Hallie Harris, Rochelle Rodrigo, Kristin I Stanford, Juan Peng, Peter C. Reifsnyder, David E Harrison, W David Arnold, and Kristy L Townsend
Control of hippocampal synaptic plasticity by microglia-dendrite interactions depends on genetic context in mouse models of Alzheimer's disease., Sarah E Heuer, Kelly J Keezer, Amanda A Hewes, Kristen D. Onos, Kourtney Graham, Gareth R Howell, and Erik B Bloss
Co-transfection of murine NXPE2 and murine glycophorin A confers reactivity with Ter-119., Gregory R Keele, Ariel M Hay, Nadia K Holness, Arijita Jash, Sarah E Ewald, Callan O'Connor, Matthew J Vincent, Monika Dzieciatkowska, Angelo D'Alessandro, Gary Churchill, and James C Zimring
Cross-sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice., Cody M Cousineau, Kaelin Loftus, Gary Churchill, and Dave Bridges
Current Protocols: Alopecia Areata Mouse Models for Drug Efficacy and Mechanism Studies., John P Sundberg, Eddy H C Wang, and Kevin J McElwee
Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML., Ataur Katebi, Xiaowen Chen, Daniel Ramirez, Sheng Li, and Mingyang Lu
David J. Glass elected to the U.S. National Academy of Sciences., Se-Jin Lee, Bruce Spiegelman, and Kevin Campbell
Deletion of Vβ3, Cheng Ye, Sadie A Clements, Weihong Gu, Aron M Geurts, Clayton E Mathews, David V. Serreze, Yi-Guang Chen, and John P Driver
De novo, Jagadish Chandrabose Sundaramurthi, Anita M Bagley, Hannah Blau, Leigh Carmody, Amy Crandall, Daniel Danis, Michael Gargano, Anxhela Gjyshi Gustafson, Ellen M Raney, Mallory Shingle, Jon R Davids, and Peter N Robinson
Design of a targeted blood transcriptional panel for monitoring immunological changes accompanying pregnancy., Tobias Brummaier, Darawan Rinchai, Mohammed Toufiq, Mohammed Y Karim, Tanwir Habib, Jürg Utzinger, Daniel H Paris, Rose McGready, Alexandra K Marr, Tomoshige Kino, Annalisa Terranegra, Souhaila Al Khodor, Damien Chaussabel, and Basirudeen Syed Ahamed Kabeer
Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model., Brianna Gurdon, Sharon C Yates, Gergely Csucs, Nicolaas E Groeneboom, Niran Hadad, Maria Telpoukhovskaia, Andrew R Ouellette, Tionna Ouellette, Kristen M S O'Connell, Surjeet Singh, Thomas J Murdy, Erin Merchant, Ingvild Bjerke, Heidi Kleven, Ulrike Schlegel, Trygve B Leergaard, Maja A Puchades, Jan G Bjaalie, and Catherine C Kaczorowski
Developing Quality Workforce Training: Breaking with Traditional Scoring, Kelly Brackett
Developing Quality Workforce Training: Considerations for the Adult Learner., Kelly Brackett
Developing Quality Workforce Training: Thoughtful Course Design, Kelly Brackett and Cheryl Thompson
Development and Application of Genetic Ancestry Reconstruction Methods to Study Diversity of Patient-Derived Models in the NCI PDXNet Consortium., Paul C Lott, Katherine Chiu, Juanita Elizabeth Quino, April Pangia Vang, Michael W Lloyd, Anuj Srivastava, Jeffrey Chuang, PDXNet Consortium, and Luis G Carvajal-Carmona
Development of an automated 3D high content cell screening platform for organoid phenotyping., Suleyman B Bozal, Greg Sjogren, Antonio P Costa, Joseph S Brown, Shannon Roberts, Dylan Baker, Paul Gabriel, Benjamin T Ristau, Michael Samuels, William F Flynn, Paul Robson, and Elise T Courtois
Development of New Diffuse Large B Cell Lymphoma Mouse Models., Syed Hassan Mehdi, Ying-Zhi Xu, Leonard D. Shultz, Eunkyung Kim, Yong Gu Lee, Samantha Kendrick, and Donghoon Yoon
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice., Sher Bahadur Poudel, Ryan R Ruff, Gozde Yildirim, Richard A Miller, David E Harrison, Randy Strong, Thorsten Kirsch, and Shoshana Yakar
Dietary restriction impacts health and lifespan of genetically diverse mice., Andrea Di Francesco, Andrew Deighan, Lev Litichevskiy, Zhenghao Chen, Alison Luciano, Laura Robinson, Gaven Garland, Hannah J Donato, Matthew J Vincent, William H. Schott, Kevin M Wright, Anil Raj, G V Prateek, Martin Mullis, Warren G Hill, Mark L Zeidel, Luanne L. Peters, Fiona Harding, David Botstein, Ron Korstanje, Christoph A Thaiss, Adam Freund, and Gary Churchill
Digitalization of toxicology: improving preclinical to clinical translation., Brian R Berridge, Szczepan W Baran, Vivek Kumar, Natalie Bratcher-Petersen, Michael Ellis, Chang-Ning Liu, and Timothy L Robertson
Discovery and validation of genes driving drug-intake and related behavioral traits in mice., Tyler A. Roy, Jason A. Bubier, Price E Dickson, Troy Wilcox, Juliet Ndukum, James Clark, S J Sukoff Rizzo, John C Crabbe, James M. Denegre, Karen L. Svenson, Robert E Braun, Vivek Kumar, Stephen A. Murray, Jacqueline K White, Vivek M. Philip, and Elissa J Chesler
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease., Yuhong Du, William J Bradshaw, Tina M Leisner, Joel K Annor-Gyamfi, Kun Qian, Frances M Bashore, Arunima Sikdar, Felix O Nwogbo, Andrey A Ivanov, Stephen V Frye, Opher Gileadi, Paul E Brennan, Allan I Levey, The Emory-Sage-SGC TREAT-AD Center, Alison D Axtman, Kenneth H Pearce, Haian Fu, and Vittorio L Katis
Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics., Rebecca L Koch, James B Stanton, Susan McClatchy, Gary Churchill, Steven W Craig, Darian N Williams, Mallory E Johns, Kylah R Chase, Dana L Thiesfeldt, Jessica C Flynt, and Robert Pazdro
Discovery of immunotherapy targets for pediatric solid and brain tumors by exon-level expression., Timothy I Shaw, Jessica Wagner, Liqing Tian, Elizabeth Wickman, Suresh Poudel, Jian Wang, Robin Paul, Selene C Koo, Meifen Lu, Heather Sheppard, Yiping Fan, Francis H O'Neill, Ching C Lau, Xin Zhou, Jinghui Zhang, and Stephen Gottschalk
Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults., Sathyabaarathi Ravichandran, Fernando Erra-Diaz, Emin Onur Karakaslar, Radu Marches, Lisa Kenyon-Pesce, Robert J Rossi, Damien Chaussabel, Djamel Nehar-Belaid, David C LaFon, Virginia Pascual, Karolina Palucka, Silke Paust, Moon H Nahm, George A Kuchel, Jacques Banchereau, and Duygu Ucar
Diverse wild-derived inbred strains provide a new community resource., Michael W Nachman and Beth L Dumont
Dominant NARS1 mutations causing axonal Charcot-Marie-Tooth disease expand NARS1-associated diseases, Danique Beijer, Sheila Marte, Jiaxin C Li, Willem De Ridder, Jessie Z Chen, Abby Tadenev, Kathy E Miers, Tine Deconinck, Richard Macdonell, Wilson Marques, Peter De Jonghe, Samia L Pratt, Rebecca Meyer-Schuman, Stephan Züchner, Anthony Antonellis, Robert W. Burgess, and Jonathan Baets
Dynamic Retrieval Augmented Generation of Ontologies using Artificial Intelligence (DRAGON-AI)., Sabrina Toro, Anna V Anagnostopoulos, Susan M. Bello, Kai Blumberg, Rhiannon Cameron, Leigh Carmody, Alexander D Diehl, Damion M Dooley, William D Duncan, Petra Fey, Pascale Gaudet, Nomi L Harris, Marcin P Joachimiak, Leila Kiani, Tiago Lubiana, Monica C Munoz-Torres, Shawn O'Neil, David Osumi-Sutherland, Aleix Puig-Barbe, Justin T Reese, Leonore Reiser, Sofia Mc Robb, Troy Ruemping, James Seager, Eric Sid, Ray Stefancsik, Magalie Weber, Valerie Wood, Melissa A Haendel, and Christopher J Mungall
Early molecular events of autosomal-dominant Alzheimer's disease in marmosets with PSEN1 mutations., Gregg E Homanics, Jung Eun Park, Lauren Bailey, David J Schaeffer, Lauren Schaeffer, Jie He, Shuoran Li, Tingting Zhang, Annat Haber, Catrina Spruce, Anna Greenwood, Takeshi Murai, Laura Schultz, Lauren Mongeau, Seung-Kwon Ha, Julia Oluoch, Brianne Stein, Sang Ho Choi, Hasi Huhe, Amantha Thathiah, Peter L Strick, Gregory W. Carter, Afonso C Silva, and Stacey J Sukoff Rizzo
Editorial: Islet cell development, heterogeneity and regeneration., Ansarullah, Adriana Migliorini, and Mostafa Bakhti
Effects of a Global Rab27a Null Mutation on Murine PVAT and Cardiovascular Function, Ashley Soucy, Christian Potts, Abigail Kaija, Anne Harrington, Marissa McGilvrey, George L. Sutphin, Ron Korstanje, Benjamin Tero, Jacob Seeker, Ilka Pinz, Calvin Vary, Larisa Ryzhova, and Lucy Liaw
Efficacy of futibatinib, an irreversible fibroblast growth factor receptor inhibitor, in FGFR-altered breast cancer., Turcin Saridogan, Argun Akcakanat, Ming Zhao, Kurt W Evans, Erkan Yuca, Stephen Scott, Bryce P Kirby, Xiaofeng Zheng, Min Jin Ha, Huiqin Chen, Patrick Ks Ng, Timothy P DiPeri, Gordon B Mills, Jordi Rodon Ahnert, Senthil Damodaran, and Funda Meric-Bernstam
Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice., Chun I. Yu, Richard S. Maser, Florentina Marches, Jacques Banchereau, and Karolina Palucka
Enhanced isradipine sensitivity in vascular smooth muscle cells due to hypoxia-induced Ca, Charlene Priscilla Poore, Jialei Yang, Shunhui Wei, Chee Kong Fhu, Zoë Bichler, Juejin Wang, Tuck Wah Soong, and Ping Liao
Enhlink infers distal and context-specific enhancer-promoter linkages., Olivier Poirion, Wulin Zuo, Catrina Spruce, Candice N Baker, Sandra Daigle, Ashley A Olson, Daniel A Skelly, Elissa J Chesler, Christopher L. Baker, and Brian S White
Evaluation of Alginate Hydrogel Microstrands for Stromal Cell Encapsulation and Maintenance., Sujith Chander Reddy Kollampally, Xulang Zhang, Nicholas Moskwa, Deirdre A Nelson, Susan T Sharfstein, Melinda Larsen, and Yubing Xie
Examining Intercage Transmission of, Michael B Palillo, Noah Mishkin, Mert Aydin, Anthony J Mourino, Rodolfo J Ricart Arbona, and Neil S Lipman
Executing plans to enhance diversity across cancer centers in the United States: opportunities and challenges., Christopher I Li, Sherise Chantell Rogers, Carol J Bult, Carmen E Guerra, Angela Talton, Lovoria B Williams, and Wendy Law
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia., Salome Funes, Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya, Matthew Unger, Karly Stallworth, Debra Cameron, Melissa S Rotunno, Pepper Dawes, Megan Fowler-Magaw, Pamela J Keagle, Justin A McDonough, Sivakumar Boopathy, Miguel Sena-Esteves, Jeffrey A Nickerson, Cathleen Lutz, William C Skarnes, Elaine T Lim, Dorothy P Schafer, Francesca Massi, John E Landers, and Daryl A Bosco
Extending support for mouse data in the Molecular Signatures Database (MSigDB)., Anthony S Castanza, Jill M. Recla, David Eby, Helga Thorvaldsdóttir, Carol J Bult, and Jill P Mesirov
FastHPOCR: pragmatic, fast, and accurate concept recognition using the human phenotype ontology., Tudor Groza, Dylan Gration, Gareth Baynam, and Peter N Robinson
Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor., Yunjae Kim, Gihyeon Kim, Sujeong Kim, Beomki Cho, Sang-Yeob Kim, Eun-Ju Do, Dong-Jun Bae, Seungil Kim, Mi-Na Kweon, Joon Seon Song, Sang Hyoung Park, Sung Wook Hwang, Mi-Na Kim, Yeongmin Kim, Kyungchan Min, Sung-Han Kim, Mark D Adams, Charles Lee, Hansoo Park, and Sook Ryun Park
Folate Deficiency and/or the Genetic Variant Mthfr(677C >T) Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner, Daniel Leclerc, Karen E Christensen, Alaina M Reagan, Vafa Keser, Yan Luan, Olga V Malysheva, Brandi Wasek, Teodoro Bottiglieri, Marie A Caudill, Gareth R Howell, and Rima Rozen
Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice., Jeremy M Sullivan, Anna M Bagnell, Jonathan Alevy, Elvia Mena Avila, Ljubica Mihaljević, Pamela C Saavedra-Rivera, Lingling Kong, Jennifer S Huh, Brett A McCray, William H Aisenberg, Aamir R Zuberi, Laurent Bogdanik, Cathleen Lutz, Zhaozhu Qiu, Katharina A Quinlan, Peter C Searson, and Charlotte J Sumner
Generation of four gene-edited human induced pluripotent stem cell lines with mutations in the ATM gene to model Ataxia-Telangiectasia., Wasifa Nurieva, Elena Ivanova, Sanabel Chehab, Parth Singh, Marina Reichlmeir, Karoly Szuhai, Georg W J Auburger, William C Skarnes, and Zoltán Ivics
Generation of glucocorticoid-producing cells derived from human pluripotent stem cells., Gerard Ruiz-Babot, Ariane Eceiza, Fernando Abollo-Jiménez, Maria Malyukov, Diana L Carlone, Kleiton Borges, Alexandra Rodrigues Da Costa, Shamma Qarin, Takuya Matsumoto, Ryuji Morizane, William C Skarnes, Barbara Ludwig, Paul J Chapple, Leonardo Guasti, Helen L Storr, Stefan R Bornstein, and David T Breault
Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice., Kellie Benzow, Kul Karanjeet, Adrian L Oblak, Gregory W. Carter, Michael Sasner, and Michael D Koob
Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains., Gregory Cary, Jesse C Wiley, Jake Gockley, Stephen Keegan, Sai Sruthi Amirtha Ganesh, Laura Heath, Robert R Butler, Lara M Mangravite, Benjamin A Logsdon, Frank M Longo, Allan Levey, Anna K Greenwood, and Gregory W. Carter
Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome., Cheyenne D Hurst, Amy R Dunn, Eric B Dammer, Duc M Duong, Sarah M Shapley, Nicholas T Seyfried, Catherine Kaczorowski, and Erik C B Johnson
Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits., Sarah E Heuer, Emily W Nickerson, Gareth R Howell, and Erik B Bloss
Genetic diversity promotes resilience in a mouse model of Alzheimer's disease., Neelakshi Soni, Lindsay A Hohsfield, Kristine M Tran, Shimako Kawauchi, Amber Walker, Dominic Javonillo, Jimmy Phan, Dina Matheos, Celia Da Cunha, Asli Uyar, Giedre Milinkeviciute, Angela Gomez-Arboledas, Katelynn Tran, Catherine C Kaczorowski, Marcelo A Wood, Andrea J Tenner, Frank M LaFerla, Gregory W. Carter, Ali Mortazavi, Vivek Swarup, Grant R MacGregor, and Kim N Green
Genetic drivers of age-related changes in urinary magnesium excretion., Wouter H van Megen, Jeroen H F de Baaij, Gary Churchill, Olivier Devuyst, Joost G J Hoenderop, and Ron Korstanje
Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro., Travis Nemkov, Alicia Key, Daniel Stephenson, Eric J Earley, Gregory R Keele, Ariel Hay, Pascal Amireault, Madeleine Casimir, Michaël Dussiot, Monika Dzieciatkowska, Julie A Reisz, Xutao Deng, Mars Stone, Steve Kleinman, Steven L Spitalnik, Kirk C Hansen, Philip J Norris, Gary Churchill, Michael P Busch, Nareg Roubinian, Grier P Page, James C Zimring, Arduino Arduini, and Angelo D'Alessandro
Genetic risk converges on regulatory networks mediating early type 2 diabetes., John T Walker, Diane C Saunders, Vivek Rai, Hung-Hsin Chen, Peter Orchard, Chunhua Dai, Yasminye D Pettway, Alexander L Hopkirk, Conrad V Reihsmann, Yicheng Tao, Simin Fan, Shristi Shrestha, Arushi Varshney, Lauren E Petty, Jordan J Wright, Christa Ventresca, Samir Agarwala, Radhika Aramandla, Greg Poffenberger, Regina Jenkins, Shaojun Mei, Nathaniel J Hart, Sharon Phillips, Hakmook Kang, Dale L Greiner, Leonard D. Shultz, Rita Bottino, Jie Liu, Jennifer E Below, The HPAP Consortium, Stephen C J Parker, Alvin C Powers, and Marcela Brissova
Genome-matched treatments and patient outcomes in the Maine Cancer Genomics Initiative (MCGI)., Eric C Anderson, John DiPalazzo, F Lee Lucas, Michael J Hall, Andrey Antov, Petra Helbig, Jennifer Bourne, Leah Graham, Lory Gaitor, Christine Lu-Emerson, Leslie S Bradford, Roger Inhorn, Sarah J Sinclair, Philip L Brooks, Christian A Thomas, Karen Rasmussen, Paul K J Han, Edison Liu, and Jens Rueter
GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis., Robyn L Ball, Molly A. Bogue, Hongping Liang, Anuj Srivastava, David G Ashbrook, Anna Lamoureux, Matthew Gerring, Alexander S Hatoum, Matthew J Kim, Hao He, Jake Emerson, Alexander Berger, David O Walton, Keith Sheppard, Baha El Kassaby, Francisco Castellanos, Govindarajan Kunde-Ramamoorthy, Lu Lu, John Bluis, Sejal Desai, Beth A. Sundberg, Gary Peltz, Zhuoqing Fang, Gary Churchill, Robert W Williams, Arpana Agrawal, Carol J Bult, Vivek M. Philip, and Elissa J Chesler
Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever., Dylan Kotliar, Siddharth Raju, Shervin Tabrizi, Ikponmwosa Odia, Augustine Goba, Mambu Momoh, John Demby Sandi, Parvathy Nair, Eric Phelan, Ridhi Tariyal, Philomena E Eromon, Samar Mehta, Refugio Robles-Sikisaka, Katherine J Siddle, Matt Stremlau, Simbirie Jalloh, Stephen K Gire, Sarah Winnicki, Bridget Chak, Stephen F Schaffner, Matthias Pauthner, Elinor K Karlsson, Sarah R Chapin, Sharon G Kennedy, Luis M Branco, Lansana Kanneh, Joseph J Vitti, Nisha Broodie, Adrianne Gladden-Young, Omowunmi Omoniwa, Pan-Pan Jiang, Nathan Yozwiak, Shannon Heuklom, Lina M Moses, George O Akpede, Danny A Asogun, Kathleen Rubins, Susan Kales, Anise N Happi, Christopher O Iruolagbe, Mercy Dic-Ijiewere, Kelly Iraoyah, Omoregie O Osazuwa, Alexander K Okonkwo, Stefan Kunz, Joseph B McCormick, S Humarr Khan, Anna N Honko, Eric S Lander, Michael B A Oldstone, Lisa Hensley, Onikepe A Folarin, Sylvanus A Okogbenin, Stephan Günther, Hanna M Ollila, Ryan Tewhey, Peter O Okokhere, John S Schieffelin, Kristian G Andersen, Steven K Reilly, Donald S Grant, Robert F Garry, Kayla G Barnes, Christian T Happi, and Pardis C Sabeti
Genomic characterization of an esthesioneuroblastoma with spinal metastases: illustrative case., Bianca M Marin, Nathan K Leclair, Erica Shen, Avery Buehler, Upendra P Hegde, Qian Wu, Kevin Becker, Lei Li, Seth Brown, Leo J Wolansky, Hilary Onyiuke, David Choi, and Ketan R Bulsara
Genomic medicine year in review: 2023., Teri A Manolio, Jahnavi Narula, Carol J Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Eric D Green, Gillian Hooker, Gail P Jarvik, George A Mensah, Erin M Ramos, Dan M Roden, Robb Rowley, and Marc S Williams
Genomic Reference Resource for African Cattle: Genome Sequences and High-Density Array Variants., Abdulfatai Tijjani, Sumaya Kambal, Endashaw Terefe, Regina Njeru, Moses Ogugo, Gideon Ndambuki, Ayao Missohou, Amadou Traore, Bashir Salim, Chukwunonso Ezeasor, Claire D'andre H, Emmanuel T Obishakin, Boubacar Diallo, Essodina Talaki, Issaka Y Abdoukarim, Oyekanmi Nash, Richard Osei-Amponsah, Simeone Ravaorimanana, Youssouf Issa, Tsadkan Zegeye, Christopher Mukasa, Christian Tiambo, James G D Prendergast, Stephen J Kemp, Jianlin Han, Karen Marshall, and Olivier Hanotte
Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing., Ningbo Chen, Xiaoting Xia, Quratulain Hanif, Fengwei Zhang, Ruihua Dang, Bizhi Huang, Yang Lyu, Xiaoyu Luo, Hucai Zhang, Huixuan Yan, Shikang Wang, Fuwen Wang, Jialei Chen, Xiwen Guan, Yangkai Liu, Shuang Li, Liangliang Jin, Pengfei Wang, Luyang Sun, Jicai Zhang, Jianyong Liu, Kaixing Qu, Yanhong Cao, Junli Sun, Yuying Liao, Zhengzhong Xiao, Ming Cai, Lan Mu, Amam Zonaed Siddiki, Muhammad Asif, Shahid Mansoor, Masroor Ellahi Babar, Tanveer Hussain, Gamamada Liyanage Lalanie Pradeepa Silva, Neena Amatya Gorkhali, Endashaw Terefe, Gurja Belay, Abdulfatai Tijjani, Tsadkan Zegeye, Mebrate Genet Gebre, Yun Ma, Yu Wang, Yongzhen Huang, Xianyong Lan, Hong Chen, Nicola Rambaldi Migliore, Giulia Colombo, Ornella Semino, Alessandro Achilli, Mikkel-Holger S Sinding, Johannes A Lenstra, Haijian Cheng, Wenfa Lu, Olivier Hanotte, Jianlin Han, Yu Jiang, and Chuzhao Lei
Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation., Lori R Bernstein, Amelia C L Mackenzie, Charles L Chaffin, Se-Jin Lee, Duane C Kraemer, and Istvan Merchenthaler
GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies., Salima Benbarche, Jose Mario Bello Pineda, Laura Baquero Galvis, Jeetayu Biswas, Bo Liu, Eric Wang, Qian Zhang, Simon J Hogg, Kadeen Lyttle, Ariana Dahi, Alexander M Lewis, Martina Sarchi, Jahan Rahman, Nina Fox, Yuxi Ai, Sanjoy Mehta, Ralph Garippa, Juliana Ortiz-Pacheco, Zhuoning Li, Mara Monetti, Robert F Stanley, Sergei Doulatov, Robert K Bradley, and Omar Abdel-Wahab
Health care utilization and behavior changes after workplace genetic testing at a large US health care system., Elizabeth Charnysh, Subhamoy Pal, Jonathan M Reader, Wendy R Uhlmann, Sarah McCain, Kunal Sanghavi, Drew Blasco, Rachael Brandt, William Gregory Feero, Rebecca Ferber, Veda N Giri, Katherine Hendy, Anya E R Prince, Charles Lee, J Scott Roberts, and INSIGHT @ Work consortium
Helper T cell immunity in humans with inherited CD4 deficiency., Antoine Guérin, Marcela Moncada-Vélez, Katherine Jackson, Masato Ogishi, Jérémie Rosain, Mathieu Mancini, David Langlais, Andrea Nunez, Samantha Webster, Jesse Goyette, Taushif Khan, Nico Marr, Danielle T Avery, Geetha Rao, Tim Waterboer, Birgitta Michels, Esmeralda Neves, Cátia Iracema Morais, Jonathan London, Stéphanie Mestrallet, Pierre Quartier Dit Maire, Bénédicte Neven, Franck Rapaport, Yoann Seeleuthner, Atar Lev, Amos J Simon, Jorge Montoya, Ortal Barel, Julio Gómez-Rodríguez, Julio C Orrego, Anne-Sophie L'Honneur, Camille Soudée, Jessica Rojas, Alejandra C Velez, Irini Sereti, Benjamin Terrier, Nancy Marin, Luis F García, Laurent Abel, Stéphanie Boisson-Dupuis, Joel Reis, Antonio Marinho, Andrea Lisco, Emilia Faria, Christopher C Goodnow, Julia Vasconcelos, Vivien Béziat, Cindy S Ma, Raz Somech, Jean-Laurent Casanova, Jacinta Bustamante, Jose Luis Franco, and Stuart G Tangye
Hematopoietic Stem Cells and Metabolic Deterioration in Alström Syndrome, a Rare Genetic Model of the Metabolic Syndrome., Francesca Dassie, Mattia Albiero, Silvia Bettini, Roberta Cappellari, Gabriella Milan, Stefano Ciciliot, Juergen K. Naggert, Angelo Avogaro, Roberto Vettor, Pietro Maffei, and Gian Paolo Fadini
Highly accurate and precise determination of mouse mass using computer vision, Malachy Guzman, Brian Q Geuther, Gautam S Sabnis, and Vivek Kumar
High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos., Patience Mukashyaka, Pooja A Kumar, David J Mellert, Shadae Nicholas, Javad Noorbakhsh, Mattia Brugiolo, Elise T Courtois, Olga Anczuków, Edison Liu, and Jeffrey Chuang
HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice., Jeremy Racine, Adel Misherghi, Jennifer R Dwyer, Richard S. Maser, Elvira Forte, Olivia Bedard, Susanne Sattler, Alberto Pugliese, Laurie Landry, Colleen Elso, Maki Nakayama, Stuart Mannering, Nadia Rosenthal, and David V. Serreze
Human-augmented large language model-driven selection of glutathione peroxidase 4 as a candidate blood transcriptional biomarker for circulating erythroid cells., Bishesh Subba, Mohammed Toufiq, Fuadur Omi, Marina Yurieva, Taushif Khan, Darawan Rinchai, Karolina Palucka, and Damien Chaussabel
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice., Zainul S Hasanali, Alfred L Garfall, Lisa Burzenski, Leonard D. Shultz, Yan Tang, Siddhant Kadu, Neil C Sheppard, Wei Liu, Derek Dopkin, Dan T Vogl, Adam D Cohen, Adam J Waxman, Sandra P Susanibar-Adaniya, Martin Carroll, Edward A Stadtmauer, and David Allman
Human inherited CCR2 deficiency underlies progressive polycystic lung disease., Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasco, Camille Soudée, Corentin Le Floc'h, Mélanie Migaud, Yoann Seeleuthner, Mi-Sun Jang, Eirini Nikolouli, Simin Seyedpour, Hugues Begueret, Jean-François Emile, Pierre Le Guen, Guido Tavazzi, Costanza Natalia Julia Colombo, Federico Capra Marzani, Micol Angelini, Francesca Trespidi, Stefano Ghirardello, Nasrin Alipour, Anne Molitor, Raphael Carapito, Mohsen Mazloomrezaei, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Chantal Brouzes, Pablo Vargas, Alessandro Borghesi, Nico Lachmann, Seiamak Bahram, Bruno Crestani, Susanta Pahari, Larry S Schlesinger, Nico Marr, Dusan Bugonovic, Stéphanie Boisson-Dupuis, Vivien Béziat, Laurent Abel, Raphael Borie, Lisa R Young, Robin Deterding, Mohammad Shahrooei, Nima Rezaei, Nima Parvaneh, Daniel Craven, Philippe Gros, Danielle Malo, Fernando E Sepulveda, Lawrence M Nogee, Nathalie Aladjidi, Bruce C Trapnell, Jean-Laurent Casanova, and Jacinta Bustamante
Human insulin as both antigen and protector in type 1 diabetes., Nitin P Amdare, Leonard D. Shultz, Dale L Greiner, and Teresa P DiLorenzo
Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria., Jonathan Bohlen, Qinhua Zhou, Quentin Philippot, Masato Ogishi, Darawan Rinchai, Tea Nieminen, Simin Seyedpour, Nima Parvaneh, Nima Rezaei, Niloufar Yazdanpanah, Mana Momenilandi, Clément Conil, Anna-Lena Neehus, Carltin Schmidt, Carlos A Arango-Franco, Tom Le Voyer, Taushif Khan, Rui Yang, Julia Puchan, Lucia Erazo, Mykola Roiuk, Taja Vatovec, Zarah Janda, Ivan Bagarić, Marie Materna, Adrian Gervais, Hailun Li, Jérémie Rosain, Jessica N Peel, Yoann Seeleuthner, Ji Eun Han, Anne-Sophie L'Honneur, Marcela Moncada-Vélez, Marta Martin-Fernandez, Michael E Horesh, Tatiana Kochetkov, Monika Schmidt, Mohammed A AlShehri, Eeva Salo, Harri Saxen, Gehad ElGhazali, Ahmad Yatim, Camille Soudée, Federica Sallusto, Armin Ensser, Nico Marr, Peng Zhang, Dusan Bogunovic, Aurélie Cobat, Mohammad Shahrooei, Vivien Béziat, Laurent Abel, Xiaochuan Wang, Stéphanie Boisson-Dupuis, Aurelio A Teleman, Jacinta Bustamante, Qian Zhang, and Jean-Laurent Casanova
Human Microbiome and Frailty: From Observations of Clinically Relevant Associations to Insights into Biological Mechanisms, Peter J Larson, Wei Zhou, Julie Robison, George A. Kuchel, and Julia Oh
IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy., Georgette Tanner, Rhiannon Barrow, Shoaib Ajaib, Muna Al-Jabri, Nazia Ahmed, Steven Pollock, Martina Finetti, Nora Rippaus, Alexander F Bruns, Khaja Syed, James A Poulter, Laura Matthews, Thomas Hughes, Erica Wilson, Colin Johnson, Frederick S Varn, Anke Brüning-Richardson, Catherine Hogg, Alastair Droop, Arief Gusnanto, Matthew A Care, Luisa Cutillo, David R Westhead, Susan C Short, Michael D Jenkinson, Andrew Brodbelt, Aruna Chakrabarty, Azzam Ismail, Roel G W Verhaak, and Lucy F Stead
IL3-Driven T Cell-Basophil Crosstalk Enhances Antitumor Immunity., Jian Wei, Colleen L Mayberry, Xiaoting Lv, Fangyan Hu, Taushif Khan, Natalie A Logan, John J Wilson, John D Sears, Damien Chaussabel, and Chih-Hao Chang
Impact and characterization of serial structural variations across humans and great apes., Wolfram Höps, Tobias Rausch, Michael Jendrusch, Jan O Korbel, and Fritz J Sedlazeck
Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines., Hillary Elrick, Kevin A Peterson, Brandon J Willis, Denise G Lanza, Elif F Acar, Edward J Ryder, Lydia Teboul, Petr Kasparek, Marie-Christine Birling, David J Adams, Allan Bradley, Robert E Braun, Steve D Brown, Adam Caulder, Gemma F Codner, Francesco J DeMayo, Mary E Dickinson, Brendan Doe, Graham Duddy, Marina Gertsenstein, Leslie O Goodwin, Yann Hérault, Lauri G Lintott, K C Kent Lloyd, Isabel Lorenzo, Matthew Mackenzie, Ann-Marie Mallon, Colin McKerlie, Helen Parkinson, Ramiro Ramirez-Solis, John R Seavitt, Radislav Sedlacek, William C Skarnes, Damien Smedley, Sara Wells, Jacqueline K White, Joshua A Wood, International Mouse Phenotyping Consortium, Stephen A Murray, Jason D Heaney, and Lauryl M J Nutter
Impaired axon initial segment structure and function in a model of, Wanqi Wang, Damian J Williams, Jia Jie Teoh, Divyalakshmi Soundararajan, Aamir Zuberi, Cathleen Lutz, Wayne N Frankel, and Christopher D Makinson
Improved DNA Extraction and Amplification Strategy for 16S rRNA Gene Amplicon-Based Microbiome Studies., Bo-Young Hong, Mark Driscoll, Dawn Gratalo, Thomas Jarvie, and George M. Weinstock
Improving laboratory animal genetic reporting: LAG-R guidelines., Lydia Teboul, James Amos-Landgraf, Fernando J Benavides, Marie-Christine Birling, Steve D M Brown, Elizabeth Bryda, Rosie Bunton-Stasyshyn, Hsian-Jean Chin, Martina Crispo, Fabien Delerue, Michael Dobbie, Craig L Franklin, Ernst-Martin Fuchtbauer, Xiang Gao, Christelle Golzio, Rebecca Haffner, Yann Hérault, Martin Hrabe de Angelis, Kevin C Kent Lloyd, Terry R Magnuson, Lluis Montoliu, Stephen A. Murray, Ki-Hoan Nam, Lauryl M J Nutter, Eric Pailhoux, Fernando Pardo Manuel de Villena, Kevin A Peterson, Laura G Reinholdt, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Cynthia Smith, Toru Takeo, Louise Tinsley, Jean-Luc Vilotte, Søren Warming, Sara Wells, C Bruce Whitelaw, Atsushi Yoshiki, Asian Mouse Mutagenesis Resource Association, CELPHEDIA infrastructure, INFRAFRONTIER consortium, International Mammalian Genome Society, International Mouse Phenotyping Consortium, International Society for Transgenic Technologies, Mutant Mouse Resource and Research Centers, Phenomics Australia, RRRC-Rat Resource and Research Center, and Guillaume Pavlovic
Improving prenatal diagnosis through standards and aggregation., Michael H Duyzend, Pilar Cacheiro, Julius O B Jacobsen, Jessica Giordano, Harrison Brand, Ronald J Wapner, Michael E Talkowski, Peter N Robinson, and Damian Smedley
Improving the predictive power of mouse models., Martin Pera, Andrew S Greene, Lon Cardon, Gregory W. Carter, Elissa J Chesler, Gary Churchill, Vivek Kumar, Cathleen Lutz, Steven C. Munger, Stephen A Murray, Kristen M S O'Connell, Laura G Reinholdt, and Nadia Rosenthal
Imputation of 3D genome structure by genetic-epigenetic interaction modeling in mice., Lauren Kuffler, Daniel A Skelly, Anne M Czechanski, Haley J Fortin, Steven C. Munger, Christopher L. Baker, Laura G Reinholdt, and Gregory W. Carter
Independent repeated mutations within the alphaviruses Ross River virus and Barmah Forest virus indicates convergent evolution and past positive selection in ancestral populations despite ongoing purifying selection., Alyssa T Pyke, Daniel J Wilson, Alice Michie, John S Mackenzie, Allison Imrie, Jane Cameron, Stephen L Doggett, John Haniotis, Lara J Herrero, Leon Caly, Stacey E Lynch, Peter T Mee, Eugene T Madzokere, Ana L Ramirez, Devina Paramitha, Jody Hobson-Peters, David W Smith, Richard Weir, Mitchell Sullivan, Julian Druce, Lorna Melville, Jennifer Robson, Robert Gibb, Andrew F van den Hurk, and Sebastian Duchene
Inference of Admixture Origins in Indigenous African Cattle., Kwondo Kim, Donghee Kim, Olivier Hanotte, Charles Lee, Heebal Kim, and Choongwon Jeong
Inferring the Cancer Cellular Epigenome Heterogeneity via DNA Methylation Patterns., Sheng Li
Inflammation impacts androgen receptor signaling in basal prostate stem cells through interleukin 1 receptor antagonist., Paula O Cooper, Jiang Yang, Hsing-Hui Wang, Meaghan M Broman, Shyaman Madhawa Jayasundara, Subhransu Sekhar Sahoo, Bingyu Yan, Gada D Awdalkreem, Gregory M Cresswell, Liang Wang, Emery Goossens, Nadia A Lanman, Rebecca W Doerge, Faye Zheng, Liang Cheng, Saeed Alqahtani, Scott A Crist, Robert E Braun, Majid Kazemian, Travis J Jerde, and Timothy L Ratliff
Information-theory analysis of mouse string-pulling agrees with Fitts's Law: Increasing task difficulty engages multiple sensorimotor modalities in a dual oscillator behavior., Pardeepak S Sandhu, Behroo Mirza Agha, Samsoon Inayat, Surjeet Singh, Hardeep S Ryait, Majid H Mohajerani, and Ian Q Whishaw
Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis., Amandine Jarysta, Abby Tadenev, Matthew Day, Barry Krawchuk, Benjamin E. Low, Michael V. Wiles, and Basile Tarchini
Integrative analysis of RNA-sequencing and microarray for the identification of adverse effects of UVB exposure on human skin., Yujin Jang, Hye-Won Na, Dong Yeop Shin, Jun Lee, Jun Pyo Han, Hyun Soo Kim, Su Ji Kim, Eun-Jeong Choi, Charles Lee, Yong Deog Hong, Hyoung-June Kim, and Young Rok Seo
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function., Binsheng Wang, Lichao Wang, Nathan S Gasek, Chia-Ling Kuo, Jia Nie, Taewan Kim, Pengyi Yan, Junyu Zhu, Blake L Torrance, Yueying Zhou, Lisa C Flores, Colton Allen, Allison M Andrade, Chun Guo, Rachel L Cohn, Evan R Jellison, Jenna M Bartley, George A Kuchel, Sheng Li, Tamar Pirtskhalava, Tamar Tchkonia, Sumit Yadav, Laura Haynes, James L Kirkland, Yuji Ikeno, and Ming Xu
Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models., Beth L Dumont, Daniel Mario Gatti, Mallory A Ballinger, Dana Lin, Megan Phifer-Rixey, Michael J Sheehan, Taichi A Suzuki, Lydia K Wooldridge, Hilda Opoku Frempong, Raman Akinyanju Lawal, Gary Churchill, Cathleen Lutz, Nadia Rosenthal, Jacqueline K White, and Michael W Nachman
In vitro development of resistance against antipseudomonal agents: comparison of novel beta-lactam/beta-lactamase inhibitor combinations and other beta-lactam agents, Mariana Castanheira, John H Kimbrough, Jill Lindley, Timothy B Doyle, Jessica M Ewald, and Helio S Sader
In vivo activity of the second-generation proteasome inhibitor ixazomib against pediatric T-cell acute lymphoblastic leukemia xenografts., Joanna Randall, Kathryn Evans, Ben Watts, Hansen J Kosasih, Christopher M Smith, Eric J Earley, Stephen W Erickson, Emily L Jocoy, Carol J Bult, Beverly A Teicher, Charles E de Bock, Malcolm A Smith, and Richard B Lock
In vivo validation of late-onset Alzheimer's disease genetic risk factors., Michael Sasner, Christoph Preuss, Ravi S Pandey, Asli Uyar, Dylan Garceau, Kevin P Kotredes, Harriet M. Jackson, Adrian L Oblak, Peter Bor-Chian Lin, Bridget Perkins, Disha Soni, Cindy Ingraham, Audrey Lee-Gosselin, Bruce T Lamb, Gareth R Howell, and Gregory W. Carter
Kdm1a safeguards the topological boundaries of PRC2-repressed genes and prevents aging-related euchromatinization in neurons., Beatriz Del Blanco, Sergio Niñerola, Ana M Martín-González, Juan Paraíso-Luna, Minji Kim, Rafael Muñoz-Viana, Carina Racovac, Jose V Sanchez-Mut, Yijun Ruan, and Ángel Barco
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127., Skye Montoya, Jessie Bourcier, Mark Noviski, Hao Lu, Meghan C Thompson, Alexandra Chirino, Jacob Jahn, Anya K Sondhi, Stefan Gajewski, Ying Siow May Tan, Stephanie Yung, Aleksandra Urban, Eric Wang, Cuijuan Han, Xiaoli Mi, Won Jun Kim, Quinlan Sievers, Paul Auger, Hugo Bousquet, Nivetha Brathaban, Brandon Bravo, Melissa Gessner, Cristiana Guiducci, James N Iuliano, Tim Kane, Ratul Mukerji, Panga Jaipal Reddy, Janine Powers, Mateo Sanchez Garcia de Los Rios, Jordan Ye, Carla Barrientos Risso, Daniel Tsai, Gabriel Pardo, Ryan Q Notti, Alejandro Pardo, Maurizio Affer, Vindhya Nawaratne, Tulasigeri M Totiger, Camila Pena-Velasquez, Joanna M Rhodes, Andrew D Zelenetz, Alvaro Alencar, Lindsey E Roeker, Sanjoy Mehta, Ralph Garippa, Adam Linley, Rajesh Kumar Soni, Sigrid S Skånland, Robert J Brown, Anthony R Mato, Gwenn M Hansen, Omar Abdel-Wahab, and Justin Taylor
Lack of effect from genetic deletion of Hdac6 in a humanized mouse model of CMT2D., Abby Tadenev, Courtney L Hatton, and Robert W. Burgess
Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior., David A Hillis, Liran Yadgary, George M. Weinstock, Fernando Pardo-Manuel de Villena, Daniel Pomp, and Theodore Garland
Large-scale annotated dataset for cochlear hair cell detection and classification., Christopher J Buswinka, David B Rosenberg, Rubina G Simikyan, Richard T Osgood, Katharine Fernandez, Hidetomi Nitta, Yushi Hayashi, Leslie W Liberman, Emily Nguyen, Erdem Yildiz, Jinkyung Kim, Amandine Jarysta, Justine Renauld, Ella Wesson, Haobing Wang, Punam Thapa, Pierrick Bordiga, Noah McMurtry, Juan Llamas, Siân R Kitcher, Ana I López-Porras, Runjia Cui, Ghazaleh Behnammanesh, Jonathan E Bird, Angela Ballesteros, A Catalina Vélez-Ortega, Albert S B Edge, Michael R Deans, Ksenia Gnedeva, Brikha R Shrestha, Uri Manor, Bo Zhao, Anthony J Ricci, Basile Tarchini, Martín L Basch, Ruben Stepanyan, Lukas D Landegger, Mark A Rutherford, M Charles Liberman, Bradley J Walters, Corné J Kros, Guy P Richardson, Lisa L Cunningham, and Artur A Indzhykulian
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modeling., Mallory Ryan, Justin A McDonough, Michael E Ward, Mark R Cookson, William C Skarnes, and Florian T Merkle
L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats., James N Bates, Paulina M Getsy, Gregory A Coffee, Santhosh M Baby, Peter M MacFarlane, Yee-Hsee Hsieh, Zackery T Knauss, Jason A. Bubier, Devin Mueller, and Stephen J Lewis
Learning from conect4children: A Collaborative Approach towards Standardisation of Disease-Specific Paediatric Research Data, Anando Sen, Victoria Hedley, Eva Degraeuwe, Steven Hirschfeld, Ronald Cornet, Ramona Walls, John Owen, Peter N Robinson, Edward G. Neilan, Thomas Liener, Giovanni Nisato, Neena Modi, Simon Woodworth, Avril Palmeri, Ricarda Gaentzsch, Melissa Walsh, Teresa Berkery, Joanne Lee, Laura Persijn, Kasey Baker, Kristina An Haack, Sonia Segovia Simon, Julius O. B. Jacobsen, Giorgio Reggiardo, Melissa A. Kirwin, Jessie Trueman, Claudia Pansieri, Donato Bonifazi, Sinéad Nally, Fedele Bonifazi, Rebecca Leary, and Volker Straub
Leaving no patient behind! Expert recommendation in the use of innovative technologies for diagnosing rare diseases., Clara D M van Karnebeek, Anne O'Donnell-Luria, Gareth Baynam, Anaïs Baudot, Tudor Groza, Judith J M Jans, Timo Lassmann, Mary Catherine V Letinturier, Stephen B Montgomery, Peter N Robinson, Stefaan Sansen, Ruty Mehrian-Shai, Charles Steward, Kenjiro Kosaki, Patricia Durao, and Bekim Sadikovic
Lethal phenotypes in Mendelian disorders., Pilar Cacheiro, Samantha Lawson, Ignatia B Van den Veyver, Gabriel Marengo, David Zocche, Stephen A Murray, Michael Duyzend, Peter N Robinson, and Damian Smedley
Levetiracetam modulates brain metabolic networks and transcriptomic signatures in the 5XFAD mouse model of Alzheimer's disease., Charles P Burton, Evgeny J Chumin, Alyssa Y Collins, Scott A Persohn, Kristen D. Onos, Ravi S Pandey, Sara K Quinney, and Paul R Territo
Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin., Richard A Miller, David E Harrison, Gino A Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G Geisler, Brett C Ginsburg, Melissa L Han, Catherine C Kaczorowski, Navasuja Kumar, Scott F Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R Mitchell, James F Nelson, Peter C. Reifsnyder, Adam B Salmon, Ron Korstanje, Nadia Rosenthal, and Randy Strong
Linking immune modulation to cardiac fibrosis, Frank Bengel, Jonathan Epstein, Robert Gropler, Uwe Haberkorn, Rafael Kramann, Kory Lavine, Florian Leuschner, Yongjian Liu, Nadia Rosenthal, and Hao Wu
Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats., James N Bates, Paulina M Getsy, Gregory A Coffee, Santhosh M Baby, Peter M MacFarlane, Yee-Hsee Hsieh, Zackery T Knauss, Jason A. Bubier, Devin Mueller, and Stephen J Lewis
Little impact of new mutations on mammalian trait variation., Beth L Dumont
L-NAC and L-NAC methyl ester prevent and overcome physical dependence to fentanyl in male rats., James N Bates, Santhosh M Baby, Paulina M Getsy, Gregory A Coffee, Yee-Hsee Hsieh, Zackery T Knauss, Albert Dahan, Jason A. Bubier, Peter M MacFarlane, Devin Mueller, and Stephen J Lewis
Localization of cadherins in the postnatal cochlear epithelium and their relation to space formation., Holly J Beaulac and Vidhya Munnamalai
Longitudinal characteristics of T2-FLAIR mismatch in IDH-mutant astrocytomas: Relation to grade, histopathology, and overall survival in the GLASS-NL cohort., Karin A van Garderen, Wies R Vallentgoed, Anna Lavrova, Johanna M Niers, Wendy W J de Leng, Youri Hoogstrate, Iris de Heer, Bauke Ylstra, Erik van Dijk, Stefan Klein, Kaspar Draaisma, Pierre A J T Robe, Roel G W Verhaak, Bart A Westerman, Pim J French, Martin J van den Bent, Mathilde C M Kouwenhoven, Johan M Kros, Pieter Wesseling, and Marion Smits
Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice., Alison Luciano, Laura Robinson, Gaven Garland, Bonnie Lyons, Ron Korstanje, Andrea Di Francesco, and Gary Churchill
Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease., Xin Zhou, Xiaotao Shen, Jethro Johnson, Daniel Spakowicz, Melissa Agnello, Wenyu Zhou, Monica Avina, Alexander Honkala, Faye Chleilat, Shirley Jingyi Chen, Kexin Cha, Shana Leopold, Chenchen Zhu, Lei Chen, Lin Lyu, Daniel Hornburg, Si Wu, Xinyue Zhang, Chao Jiang, Liuyiqi Jiang, Lihua Jiang, Ruiqi Jian, Andrew W Brooks, Meng Wang, Kévin Contrepois, Peng Gao, Sophia Miryam Schüssler-Fiorenza Rose, Thi Dong Binh Tran, Hoan Nguyen, Alessandra Celli, Bo-Young Hong, Eddy J Bautista, Yair Dorsett, Paula B Kavathas, Yanjiao Zhou, Erica Sodergren Weinstock, George M. Weinstock, and Michael P Snyder
Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles., Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Rahil Gholamipoorfard, Hans A Schlößer, Kerstin Wennhold, Martin Thelen, Maria A Garcia-Marquez, Johannes Koenig, Andreas Schneider, Tobias Braun, Frank Klawonn, Michael Damrat, Masudur Rahman, Jan-Malte Kleid, Sebastian J Theobald, Eugen Bauer, Constantin von Kaisenberg, Steven R Talbot, Leonard D. Shultz, Brian Soper, and Renata Stripecke
Loss of STING impairs lactogenic differentiation., Ramiah R Vickers, Garhett L Wyatt, Lilia Sanchez, Jordyn J VanPortfliet, A Phillip West, and Weston W Porter
Machine-guided design of cell-type-targeting cis-regulatory elements., Sager J Gosai, Rodrigo Castro, Natalia Fuentes, John C Butts, Kousuke Mouri, Michael Alasoadura, Susan Kales, Thanh Thanh L Nguyen, Ramil R Noche, Arya S Rao, Mary T Joy, Pardis C Sabeti, Steven K Reilly, and Ryan Tewhey
Mapping the metabolic responses to oxaliplatin-based chemotherapy with, Mariola Olkowicz, Khaled Ramadan, Hernando Rosales-Solano, Miao Yu, Aizhou Wang, Marcelo Cypel, and Janusz Pawliszyn
Meeting report of the annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease research., Michael Sasner, Paul R Territo, and Stacey J Sukoff Rizzo
Meeting report of the fifth annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research., Michael Sasner, Kristen D. Onos, Paul R Territo, and Stacey J Sukoff Rizzo
MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation., Zhiqiang Pang, Yao Lu, Guangyan Zhou, Fiona Hui, Lei Xu, Charles Viau, Aliya F Spigelman, Patrick E MacDonald, David S Wishart, Shuzhao Li, and Jianguo Xia
Metabolic fitness of IgA(+) plasma cells in the gut requires DOCK8, Biyan Zhang, Shuting Chen, Xiangyun Yin, Caleb D McBride, Jake A Gertie, Marina Yurieva, Agata A Bielecka, Brian Hoffmann, J Travis Hinson, Jessica D S Grassmann, Lan Xu, Emily R Siniscalco, Arielle Soldatenko, Laura Hoyt, Julie Joseph, Elizabeth B Norton, Gowthaman Uthaman, Noah W Palm, Elise Liu, Stephanie C Eisenbarth, and Adam Williams
Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease., Ravi S Pandey, Mattias Arnold, Richa Batra, Jan Krumsiek, Kevin P Kotredes, Dylan Garceau, Harriet M. Jackson, Michael Sasner, Gareth R Howell, Rima Kaddurah-Daouk, and Gregory W. Carter
Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma, Cory A Diemler, Michael MacLean, Sarah E Heuer, Amanda A Hewes, Olivia J Marola, Richard T. Libby, and Gareth R Howell
Microlearning: Evidence-based education that is effective for busy professionals and short attention spans., Therese Ingram, Emily A Edelman, Linda Steinmark, Kalisi Logan, and Kate Reed
Minimum information and guidelines for reporting a multiplexed assay of variant effect., Melina Claussnitzer, Victoria N Parikh, Alex H Wagner, Jeremy A Arbesfeld, Carol J Bult, Helen V Firth, Lara A Muffley, Alex N Nguyen Ba, Kevin Riehle, Frederick P Roth, Daniel Tabet, Benedetta Bolognesi, Andrew M Glazer, and Alan F Rubin
Mitochondrial DNA release and sensing in innate immune responses., Jordyn J VanPortfliet, Cole Chute, Yuanjiu Lei, Timothy E Shutt, and A Phillip West
Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse., Richard M. Baldarelli, Cynthia Smith, Martin Ringwald, Joel E Richardson, Carol J Bult, and Mouse Genome Informatics
Mouse phenome database: curated data repository with interactive multi-population and multi-trait analyses., Molly A. Bogue, Robyn L Ball, David O Walton, Matthew H Dunn, Georgi Kolishovski, Alexander Berger, Anna Lamoureux, Stephen C. Grubb, Matthew Gerring, Matthew Kim, Hongping Liang, Jake Emerson, Timothy M Stearns, Hao He, Gaurab Mukherjee, John Bluis, Sara Davis, Sejal Desai, Beth A. Sundberg, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, Vivek M. Philip, and Elissa J Chesler
MouseScholar: Evaluating an Image+Text Search System for Biocuration, Juan Trelles Trabucco
Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential., Mesut Yigit, Omer Faruk Basoglu, and Derya Unutmaz
Multicenter integrated analysis of noncoding CRISPRi screens., David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R Doughty, Idan Gabdank, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, and Steven K Reilly
Multiomics analyses decipher intricate changes in the cellular and metabolic landscape of steatotic livers upon dietary restriction and sleeve gastrectomy., Shuai Chen, Qinghe Zeng, Xiurong Cai, Jiaming Xue, Guo Yin, Peng Song, Liming Tang, Christophe Klein, Frank Tacke, Adrien Guillot, and Hanyang Liu
Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in genetically diverse mice., Sherry L Kurtz, Richard E Baker, Frederick J Boehm, Chelsea C Lehman, Lara R Mittereder, Hamda Khan, Amy P Rossi, Daniel M Gatti, Gillian Beamer, Christopher M Sassetti, and Karen L Elkins
Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy., Jeremy Racine, John F Bachman, Ji-Gang Zhang, Adel Misherghi, Raheem Khadour, Sana Kaisar, Olivia Bedard, Catherine Jenkins, Annie Abbott, Elvira Forte, Peter Rainer, Nadia Rosenthal, Susanne Sattler, and David V. Serreze
MVAR: A Mouse Variation Registry., Baha El Kassaby, Francisco Castellanos, Matthew Gerring, Govindarajan Kunde-Ramamoorthy, and Carol J Bult
Network-based analysis predicts interacting genetic modifiers from a meta-mapping study of spike-wave discharge in mice., Montana Kay Lara, Jeffrey L Brabec, Amanda E Hernan, Rod C Scott, Anna L. Tyler, and J Matthew Mahoney
New allele of mouse DNA/RNA helicase senataxin causes meiotic arrest and infertility, Yasuhiro Fujiwara, Kouhei Saito, Fengyun Sun, Sabrina Petri, Erina Inoue, John Schimenti, Yuki Okada, and Mary Ann Handel
New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop., Maria Telpoukhovskaia, Thomas J Murdy, Olivia J Marola, Kevin Charland, Michael MacLean, Tain Luquez, Alexandra M Lish, Sarah Neuner, Amy R Dunn, Kristen D. Onos, Jesse Wiley, Derek Archer, Matthew J Huentelman, Matthias Arnold, Vilas Menon, Alison Goate, Linda J Van Eldik, Paul R Territo, Gareth R Howell, Gregory W. Carter, Kristen M S O'Connell, Catherine Kaczorowski, and the 2022 JAX CADR Workshop
Nextflow pipeline for Visium and H&E data from patient-derived xenograft samples., Sergii Domanskyi, Anuj Srivastava, Jessica Kaster, Haiyin Li, Meenhard Herlyn, Jill C Rubinstein, and Jeffrey Chuang
NLGN4X TCR transgenic T cells to treat gliomas., Christoper Krämer, Michael Kilian, Yu-Chan Chih, Alexandros Kourtesakis, Dirk C Hoffmann, Tamara Boschert, Philipp Koopmann, Khwab Sanghvi, Alice De Roia, Stefanie Jung, Kristine Jähne, Bryan Day, Leonard D. Shultz, Miriam Ratliff, Richard Harbottle, Edward W Green, Rainer Will, Wolfgang Wick, Michael Platten, and Lukas Bunse
Node-degree aware edge sampling mitigates inflated classification performance in biomedical random walk-based graph representation learning., Luca Cappelletti, Lauren Rekerle, Tommaso Fontana, Peter Hansen, Elena Casiraghi, Vida Ravanmehr, Christopher J Mungall, Jeremy J Yang, Leonard Spranger, Guy Karlebach, J Harry Caufield, Leigh Carmody, Ben D Coleman, Tudor I Oprea, Justin Reese, Giorgio Valentini, and Peter N Robinson
Non-genetic mechanisms of drug resistance in acute leukemias., Alexander Calderon, Cuijuan Han, Sadik Karma, and Eric Wang
Nuclear factor kappa B-dependent persistence of, Taylor A Stepien, Larissa A Singletary, Fermin E Guerra, Joyce E Karlinsey, Stephen J Libby, Sarah L Jaslow, Margaret R Gaggioli, Kyle D Gibbs, Dennis C Ko, Michael A Brehm, Dale L Greiner, Leonard D. Shultz, and Ferric C Fang
OBO Foundry food ontology interconnectivity, Damion Dooley, Liliana Andres-Hernandez, Georgeta Bordea, Leigh Carmody, Duccio Cavalieri, Lauren Chan, Pol Castellano-Escuder, Carl Lachat, Fleur Mougin, Francesco Vitali, Chen Yang, Magalie Weber, Hande Kucuk McGinty, and Matthew Lange
Oncogenic composite mutations can be predicted by co-mutations and their chromosomal location., Asli Küçükosmanoglu, Carolien L van der Borden, Lisanne E A de Boer, Roel G W Verhaak, David Noske, Tom Wurdinger, Teodora Radonic, and Bart A Westerman
Oncostatin M receptor-dependent signaling assessed by RNA sequencing in mouse hematopoietic stem cells., Logan S Schwartz, Ruth L. Saxl, Timothy M Stearns, Maria Telpoukhovskaia, and Jennifer J. Trowbridge
On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging., Hope Dang, Raul Castro-Portuguez, Luis Espejo, Grant Backer, Samuel Freitas, Erica Spence, Jeremy Meyers, Karissa Shuck, Emily A Gardea, Leah M Chang, Jonah Balsa, Niall Thorns, Caroline Corban, Teresa Liu, Shannon Bean, Susan Sheehan, Ron Korstanje, and George L Sutphin
Operational description of rare diseases: a reference to improve the recognition and visibility of rare diseases., Chiuhui Mary Wang, Amy Heagle Whiting, Ana Rath, Roberta Anido, Diego Ardigò, Gareth Baynam, Hugh Dawkins, Ada Hamosh, Yann Le Cam, Helen Malherbe, Caron M Molster, Lucia Monaco, Carmencita D Padilla, Anne R Pariser, Peter N Robinson, Charlotte Rodwell, Franz Schaefer, Stefanie Weber, and Flaminia Macchia
OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity., Adriana Lofrano-Porto, Sidney Alcântara Pereira, Andrew Dauber, Jordana Cb Bloom, Audrey N Fontes, Naomi Asimow, Olívia Laquis de Moraes, Petra Ariadne T Araujo, Ana Paula Abreu, Michael H Guo, Silviene Fabiana De Oliveira, Han Liu, Charles Lee, Wendy Kuohung, Michella S Coelho, Rona S Carroll, Rulang Jiang, and Ursula B Kaiser
Patient-Derived Models of Cancer in the NCI PDMC Consortium: Selection, Pitfalls, and Practical Recommendations., Amber N Habowski, Deepthi P Budagavi, Sandra D Scherer, Arin B Aurora, Giuseppina Caligiuri, William F Flynn, Ellen M Langer, Jonathan R Brody, Rosalie C Sears, Giorgia Foggetti, Anna Arnal Estape, Don X Nguyen, Katerina A Politi, Xiling Shen, David S Hsu, Donna M Peehl, John Kurhanewicz, Renuka Sriram, Milagros Suarez, Sophie Xiao, Yuchen Du, Xiao-Nan Li, Nora M Navone, Estefania Labanca, and Christopher D Willey
Pediatric Tumors as Disorders of Development: The Case for In Vitro Modeling Based on Human Stem Cells., Cullen D Clairmont, Joanna J Gell, and Ching C Lau
Per- and polyfluoroalkyl substances (PFAS) and cancer: Detection methodologies, epidemiological insights, potential carcinogenic mechanisms, and future perspectives., Jie Zheng, Sheng Liu, Junjie Yang, Shujian Zheng, and Boshi Sun
Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids., Jie Zheng, Boshi Sun, Domenica Berardi, Lingeng Lu, Hong Yan, Shujian Zheng, Oladimeji Aladelokun, Yangzhouyun Xie, Yujun Cai, Krystal J Godri Pollitt, Sajid A Khan, and Caroline H Johnson
Persistent transcriptional changes in cardiac adaptive immune cells following myocardial infarction: New evidence from the re-analysis of publicly available single cell and nuclei RNA-sequencing data sets., Natasha de Winter, Jiahui Ji, Amalia Sintou, Elvira Forte, Michael Lee, Michela Noseda, Aoxue Li, Andrew L Koenig, Kory J Lavine, Sikander Hayat, Nadia Rosenthal, Costanza Emanueli, Prashant K Srivastava, and Susanne Sattler
Phenotype Distinctions in Mice Deficient in the Neuron-Specific α3 Subunit of Na,K-ATPase:, Yi Bessie Liu, Elena Arystarkhova, Amanda N Sacino, Margit V Szabari, Cathleen Lutz, Markus Terrey, Natalia S Morsci, Tatjana C Jakobs, Karin Lykke-Hartmann, Allison Brashear, Elenora Napoli, and Kathleen J Sweadner
Phenotypic differences in intermediate generalized junctional epidermolysis bullosa with homozygous LAMC2 mutation and a potential genetic modifier., Timothy L Cowan, John P Sundberg, Derry C. Roopenian, Thomas J. Sproule, and Dédée F Murrell
Phenotypic similarity-based approach for variant prioritization for unsolved rare disease: a preliminary methodological report., David Lagorce, Emeline Lebreton, Leslie Matalonga, Oscar Hongnat, Maroua Chahdil, Davide Piscia, Ida Paramonov, Kornelia Ellwanger, Sebastian Köhler, Peter N Robinson, Holm Graessner, Sergi Beltran, Caterina Lucano, Marc Hanauer, and Ana Rath
Pre-Covid-19, SARS-CoV-2-Negative Multisystem Inflammatory Syndrome in Children., Sarah Benezech, Liliane Khoryati, Jade Cognard, Stejara A Netea, Taushif Khan, Marion Moreews, Kahina Saker, Jean-Marie De Guillebon, Samira Khaldi-Plassart, Rémi Pescarmona, Sebastien Viel, Christophe Malcus, Magali Perret, Meriadeg Ar Gouilh, Astrid Vabret, Fabienne Venet, Solenn Remy, Emilie Chopin, Gérard Lina, François Vandenesch, Noëmi Rousseaux, Paul Bastard, Shen-Ying Zhang, Jean-Laurent Casanova, Sophie Trouillet-Assant, Thierry Walzer, Taco W Kuijpers, Etienne Javouhey, Olivier Dauwalder, Nico Marr, and Alexandre Belot
Predicting nutrition and environmental factors associated with female reproductive disorders using a knowledge graph and random forests., Lauren E Chan, Elena Casiraghi, Justin Reese, Quaker E Harmon, Kevin Schaper, Harshad Hegde, Giorgio Valentini, Charles Schmitt, Alison Motsinger-Reif, Janet E Hall, Christopher J Mungall, Peter N Robinson, and Melissa A Haendel
Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells., Alma Jukic, Zhengchang Lei, Elizabeth R Cebul, Katherine Pinter, Yommi Tadesse, Amandine Jarysta, Sandeep David, Natalie Mosqueda, Basile Tarchini, and Katie Kindt
Proteins required for stereocilia elongation during mammalian hair cell development ensure precise and steady heights during adult life., Elli I Hartig, Matthew Day, Amandine Jarysta, and Basile Tarchini
Proteomic Profiles of Human Arterioles Isolated From Fresh Adipose Tissue or Following Overnight Storage., Rajan Pandey, Michelle L Roberts, Jingli Wang, Michaela Pereckas, David Jensen, Andrew S Greene, Michael E Widlansky, and Mingyu Liang
Protocol for establishing primary human lung organoid-derived air-liquid interface cultures from cryopreserved human lung tissue., Diana Cadena, Sonia Jangra, Marina Yurieva, Jan Martinek, Megan Callender, Matthew Coxe, Angela Choi, Juan García-Bernalt Diego, Te-Chia Wu, Florentina Marches, Damien Chaussabel, Adolfo García-Sastre, Michael Schotsaert, Adam Williams, and Karolina Palucka
Protocol for large DNA transgenesis in mice using the Cas9+Bxb1 toolbox., Valerie Erhardt, Chrystal M Snow, and Vishnu Hosur
Protocol to assess bioenergetics and mitochondrial fuel usage in murine autoreactive immunocytes using the Seahorse Extracellular Flux Analyzer., Colleen L Mayberry, John J Wilson, Britney Sison, and Chih-Hao Chang
Protocol to construct humanized mice with adult CD34, Chun I. Yu, Richard S. Maser, Florentina Marches, Jacques Banchereau, and Karolina Palucka
Quantitative trait loci mapping provides insights into the genetic regulation of dendritic cell numbers in mouse tissues., Thiago Y Oliveira, Julia Merkenschlager, Thomas Eisenreich, Juliana Bortolatto, Kai-Hui Yao, Daniel M Gatti, Gary Churchill, Michel C Nussenzweig, and Gaëlle Breton
Randomized feature selection based semi-supervised latent Dirichlet allocation for microbiome analysis., Namitha Pais, Nalini Ravishanker, Sanguthevar Rajasekaran, George M. Weinstock, and Thi Dong Binh Tran
Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke., Baruc Campos, Hoseok Choi, Andrew T DeMarco, Anna Seydell-Greenwald, Sara J Hussain, Mary T Joy, Peter E Turkeltaub, and William Zeiger
Revisiting Cardiac Biology in the Era of Single Cell and Spatial Omics., Jack A Palmer, Nadia Rosenthal, Sarah A Teichmann, and Monika Litvinukova
RNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation., Yun-Suhk Suh, Jieun Lee, Joshy George, Donghyeok Seol, Kyoungyun Jeong, Seung-Young Oh, Chanmi Bang, Yukyung Jun, Seong-Ho Kong, Hyuk-Joon Lee, Jong-Il Kim, Woo Ho Kim, Han-Kwang Yang, and Charles Lee
RREB1 regulates neuronal proteostasis and the microtubule network., Emily N Griffin, Thomas Jucius, Su-Eon Sim, Belinda S. Harris, Sven Heinz, and Susan L Ackerman
Russell in mouse room, circa 1950
Sarcopenia and adipose tissue evaluation by artificial intelligence predicts the overall survival after TAVI., Matej Pekař, Otakar Jiravský, Jan Novák, Piotr Branny, Jakub Balušík, Daniel Danis, Jan Hečko, Marek Kantor, Robert Prosecky, Lubomir Blaha, and Radek Neuwirth
Satellite cells in the growth and maintenance of muscle, John F Bachman and J V. Chakkalakal
Search, The Jackson Laboratory
Search, The Jackson Laboratory
Semantic representation of neural circuit knowledge in Caenorhabditis elegans., Sharan J Prakash, Kimberly M Van Auken, David P. Hill, and Paul W Sternberg
Sex Differences in Immune System Aging and Responsiveness to Vaccination., Steven Yanicke and Duygu Ucar
Short-chain fatty acid valerate reduces voluntary alcohol intake in male mice., Suresh C Bokoliya, Jordan Russell, Yair Dorsett, Hunter A Panier, Vijender Singh, Lauren Daddi, Hanshu Yuan, Liv R Dedon, Zhongmao Liu, Yuqi Zhou, Zefang Min, Jessica R Barson, Jonathan Covault, Jason A. Bubier, and Yanjiao Zhou
Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche., Yasmin Henlon, Kavita Panir, Iona McIntyre, Chloe Hogg, Priya Dhami, Antonia O Cuff, Anna Senior, Niky Moolchandani-Adwani, Elise T Courtois, Andrew W Horne, Matthew Rosser, Sascha Ott, and Erin Greaves
Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes., Monique Mills, Chihiro Emori, Parveen Kumar, Zachary Boucher, Joshy George, and Ewelina Bolcun-Filas
Single-cell Transcriptome Landscape of DNA Methylome Regulators Associated with Orofacial Clefts in the Mouse Dental Pulp., Badam Enkhmandakh, Pujan Joshi, Paul Robson, Anushree Vijaykumar, Mina Mina, Dong-Guk Shin, and Dashzeveg Bayarsaihan
Small polymorphisms are a source of ancestral bias in structural variant breakpoint placement., Peter A Audano and Christine R Beck
Socioeconomic and urban-rural disparities in genome-matched treatment receipt and survival after genomic tumor testing., Jessica F DiBiase, Elizabeth Scharnetzki, Emily A Edelman, Kate Reed, Petra Helbig, Jens Rueter, Susan Miesfeldt, Cara L Frankenfeld, Paul K J Han, Elizabeth A Jacobs, Eric C Anderson, and Maine Cancer Genomics Initiative Working Group
Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8, Chaojia Chen, Fangcheng Zhao, Jiali Peng, Di Zhao, Liyun Xu, Huayu Li, Shuaiya Ma, Xueqi Peng, Xue Sheng, Yang Sun, Tixiao Wang, Haoqing Dong, Yuming Ding, Zhuanchang Wu, Xiaohong Liang, Lifen Gao, Hongyan Wang, Chunhong Ma, and Chunyang Li
Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation., Edgar Martínez Duncker Rebolledo, Donovan Chan, Karen E Christensen, Alaina M Reagan, Gareth R Howell, Rima Rozen, and Jacquetta Trasler
Spindle assembly checkpoint insensitivity allows meiosis-II despite chromosomal defects in aged eggs., Aleksandar I Mihajlović, Candice Byers, Laura G Reinholdt, and Greg FitzHarris
Staff Training in the Time of COVID-19, Kelly LaRue Brackett
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation., Jone López-Erauskin, Mariana Bravo-Hernandez, Maximiliano Presa, Michael W Baughn, Ze'ev Melamed, Melinda S Beccari, Ana Rita Agra de Almeida Quadros, Olatz Arnold-Garcia, Aamir Zuberi, Karen Ling, Oleksandr Platoshyn, Elkin Niño-Jara, I Sandra Ndayambaje, Melissa McAlonis-Downes, Larissa Cabrera, Jonathan W Artates, Jennifer L Ryan, Anita Hermann, John Ravits, C Frank Bennett, Paymaan Jafar-Nejad, Frank Rigo, Martin Marsala, Cathleen Lutz, Don W Cleveland, and Clotilde Lagier-Tourenne
STOP-AD portal: Selecting the optimal pharmaceutical for preclinical drug testing in Alzheimer's disease., Sara K Quinney, Kandasamy Murugesh, Adrian Oblak, Kristen D. Onos, Michael Sasner, Anna K Greenwood, Kara H Woo, Stacey J Sukoff Rizzo, and Paul R Territo
Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease., Sarah E Heuer, Erik B Bloss, and Gareth R Howell
Structured Prompt Interrogation and Recursive Extraction of Semantics (SPIRES): a method for populating knowledge bases using zero-shot learning., J Harry Caufield, Harshad Hegde, Vincent Emonet, Nomi L Harris, Marcin P Joachimiak, Nicolas Matentzoglu, HyeongSik Kim, Sierra Moxon, Justin T Reese, Melissa A Haendel, Peter N Robinson, and Christopher J Mungall
Sunitinib in Patients With Breast Cancer With, Carmen J Calfa, Michael Rothe, Pam K Mangat, Elizabeth Garrett-Mayer, Eugene R Ahn, Monika L Burness, Keerthi Gogineni, Nitin Rohatgi, Tareq Al Baghdadi, Alison Conlin, Anu Gaba, Omid Hamid, Jairam Krishnamurthy, Naga Jyothi Gavini, Philip J Gold, Jordi Rodon, Jens Rueter, Ramya Thota, Gina N Grantham, Dominique C Hinshaw, Abigail Gregory, Susan Halabi, and Richard L Schilsky
Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity., Meghan L Bucher, Amy R Dunn, Joshua M Bradner, Kristen Stout Egerton, James P Burkett, Michelle A Johnson, and Gary W Miller
Synthetic BZLF1-targeted transcriptional activator for efficient lytic induction therapy against EBV-associated epithelial cancers., Man Wu, Pok Man Hau, Linxian Li, Chi Man Tsang, Yike Yang, Aziz Taghbalout, Grace Tin-Yun Chung, Shin Yee Hui, Wing Chung Tang, Nathaniel L. Jillette, Jacqueline Jufen Zhu, Horace Hok Yeung Lee, Ee Ling Kong, Melissa Sue Ann Chan, Jason Ying Kuen Chan, Brigette Buig Yue Ma, Mei-Ru Chen, Charles Lee, Ka Fai To, Albert Cheng, and Kwok-Wai Lo
Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia., Katherine Knorr, Jahan Rahman, Caroline Erickson, Eric Wang, Mara Monetti, Zhuoning Li, Juliana Ortiz-Pacheco, Andrew Jones, Sydney X Lu, Robert F Stanley, Maria Baez, Nina Fox, Cynthia Castro, Alessandra E Marino, Caroline Jiang, Alex Penson, Simon J Hogg, Xiaoli Mi, Hideaki Nakajima, Hiroyoshi Kunimoto, Koutarou Nishimura, Daichi Inoue, Benjamin Greenbaum, David Knorr, Jeffrey Ravetch, and Omar Abdel-Wahab
Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice., Daniel Mario Gatti, Anna L. Tyler, J Matthew Mahoney, Gary Churchill, Bulent Yener, Deniz Koyuncu, Metin N Gurcan, Mk Khalid Niazi, Thomas Tavolara, Adam Gower, Denise Dayao, Emily McGlone, Melanie L Ginese, Aubrey Specht, Anas Alsharaydeh, Philipe A Tessier, Sherry L Kurtz, Karen L Elkins, Igor Kramnik, and Gillian Beamer
Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults., Paniz Jasbi, Janko Nikolich-Žugich, Jeffrey Patterson, Kenneth S Knox, Yan Jin, George M. Weinstock, Patricia Smith, Homer L Twigg, and Haiwei Gu
Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging., Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A Miller, David E Harrison, John R Strong, Mitchell B Schaffler, and Shoshana Yakar
Term-BLAST-like alignment tool for concept recognition in noisy clinical texts., Tudor Groza, Honghan Wu, Marcel E Dinger, Daniel Danis, Coleman Hilton, Anita Bagley, Jon R Davids, Ling Luo, Zhiyong Lu, and Peter N Robinson
The alliance of genome resources: transforming comparative genomics., Carol J Bult and Paul W Sternberg
The cell-permeant antioxidant D-thiol ester D-cysteine ethyl ester overcomes physical dependence to morphine in male Sprague Dawley rats, Paulina M. Getsy, Gregory A. Coffee, James N. Bates, Theodore Parran, Lee Hoffer, Santhrosh M. Baby, Peter M. MacFarlane, Zackery T. Knauss, Derek S. Damron, Yee-Hsee Hsieh, Jason A. Bubier, Devin Mueller, and Stephen J. Lewis
The complete sequence and comparative analysis of ape sex chromosomes., Kateryna D Makova, Brandon D Pickett, Robert S Harris, Gabrielle A Hartley, Monika Cechova, Karol Pal, Sergey Nurk, DongAhn Yoo, Qiuhui Li, Prajna Hebbar, Barbara C McGrath, Francesca Antonacci, Margaux Aubel, Arjun Biddanda, Matthew Borchers, Erich Bornberg-Bauer, Gerard G Bouffard, Shelise Y Brooks, Lucia Carbone, Laura Carrel, Andrew Carroll, Pi-Chuan Chang, Chen-Shan Chin, Daniel E Cook, Sarah J C Craig, Luciana de Gennaro, Mark Diekhans, Amalia Dutra, Gage H Garcia, Patrick G S Grady, Richard E Green, Diana Haddad, Pille Hallast, William T Harvey, Glenn Hickey, David A Hillis, Savannah J Hoyt, Hyeonsoo Jeong, Kaivan Kamali, Sergei L Kosakovsky Pond, Troy M LaPolice, Charles Lee, Alexandra P Lewis, Yong-Hwee E Loh, Patrick Masterson, Kelly M McGarvey, Rajiv C McCoy, Paul Medvedev, Karen H Miga, Katherine M Munson, Evgenia Pak, Benedict Paten, Brendan J Pinto, Tamara Potapova, Arang Rhie, Joana L Rocha, Fedor Ryabov, Oliver A Ryder, Samuel Sacco, Kishwar Shafin, Valery A Shepelev, Viviane Slon, Steven J Solar, Jessica M Storer, Peter H Sudmant, Sweetalana, Alex Sweeten, Michael G Tassia, Françoise Thibaud-Nissen, Mario Ventura, Melissa A Wilson, Alice C Young, Huiqing Zeng, Xinru Zhang, Zachary A Szpiech, Christian D Huber, Jennifer L Gerton, Soojin V Yi, Michael C Schatz, Ivan A Alexandrov, Sergey Koren, Rachel J O'Neill, Evan E Eichler, and Adam M Phillippy
The DO-KB Knowledgebase: a 20-year journey developing the disease open science ecosystem., J Allen Baron, Claudia Sanchez-Beato Johnson, Michael A Schor, Dustin Olley, Lance Nickel, Victor Felix, James B Munro, Susan M. Bello, Cynthia Bearer, Richard Lichenstein, Katharine Bisordi, Rima Koka, Carol Greene, and Lynn M Schriml
The effects of pathogenic and likely pathogenic variants for inherited hemostasis disorders in 140 214 UK Biobank participants., Luca Stefanucci, Janine Collins, Matthew C Sims, Inigo Barrio-Hernandez, Luanluan Sun, Oliver S Burren, Livia Perfetto, Isobel Bender, Tiffany J Callahan, Kathryn Fleming, Jose A Guerrero, Henning Hermjakob, Maria J Martin, James Stephenson, Kalpana Paneerselvam, Slavé Petrovski, Pablo Porras, Peter N Robinson, Quanli Wang, Xavier Watkins, Mattia Frontini, Roman A Laskowski, Pedro Beltrao, Emanuele Di Angelantonio, Keith Gomez, Mike Laffan, Willem H Ouwehand, Andrew D Mumford, Kathleen Freson, Keren Carss, Kate Downes, Nick Gleadall, Karyn Megy, Elspeth Bruford, and Dragana Vuckovic
The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen., Tathiane M Malta, Thais S Sabedot, Natalia S Morosini, Indrani Datta, Luciano Garofano, Wies Vallentgoed, Frederick S Varn, Kenneth Aldape, Fulvio D'Angelo, Spyridon Bakas, Jill S Barnholtz-Sloan, Hui K Gan, Mohammad Hasanain, Ann-Christin Hau, Kevin C Johnson, Simona Cazacu, Ana C deCarvalho, Mustafa Khasraw, Emre Kocakavuk, Mathilde C M Kouwenhoven, Simona Migliozzi, Simone P Niclou, Johanna M Niers, D Ryan Ormond, Sun Ha Paek, Guido Reifenberger, Peter A Sillevis Smitt, Marion Smits, Lucy F Stead, Martin J van den Bent, Erwin G Van Meir, Annemiek Walenkamp, Tobias Weiss, Michael Weller, Bart A Westerman, Bauke Ylstra, Pieter Wesseling, Anna Lasorella, Pim J French, Laila M Poisson, Roel G W Verhaak, Antonio Iavarone, and Houtan Noushmehr
The Human Phenotype Ontology in 2024: phenotypes around the world., Michael Gargano, Nicolas Matentzoglu, Ben D Coleman, Eunice B Addo-Lartey, Anna V Anagnostopoulos, Joel Anderton, Paul Avillach, Anita M Bagley, Eduard Bakštein, James P Balhoff, Gareth Baynam, Susan M Bello, Michael Berk, Holli Bertram, Somer Bishop, Hannah Blau, David F Bodenstein, Pablo Botas, Kaan Boztug, Jolana Čady, Tiffany J Callahan, Rhiannon Cameron, Seth J Carbon, Francisco Castellanos, J Harry Caufield, Lauren E Chan, Christopher G Chute, Jaime Cruz-Rojo, Noémi Dahan-Oliel, Jon R Davids, Maud de Dieuleveult, Vinicius de Souza, Bert B A de Vries, Esther de Vries, J Raymond DePaulo, Beata Derfalvi, Ferdinand Dhombres, Claudia Diaz-Byrd, Alexander J M Dingemans, Bruno Donadille, Michael Duyzend, Reem Elfeky, Shahim Essaid, Carolina Fabrizzi, Giovanna Fico, Helen V Firth, Yun Freudenberg-Hua, Janice M Fullerton, Davera L Gabriel, Kimberly Gilmour, Jessica Giordano, Fernando S Goes, Rachel Gore Moses, Ian Green, Matthias Griese, Tudor Groza, Weihong Gu, Julia Guthrie, Benjamin Gyori, Ada Hamosh, Marc Hanauer, Kateřina Hanušová, Yongqun Oliver He, Harshad Hegde, Ingo Helbig, Kateřina Holasová, Charles Tapley Hoyt, Shangzhi Huang, Eric Hurwitz, Julius O B Jacobsen, Xiaofeng Jiang, Lisa Joseph, Kamyar Keramatian, Bryan King, Katrin Knoflach, David A Koolen, Megan L Kraus, Carlo Kroll, Maaike Kusters, Markus S Ladewig, David Lagorce, Meng-Chuan Lai, Pablo Lapunzina, Bryan Laraway, David Lewis-Smith, Xiarong Li, Caterina Lucano, Marzieh Majd, Mary L Marazita, Victor Martinez-Glez, Toby H McHenry, Melvin G McInnis, Julie A McMurry, Michaela Mihulová, Caitlin E Millett, Philip B Mitchell, Veronika Moslerová, Kenji Narutomi, Shahrzad Nematollahi, Julian Nevado, Andrew A Nierenberg, Nikola Novák Čajbiková, John I Nurnberger, Soichi Ogishima, Daniel Olson, Abigail Ortiz, Harry Pachajoa, Guiomar Perez de Nanclares, Amy Peters, Tim Putman, Christina K Rapp, Ana Rath, Justin Reese, Lauren Rekerle, Angharad M Roberts, Suzy Roy, Stephan J Sanders, Catharina Schuetz, Eva C Schulte, Thomas G Schulze, Martin Schwarz, Katie Scott, Dominik Seelow, Berthold Seitz, Yiping Shen, Morgan N Similuk, Eric S Simon, Balwinder Singh, Damian Smedley, Cynthia Smith, Jake T Smolinsky, Sarah Sperry, Elizabeth Stafford, Ray Stefancsik, Robin Steinhaus, Rebecca Strawbridge, Jagadish Chandrabose Sundaramurthi, Polina Talapova, Jair A Tenorio Castano, Pavel Tesner, Rhys H Thomas, Audrey Thurm, Marek Turnovec, Marielle E van Gijn, Nicole A Vasilevsky, Markéta Vlčková, Anita Walden, Kai Wang, Ron Wapner, James S Ware, Addo A Wiafe, Samuel A Wiafe, Lisa D Wiggins, Andrew E Williams, Chen Wu, Margot J Wyrwoll, Hui Xiong, Nefize Yalin, Yasunori Yamamoto, Lakshmi N Yatham, Anastasia K Yocum, Allan H Young, Zafer Yüksel, Peter P Zandi, Andreas Zankl, Ignacio Zarante, Miroslav Zvolský, Sabrina Toro, Leigh Carmody, Nomi L Harris, Monica C Munoz-Torres, Daniel Danis, Christopher J Mungall, Sebastian Köhler, Melissa A Haendel, and Peter N Robinson
The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants., Marie Materna, Ottavia M Delmonte, Marita Bosticardo, Mana Momenilandi, Peyton E Conrey, Bénédicte Charmeteau-De Muylder, Clotilde Bravetti, Rebecca Bellworthy, Axel Cederholm, Frederik Staels, Christian A Ganoza, Samuel Darko, Samir Sayed, Corentin Le Floc'h, Masato Ogishi, Darawan Rinchai, Andrea Guenoun, Alexandre Bolze, Taushif Khan, Adrian Gervais, Renate Krüger, Mirjam Völler, Boaz Palterer, Mahnaz Sadeghi-Shabestari, Anne Langlois de Septenville, Chaim A Schramm, Sanjana Shah, John J Tello-Cajiao, Francesca Pala, Kayla Amini, Jose S Campos, Noemia Santana Lima, Daniel Eriksson, Romain Lévy, Yoann Seeleuthner, Soma Jyonouchi, Manar Ata, Fatima Al Ali, Anna Stittrich, Caroline Deswarte, Anaïs Pereira, Jérôme Mégret, Tom Le Voyer, Paul Bastard, Laureline Berteloot, Michaël Dussiot, Natasha Vladikine, Paula P Cardenas, Emmanuelle Jouanguy, Mashael Alqahtani, Amal Hasan, Thangavel Alphonse Thanaraj, Jérémie Rosain, Fahd Al Qureshah, Vito Sabato, Marie Alexandra Alyanakian, Marianne Leruez-Ville, Flore Rozenberg, Elie Haddad, Jose R Regueiro, Maria L Toribio, Judith R Kelsen, Mansoor Salehi, Shahram Nasiri, Mehdi Torabizadeh, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Nasimeh Vatandoost, Hossein Moravej, Seyed Mohammad Akrami, Mohsen Mazloomrezaei, Aurélie Cobat, Isabelle Meyts, Etsushi Toyofuku, Madoka Nishimura, Kunihiko Moriya, Tomoyuki Mizukami, Kohsuke Imai, Laurent Abel, Bernard Malissen, Fahd Al-Mulla, Fowzan Sami Alkuraya, Nima Parvaneh, Horst von Bernuth, Christian Beetz, Frédéric Davi, Daniel C Douek, Rémi Cheynier, David Langlais, Nils Landegren, Nico Marr, Tomohiro Morio, Mohammad Shahrooei, Rik Schrijvers, Sarah E Henrickson, Hervé Luche, Luigi D Notarangelo, Jean-Laurent Casanova, and Vivien Béziat
The loss of βΙ spectrin alters synaptic size and composition in the, Michael C Stankewich, Luanne L. Peters, and Jon S Morrow
The Medical Action Ontology: A tool for annotating and analyzing treatments and clinical management of human disease., Leigh Carmody, Michael Gargano, Sabrina Toro, Nicole A Vasilevsky, Margaret P Adam, Hannah Blau, Lauren E Chan, David Gomez-Andres, Rita Horvath, Megan L Kraus, Markus S Ladewig, David Lewis-Smith, Hanns Lochmüller, Nicolas A Matentzoglu, Monica C Munoz-Torres, Catharina Schuetz, Berthold Seitz, Morgan N Similuk, Teresa N Sparks, Timmy Strauss, Emilia M Swietlik, Rachel Thompson, Xingmin Aaron Zhang, Christopher J Mungall, Melissa A Haendel, and Peter N Robinson
The Monarch Initiative in 2024: an analytic platform integrating phenotypes, genes and diseases across species., Tim E Putman, Kevin Schaper, Nicolas Matentzoglu, Vincent P Rubinetti, Faisal S Alquaddoomi, Corey Cox, J Harry Caufield, Glass Elsarboukh, Sarah Gehrke, Harshad Hegde, Justin T Reese, Ian Braun, Richard M Bruskiewich, Luca Cappelletti, Seth Carbon, Anita R Caron, Lauren E Chan, Christopher G Chute, Katherina G Cortes, Vinícius De Souza, Tommaso Fontana, Nomi L Harris, Emily L Hartley, Eric Hurwitz, Julius O B Jacobsen, Madan Krishnamurthy, Bryan J Laraway, James A McLaughlin, Julie A McMurry, Sierra A T Moxon, Kathleen R Mullen, Shawn T O'Neil, Kent A Shefchek, Ray Stefancsik, Sabrina Toro, Nicole A Vasilevsky, Ramona L Walls, Patricia L Whetzel, David Osumi-Sutherland, Damian Smedley, Peter N Robinson, Christopher J Mungall, Melissa A Haendel, and Monica C Munoz-Torres
The mutant mouse resource and research center (MMRRC) consortium: the US-based public mouse repository system., Yuksel Agca, James Amos-Landgraf, Renee Araiza, Jennifer Brennan, Charisse Carlson, Dominic Ciavatta, Dave Clary, Craig Franklin, Ian Korf, Cathleen Lutz, Terry Magnuson, Fernando Pardo-Manuel de Villena, Oleg Mirochnitchenko, Samit Patel, Dan Port, Laura G Reinholdt, and K C Kent Lloyd
The origin of genetic diversity of indigenous cockfighting chickens of Pakistan by analyzing the mtDNA., Sajid Mahmood, Mian Sayed Khan, Zaib Ullah, Raman Akinyanju Lawal, and Olivier Hanotte
The promises of large language models for protein design and modeling., Giorgio Valentini, Dario Malchiodi, Jessica Gliozzo, Marco Mesiti, Mauricio Soto-Gomez, Alberto Cabri, Justin Reese, Elena Casiraghi, and Peter N Robinson
The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in hypermitotic meningiomas., Nathan Leclair, Calixto-Hope G Lucas, Kanish Mirchia, Kathleen McCortney, Craig M Horbinski, David R Raleigh, and Olga Anczuków
Three linked variants have opposing regulatory effects on isovaleryl-CoA dehydrogenase gene expression., Elizabeth A Brown, Susan Kales, Michael James Boyle, Joseph Vitti, Dylan Kotliar, Steve Schaffner, Ryan Tewhey, and Pardis C Sabeti
Tmod2 Is a Regulator of Cocaine Responses through Control of Striatal and Cortical Excitability and Drug-Induced Plasticity, Arojit Mitra, Sean P Deats, Price E. Dickson, Jiuhe Zhu, Justin M Gardin, Brian J Nieman, R Mark Henkelman, Nien-Pei Tsai, Elissa J Chesler, Zhong-Wei Zhang, and Vivek Kumar
Toward robust clinical genome interpretation: Developing a consistent terminology to characterize Mendelian disease-gene relationships-allelic requirement, inheritance modes, and disease mechanisms., Angharad M Roberts, Marina T DiStefano, Erin Rooney Riggs, Katherine S Josephs, Fowzan S Alkuraya, Joanna Amberger, Mutaz Amin, Jonathan S Berg, Fiona Cunningham, Karen Eilbeck, Helen V Firth, Julia Foreman, Ada Hamosh, Eleanor Hay, Sarah Leigh, Christa L Martin, Ellen M McDonagh, Daniel Perrett, Erin M Ramos, Peter N Robinson, Ana Rath, David W Sant, Zornitza Stark, Nicola Whiffin, Heidi L Rehm, and James S Ware
Transcriptional and functional consequences of Oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells., Logan S Schwartz, Kira Young, Timothy M Stearns, Nathan Boyer, Kristina D Mujica, and Jennifer J. Trowbridge
Transcription factor AP-2 gamma affects porcine early embryo development by regulating epigenetic modification., Daoyu Zhang, Di Wu, Sheng Zhang, Meng Zhang, Yongfeng Zhou, Xinglan An, Qi Li, and Ziyi Li
Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice., Ann E Wells, John J Wilson, Sarah E Heuer, John D Sears, Jian Wei, Raghav Pandey, Mauro W Costa, Catherine Kaczorowski, Derry C. Roopenian, Chih-Hao Chang, and Gregory W. Carter
Transcriptomic data support phylogenetic congruence and reveal genomic changes associated with the repeated evolution of annualism in aplocheiloid killifishes (Cyprinodontiformes)., Andrew W Thompson, Amanda C Black, Yu Huang, Qiong Shi, Andrew I Furness, Ingo Braasch, Federico G Hoffmann, and Guillermo Ortí
TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome., Elizabeth A Werren, Geneva R LaForce, Anshika Srivastava, Delia R Perillo, Shaokun Li, Katherine Johnson, Safa Baris, Brandon Berger, Samantha L Regan, Christian D Pfennig, Sonja de Munnik, Rolph Pfundt, Malavika Hebbar, Raúl Jimenez-Heredia, Elif Karakoc-Aydiner, Ahmet Ozen, Jasmin Dmytrus, Ana Krolo, Ken Corning, E J Prijoles, Raymond J Louie, Robert Roger Lebel, Thuy-Linh Le, Jeanne Amiel, Christopher T Gordon, Kaan Boztug, Katta M Girisha, Anju Shukla, Stephanie L Bielas, and Ashleigh E Schaffer
TRPM2 enhances ischemic excitotoxicity by associating with PKCγ., Pengyu Zong, Jianlin Feng, Nicholas Legere, Yunfeng Li, Zhichao Yue, Cindy X Li, Yasuo Mori, Barbara Miller, Bing Hao, and Lixia Yue
TTN truncation variants produce sarcomere-integrating proteins of uncertain functional significance., J Travis Hinson and Stuart G Campbell
Tuberculosis in otherwise healthy adults with inherited TNF deficiency., Andrés A Arias, Anna-Lena Neehus, Masato Ogishi, Vincent Meynier, Adam Krebs, Tomi Lazarov, Angela M Lee, Carlos A Arango-Franco, Rui Yang, Julio Orrego, Melissa Corcini Berndt, Julian Rojas, Hailun Li, Darawan Rinchai, Lucia Erazo-Borrás, Ji Eun Han, Bethany Pillay, Khoren Ponsin, Matthieu Chaldebas, Quentin Philippot, Jonathan Bohlen, Jérémie Rosain, Tom Le Voyer, Till Janotte, Krishnajina Amarajeeva, Camille Soudée, Marion Brollo, Katja Wiegmann, Quentin Marquant, Yoann Seeleuthner, Danyel Lee, Candice Lainé, Doreen Kloos, Rasheed Bailey, Paul Bastard, Narelle Keating, Franck Rapaport, Taushif Khan, Marcela Moncada-Vélez, María Camila Carmona, Catalina Obando, Jesús Alvarez, Juan Carlos Cataño, Larry Luber Martínez-Rosado, Juan P Sanchez, Manuela Tejada-Giraldo, Anne-Sophie L'Honneur, María L Agudelo, Lizet J Perez-Zapata, Diana M Arboleda, Juan Fernando Alzate, Felipe Cabarcas, Alejandra Zuluaga, Simon J Pelham, Armin Ensser, Monika Schmidt, Margarita M Velásquez-Lopera, Emmanuelle Jouanguy, Anne Puel, Martin Krönke, Stefano Ghirardello, Alessandro Borghesi, Susanta Pahari, Bertrand Boisson, Stefania Pittaluga, Cindy S Ma, Jean-François Emile, Luigi D Notarangelo, Stuart G Tangye, Nico Marr, Nico Lachmann, Hélène Salvator, Larry S Schlesinger, Peng Zhang, Michael S Glickman, Carl F Nathan, Frédéric Geissmann, Laurent Abel, José Luis Franco, Jacinta Bustamante, Jean-Laurent Casanova, and Stéphanie Boisson-Dupuis
Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber., Luana Nunes Santos, Ângela Maria Sousa Costa, Martin Nikolov, João E Carvalho, Allysson Coelho Sampaio, Frank E Stockdale, Gang Feng Wang, Hozana Andrade Castillo, Mariana Bortoletto Grizante, Stefanie Dudczig, Michelle Vasconcelos, Nadia Rosenthal, Patricia Regina Jusuf, Hieu T Nim, Paulo de Oliveira, Tatiana Guimarães de Freitas Matos, William Nikovits, Izabella Luisa Tambones, Ana Carolina Migliorini Figueira, Michael Schubert, Mirana Ramialison, and José Xavier-Neto
Unraveling the genetics of arsenic toxicity with cellular morphology QTL., Callan O'Connor, Gregory R Keele, Whitney Martin, Tim J Stodola, Daniel M Gatti, Brian Hoffmann, Ron Korstanje, Gary Churchill, and Laura G Reinholdt
Unveiling the dynamics of the breast milk microbiome: impact of lactation stage and gestational age., Parul Singh, Noora Al Mohannadi, Selvasankar Murugesan, Fajr Almarzooqi, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Annalisa Terranegra, Rose McGready, François Nosten, Damien Chaussabel, and Souhaila Al Khodor
Updates to the Alliance of Genome Resources central infrastructure., The Alliance of Genome Resources Consortium
Utility of long-read sequencing for All of Us., M Mahmoud, Y Huang, K Garimella, Peter A Audano, W Wan, N Prasad, R E Handsaker, S Hall, A Pionzio, M C Schatz, M E Talkowski, E E Eichler, S E Levy, and F J Sedlazeck
Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging., Kira Young, Maria Telpoukhovskaia, Johanna Hofmann, Jayna J Mistry, Konstantinos D Kokkaliaris, and Jennifer J. Trowbridge
Vitamin D and microRNAs, Hengguang Zhao, Marianela Forcellati, Damien Buschittari, John E. Heckel, Christopher J. Machado, Sri Ramulu N Pullagura, and Thomas S. Lisse
WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration., Alyssa M Coulter, Valerie Cortés, Corey J Theodore, Rachel E Cianciolo, Ron Korstanje, and Kenneth G Campellone
Whole-genome long-read sequencing downsampling and its effect on variant-calling precision and recall., William T Harvey, Peter Ebert, Jana Ebler, Peter A Audano, Katherine M Munson, Kendra Hoekzema, David Porubsky, Christine R Beck, Tobias Marschall, Kiran Garimella, and Evan E Eichler
Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations., Nima Nouri, Raquel Giacomelli Cao, Eleonora Bunsow, Djamel Nehar-Belaid, Radu Marches, Zhaohui Xu, Bennett Smith, Santtu Heinonen, Sara Mertz, Amy Leber, Gaby Smits, Fiona van der Klis, Asunción Mejías, Jacques Banchereau, Virginia Pascual, and Octavio Ramilo